Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
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Inflammation as a central mechanism in Alzheimer's disease
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AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
Tập 3 Số 3 - Trang 367-384 - 2017
AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Tập 3 Số 3 - Trang 291-300 - 2017
AbstractCognitive decline leading to dementia represents a global health burden.
In the absence of targeted pharmacotherapy, lifestyle approaches remain the best
option for slowing the onset of dementia. However, older adults spend very
little time doing moderate to vigorous exercise and spend a majority of time in
sedentary behavior. Sedentary behavior has been linked to poor glycemic control
and...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
Tập 4 - Trang 444-449 - 2018
AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
Tập 3 - Trang 273-283 - 2017
AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia
Tập 2 - Trang 48-59 - 2016
AbstractIntroductionBetter understanding of suicide risk and its management in
older adults with cognitive impairment and/or dementia remain significant unmet
public health needs. Urgency to address them derives from concern that CNS
treatments for dementia may impact suicide risk. Regulatory guidances requiring
assessment of emergent suicidal ideation and behavior (SI/SB) at every clinical
trial ...
A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects
Tập 1 - Trang 182-195 - 2015
AbstractIntroductionPyroglutamate‐amyloid‐β (pE‐Aβ) peptides are major
components of Aβ‐oligomers and Aβ‐plaques, which are regarded as key culprits of
Alzheimer's disease (AD) pathology. PQ912 is a competitive inhibitor of the
enzyme glutaminyl cyclase (QC), essential for the formation of pE‐Aβ
peptides.MethodsA randomized, double‐blind, placebo‐controlled, single‐ and
multiple‐ascending oral dos...
Key factors for the assessment of mobility in advanced dementia: A consensus approach
Tập 5 - Trang 409-419 - 2019
AbstractIntroductionLoss of mobility is common in advanced dementia and has
important negative consequences related to fall risk, loss of independence, and
lack of participation in meaningful activities. The causes of decline are
multifactorial, including disease‐specific changes in motor function, behavior,
and cognition. To optimize clinical management of mobility, there is a need to
better char...
Assessment of need and practice for assistive technology and telecare for people with dementia—The ATTILA (Assistive Technology and Telecare to maintain Independent Living At home for people with dementia) trial
Tập 5 - Trang 420-430 - 2019
AbstractIntroductionThe objective of this study was to define current assistive
technology and telecare (ATT) practice for people with dementia living at
home.MethodsThis is a randomized controlled trial (N = 495) of ATT assessment
and ATT installation intervention, compared with control (restricted ATT
package). ATT assessment and installation data were collected. Qualitative work
identified valu...