Alzheimer's and Dementia: Translational Research and Clinical Interventions

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The prevalence and biomarkers’ characteristic of rapidly progressive Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 107-113 - 2017
Maowen Ba, Xiaofeng Li, Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Pedro Rosa-Neto, Serge Gauthier
AbstractIntroductionThe prevalence and detailed biomarkers’ characteristic of rapidly progressive Alzheimer's disease (rpAD) remain incompletely understood.MethodsA total of 312 mild AD patients from the Alzheimer's Disease Neuroimaging Initiative database were chosen and dichotomized into rpAD and non‐rpAD groups. We performed the prevalence and comprehensive biomarker evaluation.ResultsThe preva... hiện toàn bộ
The price of progress: Funding and financing Alzheimer's disease drug development
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 330-343 - 2018
Jeffrey Cummings, Carl Reiber, Parvesh Kumar
AbstractIntroductionAdvancing research and treatment for Alzheimer's disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding approaches.MethodsWe conducted an expert review of the literature pertaining to funding and financing of translational research and drug development f... hiện toàn bộ
Proton pump inhibitors and the risk of severe cognitive impairment: The role of posttraumatic stress disorder
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 579-583 - 2017
Sean A.P. Clouston, Oren Shapira, Roman Kotov, Lan Lei, Monika Waszczuk, Evelyn J. Bromet, Benjamin J. Luft
AbstractIntroductionProton pump inhibitors (PPIs), a common treatment for gastroesophageal reflux disease (GERD), were recently associated with increased risk of dementia. However, severe or chronic stress including, for example, posttraumatic stress disorder (PTSD) was not accounted for. This study examined whether PPI use was associated with severe cognitive impairment (SCI) and whether PTSD exp... hiện toàn bộ
Bladder antimuscarinics and cognitive decline in elderly patients
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 139-148 - 2017
Daniela Claudia Moga, Erin L. Abner, Qishan Wu, Gregory A. Jicha
AbstractIntroductionThe evidence on the impact of bladder antimuscarinics initiation on cognitive function in older adults is inconsistent.MethodsA retrospective analysis of data from the National Alzheimer's Coordinating Center (NACC) on enrollees 65 years and older evaluated the association between antimuscarinic initiation and cognitive decline. We defined decline from baseline (yes/no) for cog... hiện toàn bộ
The relative efficiency of time‐to‐progression and continuous measures of cognition in presymptomatic Alzheimer's disease
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 308-318 - 2019
Dan Li, Samuel Iddi, Paul S. Aisen, Wesley K. Thompson, Michael C. Donohue
AbstractIntroductionClinical trials on preclinical Alzheimer's disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression.MethodsMultivariate continuous data are simulated from a Bayesian joint mixed‐effects model fit to d... hiện toàn bộ
General and domain‐specific cognitive reserve, mild cognitive impairment, and dementia risk in older women
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 118-128 - 2019
Andrew J. Petkus, Susan M. Resnick, Stephen R. Rapp, Mark A. Espeland, Margaret Gatz, Keith F. Widaman, Xinhui Wang, Diana Younan, Ramon Casanova, Helena Chui, Ryan T. Barnard, Sarah Gaussoin, Joseph S. Goveas, Kathleen M. Hayden, Victor W. Henderson, Bonnie C. Sachs, Santiago Saldana, Aladdin H. Shadyab, Sally A. Shumaker, Jiu-Chiuan Chen
AbstractIntroductionIn a geographically diverse sample of women, we asked whether cognitive reserve (CR) is best viewed as a general or cognitive domain‐specific construct and whether some cognitive reserve domains but not others exert protective effects on risk of developing mild cognitive impairment (MCI) or dementia.MethodsEstimates of general and domain‐specific CR were derived via variance de... hiện toàn bộ
Design of a Bayesian adaptive phase 2 proof‐of‐concept trial for BAN2401, a putative disease‐modifying monoclonal antibody for the treatment of Alzheimer's disease
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 2 - Trang 1-12 - 2016
Andrew Satlin, Jinping Wang, Veronika Logovinsky, Scott Berry, Chad Swanson, Shobha Dhadda, Donald A. Berry
AbstractIntroductionRecent failures in phase 3 clinical trials in Alzheimer's disease (AD) suggest that novel approaches to drug development are urgently needed. Phase 3 risk can be mitigated by ensuring that clinical efficacy is established before initiating confirmatory trials, but traditional phase 2 trials in AD can be lengthy and costly.MethodsWe designed a Bayesian adaptive phase 2, proof‐of... hiện toàn bộ
Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 645-651 - 2018
Ryoko Ihara, Atsushi Iwata, Kazushi Suzuki, Takeshi Ikeuchi, Ryozo Kuwano, Takeshi Iwatsubo
AbstractIntroductionThe objective of this study was to determine the frequency and clinical and cognitive characteristics of preclinical Alzheimer's disease (AD) in a Japanese population to effectively design and conduct future preventive trials on preclinical AD.MethodsThree‐year longitudinal data from cognitively normal participants who underwent cerebrospinal fluid biomarker measurement and/or ... hiện toàn bộ
Feasibility of an at‐home, web‐based, interactive exercise program for older adults
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 825-833 - 2019
Nicole C. Feng, Eliza Ryan, Mhretab Kidane, Erich S. Tusch, Brittany M. McFeeley, Roger Carlsson, Abdul H. Mohammed, Krister Håkansson, Kirk R. Daffner
AbstractIntroductionIncreased physical exercise is linked to enhanced brain health and reduced dementia risk. Exercise intervention studies usually are conducted at facilities in groups under trainer supervision. To improve scalability, accessibility, and engagement, programs may need to be structured such that individuals can execute and adjust routines in their own homes.MethodsOne hundred eight... hiện toàn bộ
Neural correlates of episodic memory in the Memento cohort
Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 224-233 - 2018
Stephane Epelbaum, Vincent Bouteloup, Jean F. Mangin, Valentina La Corte, Raffaela Migliaccio, Hugo Bertin, Marie O. Habert, Clara Fischer, Chabha Azouani, Ludovic Fillon, Marie Chupin, Bruno Vellas, Florence Pasquier, Jean F. Dartigues, Fréderic Blanc, Audrey Gabelle, Mathieu Ceccaldi, Pierre Krolak-Salmon, Jacques Hugon, Olivier Hanon
AbstractIntroductionThe free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.MethodsWe investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients pre... hiện toàn bộ
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