Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
No synergistic effect of subtherapeutic doses of donepezil and EVP‐6124 in healthy elderly subjects in a scopolamine challenge model
Tập 5 - Trang 89-98 - 2019
AbstractIntroductionDonepezil is a widely used cholinesterase inhibitor in the
management of Alzheimer's disease. Despite large‐scaled evidence for its
efficacy, elevated peripheral ACh levels often lead to side effects and are dose
limiting. The present exploratory study is designed to determine the
potentiation of the effects of donepezil by cotreatment with EVP‐6124, an
alpha‐7 nicotinic agonis...
A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy
Tập 5 - Trang 579-591 - 2019
AbstractIntroductionNeuroinflammation, which contributes to neurodegeneration,
is a consistent hallmark of dementia. Emerging evidence suggests that systemic
inflammation also contributes to disease progression.MethodsThe ability of
systemically administered lipopolysaccharide (LPS ‐ 500 μg/kg) to effect acute
and chronic behavioural changes in C57BL/6 and P301S tauopathy mice was
assessed. Marker...
Estrogen activates Alzheimer's disease genes
Tập 5 - Trang 906-917 - 2019
AbstractIntroductionWomen are at increased risk for Alzheimer's disease (AD),
but the reason why remains unknown. One hypothesis is that low estrogen levels
at menopause increases vulnerability to AD, but this remains unproven.MethodsWe
compared neuronal genes upregulated by estrogen in ovariectomized female rhesus
macaques with a database of >17,000 diverse gene sets and applied a rare variant
bu...
Randomized, controlled, proof‐of‐concept trial of MK‐7622 in Alzheimer's disease
Tập 4 - Trang 173-181 - 2018
AbstractIntroductionWe evaluated the selective M1 muscarinic positive allosteric
modulator, MK‐7622, as adjunctive cognitive enhancing therapy in individuals
with Alzheimer's disease.MethodsA randomized, double‐blind, proof‐of‐concept
trial was performed. Participants with mild‐to‐moderate Alzheimer's disease,
being treated with an acetylcholinesterase inhibitor, were randomized 1:1 to
45 mg of MK...