Design of the ExCersion‐VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 157-165 - 2017
Anna E. Leeuwis1, Astrid M. Hooghiemstra1, Raquel Amier2, Doeschka A. Ferro3, Leonie Franken1, Robin Nijveldt, Joost P.A. Kuijer4, Anne-Sophie G.T. Bronzwaer5,6, Johannes J. van Lieshout5,6,7, Marc B. Rietberg8, Janne M. Veerbeek8, Rosalie J. Huijsmans8, Frank J.G. Backx9, Charlotte E. Teunissen10, Esther E. Bron11, Frederik Barkhof12,13,14, Niels D. Prins1, Rahil Shahzad15, Wiro J. Niessen11,16, Albert de Roos17
1Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
2Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
3Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
4Department of Physics and Medical Technology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
5Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
6Laboratory for Clinical Cardiovascular Physiology, Center for Heart Failure Research, Academic, Medical Center, Amsterdam, The Netherlands
7MRC/ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, The Medical School, University of Nottingham, United Kingdom
8Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
9Department of Rehabilitation, Physical Therapy Science and Sport, University Medical Centre Utrecht, Utrecht, The Netherlands
10Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
11Biomedical Imaging Group Rotterdam, Departments of Medical Informations and Radiology, Erasmus MC, Rotterdam, The Netherlands
12Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
13Institute of Neurology, UCL, London, United Kingdom
14Institute of Healthcare Engineering, UCL, London, United Kingdom
15Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
16Imaging Physics, Applied Sciences, Delft University of Technology, Delft, The Netherlands
17Department of Radiology, C.J. Gorter Center for high field MRI, Leiden University Medical Center, Leiden, The Netherlands

Tóm tắt

AbstractThere is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single‐blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini‐Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 3

157-165

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