Engine shutdown: migrastatic strategies and prevention of metastases
Tài liệu tham khảo
Nguyen, 2009, Metastasis: from dissemination to organ-specific colonization, Nat. Rev. Cancer, 9, 274, 10.1038/nrc2622
Palmer, 2011, Targeting tumor cell motility to prevent metastasis, Adv. Drug Deliv. Rev., 63, 568, 10.1016/j.addr.2011.04.008
Li, 2019, On the energy efficiency of cell migration in diverse physical environments, Proc. Natl. Acad. Sci. U. S. A., 116, 23894, 10.1073/pnas.1907625116
Zhang, 2019, Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells, Proc. Natl. Acad. Sci. U. S. A., 116, 7867, 10.1073/pnas.1809964116
Zanotelli, 2019, Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Nat. Commun., 10, 4185, 10.1038/s41467-019-12155-z
Paul, 2017, Cancer cell motility: lessons from migration in confined spaces, Nat. Rev. Cancer, 17, 131, 10.1038/nrc.2016.123
Yamada, 2019, Mechanisms of 3D cell migration, Nat. Rev. Mol. Cell Biol., 20, 738, 10.1038/s41580-019-0172-9
Garde, 2021, Fueling cell invasion through extracellular matrix, Trends Cell Biol., 31, 445, 10.1016/j.tcb.2021.01.006
Horssen, 2008, Modulation of cell motility by spatial repositioning of enzymatic ATP/ADP exchange capacity, J. Biol. Chem., 284, 1620, 10.1074/jbc.M806974200
Papalazarou, 2020, The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis, Nat. Metab., 2, 62, 10.1038/s42255-019-0159-z
Raudenska, 2019, Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation, Sci. Rep., 9, 1660, 10.1038/s41598-018-38199-7
Machacek, 2009, Coordination of Rho GTPase activities during cell protrusion, Nature, 461, 99, 10.1038/nature08242
Huttenlocher, 2011, Integrins in cell migration, Cold Spring Harb. Perspect. Biol., 3, 10.1101/cshperspect.a005074
Wolf, 2013, Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force, J. Cell Biol., 201, 1069, 10.1083/jcb.201210152
Harada, 2014, Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival, J. Cell Biol., 204, 669, 10.1083/jcb.201308029
Fingleton, 2008, MMP inhibitor clinical trials – the past, present, and future, 759
Zucker, 2000, Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment, Oncogene, 19, 6642, 10.1038/sj.onc.1204097
Balzer, 2012, Physical confinement alters tumor cell adhesion and migration phenotypes, FASEB J., 26, 4045, 10.1096/fj.12-211441
Kopf, 2020, Microtubules control cellular shape and coherence in amoeboid migrating cells, J. Cell Biol., 219, 10.1083/jcb.201907154
Friedl, 2003, Tumour-cell invasion and migration: diversity and escape mechanisms, Nat. Rev. Cancer, 3, 362, 10.1038/nrc1075
Jones, 2017, Dual targeting of mesenchymal and amoeboid motility hinders metastatic behavior, Mol. Cancer Res., 15, 670, 10.1158/1541-7786.MCR-16-0411
Sahai, 2003, Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis, Nat. Cell Biol., 5, 711, 10.1038/ncb1019
Ying, 2006, The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models, Mol. Cancer Ther., 5, 2158, 10.1158/1535-7163.MCT-05-0440
Guerra, 2017, ROCK inhibition with fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells, Sci. Rep., 7, 10.1038/s41598-017-14216-z
Rath, 2017, ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth, EMBO Mol. Med., 9, 198, 10.15252/emmm.201606743
Carragher, 2006, Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function, Oncogene, 25, 5726, 10.1038/sj.onc.1209582
Chang, 2018, ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanoma cells, Cancer Sci., 109, 3428, 10.1111/cas.13786
Salhia, 2005, Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1, Cancer Res., 65, 8792, 10.1158/0008-5472.CAN-05-0160
Stokes, 2011, Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment, Mol. Cancer Ther., 10, 2135, 10.1158/1535-7163.MCT-11-0261
