Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 Số 3 - Trang 291-300 - 2017
Michael J. Wheeler1,2, Paddy C. Dempsey1,3, Megan S. Grace1, Kathryn A. Ellis4,5,6, Paul A. Gardiner7,8, Daniel J. Green9,2, David W. Dunstan1,10,2
1Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
2School of Human Sciences (Exercise and Sport Science), The University of Western Australia Perth Western Australia Australia
3Swinburne University of Technology, Melbourne, Victoria, Australia
4Department of PsychiatryUniversity of MelbourneParkvilleVictoriaAustralia
5The Florey Institute of Neuroscience and Mental Health, The University of Melbourne Parkville Parkville Victoria Australia
6The Florey Institute of Neuroscience and Mental Health, The University of Melbourne ParkvilleParkvilleVictoriaAustralia
7Centre for Health Services Research The University of Queensland South Brisbane Queensland Australia
8Mater Research Institute, The University of Queensland, South Brisbane, Queensland, Australia
9Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
10Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia

Tóm tắt

AbstractCognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all‐cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light‐intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.

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Thông tin xuất bản

Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 3 Số 3

291-300

Thông tin tác giả