Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence

Ahl, 1991, Subclass distribution of salivary secretory immunoglobulin A antibodies to oral streptococci., Infect. Immun., 59, 3619, 10.1128/IAI.59.10.3619-3625.1991

Ahl, 1991, Detection of immunoglobulin A1 protease-induced Fab alpha fragments on dental plaque bacteria., Infect. Immun., 59, 563, 10.1128/IAI.59.2.563-569.1991

Bachovchin, 1990, Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids., J. Biol. Chem., 265, 3738, 10.1016/S0021-9258(19)39656-5

Barington, 1994, Heavy-chain isotype patterns of human antibody-secreting cells induced by Haemophilus influenzae type b conjugate vaccines in relation to age and preimmunity., Infect. Immun., 62, 3066, 10.1128/IAI.62.8.3066-3074.1994

Benjelloun-Touimi, 1995, SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion., Molec. Microbiol., 17, 123, 10.1111/j.1365-2958.1995.mmi_17010123.x

Bessen, 1988, Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A., J. Exp. Med., 167, 1945, 10.1084/jem.167.6.1945

Binscheck, 1995, IgA protease from Neisseria gonorrhoeae inhibits exocytosis in bovine chromaffin cells like tetanus toxin., J. Biol. Chem., 270, 1770, 10.1074/jbc.270.4.1770

Blake, 1979, Studies on gonococcus infection. XVII. IgA1-cleaving protease in vaginal washings from women with gonorrhoea, J. Infect. Dis., 139, 89, 10.1093/infdis/139.1.89

Brandtzaeg, 1995, Molecular and cellular aspects of the secretory immunoglobulin system., APMIS, 103, 1, 10.1111/j.1699-0463.1995.tb01073.x

Bricker, 1983, IgA1 proteases of Haemophilus influenzae: cloning and characterization in Escherichia coli K-12., Proc. Natl. Acad. Sci., 80, 2681, 10.1073/pnas.80.9.2681

Bronson, 1987, The effect of an IgA1 protease on immunoglobulins bound to the sperm surface and sperm cervical mucus penetrating ability., Fertil. Steril., 47, 985, 10.1016/S0015-0282(16)59234-6

Brooks, 1995, Jawetz, Melnick & Adelberg's Medical Microbiology

Brooks, 1992, Antibodies against IgA1 protease are stimulated both by clinical disease and asymptomatic carriage of serogroup A Neisseria meningitidis., J. Infect. Dis., 166, 1316, 10.1093/infdis/166.6.1316

Brown, 1985, Immunoglobulin A subclass distribution of naturally occurring salivary antibodies to microbial antigens., Infect. Immun., 49, 459, 10.1128/IAI.49.2.459-462.1985

Brown, 1995, The hinge deletion allelic variant of porcine IgA results from a mutation at the splice acceptor site in the first Cα intron., J. Immunol., 154, 3836, 10.4049/jimmunol.154.8.3836

16. Burbach, S. : Reklassifizierung der Gattung Haemophilus Winslow et al. 1917 auf Grund der DNA-Basensequenzhomologie. Thesis, Philipps-Universität Marburg, 1987.

Chintalacharuvu, 1994, Divergence of human α-chain constant region gene sequences: A novel recombinant α2 gene., J. Immunol., 152, 5299, 10.4049/jimmunol.152.11.5299

Cole, 1991, Cleavage of chimpanzee secretory immunoglobulin A by Haemophilus influenzae IgA1 protease., Microb. Pathogen., 11, 39, 10.1016/0882-4010(91)90092-O

Cole, 1994, Pioneer oral streptococci produce immunoglobulin A1 protease., Infect. Immun., 62, 2165, 10.1128/IAI.62.6.2165-2168.1994

Cooper, 1984, Attachment to and invasion of human fallopian tube mucosa by an IgA1 protease-deficient mutant of Neisseria gonorrhoeae and its wild-type parent., J. Infect. Dis., 150, 737, 10.1093/infdis/150.5.737

Crago, 1984, Distribution of IgA1- and IgA2- and J chain-containing cells in human tissues., J. Immunol., 132, 16, 10.4049/jimmunol.132.1.16

