Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing

Advanced Science - Tập 9 Số 11 - 2022
Xiaoliang Qi1, Yijing Huang2, Shengye You3, Yajing Xiang3, Erya Cai3, Ruiting Mao3, Wenhao Pan3, Xianqin Tong3, Wei Dong2, Fangfu Ye4, Jianliang Shen5,1,4
1State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
2School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China
3School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
4Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China
5Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325001, China

Tóm tắt

AbstractPolydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in photothermal antibacterial therapy due to their ease of synthesis, good biodegradability, long‐term safety, and excellent photostability. However, the therapeutic effects of PDA nanoparticles are generally limited by the low photothermal conversion efficiency (PCE). Herein, PDA@Ag nanoparticles are synthesized via growing Ag on the surface of PDA nanoparticles and then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits a high PCE (38.2%), which is more than two times higher than that of pure PDA (16.6%). More importantly, the formulated CG/PDA@Ag hydrogel with many active groups can capture and kill bacteria through effective interactions between hydrogel and bacteria, thereby benefiting the antibacterial effect. As anticipated, the designed CG/PDA@Ag system combined the advantages of PDA@Ag nanoparticles (high PCE) and hydrogel (preventing aggregation of PDA@Ag nanoparticles and possessing inherent antibacterial ability) is demonstrated to have superior antibacterial efficacy both in vitro and in vivo. This study develops a facile approach to boost the PCE of PDA for photothermal antibacterial therapy, providing a significant step forward in advancing the application of PDA nano‐photothermal agents.

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Advanced Science

Tập 9 Số 11

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