Acta Psychiatrica Scandinavica
1600-0447
0001-690X
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
Psychiatry and Mental Health
Phân tích ảnh hưởng
Thông tin về tạp chí
Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
Các bài báo tiêu biểu
Psychometric properties of the Temperament and Character Inventory (TCI) questionnaire in a Spanish psychiatric population Objective: The psychometric properties of the Spanish version of Cloninger's Temperament and Character Inventory (TCI) were examined in a psychiatric population. Method: Internal consistency, factor structure and concurrent validity were studied in a sample of 416 psychiatric patients. Results: A moderate to high internal consistency for all personality dimensions was found, except for Persistence. A confirmatory factor analysis of the TCI performed at the subscale level revealed an uncertain factor structure. However, when analysed separately, both the 11 temperament subscales (plus Persistence) and the 13 character subscales shaped four and three factors, respectively, in agreement with the biosocial model of personality. Finally, concurrent validity analyses were conducted using EPQ, SPSR and SSS questionnaires showing results consistent with theory. Conclusion: The Spanish version of the TCI is a reliable and valid instrument, although the Persistence dimension might require further revision.
Tập 103 Số 2 - Trang 143-147 - 2001
Diabetes and schizophrenia – effect of disease or drug? Results from a randomized, double‐blind, controlled prospective study in first‐episode schizophrenia Objective: There have been innumerable advances in the pharmacotherapy of schizophrenia, but problems have emerged hand‐in‐glove, such as the presence of treatment‐emergent glucose intolerance and frank diabetes mellitus (DM).Method: Medication‐naïve patients with schizophrenia (n = 99) underwent baseline fasting and 2 h post‐prandial plasma glucose measurements repeated after 6 weeks after randomization to receive olanzapine, risperidone or haloperidol. The results were compared with a matched healthy control group.Results: A significant difference (P = 0.002) in baseline 2 h post‐prandial blood sugar (PPBS) was noted between the control group and the treatment group along with a significant increase in weight (P < 0.001), fasting blood sugar (P = 0.01) and 2 h PPBS (P < 0.001) from baseline to endpoint between the groups. A statistical significance in the incidence of DM at endpoint by the WHO criteria (10.1%) was also noted.Conclusion: Male patients with schizophrenia are liable to develop DM. Antipsychotic treatment leads to the development of DM in a significant 10.1% within 6 weeks.
Tập 117 Số 5 - Trang 342-347 - 2008
Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis in major depression Goldstein MR, Plante DT, Hulse BK, Sarasso S, Landsness EC, Tononi G, Benca RM. Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis in major depression. Objective: Sleep homeostasis is altered in major depressive disorder (MDD). Pre‐ to postsleep decline in waking auditory evoked potential (AEP) amplitude has been correlated with sleep slow wave activity (SWA), suggesting that overnight changes in waking AEP amplitude are homeostatically regulated in healthy individuals. This study investigated whether the overnight change in waking AEP amplitude and its relation to SWA is altered in MDD.Method: Using 256‐channel high‐density electroencephalography, all‐night sleep polysomnography and single‐tone waking AEPs pre‐ and postsleep were collected in 15 healthy controls (HC) and 15 non‐medicated individuals with MDD.Results: N1 and P2 amplitudes of the waking AEP declined after sleep in the HC group, but not in MDD. The reduction in N1 amplitude also correlated with fronto‐central SWA in the HC group, but a comparable relationship was not found in MDD, despite equivalent SWA between groups. No pre‐ to postsleep differences were found for N1 or P2 latencies in either group. These findings were not confounded by varying levels of alertness or differences in sleep variables between groups.Conclusion: MDD involves altered sleep homeostasis as measured by the overnight change in waking AEP amplitude. Future research is required to determine the clinical implications of these findings.
Tập 125 Số 6 - Trang 468-477 - 2012
Symptomatic recovery and social functioning in major depression Objective: To determine whether social functional recovery precedes, runs in parallel with, or lags behind symptomatic recovery from major depressive episodes. Method: Psychiatric out‐patients or in‐patients aged 18 years or over, diagnosed with unipolar major depressive disorder according to DSM‐IV, and who had received no antidepressant medication in the preceding 3 months were identified at 23 collaborating centres from all over Japan (n =95). They were rated with the 17‐item Hamilton Rating Scale for Depression (HRSD) and the Global Assessment Scale (GAS) monthly, and with the Social Adjustment Scale‐Self Report (SAS‐SR) 6‐monthly. Remission was defined as 7 or less on the HRSD and recovery as 2 or more consecutive months of remission. Results: The GAS ratings showed continuous amelioration from baseline to remission, remission to recovery, and after sustained recovery. The same trends were observed for SAS‐SR scores. Conclusion: We can expect further amelioration in social adjustment after symptomatic remission and recovery of major depressive episodes.