Delacroix, 1982, IgA subclasses in various secretions and in serum., Immunology, 47, 383

Devenyi, 1993, Post-infectious human serum antibodies inhibit IgA1 proteinases by interaction with the cleavage site specificity determinant., Mol. Immunol., 30, 1243, 10.1016/0161-5890(93)90039-E

Endo, 1994, Carbohydrate heterogeneity of human myeloma proteins of the IgA1 and IgA2 subclasses., Molec. Immunol., 31, 1415, 10.1016/0161-5890(94)90157-0

Engström, 1990, Subclass distribution of antigen-specific IgA antibodies in normal donors and individuals with homozygous Cα1 or Cα2 gene deletions., J. Immunol., 145, 109, 10.4049/jimmunol.145.1.109

Falkow, 1992, Molecular Basis of Bacterial Pathogenesis, 3

Farley, 1986, Pathogenesis of IgA1 protease-producing and -nonproducing Haemophilus influenzae in human nasopharyngeal organ cultures., J. Infect. Dis., 154, 752, 10.1093/infdis/154.5.752

Fitzsimmons, 1994, Immunoglobulin A subclasses in infants' saliva and in saliva and milk from their mothers., J. Pediatr., 124, 566, 10.1016/S0022-3476(05)83135-X

Frandsen, 1987, Enzymatic and antigenic characterization of immunoglobulin A1 proteases from Baeteroides and Capnocytophaga spp., Infect. Immun., 55, 631, 10.1128/IAI.55.3.631-638.1987

Frandsen, 1995, In vivo: cleavage of immunoglobulin A1 by immunoglobulin A1 proteases from Prevotella and Capnocytophaga species., Oral Microbiol. Immunol., 10, 291, 10.1111/j.1399-302X.1995.tb00157.x

Frandsen, 1986, Proportions and identity of IgA1-degrading bacteria in periodontal pockets from patients with juvenile and rapidly progressive periodontitis., J. Periodont. Res., 21, 613, 10.1111/j.1600-0765.1986.tb01498.x

Fujiyama, 1986, The site of cleavage in human alpha chains of IgA1 and IgA2:A2m(1) allotype paraproteins by the clostridial IgA protease., Mol. Immunol., 23, 147, 10.1016/0161-5890(86)90036-2

Fujiyama, 1985, A novel IgA protease from Clostridium sp. capable of cleaving IgA1 and IgA2 A2m(1) but not IgA2 A2m(2) allotype paraproteins., J. Immunol., 134, 573, 10.4049/jimmunol.134.1.573

Genco, 1975, Evaluation of human oral organisms and pathogenic Streptococcus for production of IgA protease., J. Infect. Dis., 131, S17, 10.1093/infdis/131.Supplement.S17

Gilbert, 1983, Inhibition of microbial IgA proteases by human secretory IgA and serum., Mol. Immunol., 20, 1039, 10.1016/0161-5890(83)90045-7

Gilbert, 1991, Analysis of the immunoglobulin A protease gene of Streptococcus sanguis., Infect. Immun., 59, 7, 10.1128/IAI.59.1.7-17.1991

Gilbert, 1988, Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli., Infect. Immun., 56, 1961, 10.1128/IAI.56.8.1961-1966.1988

Ginsburg, 1978, Association between cross-reacting Escherichia coli K100 and disease caused by Haemophilus influenzae type b., Infect. Immun., 22, 339, 10.1128/IAI.22.2.339-342.1978

Griffiss, 1982, Epidemic meningococcal disease: Synthesis of a hypothetical immunoepide-miologic model., Rev. Infect. Dis., 4, 159, 10.1093/clinids/4.1.159

Griffiss, 1995, Meningococcal Disease, 35

Hajishengallis, 1992, Inhibition of Streptococcus mutans adherence to saliva-coated hydroxyapatite by human secretory immunoglobulin A (S-IgA) antibodies to cell surface protein antigen I/II: reversal by IgA1 protease cleavage., Infect. Immun., 60, 5057, 10.1128/IAI.60.12.5057-5064.1992