Poisson, 2020, Rock inhibition promotes NaV1.5 sodium channel-dependent SW620 colon cancer cell invasiveness, Sci. Rep., 10, 13350, 10.1038/s41598-020-70378-3
Gurkar, 2013, Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress, Nat. Commun., 4, 2189, 10.1038/ncomms3189
Jing, 2020, KD025, an anti-adipocyte differentiation drug, enhances the efficacy of conventional chemotherapeutic drugs in ABCG2-overexpressing leukemia cells, Oncol. Lett., 20, 309-309, 10.3892/ol.2020.12172
Libanje, 2019, ROCK2 inhibition triggers the collective invasion of colorectal adenocarcinomas, EMBO J., 38, 10.15252/embj.201899299
Zeng, 2020, Rho–ROCK signaling mediates entotic cell death in tumor, Cell Death Dis., 6, 4, 10.1038/s41420-020-0238-7
Sadok, 2015, Rho kinase inhibitors block melanoma cell migration and inhibit metastasis, Cancer Res., 75, 2272, 10.1158/0008-5472.CAN-14-2156
Davies, 2009, CCT129254 (AT11854) is a well tolerated, orally bioavailable inhibitor of AKT/PKB with pharmacodynamic and antitumor activity in a range of xenograft models, Mol. Cancer Ther., 8, C208-C208, 10.1158/1535-7163.TARG-09-C208
McLeod, 2020, First-in-human study of AT13148, a dual ROCK–AKT inhibitor in patients with solid tumors, Clin. Cancer Res., 26, 4777, 10.1158/1078-0432.CCR-20-0700
Seetharaman, 2020, Cytoskeletal crosstalk in cell migration, Trends Cell Biol., 30, 720, 10.1016/j.tcb.2020.06.004
D'Amore, 2019, A journey through the cytoskeleton with protein kinase CK2, Curr. Protein Pept. Sci., 20, 547, 10.2174/1389203720666190119124846
Chua, 2017, CK2 in cancer: cellular and biochemical mechanisms and potential therapeutic target, Pharmaceuticals (Basel), 10, 18, 10.3390/ph10010018
Birus, 2022, 4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects, FEBS Open Bio., 12, 394, 10.1002/2211-5463.13346
Stehn, 2013, A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells, Cancer Res., 73, 5169, 10.1158/0008-5472.CAN-12-4501
Sharma, 2014, The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells, Integr. Biol., 6, 611, 10.1039/C3IB40246K
Vassilopoulos, 2014, Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors, J. Biol. Chem., 289, 24202, 10.1074/jbc.M114.567552
Raudenska, 2019, Unexpected therapeutic effects of cisplatin, Metallomics, 11, 1182, 10.1039/c9mt00049f
Wang, 2021, Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel, Theranostics, 11, 2442, 10.7150/thno.46460
Kung, 2016, Nanoscale characterization illustrates the cisplatin-mediated biomechanical changes of B16-F10 melanoma cells, Phys. Chem. Phys., 18, 7124, 10.1039/C5CP07971C
Li, 2012, Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance, Oncogene, 31, 2412, 10.1038/onc.2011.426
Jayatilaka, 2018, EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration, FASEB J., 32, 1207, 10.1096/fj.201700444RR
Yang, 2010, Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs, J. Biol. Chem., 285, 32242, 10.1074/jbc.M110.160820
Čermák, 2020, Microtubule-targeting agents and their impact on cancer treatment, Eur. J. Cell Biol., 99, 10.1016/j.ejcb.2020.151075
Kamath, 2014, Mechanisms of inhibition of endothelial cell migration by taxanes, Cytoskeleton (Hoboken), 71, 46, 10.1002/cm.21153
Bonezzi, 2012, Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies, Neoplasia (New York, N.Y.), 14, 846, 10.1593/neo.12728
Ganguly, 2015, Peloruside A is a microtubule-stabilizing agent with exceptional anti-migratory properties in human endothelial cells, Oncoscience, 2, 585, 10.18632/oncoscience.169
Kikuchi, 2008, WAVE2- and microtubule-dependent formation of long protrusions and invasion of cancer cells cultured on three-dimensional extracellular matrices, Cancer Sci., 99, 2252, 10.1111/j.1349-7006.2008.00927.x
Currier, 2017, Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs, Mol. Cancer Ther., 16, 1555, 10.1158/1535-7163.MCT-16-0873
