Role of interferons and other cytokines in the regulation of the immune responseAPMIS - Tập 103 Số 1-6 - Trang 161-179 - 1995
Filippo Belardelli
Cytokines represent the major factors involved in the communication between T cells, macrophages and other immune cells in the course of an immune response to antigens and infectious agents. A number of studies on mouse and human T helper (Th) clones have recently provided extensive evidence for the existence of different activities exhibited by Th cells (called Th1 and Th2), which was app...... hiện toàn bộ
erm genes in erythromycin‐resistant Staphylococcus aureus and coagulase‐negative staphylococciAPMIS - Tập 103 Số 1-6 - Trang 225-232 - 1995
Henrik Westh, David M. Hougaard, Jens Vuust, V T Rosdahl
Erythromycin‐resistant S. aureus from general practice and a dermatology ward with a very high consumption of erythromycin was studied for ermA and ermC content by Southern blot analysis. The prevalence of these erm genes was also studied in coagulase‐negative staphylococci from the ...... hiện toàn bộ
Foreign DNA in mammalian systemsAPMIS - Tập 106 Số S84 - Trang 62-68 - 1998
Walter Doerfler, Rainer Schubbert, Hilde Heller, Jennifer Hertz, Ralph Remus, Jörg Schröer, Christina Kämmer, Kristina Hilger-Eversheim, URTE GERHARDT, Birgit Schmitz, Doris Renz, Gudrun Schell
Lactoferrin: A multifunctional glycoproteinAPMIS - Tập 107 Số 7-12 - Trang 971-981 - 1999
Lars H. Vorland
Lactoferrin is an iron‐binding glycoprotein found in milk, exocrine secretions of mammals, and in secondary granules from polymorphonuclear neutrophils. This review describes the wide spectrum of functions ascribed to lactoferrin, with special emphasis on the antimicrobial properties of this protein, and its derived peptides.
Endogenous angiogenesis inhibitorsAPMIS - Tập 112 Số 7-8 - Trang 496-507 - 2004
Judah Folkman
When the FDA commissioner announced in February 2004 the approval of Avastin for the treatment of patients with colon cancer, he called angiogenesis inhibitors a fourth modality of anti‐cancer therapy. Because angiogenesis inhibitors are relatively less toxic than conventional chemotherapy and have a lower risk of drug resistance, they may also represent a new class of anti‐cancer agents, ...... hiện toàn bộ
The Legionella micdadei flagellin: Expression in Escherichia coli K 12 and DNA sequence of the geneAPMIS - Tập 103 Số 7-8 - Trang 869-877 - 1995
Jette Bangsborg, Peter Hindersson, G H Shand, Niels Høiby
To study the structure and function of the Legionella flagellum, we screened a genomic L. micdadei library in Escherichia coli for expression of the flagellin (Fla) subunit. One recombinant clone, JM105 (pHI5588), producing a truncated Fla protein of 40.5 kDa was identified. The plasmid pHI5588 carried a ... hiện toàn bộ
Pathophysiological effects of human TNF‐alpha‐producing tumor xenografts in immunosuppressed miceAPMIS - Tập 107 Số 7-12 - Trang 903-912 - 1999
Tünde Nagy, T. J ́nossy, Csaba Vízler, K Bohus, Frank Joa, P Végh, E. Duda
Groups of CBA mice immunosuppressed with antithymocyte serum (ATS) treatment were xeno‐transplanted with either HeLa human cervical carcinoma cells or genetically modified cells expressing the human tumor necrosis factor‐α (TNF) gene (All cells). Both cell lines were highly resistant to the cytotoxic effects of TNF. If 3 times 106 tumor cells were inoculated s.c. into ...... hiện toàn bộ