Why are Astrocytes Important?

Hyden H, Lange PW (1965) Rhythmic enzyme changes in neurons and glia during sleep. Science 149:654–656

Hyden H, Lange PW (1965) The steady state and sndogenous sespiration in neuron and glia. Acta Physiol Scand 64:6–14

van den Berg CJ, Garfinkel D (1971) A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem J 123:211–218

Benjamin AM, Quastel JH (1972) Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids. Biochem J 128:631–646

Norenberg MD, Lapham LW, Eastland MW, May AG (1972) Division of protoplasmic astrocytes in acute experimental hepatic encephalopathy. An electron microscopic study. Am J Pathol 67:403–411

Martinez-Hernandez A, Bell KP, Norenberg MD (1977) Glutamine synthetase: glial localization in brain. Science 195:1356–1358

Norenberg MD, Martinez-Hernandez A (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161:303–310

Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci USA 95:316–321

Hyder F, Fulbright RK, Shulman RG, Rothman DL (2013) Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy. J Cereb Blood Flow Metab 33:339–347

Bringmann A, Grosche A, Pannicke T, Reichenbach A (2013) GABA and glutamate uptake and metabolism in retinal glial (Muller) cells. Front Endocrinol 4:48

Schousboe A, Bak LK, Waagepetersen HS (2013) Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA. Front Endocrinol 4:102

Pardo B, Rodrigues TB, Contreras L, Garzon M, Llorente-Folch I, Kobayashi K, Saheki T, Cerdan S, Satrustegui J (2011) Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation. J Cereb Blood Flow Metab 31:90–101

Pardo B, Contreras L, Satrustegui J (2013) Synthesis of glial glutamate and glutamine in young mice requires aspartate provided by the neuronal mitochondrial aspartate–glutamate carrier aralar/AGC1. Front Endocrinol 4:149

Cooper AJ (2013) Quantitative analysis of neurotransmitter pathways under steady state conditions—a perspective. Front Endocrinol 4:179

Hertz L (2013) The Glutamate-Glutamine (GABA) Cycle: importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation. Front Endocrinol 4:59

McKenna MC, Sonnewald U, Huang X, Stevenson J, Zielke HR (1996) Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J Neurochem 66:386–393

Rothman DL, De Feyter HM, de Graaf RA, Mason GF, Behar KL (2011) 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR Biomed 24:943–957

Bauer DE, Jackson JG, Genda EN, Montoya MM, Yudkoff M, Robinson MB (2012) The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism. Neurochem Int 61:566–574

Genda EN, Jackson JG, Sheldon AL, Locke SF, Greco TM, O’Donnell JC, Spruce LA, Xiao R, Guo W, Putt M, Seeholzer S, Ischiropoulos H, Robinson MB (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 31:18275–18288

Jackson JG, O’Donnell JC, Takano H, Coulter DA, Robinson MB (2014) Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters. J Neurosci 34:1613–1624

McKenna MC (2012) Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. Neurochem Res 37:2613–2626

McKenna MC (2013) Glutamate pays its own way in astrocytes. Front Endocrinol 4:191

Whitelaw BS, Robinson MB (2013) Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes. Front Endocrinol 4:123

Barnett NL, Pow DV, Robinson SR (2000) Inhibition of Muller cell glutamine synthetase rapidly impairs the retinal response to light. Glia 30:64–73

Ola MS, Hosoya K, LaNoue KF (2011) Regulation of glutamate metabolism by hydrocortisone and branched chain keto acids in cultured rat retinal Muller cells (TR-MUL). Neurochem Int 59:656–663

Gorovits R, Avidan N, Avisar N, Shaked I, Vardimon L (1997) Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc Natl Acad Sci USA 94:7024–7029

Nissen-Meyer LS, Chaudhry FA (2013) Protein kinase c phosphorylates the system N glutamine transporter SN1 (Slc38a3) and regulates its membrane trafficking and degradation. Front Endocrinol 4:138

Bak LK, Sickmann HM, Schousboe A, Waagepetersen HS (2005) Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures. J Neurosci Res 79:88–96

Rothman DL, De Feyter HM, Maciejewski PK, Behar KL (2012) Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes? Neurochem Res 37:2597–2612

Calvetti D, Somersalo E (2013) Quantitative in silico analysis of neurotransmitter pathways under steady state conditions. Front Endocrinol 4:137

Nagaraja TN, Brookes N (1998) Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes. Am J Physiol 274:C883–C891

Palaiologos G, Hertz L, Schousboe A (1989) Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons. Neurochem Res 14:359–366

Bak LK, Zieminska E, Waagepetersen HS, Schousboe A, Albrecht J (2008) Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix. Neurochem Res 33:273–278

Lund TM, Risa O, Sonnewald U, Schousboe A, Waagepetersen HS (2009) Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons. J Neurochem 110:80–91