Wang, 2020, Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects, Mol. Cancer Res., 18, 1074, 10.1158/1541-7786.MCR-19-1122
Cheng, 2021, Nano-strategies targeting the integrin αvβ3 network for cancer therapy, Cells, 10, 1684, 10.3390/cells10071684
Hao, 2021, Molybdenum dioxide (MoS2)/gadolinium (Gd) containing arginine-glycine-aspartic acid (RGD) sequences as new nano-contrast agent for cancer magnetic resonance imaging (MRI), J. Nanosci. Nanotechnol., 21, 1403, 10.1166/jnn.2021.18894
Ali, 2017, Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins, Proc. Natl. Acad. Sci., 114, E5655, 10.1073/pnas.1703151114
Wang, 2012, Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy, ACS Nano, 6, 5070, 10.1021/nn300694v
Ali, 2016, Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis, Int. J. Nanomedicine, 11, 4849, 10.2147/IJN.S109470
Ali, 2017, Nuclear membrane-targeted gold nanoparticles inhibit cancer cell migration and invasion, ACS Nano, 11, 3716, 10.1021/acsnano.6b08345
Tay, 2014, Nanoparticles strengthen intracellular tension and retard cellular migration, Nano Lett., 14, 83, 10.1021/nl4032549
Soenen, 2010, High intracellular iron oxide nanoparticle concentrations affect cellular cytoskeleton and focal adhesion kinase-mediated signaling, Small, 6, 832, 10.1002/smll.200902084
Roshini, 2018, pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line, Mater. Sci. Eng. C Mater. Biol. Appl., 92, 477, 10.1016/j.msec.2018.06.073
Lyu, 2019, Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis, Signal Transduct. Target Ther., 4, 26, 10.1038/s41392-019-0054-9
Rocha, 2020, Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells, J. Nanobiotechnology, 18, 43, 10.1186/s12951-020-00604-7
Zanotelli, 2018, Regulation of ATP utilization during metastatic cell migration by collagen architecture, Mol. Biol. Cell, 29, 1, 10.1091/mbc.E17-01-0041
Mayor, 2016, The front and rear of collective cell migration, Nat. Rev. Mol. Cell Biol., 17, 97, 10.1038/nrm.2015.14
Commander, 2020, Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion, Nat. Commun., 11, 1533, 10.1038/s41467-020-15219-7
Tan, 2015, Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA, Cell Metab., 21, 81, 10.1016/j.cmet.2014.12.003
Bajzikova, 2019, Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells, Cell Metab., 29, 399, 10.1016/j.cmet.2018.10.014
Cunniff, 2016, AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion, Mol. Biol. Cell, 27, 2662, 10.1091/mbc.e16-05-0286
Caino, 2015, PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion, Proc. Natl. Acad. Sci. U. S. A., 112, 8638, 10.1073/pnas.1500722112
Schuler, 2017, Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration, Mol. Biol. Cell, 28, 2159, 10.1091/mbc.e16-10-0741
Caino, 2016, A neuronal network of mitochondrial dynamics regulates metastasis, Nat. Commun., 7, 13730, 10.1038/ncomms13730
Zhao, 2013, Mitochondrial dynamics regulates migration and invasion of breast cancer cells, Oncogene, 32, 4814, 10.1038/onc.2012.494
Shimada-Shimizu, 2013, Evidence that Na+/H+ exchanger 1 is an ATP-binding protein, FEBS J., 280, 1430, 10.1111/febs.12138
Drechsel, 2008, Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease, Free Radic. Biol. Med., 44, 1873, 10.1016/j.freeradbiomed.2008.02.008
Heinz, 2017, Mechanistic investigations of the mitochondrial complex I inhibitor rotenone in the context of pharmacological and safety evaluation, Sci. Rep., 7, 10.1038/srep45465
Xiao, 2020, Rotenone restrains colon cancer cell viability, motility and epithelial–mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway, Int. J. Mol. Med., 46, 700, 10.3892/ijmm.2020.4637
Jeon, 2016, Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity, Exp. Mol. Med., 48, 10.1038/emm.2016.129
