Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy
Tập 5 - Trang 579-591 - 2019
AbstractIntroductionNeuroinflammation, which contributes to neurodegeneration,
is a consistent hallmark of dementia. Emerging evidence suggests that systemic
inflammation also contributes to disease progression.MethodsThe ability of
systemically administered lipopolysaccharide (LPS ‐ 500 μg/kg) to effect acute
and chronic behavioural changes in C57BL/6 and P301S tauopathy mice was
assessed. Marker...
Case‐finding in clinical practice: An appropriate strategy for dementia identification?
Tập 4 - Trang 288-296 - 2018
AbstractEarlier diagnosis of dementia is increasingly being recognized as a
public health priority. As screening is not generally recommended, case‐finding
in clinical practice is encouraged as an alternative dementia identification
strategy. The approaches of screening and case‐finding are often confused, with
uncertainty about what case‐finding should involve and under what circumstances
it is a...
The relative efficiency of time‐to‐progression and continuous measures of cognition in presymptomatic Alzheimer's disease
Tập 5 - Trang 308-318 - 2019
AbstractIntroductionClinical trials on preclinical Alzheimer's disease are
challenging because of the slow rate of disease progression. We use a simulation
study to demonstrate that models of repeated cognitive assessments detect
treatment effects more efficiently than models of time to
progression.MethodsMultivariate continuous data are simulated from a Bayesian
joint mixed‐effects model fit to d...
A metabolite‐based machine learning approach to diagnose Alzheimer‐type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
Tập 5 - Trang 933-938 - 2019
AbstractIntroductionMachine learning (ML) may harbor the potential to capture
the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the
performance of metabolites in blood to categorize AD when compared to CSF
biomarkers.MethodsThis study analyzed samples from 242 cognitively normal (CN)
people and 115 with AD‐type dementia utilizing plasma metabolites (n = 883).
Deep Learnin...