Halter, 1989, Mosaiclike organization of IgA protease genes in Neisseria gonorrhoeae generated by horizontal genetic exchange in vivo., EMBO J., 8, 2737, 10.1002/j.1460-2075.1989.tb08415.x

Handzel, 1975, Heteroimmunization to the capsular polysaccharide of Haemophilus influenzae type b induced by enteric cross-reacting bacteria., Infect. Immun., 11, 1045, 10.1128/IAI.11.5.1045-1052.1975

Hashim, 1991, Actions of three clostridial IgA proteases on distinct forms of immunoglobulin A molecules., Immunology, 73, 235

Heck, 1990, Degradation of IgA proteins by Pseudomonas aeruginosa elastase., J. Immunol., 144, 2253, 10.4049/jimmunol.144.6.2253

Heilman, 1988, Subclass of individual IgA-secreting human lymphocytes. Investigation of in vivo pneumococcal polysaccharide-induced and in vitro mitogen-induced blood B cells by monolayer plaque-forming cell assays., J. Immunol., 140, 1496, 10.4049/jimmunol.140.5.1496

Insel, 1982, Seminars in Infectious Disease, 225

Jarvis, 1991, Human IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule., J. Immunol., 147, 1962, 10.4049/jimmunol.147.6.1962

Jose, 1995, Common structural features of IgA1 protease-like outer membrane protein autotransporters., Molec. Microbiol., 18, 378, 10.1111/j.1365-2958.1995.mmi_18020378.x

Kapatais-Zoumbos, 1985, Survey of immunoglobulin A protease activity among selected species of Ureaplasma and Mycoplasma: specificity for host immunoglobulin A., Infect. Immun., 47, 704, 10.1128/IAI.47.3.704-709.1985

Kawamura, 1990, Evolutionary hypervariability in the hinge region of the immunoglobulin alpha gene., J. Mol. Biol., 215, 201, 10.1016/S0022-2836(05)80336-5

Käyhty, 1981, Antibody response to capsular polysaccharides of group A and C Neissseria meningitidis and Haemophilus influenzae type b during bacteremic disease., J. Infect. Dis., 143, 32, 10.1093/infdis/143.1.32

Kelsall, 1993, Degradation of human IgA by Entamoeba histolytica., J. Infect. Dis., 168, 1319, 10.1093/infdis/168.5.1319

Kett, 1986, Different subclass distribution of IgA- producing cells in human lymphoid organs and various secretory tissues., J. Immunol., 136, 3631, 10.4049/jimmunol.136.10.3631

Kelt, 1995, Intestinal B-cell iso-type response in relation to local bacterial load: evidence for immunoglobulin A subclass adaptation., Gastroenterology, 109, 819, 10.1016/0016-5085(95)90389-5

Kilian, 1981, Degradation of immunoglobulins A1, A2, and G by suspected principal periodontal pathogens., Infect. Immun., 34, 757, 10.1128/IAI.34.3.757-765.1981

Kilian, 1984, Immunoglobulin A1 protease activity in strains of Ureaplasma urealyticum., Acta path. microbiol. immunol. scand. Sect. B, 92, 61

Kilian, 1981, Ecology and nature of immunoglobulin A1 protease-producing streptococci in the human oral cavity and pharynx., Infect. Immun., 31, 868, 10.1128/IAI.31.3.868-873.1981

Kilian, 1995, Increased proportions of bacteria capable of cleaving IgA1 in the pharynx of infants with atopic disease., Pediatr. Res., 38, 182, 10.1203/00006450-199508000-00008

Kilian, 1988, Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases., Microbiol. Rev., 52, 296, 10.1128/MMBR.52.2.296-303.1988

Kilian, 1979, Pathogenic species of Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease., Infect. Immun., 26, 143, 10.1128/IAI.26.1.143-149.1979

Kilian, 1989, Taxonomic study of viridans streptococci: Description of Streptococcus gordonii sp.nov. and emended descriptions of Streptococcus sanguis (While & Niven 1946), Streptococcus oralis (Bridge & Sneath 1982), and Streptococcus mitis (Andrewes and Horder 1906)., Int. J. Syst. Bacteriol., 39, 471, 10.1099/00207713-39-4-471

