Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Hearing treatment for reducing cognitive decline: Design and methods of the Aging and Cognitive Health Evaluation in Elders randomized controlled trial
Tập 4 - Trang 499-507 - 2018
AbstractIntroductionHearing impairment is highly prevalent and independently
associated with cognitive decline. The Aging and Cognitive Health Evaluation in
Elders study is a multicenter randomized controlled trial to determine efficacy
of hearing treatment in reducing cognitive decline in older adults.
Clinicaltrials.gov Identifier: NCT03243422.MethodsEight hundred fifty
participants without deme...
Proof of concept demonstration of optimal composite MRI endpoints for clinical trials
Tập 2 - Trang 177-181 - 2016
AbstractIntroductionAtrophy measures derived from structural MRI are promising
outcome measures for early phase clinical trials, especially for rare diseases
such as primary progressive aphasia (PPA), where the small available subject
pool limits our ability to perform meaningfully powered trials with traditional
cognitive and functional outcome measures.MethodsWe investigated a composite
atrophy ...
Reconsidering frameworks of Alzheimer's dementia when assessing psychosocial outcomes
Tập 5 - Trang 388-397 - 2019
AbstractThe purpose of this introductory article to the special issue on
psychosocial outcome measures in Alzheimer's & Dementia: Translational Research
& Clinical Interventions is to outline new frameworks to more effectively
capture and measure the full range of how people living with Alzheimer's
dementia and their family caregivers experience the disease process.
Specifically, we consider the s...
Insufficient evidence for vitamin E in Alzheimer's disease
Tập 2 - Trang 199-201 - 2016
AbstractVitamin E has recently been suggested to slow down the progression of
Alzheimer's disease. Current evidence is based on three studies in patients with
Alzheimer's disease and one study in patients with mild cognitive impairment
which all together included only 1756 patients. Importantly, two of these
studies were negative, and the two other studies had severe methodological
weaknesses that...