Sonnewald U, McKenna M (2002) Metabolic compartmentation in cortical synaptosomes: influence of glucose and preferential incorporation of endogenous glutamate into GABA. Neurochem Res 27:43–50

Chowdhury GM, Jiang L, Rothman DL, Behar KL (2014) The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo. J Cereb Blood Flow Metab 34:1233–1242

Bjornsen LP, Hadera MG, Zhou Y, Danbolt NC, Sonnewald U (2014) The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse. J Neurochem 128:641–649

Zhou Y, Danbolt NC (2013) GABA and glutamate transporters in brain. Front Endocrinol 4:165

Cruz NF, Ball KK, Dienel GA (2007) Functional imaging of focal brain activation in conscious rats: impact of [14C]glucose metabolite spreading and release. J Neurosci Res 85:3254–3266

Frigerio F, Karaca M, De Roo M, Mlynarik V, Skytt DM, Carobbio S, Pajecka K, Waagepetersen HS, Gruetter R, Muller D, Maechler P (2012) Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission. J Neurochem 123:342–348

Kurz GM, Wiesinger H, Hamprecht B (1993) Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures. J Neurochem 60:1467–1474

Hertz L, Peng L, Dienel GA (2007) Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J Cereb Blood Flow Metab 27:219–249

Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL (2005) The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. Proc Natl Acad Sci USA 102:5588–5593

Yogeeswari P, Sriram D, Vaigundaragavendran J (2005) The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders. Curr Drug Metab 6:127–139

Wong E, Schousboe A, Saito K, Wu JY, Roberts E (1974) Immunochemical studies of brain glutamate decarboxylase and GABA-transaminase of six inbred strains of mice. Brain Res 68:133–142

Schousboe I, Bro B, Schousboe A (1977) Intramitochondrial localization of the 4-aminobutyrate-2-oxoglutarate transaminase from ox brain. Biochem J 162:303–307

McKenna MC, Sonnewald U (2005) GABA alters the metabolic fate of U−13Cglutamate in cultured cortical astrocytes. J Neurosci Res 79:81–87

Schousboe A (1972) Development of potassium effects on ion concentrations and indicator spaces in rat brain-cortex slices during postnatal ontogenesis. Exp Brain Res 15:521–531

Rothman DL, Behar KL, Hyder F, Shulman RG (2003) In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol 65:401–427

Gruetter R, Seaquist ER, Ugurbil K (2001) A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol 281:E100–E112

Miller FD, Gauthier AS (2007) Timing is everything: making neurons versus glia in the developing cortex. Neuron 54:357–369

Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, Pfrieger FW (2001) CNS synaptogenesis promoted by glia-derived cholesterol. Science 294:1354–1357

Pfrieger FW (2010) Role of glial cells in the formation and maintenance of synapses. Brain Res Rev 63:39–46

Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J (2009) Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 29:3974–3980

Araque A, Parpura V, Sanzgiri RP, Haydon PG (1999) Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 22:208–215

De Leo JA, Tawfik VL, LaCroix-Fralish ML (2006) The tetrapartite synapse: path to CNS sensitization and chronic pain. Pain 122:17–21

Dityatev A, Rusakov DA (2011) Molecular signals of plasticity at the tetrapartite synapse. Curr Opin Neurobiol 21:353–359

Verkhratsky A, Nedergaard M (2014) Astroglial cradle in the life of the synapse. Phil Trans Roy Soc Ser B (in press)

Witcher MR, Kirov SA, Harris KM (2007) Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus. Glia 55:13–23

Reichenbach A, Derouiche A, Kirchhoff F (2010) Morphology and dynamics of perisynaptic glia. Brain Res Rev 63:11–25

Wolff JR, Chao TI (2004) Cytoarchitectonics of non-neuronal cells in the nervous system. In: Hertz L (ed) Non-neuronal cells of the nervous system: function and dysfunction. Elsevier, Amsterdam, pp 1–51

Patrushev I, Gavrilov N, Turlapov V, Semyanov A (2013) Subcellular location of astrocytic calcium stores favors extrasynaptic neuron–astrocyte communication. Cell Calcium 54:343–349

Grosche J, Kettenmann H, Reichenbach A (2002) Bergmann glial cells form distinct morphological structures to interact with cerebellar neurons. J Neurosci Res 68:138–149

Kirischuk S, Parpura V, Verkhratsky A (2012) Sodium dynamics: another key to astroglial excitability? Trends Neurosci 35:497–506

Parpura V, Verkhratsky A (2012) Homeostatic function of astrocytes: Ca2+ and Na+ signalling. Transl Neurosci 3:334–344

Oliet SH, Bonfardin VD (2010) Morphological plasticity of the rat supraoptic nucleus–cellular consequences. Eur J Neurosci 32:1989–1994