Kilian, 1987, A hypothetical model for the development of invasive infection due to IgA1 protease-producing bacteria, Adv. Exp. Med. Biol., 216B, 1261

Kilian, 1983, Perturbation of mucosal immune defence mechanisms by bacterial IgA proteases., Bull. Eur. Physiopathol. Respir., 19, 99

Kilian, 1994, Handbook of Mucosal Immunology, 127, 10.1016/B978-0-12-524730-6.50016-6

Kilian, 1983, Antigenic heterogeneity of immunoglobulin A1 proteases from encapsulated and non-encapsulated Haemophilus influenzae., Infect. Immun., 42, 126, 10.1128/IAI.42.1.126-132.1983

Kilian, 1983, Occurrence and nature of bacterial IgA proteases., Ann. N. Y. Acad. Sci., 409, 612, 10.1111/j.1749-6632.1983.tb26903.x

Kobayashi, 1987, Resistance of normal serum IgA and secretory IgA to bacterial IgA proteases: evidence for the presence of enzyme-neutralizing antibodies in both serum and secretory IgA, and also in serum IgG., Microbiol. Immunol., 31, 1097, 10.1111/j.1348-0421.1987.tb01341.x

Koomey, 1982, Genetic and biochemical analysis of gonococcal IgA1 protease: cloning in Escherichia coli and construction of mutants of gonococci that fail to produce the activity., Proc. Natl. Acad. Sci., 79, 7881, 10.1073/pnas.79.24.7881

Koomey, 1984, Nucleotide sequence homology between the immunoglobulin A1 protease genes of Neisseria gonorrhoeae. Neisseria meningitidis, and, Haemophilus influenzae. Infect. Immun., 43, 101, 10.1128/IAI.43.1.101-107.1984

Kornfeld, 1981, Secretory immunity and the bacterial IgA proteases., Rev. Infect. Dis., 3, 521, 10.1093/clinids/3.3.521

Kuklinska, 1984, Relative proportions of Haemophilus species in the throat of healthy children and adults., Eur. J. Clin. Microbiol., 3, 249, 10.1007/BF02014895

Kutteh, 1988, Secretory immune system of the female reproductive tract: I. immunoglobulin and secretory component-containing cells., Obstet. Gynecol., 71, 56

Lamm, 1995, IgA and mucosal defence., APMIS, 103, 241, 10.1111/j.1699-0463.1995.tb01101.x

Loghem, 1983, Allotypic and isotypic aspects of human immunoglobulin A., Mol. Immunol., 20, 1001, 10.1016/0161-5890(83)90041-X

Lomholt, 1995, Evidence of recombination and an antigenically diverse immunoglobulin A1 protease among strains of Streptococcus pneumoniae., Infect. Immun., 63, 4238, 10.1128/IAI.63.11.4238-4243.1995

Lomholt, Molecular biology and vaccine aspects of bacterial immunoglobulin A1 proteases, APMIS

Lomholt, 1994, Antigenic relationships among immunoglobulin A1 proteases from Haemophilus, Neisseria, and Streptococcus species., Infect. Immun., 62, 3178, 10.1128/IAI.62.8.3178-3183.1994

Lomholt, 1995, Neisseria gonorrhoeae IgA1 proteases share epitopes recognized by neutralizing antibodies., Vaccine, 13, 1213, 10.1016/0264-410X(95)00057-8

Lomholt, 1992, Molecular polymorphism and epidemiology of Neisseria meningitidis immunoglobulin A1 proteases., Proc. Natl. Acad. Sci., 89, 2120, 10.1073/pnas.89.6.2120

Lomholt, 1995, Comparative characterization of the iga gene encoding IgA1 protease in Neisseria meningitidis. Neisseria gonorrhoeae and, Haemophilus influenzae. Mol. Microbiol., 15, 495, 10.1111/j.1365-2958.1995.tb02263.x

Lomholt, 1993, Antigenic variation of immunoglobulin A1 proteases among sequential isolates of Haemophilus influenzae from healthy children and patients with chronic obstructive pulmonary disease., Infect. Immun., 61, 4575, 10.1128/IAI.61.11.4575-4581.1993

