HDL, ApoA-I and ApoE-Mimetic Peptides: Potential Broad Spectrum Agent for Clinical Use?

Springer Science and Business Media LLC - Tập 28 - Trang 1-11 - 2022
Sunil A. Nankar1,2, Priyanka S. Kawathe1, Abhay H. Pande1
1Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India
2Department of Formulation and Drug Product Development, Dr. Reddy’s Laboratories Ltd. (Biologics Unit), Hyderabad, India

Tóm tắt

Peptides mimicking the biological properties of apolipoproteins have shown beneficial properties against a variety of diseases and have emerged as a potential candidate for their treatments. In this review, we have discussed the emerging field of apolipoprotein-mimetic peptides for clinical use. We have briefly discussed the latest in the field of development of high-density lipoprotein mimetics and apolipoprotein-A and apolipoprotein-E mimetic peptides. We primarily focused on the therapeutic potential of apolipoprotein-mimetic peptides in terms of their broad spectrum applications reported in pre-clinical and clinical studies. We conclude with a discussion on the emergence of apolipoprotein-mimetic peptides as potential candidates for the treatment of a broad spectrum of disorders.

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