Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977–2017
Tập 5 - Trang 146-153 - 2019
AbstractIntroductionPregnancy losses may be associated with increased risks of
dementia.MethodsWe conducted a register‐based cohort study in 1,243,957 women
with ≥1 pregnancy in Denmark in the period 1977–2015. Using Cox regression, we
estimated hazard ratios (HRs) comparing risks of dementia in women with and
without pregnancy losses.ResultsDuring 21,672,433 person‐years of follow‐up,
261,279 wom...
Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5
Tập 3 - Trang 668-677 - 2017
AbstractIntroductionAmyloid‐related decline in semantic memory was recently
shown to be observable in the preclinical period of Alzheimer's disease.
Cognitive composites designed to be sensitive to cognitive change in preclinical
Alzheimer's disease (e.g., preclinical Alzheimer's cognitive composite [PACC])
and currently used in secondary prevention trials do not currently integrate
measures of se...
Technology for home dementia care: A prototype locating system put to the test
Tập 3 - Trang 332-338 - 2017
AbstractIntroductionThe user experience of persons with dementia and their
primary caregivers with locating systems is not firmly
established.MethodsEighteen dyads used a prototype locating system during 4
weeks. Primary outcome measures were ratings of usability, and product functions
and features. Secondary outcome measures were caregiver burden, perceived
self‐efficacy, frequency of use, and wi...
Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort
Tập 4 - Trang 645-651 - 2018
AbstractIntroductionThe objective of this study was to determine the frequency
and clinical and cognitive characteristics of preclinical Alzheimer's disease
(AD) in a Japanese population to effectively design and conduct future
preventive trials on preclinical AD.MethodsThree‐year longitudinal data from
cognitively normal participants who underwent cerebrospinal fluid biomarker
measurement and/or ...