Loomes, 1990, A proteolytic enzyme secreted by Proteus mirabilis degrades immunoglobulins of the immunoglobulin A1 (IgA1), IgA2, and IgG isotypes., Infect. Immun., 58, 1979, 10.1128/IAI.58.6.1979-1985.1990

Lue, 1988, Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies., J. Immunol., 140, 3793, 10.4049/jimmunol.140.11.3793

Ma, 1990, An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutans., Infect. Immun., 58, 3407, 10.1128/IAI.58.10.3407-3414.1990

Magnusson, 1982, Mucosal barrier mechanisms. Interplay between secretory IgA (SIgA), IgG and mucins on the surface properties and association of salmonellae with intestine and granulocytes., Immunology, 45, 239

Male, 1979, Immunoglobulin A1 protease production by Haemophilus influenzae and Streptococcus pneumoniae., Infect. Immun., 26, 254, 10.1128/IAI.26.1.254-261.1979

Mallett, 1984, Competent antigen-binding fragments (Fab) from secretory immunoglobulin A using Streptococcus sanguis immunoglobulin A protease., Caries Res., 18, 201, 10.1159/000260766

Mansa, 1986, Retained antigen-binding activity of Fab alpha fragments of human monoclonal immunoglobulin A1 (IgA1) cleaved by IgA1 protease., Infect. Immun., 52, 171, 10.1128/IAI.52.1.171-174.1986

Mazanec, 1992, Intracellular neutralization of virus by immunoglobulin A antibodies., Proc. Natl. Acad. Sci., 89, 6901, 10.1073/pnas.89.15.6901

Mazanec, 1987, Immunoglobulin A monoclonal antibodies protect against Sendai virus., J. Virol., 61, 2624, 10.1128/JVI.61.8.2624-2626.1987

McClure, 1980, The Comparative Pathology of Zoo Animals, 197

Mestecky, 1986, IgA subclasses., Monogr. Allergy, 19, 277

Metha, 1973, Human immunoglobulin A: production of an Fc fragment by an enteric microbial proteolytic enzyme., J. Immunol., 111, 1274, 10.4049/jimmunol.111.4.1274

Meyer, 1990, Pathogenic neisseriae - a model of bacterial virulence and genetic flexibility., Int. J. Med. Microbiol., 274, 135

Meyer, 1994, Bacterial Pathogenesis of Plants and Animals. Molecular and Cellular Mechanisms, 283, 10.1007/978-3-642-78624-2_13

Milazzo, 1984, Immunoglobulin A proteases in Gram-negative bacteria isolated from human urinary tract infections., Infect. Immun., 43, 11, 10.1128/IAI.43.1.11-13.1984

Moldoveanu, 1987, IgA subclass responses to lipopolysaccharide in humans, Adv. Exp. Med. Biol., 216B, 1199

Molla, 1988, Cleavage of immunoglobulin G (IgG) and IgA around the hinge region by proteases from Serratia marceseens., Infect. Immun., 56, 916, 10.1128/IAI.56.4.916-920.1988

Morelli, 1994, Immunogenicity and evolutionary variability of epitopes within IgA1 protease from serogroup A Neisseria meningitidis., Mol. Microbiol., 11, 175, 10.1111/j.1365-2958.1994.tb00299.x

Mortensen, 1984, Purification and characterization of an immunoglobulin A1 protease from Bacteroides melaninogenicus., Infect. Immun., 45, 550, 10.1128/IAI.45.3.550-557.1984

Mulks, Bacterial Enzymes and Virulence, 81

Mulks, 1980, Genetics and Immunobiology of Pathogenic Neisseria, 217

Mulks, 1994, Bacterial immunoglobulin A1 proteases., Methods. Enzymol., 235, 543, 10.1016/0076-6879(94)35169-4

Musser, 1985, A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae., Proc. Natl. Acad. Sci., 82, 5078, 10.1073/pnas.82.15.5078

Negrete-Abascal, 1994, Secreted proteases from Actinobacillus pleuropneumoniae serotype 1 degrade porcine gelatin, hemoglobin and immunoglobulin A., Can. J. Vet. Res., 58, 83

