Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease

EBioMedicine - Tập 2 - Trang 19-36 - 2015
Björn Tampe1,2, Desiree Tampe1,2, Elisabeth M. Zeisberg2,3,4, Gerhard A. Müller1, Wibke Bechtel-Walz2,5, Michael Koziolek1, Raghu Kalluri2,6, Michael Zeisberg1,2
1Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Robert Koch Street 40, Göttingen, Germany
2Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA, USA
3Department of Cardiology and Pneumology, Göttingen University Medical Center, Georg August University, Robert Koch Street 40, Göttingen, Germany
4German Center for Cardiovascular Research (DZHK), Robert Koch Street 40, Göttingen, Germany
5Renal Division, University Hospital Freiburg, Hugstetter Street 55, Freiburg, Germany
6Department of Cancer Biology and the Metastasis Research Center, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA

Tài liệu tham khảo

Bechtel, 2010, Methylation determines fibroblast activation and fibrogenesis in the kidney, Nat. Med., 16, 544, 10.1038/nm.2135

Bhutani, 2011, DNA demethylation dynamics, Cell, 146, 866, 10.1016/j.cell.2011.08.042

Chuang, 2005, Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine, Mol. Cancer Ther., 4, 1515, 10.1158/1535-7163.MCT-05-0172

Druey, inventor Ciba Pharm Prod Inc., assignee. 1,4-hydrazo-phtalazine and its acid salts. USA patent US2484785A. 1949.

Fern, 1999, Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice, J. Clin. Invest., 103, 39, 10.1172/JCI4236

Foulks, 2012, Epigenetic drug discovery: targeting DNA methyltransferases, J. Biomol. Screen., 17, 2, 10.1177/1087057111421212

Heagerty, 1982, The addition of prazosin to standard triple therapy in the treatment of severe hypertension, Br. J. Clin. Pharmacol., 13, 539, 10.1111/j.1365-2125.1982.tb01418.x

Hollander, 1956, The effects of intravenous apresoline (hydralazine) on cardiovascular and renal function in patients with and without congestive heart failure, Circulation, 13, 664, 10.1161/01.CIR.13.5.664

Knowles, 2004, Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases, Circ. Res., 95, 162, 10.1161/01.RES.0000134924.89412.70

LeBleu, 2009, Stem cell therapies benefit Alport syndrome, J. Am. Soc. Nephrol., 20, 2359, 10.1681/ASN.2009010123

Ma, 2003, Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(−/−) mice, Am. J. Pathol., 163, 1261, 10.1016/S0002-9440(10)63486-4

Mogensen, 1976, Progression of nephropathy in long-term diabetics with proteinuria and effect of initial anti-hypertensive treatment, Scand. J. Clin. Lab. Invest., 36, 383, 10.3109/00365517609055274

Parving, 1993, Effective antihypertensive treatment postpones renal insufficiency in diabetic nephropathy, Am. J. Kidney Dis., 22, 188, 10.1016/S0272-6386(12)70185-3

Pierpont, 1980, Effect of hydralazine on renal failure in patients with congestive heart failure, Circulation, 61, 323, 10.1161/01.CIR.61.2.323

Rayner, 2014, Does community-wide chronic kidney disease management improve patient outcomes?, Nephrol. Dial. Transplant., 29, 644, 10.1093/ndt/gft486

Schwarzenbach, 2011, Cell-free nucleic acids as biomarkers in cancer patients, Nat. Rev. Cancer, 11, 426, 10.1038/nrc3066

Science JMECfCDaC, 2012, Management of chronic kidney disease stages 1–3

Sugimoto, 2012, Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis, Nat. Med., 18, 396, 10.1038/nm.2629

Sugiyama, 2005, Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice, Nephrol. Dial. Transplant., 20, 2670, 10.1093/ndt/gfi045

Tampe, 2014, Potential approaches to reverse or repair renal fibrosis, Nat. Rev. Nephrol., 10, 226, 10.1038/nrneph.2014.14

Tampe, 2014, Evidence for the involvement of epigenetics in the progression of renal fibrogenesis, Nephrol. Dial. Transplant., 29, i1, 10.1093/ndt/gft361

Tampe, 2014, Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis, J. Am. Soc. Nephrol., 25, 905, 10.1681/ASN.2013070723

Velasquez, 1997, Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat, Hypertension, 30, 1232, 10.1161/01.HYP.30.5.1232

Xu, 2012, Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development, Cell, 151, 1200, 10.1016/j.cell.2012.11.014

Zambrano, 2005, A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes, BMC Cancer, 5, 44, 10.1186/1471-2407-5-44

Zeisberg, 2013, The role of promoter hypermethylation in fibroblast activation and fibrogenesis, J. Pathol., 229, 264, 10.1002/path.4120