Nakayama, 2016, Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma, Int. J. Oncol., 49, 1890, 10.3892/ijo.2016.3676
Liang, 2018, Metformin inhibited growth, invasion and metastasis of esophageal squamous cell carcinoma in vitro and in vivo, Cell. Physiol. Biochem., 51, 1276, 10.1159/000495539
Fan, 2019, Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway, Carcinogenesis, 40, 669, 10.1093/carcin/bgy160
Liu, 2020, Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway, J. Cell. Mol. Med., 24, 5786, 10.1111/jcmm.15241
Zheng, 2017, Synergistic chemopreventive and therapeutic effects of co-drug UA-Met: implication in tumor metastasis, J. Agric. Food Chem., 65, 10973, 10.1021/acs.jafc.7b04378
Jin, 2018, The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC, EBioMedicine, 37, 188, 10.1016/j.ebiom.2018.10.044
Rattan, 2011, Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo, Neoplasia, 13, 483, 10.1593/neo.11148
Coyle, 2016, Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis, Ann. Oncol., 27, 2184, 10.1093/annonc/mdw410
Cheng, 2016, Mitochondria-targeted analogues of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells, Cancer Res., 76, 3904, 10.1158/0008-5472.CAN-15-2534
Molina, 2018, An inhibitor of oxidative phosphorylation exploits cancer vulnerability, Nat. Med., 24, 1036, 10.1038/s41591-018-0052-4
Sahlgren, 2008, Notch signaling mediates hypoxia-induced tumor cell migration and invasion, Proc. Natl. Acad. Sci., 105, 6392, 10.1073/pnas.0802047105
Ellinghaus, 2013, BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I, Cancer med., 2, 611, 10.1002/cam4.112
Bastian, 2017, AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization, Cancer Lett., 388, 149, 10.1016/j.canlet.2016.11.040
Morgan, 2015, Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells, Mar Drugs, 13, 1552, 10.3390/md13031552
Ashton, 2018, Oxidative phosphorylation as an emerging target in cancer therapy, Clin. Cancer Res., 24, 2482, 10.1158/1078-0432.CCR-17-3070
Moreira, 2006, Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure, J. Biol. Chem., 281, 10143, 10.1074/jbc.M510249200
Ma, 2015, Tamoxifen inhibits ER-negative breast cancer cell invasion and metastasis by accelerating Twist1 degradation, Int. J. Biol. Sci., 11, 618, 10.7150/ijbs.11380
Dong, 2020, Mitocans revisited: mitochondrial targeting as efficient anti-cancer therapy, Int. J. Mol. Sci., 21, 7941, 10.3390/ijms21217941
Rohlenova, 2017, Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer, Antioxid. Redox Signal., 26, 84, 10.1089/ars.2016.6677
Krejcir, 2019, A cyclic pentamethinium salt induces cancer cell cytotoxicity through mitochondrial disintegration and metabolic collapse, Int. J. Mol. Sci., 20, 4208, 10.3390/ijms20174208
Fialova, 2022, Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration, Biomed. Pharmacother., 154, 10.1016/j.biopha.2022.113582
Yamaguchi, 2019, PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis, Elife, 8, 10.7554/eLife.52135
Grisar, 2004, Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells, Ann. Rheum. Dis., 63, 1632, 10.1136/ard.2003.018440
Quintela-Fandino, 2020, Randomized Phase 0/I trial of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early HER2-negative Breast cancer, Clin. Cancer Res., 26, 35, 10.1158/1078-0432.CCR-19-2023
Modica-Napolitano, 2019, The anticancer agent elesclomol has direct effects on mitochondrial bioenergetic function in isolated mammalian mitochondria, Biomolecules, 9, 298, 10.3390/biom9080298
Blackman, 2012, Mitochondrial electron transport is the cellular target of the oncology drug elesclomol, PLoS One, 7, 10.1371/journal.pone.0029798
Sandoval-Acuña, 2021, Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy, Cancer Res., 81, 2289, 10.1158/0008-5472.CAN-20-1628