Neutra, 1994, Physiology of the Gastrointestinal Tract, 975

Nikolova, 1994, The role of the carbohydrate chains in complement (C3) fixation by solid-phase-bound human IgA., Immunol., 82, 321

Nyvad, 1990, Comparison of the initial streptococcal microflora on dental enamel in caries-active and in caries-inactive individuals., Caries Res., 24, 267, 10.1159/000261281

Ogra, 1994, Handbook of Mucosal Immunology

Plaut, 1992, Growth of Haemophilus influenzae in human milk: synthesis, distribution, and activity of IgA protease as determined by study of iga+ and mutant iga-cells., J. Infect. Dis., 166, 43, 10.1093/infdis/166.1.43

Plaut, 1978, Microbial IgA proteases., N. Engl. J. Med., 298, 1459, 10.1056/NEJM197806292982608

Plaut, 1994, IgA-specific prolyl endopeptidases: serine type., Methods Enzymol., 244, 137, 10.1016/0076-6879(94)44012-3

Plaut, 1974, Isolation of an enzyme from Streptococcus sanguis which specifically cleaves IgA., J. Immunol., 113, 289, 10.4049/jimmunol.113.1.289

Plaut, 1975, Neisseria gonorrhoeae and Neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A., Science, 193, 1103, 10.1126/science.810892

Plaut, 1974, Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease., J. Clin. Invest., 54, 1295, 10.1172/JCI107875

Pohlner, 1987, Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease., Nature, 325, 458, 10.1038/325458a0

Pohlner, 1992, Sequence-specific cleavage of protein fusions using a recombinant Neisseria type 2 IgA protease., Biotechnology N.Y., 10, 799, 10.1038/nbt0792-799

Pohlner, 1995, Uptake and nuclear transport of Neisseria IgA1 protease-associated α-proteins in human cells., Mol. Microbiol., 17, 1073, 10.1111/j.1365-2958.1995.mmi_17061073.x

Pouedras, 1992, Cleavage of immunoglobulin A1, A2 and G by proteases from clinical isolates of Pasteurella multocida., J. Med. Microbiol., 37, 128, 10.1099/00222615-37-2-128

Poulsen, 1989, Cloning and sequencing of the immunoglobulin A1 protease gene (iga) of Haemophilus influenzae serotype b., Infect. Immun., 57, 3097, 10.1128/IAI.57.10.3097-3105.1989

Poulsen, 1988, Limited diversity of the immunoglobulin A1 protease gene (iga) among Haemophilus influenzae serotype b strains., Infect. Immun., 56, 987, 10.1128/IAI.56.4.987-992.1988

Poulsen, 1992, A comparative genetic study of serologically distinct Haemophilus influenzae type 1 immunoglobulin Al proteases., J. Bacteriol., 174, 2913, 10.1128/jb.174.9.2913-2921.1992

Proctor, 1990, Production of immunoglobulin A protease by Streptococcus pneumoniae from animals., Infect. Immun., 58, 2733, 10.1128/IAI.58.9.2733-2737.1990

Provence, 1994, Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli strain., Infect. Immun., 62, 1369, 10.1128/IAI.62.4.1369-1380.1994

Quezada-Calvillo, 1987, IgA protease in Entamoeba histolytica trophozoites, Adv. Exp. Med. Biol., 216B, 1283

Reinholdt, 1993, Similar proportions of immunoglobulin A1 (IgA1) protease-producing streptococci in initial dental plaque of selectively IgA-deficient and normal individuals., Infect. Immun., 61, 3998, 10.1128/IAI.61.9.3998-4000.1993

Reinholdt, 1987, Interference of IgA protease with the effect of secretory IgA on adherence of oral streptococci to saliva-coated hydroxyapatite., J. Dent. Res., 66, 492, 10.1177/00220345870660021801

Reinholdt, 1991, Lack of cleavage of immunoglobulin A (IgA) from rhesus monkeys by bacterial IgA1 proteases., Infect. Immmun., 59, 2219, 10.1128/IAI.59.6.2219-2221.1991

Reinholdt, 1995, Advances in Mucosal Immunology., 605, 10.1007/978-1-4615-1941-6_127

131. Reinholdt, J. & Kilian, M. : Comparative analysis of IgA1 protease activity among bacteria representing different genera, species and clones (In preparation).

