Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
A novel two‐day intervention reduces stress in caregivers of persons with dementia
Tập 4 - Trang 450-460 - 2018
AbstractIntroductionCaregivers of individuals with dementia are at heightened
risk for stress‐related mental and physical illnesses, and this problem is
growing. There is a critical need to develop effective interventions for
caregivers. This study tested whether a 2‐day intervention improved
psychological health in caregivers of individuals with dementia.MethodsFamily
caregivers (N = 104) were ra...
Alzheimer's disease Archimedes condition‐event simulator: Development and validation
Tập 4 - Trang 76-88 - 2018
AbstractIntroductionSeveral advances have been made in Alzheimer's Disease (AD)
modeling, however, there remains a need for a simulator that represents the full
scope of disease progression and can be used to study new disease‐modifying
treatments for early‐stage and even prodromal AD.MethodsWe developed AD
Archimedes condition‐event simulator, a patient‐level simulator with a focus on
simulating ...
African Americans are less likely to enroll in preclinical Alzheimer's disease clinical trials
Tập 3 - Trang 57-64 - 2017
AbstractIntroductionAlzheimer's disease (AD) incidence is disproportionately
high in African Americans, yet, recruitment of this community to AD clinical
trials is challenging.MethodsWe compared 47 African Americans and 78 whites in
their willingness to enroll in a hypothetical preclinical AD trial and examined
barriers and facilitators in their decision making.ResultsAfrican American race
(OR = 0...
Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease
Tập 5 - Trang 740-750 - 2019
AbstractIntroductionNeuronal p3‐Alcβ peptides are generated from the precursor
protein Alcadein β (Alcβ) through cleavage by α‐ and γ‐secretases of the amyloid
β (Aβ) protein precursor (APP). To reveal whether p3‐Alcβ is involved in
Alzheimer's disease (AD) contributes for the development of novel therapy and/or
drug targets.MethodsWe developed new sandwich enzyme‐linked immunosorbent assay
(sELIS...