APMIS
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3‐Hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in miceStatins, 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG ‐CoA ) reductase inhibitors, have been shown to ameliorate a number of vascular diseases. We evaluated the inflammatory and angiogenic components of the fibrovascular tissue induced by subcutaneous implants in mice and... ... hiện toàn bộ
APMIS - Tập 121 Số 5 - Trang 422-430 - 2013
Dental biofilm infections – an updateTeeth are colonized by oral bacteria from saliva containing more than 700 different bacterial species. If removed regularly, the dental biofilm mainly comprises oral streptococci and is regarded as resident microflora. But if left undisturbed, a complex biofilm containing up to 100 bacterial species at a site will build up and may eventually cause development of disease. Depending on local... ... hiện toàn bộ
APMIS - Tập 125 Số 4 - Trang 376-384 - 2017
Lipofuscin: Mechanisms of formation and increase with ageLipofuscin (age pigment) is a brown‐yellow, electron‐dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes. The exact mechanisms behind this accumulation are still unclear. This review outlines the present knowledge of age pigment formation, and considers possible mechanisms responsible for the incre... ... hiện toàn bộ
APMIS - Tập 106 Số 1-6 - Trang 265-276 - 1998
APMIS - Tập 124 Số 6 - Trang 453-461 - 2016
Immunological mechanisms of contact hypersensitivity in miceChristensen AD, Haase C. Immunological mechanisms of contact hypersensitivity in mice. APMIS 2012; 120: 1–27. Contact hypersensitivity (CHS) is an animal model in which the immunological mechanisms of allergic contact dermatitis (ACD) in humans can be studied but is also widely used in the study of many basic immunological mechanisms. In CHS, a pre‐sensitized animal is re‐e... ... hiện toàn bộ
APMIS - Tập 120 Số 1 - Trang 1-27 - 2012
Pathophysiological effects of human TNF‐alpha‐producing tumor xenografts in immunosuppressed miceGroups of CBA mice immunosuppressed with antithymocyte serum (ATS) treatment were xeno‐transplanted with either HeLa human cervical carcinoma cells or genetically modified cells expressing the human tumor necrosis factor‐α (TNF) gene (All cells). Both cell lines were highly resistant to the cytotoxic effects of TNF. If 3 times 106 tumor cells were inoculated s.c. into ... ... hiện toàn bộ
APMIS - Tập 107 Số 7-12 - Trang 903-912 - 1999
TNF blockade in rheumatoid arthritis: Implications for therapy and pathogenesisThe role of the immune response in rheumatoid arthritis (RA) is a subject of debate, although it is widely believed to be a T‐cell‐driven disease. Progress is being hindered by lack of convincing evidence of a defined specific antigen initiating or perpetuating the response. Clinical trials using monoclonal antibodies directed against T‐cell surface molecules such as CD4, CD5, and CD7 have... ... hiện toàn bộ
APMIS - Tập 105 Số 1-6 - Trang 257-263 - 1997
Evaluation of the rapid loop‐mediated isothermal amplification assay Illumigene for diagnosis of C lostridium difficile in an outbreak situation
APMIS - Tập 122 Số 2 - Trang 155-160 - 2014
The Legionella micdadei flagellin: Expression in Escherichia coli K 12 and DNA sequence of the geneTo study the structure and function of the Legionella flagellum , we screened a genomic L. micdadei library in Escherichia coli for expression of the flagellin (Fla) subunit. One recombinant clone, JM105 (pHI5588), producing a truncated Fla protein of 40.5 kDa was identified. The plasmid pHI5588 carried a ... hiện toàn bộ
APMIS - Tập 103 Số 7-8 - Trang 869-877 - 1995
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