Neural correlates of episodic memory in the Memento cohort

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 224-233 - 2018
Stephane Epelbaum1,2, Vincent Bouteloup3,4, Jean F. Mangin5,6, Valentina La Corte7,8, Raffaela Migliaccio1,2, Hugo Bertin5,9,10, Marie O. Habert5,9,10, Clara Fischer5,6, Chabha Azouani5, Ludovic Fillon5, Marie Chupin5, Bruno Vellas11,12, Florence Pasquier13, Jean F. Dartigues3,14, Fréderic Blanc15, Audrey Gabelle16,17, Mathieu Ceccaldi18,19, Pierre Krolak-Salmon20, Jacques Hugon21, Olivier Hanon22
1Institut de la mémoire et de la maladie d'Alzheimer, Département de neurologie, Hôpital de la Pitié Salpêtrière, Paris, France
2Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, and Inserm U 1127, and CNRS UMR 7225, and ICM, Paris, France
3Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France
4CHU de Bordeaux, Pole Santé Publique, Bordeaux, France
5CATI Multicenter Neuroimaging platform, http://cati-neuroimaging.com, Gif sur Yvette, France
6Neurospin, DRF, CEA, Paris Saclay University, Gif sur Yvette, France
7Institut de Psychologie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
8Inserm UMR 894, Centre de psychiatrie et neurosciences, Laboratoire mémoire et cognition, Paris, France
9Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d’Imagerie Biomédicale, Paris, France
10Département de Médecine Nucléaire, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France
11Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
12Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France
13Univ Lille, Inserm 1171, CHU, Centre Mémoire (CMRR) Distalz, Lille, France
14CHU de Bordeaux, CMRR, Pôle Neurosciences, Bordeaux, France
15Centre Mémoire (CMRR), Hôpital Universitaire de Strasbourg, Département de Gériatrie, Hôpital de Jour Gériatrique, Strasbourg, France
16Department of Neurology and Memory Research and Resources Center, Gui de Chauliac University Hospital, Montpellier, France
17CHRU de Montpellier, Université de Montpellier, Institute of Regenerative Medicine and Bio-therapy (IRMB), INSERM U1183, CCBHM, Laboratoire de Biochimie Protéomique Clinique, Montpellier, France
18Université Aix-Marseille, INSERM, Institut des Neurosciences des Systèmes (INS) UMR 1106, Marseille, France
19APHM, Hôpitaux de la Timone, Service de Neurologie et de Neuropsychologie, Marseille, France
20Clinical and Research Memory Center of Lyon, Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France
21Centre Mémoire (CMRR) Paris Nord Ile de France, Groupe Hospitalier Lariboisiere FW Saint-Louis, APHP, Université Paris Diderot, Paris, France
22Service de Gériatrie, Université Paris Descartes, Hôpital Broca, Paris, France

Tóm tắt

AbstractIntroductionThe free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.MethodsWe investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose–positron emission tomography evaluations.ResultsEncoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions.DiscussionThe neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.

Tài liệu tham khảo

Tulving E., 1972, Organization of Memory Birrer R.B., 2004, Depression in later life: a diagnostic and therapeutic challenge, Am Fam Physician, 69, 2375 10.1037/a0020857 10.1212/WNL.0b013e3181cef85d 10.1016/S1474-4422(14)70090-0 10.1016/j.neuropsychologia.2013.01.013 10.1212/WNL.58.8.1188 10.1212/WNL.54.9.1760 10.1002/ana.21509 10.1056/NEJMoa1202753 10.3233/JAD-150013 10.1212/01.WNL.0000055813.36504.BF 10.1001/archneur.57.6.839 10.1101/cshperspect.a006171 10.1212/WNL.56.9.1133 10.1016/j.jalz.2016.12.003 10.1016/j.jalz.2014.01.001 10.1037/h0026069 10.1016/j.jalz.2016.12.014 10.1212/WNL.0b013e31828ab2c9 Lemos R., 2015, The free and cued selective reminding test for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: a prospective longitudinal study, J Neuropsychol, 11, 40, 10.1111/jnp.12075 10.1212/01.wnl.0000279336.36610.f7 10.1016/S1474-4422(07)70178-3 10.1136/jnnp.58.5.590 10.3233/JAD-2010-091150 10.1038/nrn2459 10.3758/BF03212412 10.1016/j.neuropsychologia.2016.05.006 10.1093/cercor/bhm048 10.1016/j.cortex.2008.07.003 10.1162/jocn.2008.20091 10.1016/S1053-8119(03)00179-4 10.1016/j.neuroimage.2005.09.025 10.1002/hipo.20406 10.1162/jocn.2009.21344 10.1016/j.bandc.2012.05.004 10.1186/s13195-017-0288-0 10.1212/WNL.43.11.2412-a 10.1212/WNL.38.6.900 Van der Linden M., 2004, L'évaluation des troubles de la mémoire: présentation de quatre tests de mémoire épisodique avec leur étalonnage, 25 Rey A., 1941, L'examen psychologique dans les cas d'encéphalopathie traumatique, Arch de Psychol, 28, 286 10.1111/j.1365-2796.2004.01388.x 10.1016/j.neuroimage.2005.02.018 10.1016/j.neuroimage.2009.02.013 10.1016/j.neuroimage.2006.10.035 10.1016/j.neuroimage.2006.01.021 10.1073/pnas.200033797 10.1186/s40658-016-0141-8 10.1016/j.neuroimage.2015.07.075 10.1002/sim.4780090710 10.1093/aje/kwk017 10.1111/j.1541-0420.2006.00573.x 10.1136/jnnp.2005.068726 10.1016/j.neurobiolaging.2009.12.018 10.1006/nimg.2002.1063 10.1016/j.neuroimage.2008.06.006 10.1016/j.neurobiolaging.2008.02.005 10.1212/WNL.0b013e3181df0959 10.1097/WAD.0b013e3181cfc78b 10.1136/jnnp-2013-305078 10.1002/ana.22615 10.1007/BF00308809 10.1016/j.neuron.2016.01.028 10.1212/WNL.58.12.1791 10.1093/brain/awv112 10.1212/WNL.0000000000003812 10.1212/01.WNL.0000055847.17752.E6 10.1073/pnas.2635903100 10.1212/WNL.54.4.827 10.1016/j.neuroimage.2010.09.005 10.1212/WNL.0b013e31823efc6c 10.4088/JCP.15m10413 10.1016/j.jalz.2014.10.003 10.1016/j.neurobiolaging.2007.03.004 10.1056/NEJMoa050151 10.1016/S1474-4422(18)30029-2 10.1001/jamaneurol.2014.803 10.1016/j.trci.2017.10.004 Chhetri J.K., 2018, Trajectory of the MAPT‐PACC‐preclinical Alzheimer cognitive composite in the Placebo Group of a Randomized Control Trial: results from the MAPT Study: lessons for Further Trials, J Prev Alzheimer's Dis, 5, 31 10.1162/jocn.2009.21314 10.1073/pnas.1602413113 10.1007/s12021-016-9295-8 10.3233/JAD-142280
Thông tin
Thông tin xuất bản

Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 4

224-233

Thông tin tác giả