Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Inflammation as a central mechanism in Alzheimer's disease
Tập 4 Số 1 - Trang 575-590 - 2018
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
Online study partner‐reported cognitive decline in the Brain Health Registry
Tập 4 - Trang 565-574 - 2018
AbstractIntroductionMethods for efficiently identifying cognitive decline and
Alzheimer's disease (AD) are a critical unmet need. The goal of this work was to
validate novel online study partner (SP)‐reported outcomes to identify cognitive
decline in older adults.MethodsIn older adults enrolled in the Brain Health
Registry, we analyzed associations between SP‐reported cognitive decline,
measured b...
Adherence/Retention Alzheimer's Prevention Initiative Colombia Plan
Tập 4 - Trang 283-287 - 2018
AbstractIntroductionThe Alzheimer's Prevention Initiative Colombia Trial is a
collaborative project involving the Neurosciences Group of Antioquia,
Genentech/Roche, and the Banner Alzheimer's Institute, studying whether
crenezumab can delay or prevent the clinical onset of Alzheimer's disease in
cognitively unimpaired individuals who carry the PSEN1 E280A mutation. In an
effort to optimize partici...
Poor cerebrovascular function is an early marker of cognitive decline in healthy postmenopausal women
Tập 2 - Trang 162-168 - 2016
AbstractIntroductionImpairment of cerebrovascular function becomes evident after
menopause. No study has yet explored relationships between deficits in
cerebrovascular function, cognitive performance, and mood in postmenopausal
women.MethodCerebrovascular function was assessed in 80 healthy postmenopausal
women by monitoring blood flow velocity (BFV) in the middle and posterior
cerebral arteries u...
Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary report
Tập 3 - Trang 177-188 - 2017
AbstractIntroductionTraumatic brain injury (TBI) and posttraumatic stress
disorder (PTSD) have previously been reported to be associated with increased
risk of Alzheimer's disease (AD). We are using biomarkers to study Vietnam
Veterans with/without mild cognitive impairment with a history of at least one
TBI and/or ongoing PTSD to determine whether these contribute to the development
of AD.Methods...