Hirrlinger J, Hulsmann S, Kirchhoff F (2004) Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur J Neurosci 20:2235–2239

Nedergaard M, Verkhratsky A (2012) Artifact versus reality—how astrocytes contribute to synaptic events. Glia 60:1013–1023

MacAulay N, Zeuthen T (2012) Glial K+ clearance and cell swelling: key roles for cotransporters and pumps. Neurochem Res 37:2299–2309

Olsen ML, Sontheimer H (2008) Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation. J Neurochem 107:589–601

Bay V, Butt AM (2012) Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels. Glia 60:651–660

Xu J, Song D, Xue Z, Gu L, Hertz L, Peng L (2013) Requirement of glycogenolysis for uptake of increased extracellular K+ in astrocytes: potential implications for K+ homeostasis and glycogen usage in brain. Neurochem Res 38:472–485

Zanotti S, Charles A (1997) Extracellular calcium sensing by glial cells: low extracellular calcium induces intracellular calcium release and intercellular signaling. J Neurochem 69:594–602

Deitmer JW, Rose CR (2010) Ion changes and signalling in perisynaptic glia. Brain Res Rev 63:113–129

Song D, Man Y, Li B, Xu J, Hertz L, Peng L (2013) Comparison between drug-induced and K+-induced changes in molar acid extrusion fluxes (JH+) and in energy consumption rates in astrocytes. Neurochem Res 38:2364–2374

Amiry-Moghaddam M, Ottersen OP (2003) The molecular basis of water transport in the brain. Nat Rev Neurosci 4:991–1001

Haj-Yasein NN, Jensen V, Ostby I, Omholt SW, Voipio J, Kaila K, Ottersen OP, Hvalby O, Nagelhus EA (2012) Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus. Glia 60:867–874

Boison D, Chen JF, Fredholm BB (2010) Adenosine signaling and function in glial cells. Cell Death Differ 17:1071–1082

Li B, Gu L, Hertz L, Peng L (2013) Expression of nucleoside transporter in freshly isolated neurons and astrocytes from mouse brain. Neurochem Res 38:2351–2358

Pellerin L, Magistretti PJ (2012) Sweet sixteen for ANLS. J Cereb Blood Flow Metab 32:1152–1166

Mangia S, DiNuzzo M, Giove F, Carruthers A, Simpson IA, Vannucci SJ (2011) Response to ‘comment on recent modeling studies of astrocyte–neuron metabolic interactions’: much ado about nothing. J Cereb Blood Flow Metab 31:1346–1353

Patel AB, Lai JC, Chowdhury GM, Hyder F, Rothman DL, Shulman RG, Behar KL (2014) Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc Natl Acad Sci USA 111:5385–5390

Nagelhus EA, Ottersen OP (2013) Physiological roles of aquaporin-4 in brain. Physiol Rev 93:1543–1562

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Trans Med 4:147ra111

Mathiisen TM, Lehre KP, Danbolt NC, Ottersen OP (2010) The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 58:1094–1103

Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123:1299–1309

Iliff JJ, Nedergaard M (2013) Is there a cerebral lymphatic system? Stroke 44:S93–S95

Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M (2013) Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J Neurosci 33:18190–18199

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O’Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M (2013) Sleep drives metabolite clearance from the adult brain. Science 342:373–377

Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M (2013) Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Sci Rep 3:2582

Coulter DA, Eid T (2012) Astrocytic regulation of glutamate homeostasis in epilepsy. Glia 60:1215–1226

Giaume C, Kirchhoff F, Matute C, Reichenbach A, Verkhratsky A (2007) Glia: the fulcrum of brain diseases. Cell Death Differ 14:1324–1335

Rajkowska G, Stockmeier CA (2013) Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets 14:1225–1236

Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodriguez JJ, Nedergaard M (2012) Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro 4:00082

Burda JE, Sofroniew MV (2014) Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81:229–248

Pekny M, Nilsson M (2005) Astrocyte activation and reactive gliosis. Glia 50:427–434

Pekny M, Wilhelmsson U, Pekna M (2014) The dual role of astrocyte activation and reactive gliosis. Neurosci Lett 565C:30–38

Sofroniew MV (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32:638–647

Hazell AS (2009) Astrocytes are a major target in thiamine deficiency and Wernicke’s encephalopathy. Neurochem Int 55:129–135

Hazell AS, Sheedy D, Oanea R, Aghourian M, Sun S, Jung JY, Wang D, Wang C (2009) Loss of astrocytic glutamate transporters in Wernicke encephalopathy. Glia 58:148–156

Heneka MT, Rodriguez JJ, Verkhratsky A (2010) Neuroglia in neurodegeneration. Brain Res Rev 63:189–211