Reinholdt, 1987, Degradation of IgA1, IgA2, and S-IgA by Candida and Torulopsis species., Acta path, microbiol. immunol. scand. sect. C., 95, 265

Reinholdt, 1990, Molecular aspects of immunoglobulin A1 degradation by oral streptococci., Infect. Immun., 58, 1186, 10.1128/IAI.58.5.1186-1194.1990

Renegar, 1991, Passive transfer of local immunity to influenza virus infection by IgA antibody., J. Immunol., 146, 1972, 10.4049/jimmunol.146.6.1972

Robertson, 1984, Immunoglobulin A protease activity of Ureaplasma urealyticum., J. Clin. Microbiol., 19, 255, 10.1128/JCM.19.2.255-258.1984

Rüchel, 1986, Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida., Microbiol. Sci., 3, 316

Russell, 1989, Anti-inflammatory activity of human IgA antibodies and their Fab alpha fragments: inhibition of IgG-mediated complement activation., Eur. J. Immunol., 19, 2243, 10.1002/eji.1830191210

Salyers, 1994, Bacterial Pathogenesis. A molecular approach

Saltzman, 1994, Antibody diffusion in human cervical mucus., Biophys. J., 66, 508, 10.1016/S0006-3495(94)80802-1

Senda, 1985, Clostridium ramosum, an IgA protease-producing species and its ecology in the human intestinal tract., Microbiol. Immunol., 29, 1019, 10.1111/j.1348-0421.1985.tb00892.x

Senior, 1991, The production and activity in vivo of Proteus mirabilis IgA protease in infections of the urinary tract., J. Med. Microbiol., 35, 203, 10.1099/00222615-35-4-203

Shimm, 1969, Self-protective activity of colostral IgA against tryptic digestion., Nature (London), 222, 787, 10.1038/222787a0

Shoberg, 1991, Proteolysis of bacterial membrane proteins by Neisseria gonorrhoeae type 2 immunoglobulin A1 protease., Infect. Immun., 59, 2535, 10.1128/IAI.59.8.2535-2541.1991

Simpson, 1988, Purification, characterization, and comparison of the immunoglobulin A1 proteases of Neisseria gonorrhoeae., J. Bacteriol., 170, 1866, 10.1128/jb.170.4.1866-1873.1988

Smith, 1989, Isotype, subclass and molecular size of immunoglobulins in saliva from young infants., Clin. Exp. Immunol., 76, 97

Sparling, 1990, Gonococci are survivors., Scand. J. Infect. Dis., 69, 125

Spinola, 1986, Epidemiology of colonization by nontypable Haemophilus influenzae in children; a longitudinal study., J. Infect. Dis., 154, 100, 10.1093/infdis/154.1.100

Spooner, 1992, Characterization of the immunoglobulin A protease of Ureaplasma urealyticum., Infect. Immun., 60, 2544, 10.1128/IAI.60.6.2544-2546.1992

Steele, 1975, Further evidence for cross-linking as a protective factor in experimental cholera: Properties of antibody fragments., J. Infect. Dis., 132, 175, 10.1093/infdis/132.2.175

Geme, 1994, A Haemophilus influenzae IgA protease-like protein promotes intimate interaction with human epithelial cells., Mol. Microbiol., 14, 217, 10.1111/j.1365-2958.1994.tb01283.x

Sørensen, 1984, Bacterium-induced cleavage of IgA in nasopharyngeal secretions from atopic children., Acta path. microbiol. immunol. scand. Sect. C., 92, 85

Tomana, 1988, Receptor-mediated binding and uptake of immunoglobulin A by human liver., Gastroenterology, 94, 762, 10.1016/0016-5085(88)90252-1

Underdown, 1994, Handbook of Mucosal Immunology, 79, 10.1016/B978-0-12-524730-6.50012-9

Winner, 1991, New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection., Infect. Immun., 59, 977, 10.1128/IAI.59.3.977-982.1991

Wold, 1990, Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin., Infect. Immun., 58, 3073, 10.1128/IAI.58.9.3073-3077.1990