Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
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Inflammation as a central mechanism in Alzheimer's disease
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AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
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AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
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AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
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AbstractCognitive decline leading to dementia represents a global health burden.
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AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
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from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
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AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
(mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of
community‐dwe...
Forecasting the progression of Alzheimer's disease using neural networks and a novel preprocessing algorithm
Tập 5 - Trang 483-491 - 2019
AbstractIntroductionThere is a 99.6% failure rate of clinical trials for drugs
to treat Alzheimer's disease, likely because Alzheimer's disease (AD) patients
cannot be easily identified at early stages. This study investigated machine
learning approaches to use clinical data to predict the progression of AD in
future years.MethodsData from 1737 patients were processed using the “All‐Pairs”
techniq...
Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse
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AbstractIntroductionTranslational inhibition of amyloid precursor protein (APP)
by Posiphen has been shown to reduce APP and its fragments in cell culture,
animal models, and mildly cognitively impaired patients, making it a promising
drug candidate for the treatment of Alzheimer's disease.MethodsWe used a mouse
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pharma...
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AbstractIntroductionThe objective of this study was to define current assistive
technology and telecare (ATT) practice for people with dementia living at
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Minimotifs dysfunction is pervasive in neurodegenerative disorders
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AbstractMinimotifs are modular contiguous peptide sequences in proteins that are
important for posttranslational modifications, binding to other molecules, and
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proteins in cellular pathways can be predicted from minimotif consensus
sequences identified through experimentation. While a role for minimotifs in
regulating si...