Tight blood pressure control decreases apoptosis during renal damage

USRDS, 1995, United States Renal Data System 1995 Annual Data Report: Incidence and causes of treated end-stage renal disease, Am J Kidney Dis, 26, S39 Riao, 2001, Prevalence of hypertension in renal disease, Nephrol Dial Transplant, 16, 70 Marin, 2002, Arterial hypertension and renal vascular disease: Nephroangiosclerosis, Nefrología, 22, 36 Ortiz, 2001, Contribution of apoptotic cell death to renal injury, J Cell Mol Med, 5, 18, 10.1111/j.1582-4934.2001.tb00135.x Ortiz, 2000, Role and regulation of apoptotic cell death in the kidney. Y2K update, Front Biosci, 5, D735 Ying, 2000, Induction of apoptosis during development of hypertensive nephrosclerosis, Kidney Int, 58, 2000, 10.1111/j.1523-1755.2000.00373.x Reed, 1997, Bcl-2 family proteins: Strategies for overcoming chemoresistance in cancer, Adv Pharmacol, 41, 501, 10.1016/S1054-3589(08)61070-4 Sedlak, 1995, Multiple Bcl-2 family members demonstrate selective dimerizations with Bax, Proc Natl Acad Sci USA, 92, 834, 10.1073/pnas.92.17.7834 González-García, 1994, Bcl-XL is the major Bcl-x mRNA form expressed during murine development and its product localizes to mitochondria, Development, 120, 3033, 10.1242/dev.120.10.3033 Bidani, 1994, Renal ablation acutely transforms “benign” hypertension to “malignant” nephrosclerosis in hypertensive rats, Hypertension, 24, 309, 10.1161/01.HYP.24.3.309 Gyure, 1977, Comparison of several methods for semiquantitative determination of urinary protein, Clin Chem, 23, 876, 10.1093/clinchem/23.5.876 Sugiyama, 1996, Apoptosis in glomerular sclerosis, Kidney Int, 49, 103, 10.1038/ki.1996.14 Gómez-Garre, 2001, Activation of NF-κB in tubular epithelial cells of rats with intense proteinuria. Role of angiotensin II and endothelin-1, Hypertension, 37, 1171, 10.1161/01.HYP.37.4.1171 Moreau, 1997, Altered balance between cell replication and apoptosis in hearts and kidneys of newborn SHR, Hypertension, 30, 720, 10.1161/01.HYP.30.3.720 Wesson, 1989, Compensatory renal growth and other growth responses of kidney, Nephron, 51, 149, 10.1159/000185282 Klahr, 2001, Progression of chronic renal disease, Heart Dis, 3, 205, 10.1097/00132580-200105000-00013 Kliem, 1996, Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats, Kidney Int, 49, 666, 10.1038/ki.1996.95 Arends, 1991, Apoptosis. Mechanisms and role in pathology, Int Rev Exp Pathol, 32, 223, 10.1016/B978-0-12-364932-4.50010-1 Bravo, 1987, Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites, J Cell Biol, 105, 1549, 10.1083/jcb.105.4.1549 Thomas, 1998, Cellular apoptosis and proliferation in experimental renal fibrosis, Nephrol Dial Transplant, 13, 2216, 10.1093/ndt/13.9.2216 Hamet, 1996, The time window of apoptosis: A new component in the therapeutic strategy for cardiovascular remodeling, J Hypertens, 14, S65 Ots, 1998, Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation, J Am Soc Nephrol, 9, 224, 10.1681/ASN.V92224 Gómez-Garre, 1996, Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth, Hypertension, 27, 885, 10.1161/01.HYP.27.4.885 Mezzano, 2001, Angiotensin II and renal fibrosis, Hypertension, 38, 635, 10.1161/hy09t1.094234 Diep, 1999, In vivo study of AT1 and AT2 angiotensin receptors in apoptosis in rat blood vessels, Hypertension, 34, 617, 10.1161/01.HYP.34.4.617 Aizawa, 2001, Different effects of angiotensin II and catecholamine on renal cell apoptosis and proliferation in rats, Kidney Int, 59, 645, 10.1046/j.1523-1755.2001.059002645.x Dimmeler, 1997, Angiotensin II induces apoptosis of human endotelial cells. Protective effect of nitric oxide, Circ Res, 81, 970, 10.1161/01.RES.81.6.970 De Gasparo, 1999, The AT2 receptor: Fact, fancy and fantasy, Regulatory Peptides, 81, 11, 10.1016/S0167-0115(99)00023-3 Zimpelmann, 2001, Angiotensin II AT2 receptors inhibit growth responses in proximal tubule cells, Am J Physiol Renal, 281, F300, 10.1152/ajprenal.2001.281.2.F300 Kajstura, 1997, Angiotensin II induces apoptosis of adult ventricular myocytes in vitro, J Mol Cell Cardiol, 29, 859, 10.1006/jmcc.1996.0333 Fortuño, 1998, Overexpression of Bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats: Effects of AT1 blockade with losartan, Hypertension, 32, 280, 10.1161/01.HYP.32.2.280 Ravassa, 2000, Mechanisms of increased susceptibility to angiotensin II-induced apoptosis in ventricular cardiomyocytes of spontaneously hypertensive rats, Hypertension, 36, 1065, 10.1161/01.HYP.36.6.1065 Miura, 2000, Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis, EMBO J, 19, 4026, 10.1093/emboj/19.15.4026 Tea, 1999, Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats. Temporal regulation and spatial heterogeneity, Hypertension, 34, 229, 10.1161/01.HYP.34.2.229 Munzel, 1996, Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug, J Clin Invest, 98, 1465, 10.1172/JCI118935 Yang, 2001, Expression of apoptosis-related genes and proteins in experimental chronic renal scarring, J Am Soc Nephrol, 12, 275, 10.1681/ASN.V122275 Ortiz, 2000, Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure, Kidney Int, 57, 969, 10.1046/j.1523-1755.2000.00925.x Isenmann, 1998, Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat, Brain Pathol, 8, 49, 10.1111/j.1750-3639.1998.tb00134.x Blanco-Colio, 2003, Bcl-xL overexpression protects from apoptosis induced by HMG-CoA reductase inhibitors in murine tubular cells, Kidney Int, 64, 181, 10.1046/j.1523-1755.2003.00080.x Gómez-Garre, 2003, Papel del NF-κB en la susceptibilidad a la apoptosis mostrada por las células mesangiales de ratas espontáneamente hipertensas, Investigación Cardiovascular, 6, 54 Liu, 2000, Increased apoptosis in the heart of genetic hypertension, associated with increased fibroblasts, Cardiovasc Res, 45, 729, 10.1016/S0008-6363(99)00382-X Grad, 2000, Regulation of Bcl-xL: A little bit of this and a little bit of STAT, Curr Opin Oncol, 12, 543, 10.1097/00001622-200011000-00006 Mukhopadhyay, 2001, Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines, Oncogene, 20, 7597, 10.1038/sj.onc.1204997 Ravi, 2001, Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB, Nat Cell Biol, 3, 409, 10.1038/35070096