Prostaglandin D 2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

American Association for the Advancement of Science (AAAS) - Tập 4 Số 126 - 2012
Luis A. Garza1, Yaping Liu2, Zaixin Yang1, Brinda Alagesan1, John A. Lawson3, Scott M. Norberg1, Dorothy E. Loy4, Tailun Zhao1, Hanz Blatt1, David C. Stanton5, Lee Carrasco5, Gurpreet S. Ahluwalia6, Susan M. Fischer7, Garret A. FitzGerald3, George Cotsarelis1
1Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
2Screening and Protein Sciences, Merck & Company, North Wales, PA 19454, USA.
3Department of Pharmacology and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
4Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
5Department of Oral and Maxillofacial Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
6Gillette Corporation, Foxborough, MA 02035, USA.
7University of Texas M. D. Anderson Cancer Center, Science Park–Research Division, Smithville, TX 78957, USA.

Tóm tắt

Prostaglandin D 2 inhibits hair growth through its receptor, GPR44, and this pathway could serve as a new target for developing treatments for male pattern baldness.

Từ khóa


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American Association for the Advancement of Science (AAAS)

Tập 4 Số 126

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