O'Day, 2013, Final results of Phase III SYMMETRY study: randomized, double-blind trial of elesclomol plus paclitaxel versus paclitaxel alone as treatment for chemotherapy-naive patients with advanced melanoma, J. Clin. Oncol., 31, 1211, 10.1200/JCO.2012.44.5585
Ho, 2012, Importance of glycolysis and oxidative phosphorylation in advanced melanoma, Mol. Cancer, 11, 76, 10.1186/1476-4598-11-76
Yamasaki, 2011, Deferoxamine for advanced hepatocellular carcinoma, N. Engl. J. Med., 365, 576, 10.1056/NEJMc1105726
Gottwald, 2020, The iron chelator deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability, Sci. Rep., 10, 1577, 10.1038/s41598-020-58386-9
Lui, 2013, The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action, Mol. Pharmacol., 83, 179, 10.1124/mol.112.081893
Fryknäs, 2016, Iron chelators target both proliferating and quiescent cancer cells, Sci. Rep., 6, 38343, 10.1038/srep38343
Hooda, 2013, Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells, PLoS One, 8, 10.1371/journal.pone.0063402
Kalainayakan, 2019, Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression, Sci. Rep., 9, 1405, 10.1038/s41598-018-38345-1
Marlein, 2019, CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma, Cancer Res., 79, 2285, 10.1158/0008-5472.CAN-18-0773
Sahu, 2018, Tunneling nanotubes: a versatile target for cancer therapy, Curr. Cancer Drug Targets, 18, 514, 10.2174/1568009618666171129222637
Desgrosellier, 2010, Integrins in cancer: biological implications and therapeutic opportunities, Nat. Rev. Cancer, 10, 9, 10.1038/nrc2748
Veevers-Lowe, 2011, Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals, J. Cell Sci., 124, 1288, 10.1242/jcs.076935
Cianfrocca, 2006, Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours, Br. J. Cancer, 94, 1621, 10.1038/sj.bjc.6603171
Infante, 2012, Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors, J. Clin. Oncol., 30, 1527, 10.1200/JCO.2011.38.9346
Dawson, 2021, Targeting FAK in anticancer combination therapies, Nat. Rev. Cancer, 21, 313, 10.1038/s41568-021-00340-6
Mak, 2019, A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours, Br. J. Cancer, 120, 975, 10.1038/s41416-019-0452-3
Grimes, 2021, The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo, BMC Cancer, 21, 40, 10.1186/s12885-020-07716-1
Hsu, 2018, NVP-BEZ235 attenuated cell proliferation and migration in the squamous cell carcinoma of oral cavities and p70S6K inhibition mimics its effect, Int. J. Mol. Sci., 19, 3546, 10.3390/ijms19113546
Rispal, 2015, Target of rapamycin complex 2 regulates actin polarization and endocytosis via multiple pathways, J. Biol. Chem., 290, 14963, 10.1074/jbc.M114.627794
Bonelli, 2015, Inhibition of PI3K pathway reduces invasiveness and epithelial-to-mesenchymal transition in squamous lung cancer cell lines harboring PIK3CA gene alterations, Mol. Cancer Ther., 14, 1916, 10.1158/1535-7163.MCT-14-0892
Nakashima, 1998, Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage, Neurol. Med. Chir. (Tokyo), 38, 805, 10.2176/nmc.38.805
Teiti, 2015, In vivo effects in melanoma of ROCK inhibition-induced FasL overexpression, Front. Oncol., 5, 156, 10.3389/fonc.2015.00156
Patel, 2012, RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer, Cancer Res., 72, 5025, 10.1158/0008-5472.CAN-12-0954
Borad, 2021, Silmitasertib (CX-4945) in combination with gemcitabine and cisplatin as first-line treatment for patients with locally advanced or metastatic cholangiocarcinoma: a phase Ib/II study, J. Clin. Oncol., 39, 312, 10.1200/JCO.2021.39.3_suppl.312
Stemberkova-Hubackova, 2022, Simultaneous targeting of mitochondrial metabolism and immune checkpoints as a new strategy for renal cancer therapy, Clin. Transl. Med., 12, 10.1002/ctm2.645
Hayat, 2022, Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor, Cancer Biol. Ther., 23, 117, 10.1080/15384047.2022.2029132