Addiction Biology

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Identifying the neural circuitry of alcohol craving and relapse vulnerability
Addiction Biology - Tập 14 Số 1 - Trang 108-118 - 2009
Andreas Heinz, Anne Beck, Sabine M. Grüsser, Anthony A. Grace, Jana Wrase
ABSTRACTWith no further intervention, relapse rates in detoxified alcoholics are high and usually exceed 80% of all detoxified patients. It has been suggested that stress and exposure to priming doses of alcohol and to alcohol‐associated stimuli (cues) contribute to the relapse risk after detoxification. This article focuses on neuronal correlates of cue responses ...... hiện toàn bộ
Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment
Addiction Biology - Tập 24 Số 4 - Trang 754-764 - 2019
Amir Ghaderi, Hamid Reza Banafshe, Naghmeh Mirhosseini, Maryam Motmaen, Fatemeh Mehrzad, Fereshteh Bahmani, Esmat Aghadavod, Mohammad Alì Mansournia, Rüssel J. Reiter, Mohammad‐Amin Karimi, Zatollah Asemi
AbstractThis investigation was designed to determine the effect of melatonin supplementation on mental health parameters, metabolic and genetic profiles in patients under methadone maintenance treatment (MMT). This randomized, double‐blind, placebo‐controlled, clinical trial was conducted among 54 patients under MMT. Participants were randomly allocated to receive ...... hiện toàn bộ
Gender differences in the pharmacology of nicotine addiction
Addiction Biology - Tập 3 Số 4 - Trang 383-404 - 1998
Neal L. Benowitz, Dorothy K. Hatsukami
AbstractSmoking rates have declined in recent years less rapidly in women than in men. More adolescent girls than boys are currently smoking. Quitting smoking is reported in many studies to be more difficult in women than in men. These observations suggest that there may be gender differences in the nature of nicotine addiction. Gender differences in various pharma...... hiện toàn bộ
Cocaine use severity and cerebellar gray matter are associated with reversal learning deficits in cocaine-dependent individuals
Addiction Biology - Tập 20 Số 3 - Trang 546-556 - 2015
Laura Moreno-López, José C. Perales, Dana Van Son, Natalia Albein‐Urios, Carles Soriano‐Mas, José Miguel Martínez González, Reínout W. Wiers, Antonio Verdejo‐García
Nicotine self‐administration reverses cognitive deficits in a rat model for schizophrenia
Addiction Biology - Tập 23 Số 2 - Trang 620-630 - 2018
Uta Waterhouse, Katharine A. Brennan, Bart Ellenbroek
AbstractHigh comorbidity between schizophrenia and tobacco addiction has been well established. Explanatory theories include nicotine as a cognitive enhancer ameliorating symptoms of schizophrenia and underlying shared substrates increasing susceptibility to addiction in these individuals. To test these non‐mutually exclusive theories, the maternal immune activatio...... hiện toàn bộ
The effect of tobacco smoking on subjective symptoms of inadequacy (“not holding”) of methadone dose among opiate addicts in methadone maintenance treatment
Addiction Biology - Tập 6 Số 2 - Trang 137-145 - 2001
Ulrich Tacke, Kim Wolff, Emily Finch, John Strang
AbstractThe objective of this study was to examine the relationship between subjective symptoms of inadequacy of methadone dose (not feeling “held”) and tobacco smoking in patients in methadone maintenance treatment (MMT). This was a cross‐sectional study of smoking behaviour, investigating subjective, physiological and psychological symptoms. The study took place ...... hiện toàn bộ
Ethanol metabolism in the brain
Addiction Biology - Tập 2 Số 4 - Trang 387-400 - 1997
С. М. Зиматкин, Richard A. Deitrich
AbstractAcetaldehyde is suspected of being involved in the central mechanism of central nervous system depression and addiction to ethanol, but in contrast to ethanol, it can not penetrate easily from blood into the brain because of metabolic barriers. Therefore, the possibility of ethanol metabolism and acetaldehyde formation inside the brain has been one of the c...... hiện toàn bộ
Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test
Addiction Biology - Tập 17 Số 1 - Trang 33-46 - 2012
Erika Roman, Robert B. Stewart, Megan L. Bertholomey, Meredith L. Jensen, Giancarlo Colombo, Petri Hyytiä, Nancy E. Badia‐Elder, Nicholas J. Grahame, Ting‐Kai Li, Lawrence Lumeng
ABSTRACTGenetic aspects of alcoholism have been modeled using rats selectively bred for extremes of alcohol preference and voluntary alcohol intake. These lines show similar alcohol drinking phenotypes but have different genetic and environmental backgrounds and may therefore display diverse behavioral traits as seen in human alcoholics. The multivariate concentric...... hiện toàn bộ
REVIEW: The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake
Addiction Biology - Tập 11 Số 3-4 - Trang 310-323 - 2006
Marı́a Elena Quintanilla, Yedy Israel, Amalia Sapag, Lutske Tampier
ABSTRACTEthanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar colony have been selectively bred at the University of Chile for over 70 generations. Two main differences between these lines are clear. (1) Drinker rats display a markedly faster acute tolerance than non‐drinker rats. In F2... hiện toàn bộ
Neural network activation during a stop‐signal task discriminates cocaine‐dependent from non‐drug‐abusing men
Addiction Biology - Tập 19 Số 3 - Trang 427-438 - 2014
Amanda Elton, J. A. Young, Sonet Smitherman, Robin Gross, Tanja Mletzko, Clinton D. Kilts
AbstractCocaine dependence is defined by a loss of inhibitory control over drug‐use behaviors, mirrored by measurable impairments in laboratory tasks of inhibitory control. The current study tested the hypothesis that deficits in multiple subprocesses of behavioral control are associated with reliable neural‐processing alterations that define cocaine addiction. Whi...... hiện toàn bộ
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