Tập 103 Số 4 - Trang 257-261 - 2001
Atypical antipsychotics and weightgain — a systematic review Objective: To review systematically data relating to weight changes with atypical antipsychotics. Method: We conducted a Medline search on October 29 1999 and covered the period 1980–99. All recovered papers were examined for further relevant reports. In addition, we wrote to pharmaceutical manufacturers and 10 practising clinicians to ask them to provide other relevant reports known to them. Results: Eighty reports mentioning change in body weight were retrieved. Data relating to weight changes were of variable quality. Weight changes were indicated by a variety of measures. The majority of reports related to short‐term changes. Conclusion: All atypical drugs, with the exception of ziprasidone, have been associated with weight increases. Clozapine seems to have the highest risk of weight gain, followed by olanzapine and quetiapine. There is probably a lower risk with risperidone, sertindole and zotepine and a still lower risk with amisulpride. Ziprasidone appears not to be associated with weight gain. In the absence of more compelling data, these rankings must be considered approximate and preliminary. Longer, more robust trials are needed.
Tập 101 Số 6 - Trang 416-432 - 2000
Internal consistency and factor structure of the Chinese Health Questionnaire ABSTRACT The internal consistency and factor structure of the Chinese Health Questionnaire (CHQ) were investigated in 2 samples in Taiwan, one from 3 communities (n = 1023) and the other from consecutive attenders for health screening in a general hospital (n = 386). Cronbach's alpha coefficients were calculated to be 0.84 and 0.83 for the 12‐item and 0.90 and 0.92 for the 30‐item CHQ version. Four factors similarly extracted for the CHQ‐30 in both samples include somatic symptoms, anxiety and worrying, social dysfunction, and depression and poor family relationship. The implications of these findings were discussed from a cross‐cultural perspective.
Tập 82 Số 4 - Trang 304-308 - 1990
The effect of temperament and character on response to selective serotonin reuptake inhibitors in panic disorder Objective: In this prospective study, temperament and character were evaluated in patients with panic disorder (PD), before 1 year of medication therapy, to verify whether these factors influenced the outcome of treatment.Method: Seventy‐one PD patients were evaluated with the SCID‐IV, the Temperament and Character Inventory (TCI), the SCL‐90, the Ham‐A and the Ham‐D. Patients were treated with pharmacotherapy and were evaluated monthly over 1 year.Results: Before treatment, non‐remitted patients showed higher levels of harm avoidance (HA) and lower levels of persistence (P), self‐directedness (SD) and cooperativeness (C), whereas remitted patients showed only higher levels of HA. After controlling the effect of the confounding variables, the likelihood to achieve remission was positively related to SD score (OR = 1.12; P = 0.002), particularly ‘self‐acceptance’ SD dimension (OR = 1.30; P = 0.02).Conclusions: Our data suggest that in PD: i) the evaluation of personality, using the Cloninger's model, confirms the presence of personality pathology as one predictor of non‐response to treatment; ii) in patients with low SD a combination of medication and cognitive‐behaviour therapy should be the most effective treatment.
Tập 114 Số 3 - Trang 203-210 - 2006
A comparative study of immune status in panic disorder patients and controls Alterations of immunocompetence in various mental disorders have been reported. We studied white blood cell counts and immunoglobulin levels in 59 panic disorder patients and 30 controls. The significantly increased IgA levels and tendency toward increase in other immunoglobulins in panic disorder patients suggest an immune dysfunction.
Tập 84 Số 4 - Trang 396-397 - 1991
Abnormal thalamic volume in treatment‐naïve boys with Tourette syndrome Objective: Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment‐naïve boys with TS using magnetic resonance imaging (MRI).Method: Volumetric MRI was performed on 18 treatment‐naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume.Results: Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects.Conclusion: Our findings provide new evidence of abnormal thalamic volume in pediatric TS.
Tập 113 Số 1 - Trang 64-67 - 2006
A double‐blind randomized placebo‐controlled study of the efficacy and safety of pirlindole, a reversible monoamine oxidase A inhibitor, in the treatment of depression The efficacy and safety of pirlindole (300 mg/day), a new reversible inhibitor of monoamine oxidase A, have been evaluated in a multicentre placebo‐controlled double‐blind randomized trial in 103 in‐patients suffering from unipolar major depression (DSM‐III‐R 296.2, 296.3) over a 42‐day period after a run‐in placebo period of 6 days. Pirlindole produced a significantly greater decrease than placebo in the Hamilton depression score (from day 28), the Hamilton anxiety score (from day 28) and the Montgomery‐Asberg depression score (on day 42). On day 42, the Hamilton depression score was ≤ 7, ≥8 and ≤15, or ≥16 in 21 %, 45% and 34%, respectively, in the placebo group compared to 72%, 24% and 3.4%, respectively, in the pirlindole group (P < 0.001). The differences between the two groups in terms of tolerance and safety were not statistically significant.
Tập 94 Số 6 - Trang 404-410 - 1996