Addiction Biology
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Identifying the neural circuitry of alcohol craving and relapse vulnerability
Addiction Biology - Tập 14 Số 1 - Trang 108-118 - 2009
ABSTRACTWith no further intervention, relapse rates in detoxified alcoholics are
high and usually exceed 80% of all detoxified patients. It has been suggested
that stress and exposure to priming doses of alcohol and to alcohol‐associated
stimuli (cues) contribute to the relapse risk after detoxification. This article
focuses on neuronal correlates of cue responses in detoxified alcoholics.
Current...
Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment
Addiction Biology - Tập 24 Số 4 - Trang 754-764 - 2019
AbstractThis investigation was designed to determine the effect of melatonin
supplementation on mental health parameters, metabolic and genetic profiles in
patients under methadone maintenance treatment (MMT). This randomized,
double‐blind, placebo‐controlled, clinical trial was conducted among 54 patients
under MMT. Participants were randomly allocated to receive either 10 mg
melatonin (2 melaton...
Gender differences in the pharmacology of nicotine addiction
Addiction Biology - Tập 3 Số 4 - Trang 383-404 - 1998
AbstractSmoking rates have declined in recent years less rapidly in women than
in men. More adolescent girls than boys are currently smoking. Quitting smoking
is reported in many studies to be more difficult in women than in men. These
observations suggest that there may be gender differences in the nature of
nicotine addiction. Gender differences in various pharmacological processes
involved in n...
Cocaine use severity and cerebellar gray matter are associated with reversal learning deficits in cocaine-dependent individuals
Addiction Biology - Tập 20 Số 3 - Trang 546-556 - 2015
Nicotine self‐administration reverses cognitive deficits in a rat model for schizophrenia
Addiction Biology - Tập 23 Số 2 - Trang 620-630 - 2018
AbstractHigh comorbidity between schizophrenia and tobacco addiction has been
well established. Explanatory theories include nicotine as a cognitive enhancer
ameliorating symptoms of schizophrenia and underlying shared substrates
increasing susceptibility to addiction in these individuals. To test these
non‐mutually exclusive theories, the maternal immune activation (MIA) model was
utilized. To th...
The effect of tobacco smoking on subjective symptoms of inadequacy (“not holding”) of methadone dose among opiate addicts in methadone maintenance treatment
Addiction Biology - Tập 6 Số 2 - Trang 137-145 - 2001
AbstractThe objective of this study was to examine the relationship between
subjective symptoms of inadequacy of methadone dose (not feeling “held”) and
tobacco smoking in patients in methadone maintenance treatment (MMT). This was a
cross‐sectional study of smoking behaviour, investigating subjective,
physiological and psychological symptoms. The study took place in a
community‐based methadone ma...
Ethanol metabolism in the brain
Addiction Biology - Tập 2 Số 4 - Trang 387-400 - 1997
AbstractAcetaldehyde is suspected of being involved in the central mechanism of
central nervous system depression and addiction to ethanol, but in contrast to
ethanol, it can not penetrate easily from blood into the brain because of
metabolic barriers. Therefore, the possibility of ethanol metabolism and
acetaldehyde formation inside the brain has been one of the crucial questions in
biomedical re...
Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test
Addiction Biology - Tập 17 Số 1 - Trang 33-46 - 2012
ABSTRACTGenetic aspects of alcoholism have been modeled using rats selectively
bred for extremes of alcohol preference and voluntary alcohol intake. These
lines show similar alcohol drinking phenotypes but have different genetic and
environmental backgrounds and may therefore display diverse behavioral traits as
seen in human alcoholics. The multivariate concentric square field™ (MCSF) test
is des...
REVIEW: The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake
Addiction Biology - Tập 11 Số 3-4 - Trang 310-323 - 2006
ABSTRACTEthanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an
original Wistar colony have been selectively bred at the University of Chile for
over 70 generations. Two main differences between these lines are clear. (1)
Drinker rats display a markedly faster acute tolerance than non‐drinker rats. In
F2 UChA × UChB rats (in which all genes are ‘shuffled’), a high acute tolerance
o...
Neural network activation during a stop‐signal task discriminates cocaine‐dependent from non‐drug‐abusing men
Addiction Biology - Tập 19 Số 3 - Trang 427-438 - 2014
AbstractCocaine dependence is defined by a loss of inhibitory control over
drug‐use behaviors, mirrored by measurable impairments in laboratory tasks of
inhibitory control. The current study tested the hypothesis that deficits in
multiple subprocesses of behavioral control are associated with reliable
neural‐processing alterations that define cocaine addiction. While undergoing
functional magnetic...
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