Advanced Science

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Cancer Cells Enter an Adaptive Persistence to Survive Radiotherapy and Repopulate Tumor
Advanced Science - Tập 10 Số 8 - 2023
Yucui Zhao, Tingting Lü, Yanwei Song, Yanqin Wen, Zheng Deng, Jiahui Fan, Minghui Zhao, Ruyi Zhao, Yuntao Luo, Jianzhu Xie, Binjie Hu, Haoran Sun, Yiwei Wang, Sijia He, Yanping Gong, Jin Cheng, Xinjian Liu, Yukui Zhang, Jikun Li, Chuan‐Yuan Li, Yongyong Shi, Qian Huang
AbstractRepopulation of residual tumor cells impedes curative radiotherapy, yet the mechanism is not fully understood. It is recently appreciated that cancer cells adopt a transient persistence to survive the stress of chemo‐ or targeted therapy and facilitate eventual relapse. Here, it is shown that cancer cells likewise enter a “radiation‐tolerant persister” (RTP) state to evade radiation pressu... hiện toàn bộ
Aldehyde Dehydrogenase 2 Mediates Alcohol‐Induced Colorectal Cancer Immune Escape through Stabilizing PD‐L1 Expression
Advanced Science - Tập 8 Số 10 - 2021
Hong Zhang, Yuhui Xia, Fang Wang, Min Luo, Ke Yang, Shaobo Liang, Sainan An, Shaocong Wu, Chuan Yang, Da Chen, Meng Xu, Muyan Cai, Kenneth K.W. To, Liwu Fu
AbstractDespite the great success of immunotherapy in a small subset of cancer patients, most colorectal cancer (CRC) patients do not respond to programmed cell death receptor 1 (PD‐1) blockade immunotherapy. There is an urgent medical need to elucidate how cancer cells evade immune response and to develop novel means to boost the efficacy of immune checkpoint inhibitors. In this study, alcohol in... hiện toàn bộ
Phase‐Changing Microcapsules Incorporated with Black Phosphorus for Efficient Solar Energy Storage
Advanced Science - Tập 7 Số 23 - 2020
Hao Huang, Tongyu Shi, Rui He, Jiahong Wang, Paul K. Chu, Xue‐Feng Yu
AbstractA new solar energy storage system is designed and synthesized based on phase‐changing microcapsules incorporated with black phosphorus sheets (BPs). BPs are 2D materials with broad light absorption and high photothermal performance, which are synthesized and covalently modified with poly(methyl methacrylate) (PMMA) to produce the PMMA‐modified BPs (mBPs). With the aid of PMMA, the mBPs and... hiện toàn bộ
Lead‐Free Halide Double Perovskite Nanocrystals for Light‐Emitting Applications: Strategies for Boosting Efficiency and Stability
Advanced Science - Tập 8 Số 7 - 2021
Huidong Tang, Yanqiao Xu, Xiaobo Hu, Qing Hu, Ting Chen, Weihui Jiang, Lianjun Wang, Wan Jiang
AbstractLead‐free halide double perovskite (HDP) nanocrystals are considered as one of the most promising alternatives to the lead halide perovskite nanocrystals due to their unique characteristics of nontoxicity, robust intrinsic thermodynamic stability, rich and tunable optoelectronic properties. Although lead‐free HDP variants with highly efficient emission are synthesized and characterized, th... hiện toàn bộ
Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?
Advanced Science - Tập 5 Số 2 - 2018
Lusheng Liang, Peng Gao
AbstractMany years since the booming of research on perovskite solar cells (PSCs), the hybrid perovskite materials developed for photovoltaic application form three main categories since 2009: (i) high‐performance unstable lead‐containing perovskites, (ii) low‐performance lead‐free perovskites, and (iii) moderate performance and stable lead‐containing perovskites. The search for alternative materi... hiện toàn bộ
Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors
Advanced Science - Tập 9 Số 10 - 2022
Ruotao Li, Kai Liu, Xu Huang, Di Li, Jianxun Ding, Bin Liu, Xuesi Chen
AbstractSkin wound repair is a multistage process involving multiple cellular and molecular interactions, which modulate the cell behaviors and dynamic remodeling of extracellular matrices to maximize regeneration and repair. Consequently, abnormalities in cell functions or pathways inevitably give rise to side effects, such as dysregulated inflammation, hyperplasia of nonmigratory epithelial cell... hiện toàn bộ
Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing
Advanced Science - Tập 9 Số 11 - 2022
Xiaoliang Qi, Yijing Huang, Shengye You, Yajing Xiang, Erya Cai, Ruiting Mao, Wenhao Pan, Xianqin Tong, Wei Dong, Fangfu Ye, Jianliang Shen
AbstractPolydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in photothermal antibacterial therapy due to their ease of synthesis, good biodegradability, long‐term safety, and excellent photostability. However, the therapeutic effects of PDA nanoparticles are generally limited by the low photothermal conversion efficiency (PCE). Herein, PDA@Ag nanoparticles ... hiện toàn bộ
Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery
Advanced Science - Tập 6 Số 5 - 2019
Yuanxin Chen, Xiujie Liu, Yuan Hou, Zhaogang Yang, Christina A. Von Roemeling, Yaqing Qie, Zhao Hai, Yifan Wang, Wen Jiang, Betty Y.S. Kim
AbstractA major challenge in the development of cancer nanomedicine is the inability for nanomaterials to efficiently penetrate and deliver therapeutic agents into solid tumors. Previous studies have shown that tumor vasculature and extracellular matrix regulate the transvascular and interstitial transport of nanoparticles, both critical for successfully delivering nanomedicine into solid tumors. ... hiện toàn bộ
Spontaneous Alignment of Graphene Oxide in Hydrogel during 3D Printing for Multistimuli‐Responsive Actuation
Advanced Science - Tập 7 Số 6 - 2020
Mingchao Zhang, Yiliang Wang, Muqiang Jian, Chunya Wang, Xiaoping Liang, Jiali Niu, Yingying Zhang
AbstractNatural materials are often compositionally and structurally heterogeneous for realizing particular functions. Inspired by nature, researchers have designed hybrid materials that possess properties beyond each of the components. Particularly, it remains a great challenge to realize site‐specific anisotropy, which widely exists in natural materials and is responsible for unique mechanical p... hiện toàn bộ
Materials Design and System Construction for Conventional and New‐Concept Supercapacitors
Advanced Science - Tập 4 Số 6 - 2017
Zhong Wu, Lin Li, Jun‐Min Yan, Xinbo Zhang
With the development of renewable energy and electrified transportation, electrochemical energy storage will be more urgent in the future. Supercapacitors have received extensive attention due to their high power density, fast charge and discharge rates, and long‐term cycling stability. During past five years, supercapacitors have been boomed benefited from the development of nanostructured materi... hiện toàn bộ
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