Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
Tolerability of ORM‐12741 and effects on episodic memory in patients with Alzheimer's disease
Tập 3 - Trang 1-9 - 2017
AbstractIntroductionORM‐12741 is a novel selective antagonist of alpha‐2C
adrenoceptors. This trial evaluated the safety and efficacy of ORM‐12741 in
patients with Alzheimer's disease (AD).MethodsA randomized, double‐blind,
placebo‐controlled, exploratory phase 2a trial was conducted in 100 subjects
with AD and neuropsychiatric symptoms. Participants were randomized to receive
one of two flexible ...
TOMMORROW neuropsychological battery: German language validation and normative study
Tập 4 - Trang 314-323 - 2018
AbstractIntroductionAssessment of preclinical Alzheimer's disease (AD) requires
reliable and validated methods to detect subtle cognitive changes. The battery
of standardized cognitive assessments that is used for diagnostic criteria for
mild cognitive impairment due to AD in the TOMMORROW study have only been fully
validated in English‐speaking countries. We conducted a validation and normative
s...
Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease
Tập 2 - Trang 182-191 - 2016
AbstractIntroductionVitamin E family, composed by tocopherols and tocotrienols,
is a group of compounds with neuroprotective properties. The exact role in the
pathogenesis and the benefit of vitamin E as treatment for Alzheimer's disease
(AD) are still under debate.MethodsA literature search in PubMed, Medline, and
Cochrane databases has been carried out. All types of studies, from bench and
anima...
The Brain Health Champion study: Health coaching changes behaviors in patients with cognitive impairment
Tập 5 - Trang 771-779 - 2019
AbstractIntroductionConverging evidence suggests that increasing healthy
behaviors may slow or prevent cognitive decline.MethodsWe piloted a six‐month,
randomized, controlled investigation of 40 patients with mild dementia, mild
cognitive impairment, or subjective cognitive decline. The intervention
consisted of weekly motivational interviewing phone calls and three visits with
a “Brain Health Cha...