Rossi D, Brambilla L, Valori CF, Roncoroni C, Crugnola A, Yokota T, Bredesen DE, Volterra A (2008) Focal degeneration of astrocytes in amyotrophic lateral sclerosis. Cell Death Differ 15:1691–1700

De Keyser J, Mostert JP, Koch MW (2008) Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders. J Neurol Sci 267:3–16

Butterworth RF (2010) Altered glial–neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy. Neurochem Int 57:383–388

Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M (2013) Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering. Nat Med 19:1643–1648

Rose CF, Verkhratsky A, Parpura V (2013) Astrocyte glutamine synthetase: pivotal in health and disease. Biochem Soc Trans 41:1518–1524

Hertz L, Peng L, Song D (2014) Ammonia, like K+, stimulates the Na+, K+, 2 Cl− cotransporter NKCC1 and the Na+, K+-ATPase and interacts with endogenous ouabain in astrocytes. Neurochem Res. doi:10.1007/s11064-014-1352-9

Rodriguez JJ, Verkhratsky A (2011) Neuroglial roots of neurodegenerative diseases? Mol Neurobiol 43:87–96

Kulijewicz-Nawrot M, Verkhratsky A, Chvatal A, Sykova E, Rodriguez JJ (2012) Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease. J Anat 221:252–262

Yeh CY, Vadhwana B, Verkhratsky A, Rodriguez JJ (2011) Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer’s disease. ASN Neuro 3:271–279

Duran J, Saez I, Gruart A, Guinovart JJ, Delgado-Garcia JM (2013) Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain. J Cereb Blood Flow Metab 33:550–556

Gibbs ME, Hutchinson D, Hertz L (2008) Astrocytic involvement in learning and memory consolidation. Neurosci Biobehav Rev 32:927–944

Kondziella D, Brenner E, Eyjolfsson EM, Sonnewald U (2007) How do glial–neuronal interactions fit into current neurotransmitter hypotheses of schizophrenia? Neurochem Int 50:291–301

Steiner J, Bogerts B, Sarnyai Z, Walter M, Gos T, Bernstein HG, Myint AM (2012) Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: potential role of glial NMDA receptor modulators and impaired blood–brain barrier integrity. Biol Psychiatry 13:482–492

Guidetti P, Hoffman GE, Melendez-Ferro M, Albuquerque EX, Schwarcz R (2007) Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Glia 55:78–92

Alexander KS, Wu HQ, Schwarcz R, Bruno JP (2012) Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the a7 positive modulator galantamine. Psychopharmacol 220:627–637

Schwarcz R, Hunter CA (2007) Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid? Schizophr Bull 33:652–653

Zeidan-Chulia F, Salmina AB, Malinovskaya NA, Noda M, Verkhratsky A, Moreira JC (2014) The glial perspective of autism spectrum disorders. Neurosci Biobehav Rev 38:160–172

Tierney E, Bukelis I, Thompson RE, Ahmed K, Aneja A, Kratz L, Kelley RI (2006) Abnormalities of cholesterol metabolism in autism spectrum disorders. Am J Med Gen 141B:666–668

Dringen R, Hirrlinger J (2003) Glutathione pathways in the brain. Biol Chem 384:505–516

Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M (2008) Loss of astrocytic domain organization in the epileptic brain. J Neurosci 28:3264–3276

Carmignoto G, Haydon PG (2012) Astrocyte calcium signaling and epilepsy. Glia 60:1227–1233

Seifert G, Steinhauser C (2011) Neuron-astrocyte signaling and epilepsy. Exp Neurol 244:4–10

Eid T, Lee TS, Wang Y, Perez E, Drummond J, Lauritzen F, Bergersen LH, Meador-Woodruff JH, Spencer DD, de Lanerolle NC, McCullumsmith RE (2013) Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy. Epilepsia 54:228–238

Kielar C, Maddox L, Bible E, Pontikis CC, Macauley SL, Griffey MA, Wong M, Sands MS, Cooper JD (2007) Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis. Neurobiol Dis 25:150–162

Macauley SL, Pekny M, Sands MS (2011) The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. J Neurosci 31:15575–15585

Olabarria M, Noristani HN, Verkhratsky A, Rodriguez JJ (2010) Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer’s disease. Glia 58:831–838

Valori CF, Brambilla L, Martorana F, Rossi D (2014) The multifaceted role of glial cells in amyotrophic lateral sclerosis. Cell Mol Life Sci 71:287–297

Potts R, Leech RW (2005) Thalamic dementia: an example of primary astroglial dystrophy of Seitelberger. Clin Neuropathol 24:271–275

Hertz L, Rodrigues TB (2014) Astrocytic-neuronal-astrocytic pathway selection for formation and degradation of glutamate/GABA. Frontiers Endocrinology e-book, Lausanne