Alzheimer's and Dementia: Translational Research and Clinical Interventions
ESCI-ISI SCOPUS (2015-2025)
2352-8737
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Psychiatry and Mental HealthNeurology (clinical)
Phân tích ảnh hưởng
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Inflammation as a central mechanism in Alzheimer's disease
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AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder
that is characterized by cognitive decline and the presence of two core
pathologies, amyloid β plaques and neurofibrillary tangles. Over the last
decade, the presence of a sustained immune response in the brain has emerged as
a third core pathology in AD. The sustained activation of the brain's resident
macrophages (micro...
Alzheimer's disease drug development pipeline: 2018
Tập 4 Số 1 - Trang 195-214 - 2018
AbstractIntroductionTreatments for Alzheimer's disease (AD) are needed due to
the growing number of individuals with preclinical, prodromal, and dementia
forms of AD. Drug development for AD therapies can be examined by inspecting the
drug development pipeline as represented on
clinicaltrials.gov.MethodsClinicaltrials.gov was assessed as of January 30, 2018
to determine AD therapies represented in...
Alzheimer's disease drug development pipeline: 2017
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AbstractIntroductionThere is an urgent need to develop new treatments for
Alzheimer's disease (AD) and to understand the drug development process for new
AD therapies.MethodsWe assessed the agents in the AD pipeline as documented in
clinicaltrials.gov for phase I, phase II, and phase III, accessed
1/5/2017.ResultsThere are 105 agents in the AD treatment development pipeline,
of which 25 agents are...
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
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AbstractCognitive decline leading to dementia represents a global health burden.
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sedentary behavior. Sedentary behavior has been linked to poor glycemic control
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Amyloid‐associated increases in longitudinal report of subjective cognitive complaints
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AbstractIntroductionTo investigate whether baseline subjective cognitive
complaints (SCCs) predict longitudinal decline on neuropsychological testing and
whether SCC increases longitudinally, in the setting of high levels of amyloid
burden.MethodsTwo hundred seventy‐nine clinically normal older participants
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community‐dwe...
Accelerating drug development for Alzheimer's disease through the use of data standards
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AbstractIntroductionThe exceedingly high rate of failed trials in Alzheimer's
disease (AD) calls for immediate attention to improve efficiencies and learning
from past, ongoing, and future trials. Accurate, highly rigorous standardized
data are at the core of meaningful scientific research. Data standards allow for
proper integration of clinical data sets and represent the essential foundation
for...
TOMMORROW neuropsychological battery: German language validation and normative study
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AbstractIntroductionAssessment of preclinical Alzheimer's disease (AD) requires
reliable and validated methods to detect subtle cognitive changes. The battery
of standardized cognitive assessments that is used for diagnostic criteria for
mild cognitive impairment due to AD in the TOMMORROW study have only been fully
validated in English‐speaking countries. We conducted a validation and normative
s...
Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide
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AbstractThe research into vascular contributions to cognitive impairment and
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impact on dementia‐related disease burden and is thus a critical emerging
objective in dementia research. This article presents VCID consortia focused on
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Insufficient evidence for vitamin E in Alzheimer's disease
Tập 2 - Trang 199-201 - 2016
AbstractVitamin E has recently been suggested to slow down the progression of
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Alzheimer's disease and one study in patients with mild cognitive impairment
which all together included only 1756 patients. Importantly, two of these
studies were negative, and the two other studies had severe methodological
weaknesses that...
FDA position statement “Early Alzheimer's disease: Developing drugs for treatment, Guidance for Industry”
Tập 5 - Trang 13-19 - 2019
AbstractDespite billions of dollars invested in clinical trials to develop novel
therapeutics for Alzheimer's disease, no approved treatments have been developed
in the past 15 years. In that span, new classes of drugs have been developed and
tested, including monoclonal antibodies, γ‐secretase modulators, γ‐secretase
inhibitors, BACE inhibitors, RAGE inhibitors, nicotinic agonists, 5HT6
antagonis...