Regulators of mitochondrial dynamics in cancer

Current Opinion in Cell Biology - Tập 39 - Trang 43-52 - 2016
Daniela Senft1, Ze’ev A Ronai1
1Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla, CA 92037, United States

Tài liệu tham khảo

Von Stockum, 2015, Mitochondrial dynamics and mitophagy in Parkinson's disease: a fly point of view, Neurobiol Disease Youle, 2012, Mitochondrial fission, fusion, and stress, Science, 337, 1062, 10.1126/science.1219855 Mitra, 2009, A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase, Proc Natl Acad Sci U S A, 106, 11960, 10.1073/pnas.0904875106 Kashatus, 2011, RALA and RALBP1 regulate mitochondrial fission at mitosis, Nat Cell Biol, 13, 1108, 10.1038/ncb2310 Kim, 2011, Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia, Mol Cell, 44, 532, 10.1016/j.molcel.2011.08.045 Rambold, 2011, Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation, Proc Natl Acad Sci U S A, 108, 10190, 10.1073/pnas.1107402108 Rossignol, 2004, Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells, Cancer Res, 64, 985, 10.1158/0008-5472.CAN-03-1101 Serasinghe, 2015, Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors, Mol Cell, 57, 521, 10.1016/j.molcel.2015.01.003 Senft, 2015, UPR, autophagy, and mitochondria crosstalk underlies the ER stress response, Trends Biochem Sci, 40, 141, 10.1016/j.tibs.2015.01.002 Chen, 2003, Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development, J Cell Biol, 160, 189, 10.1083/jcb.200211046 Ishihara, 2009, Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice, Nat Cell Biol, 11, 958, 10.1038/ncb1907 Wakabayashi, 2009, The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice, J Cell Biol, 186, 805, 10.1083/jcb.200903065 Burte, 2015, Disturbed mitochondrial dynamics and neurodegenerative disorders, Nat Rev Neurol, 11, 11, 10.1038/nrneurol.2014.228 Song, 2015, Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart, Cell Metabol, 21, 195, 10.1016/j.cmet.2014.12.019 Sugiura, 2014, A new pathway for mitochondrial quality control: mitochondrial-derived vesicles, EMBO J, 33, 2142, 10.15252/embj.201488104 Lazarou, 2015, The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy, Nature, 524, 309, 10.1038/nature14893 Koyano, 2014, Ubiquitin is phosphorylated by PINK1 to activate parkin, Nature, 510, 162, 10.1038/nature13392 Chen, 2013, PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria, Science, 340, 471, 10.1126/science.1231031 Ziviani, 2010, Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin, Proc Natl Acad Sci U S A, 107, 5018, 10.1073/pnas.0913485107 McLelland, 2014, Parkin PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control, EMBO J, 33, 282 Norris, 2015, Convergence of Parkin, PINK1, and alpha-synuclein on stress-induced mitochondrial morphological remodeling, J Biol Chem, 290, 13862, 10.1074/jbc.M114.634063 Hollville, 2014, Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy, Mol Cell, 55, 451, 10.1016/j.molcel.2014.06.001 Carroll, 2014, Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1, Cell Rep, 9, 1538, 10.1016/j.celrep.2014.10.046 Wang, 2015, Deubiquitinating enzymes regulate PARK2-mediated mitophagy, Autophagy, 11, 595, 10.1080/15548627.2015.1034408 Liang, 2015, USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death, EMBO Reports, 16, 618, 10.15252/embr.201439820 Gomes, 2011, During autophagy mitochondria elongate, are spared from degradation and sustain cell viability, Nat Cell Biol, 13, 589, 10.1038/ncb2220 Vance, 2014, MAM. (mitochondria-associated membranes) in mammalian cells: lipids and beyond, Biochim Biophys Acta, 1841, 595, 10.1016/j.bbalip.2013.11.014 Morciano, 2016, Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death, Mol Biol Cell, 27, 20, 10.1091/mbc.E15-01-0028 Szabadkai, 2004, Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis, Mol Cell, 16, 59, 10.1016/j.molcel.2004.09.026 Twig, 2008, Fission and selective fusion govern mitochondrial segregation and elimination by autophagy, EMBO J, 27, 433, 10.1038/sj.emboj.7601963 Renault, 2015, Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis, Mol Cell, 57, 69, 10.1016/j.molcel.2014.10.028 Prudent, 2015, MAPL SUMOylation of Drp1 stabilizes an ER/mitochondrial platform required for cell death, Mol Cell, 59, 941, 10.1016/j.molcel.2015.08.001 Rehman, 2012, Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer, FASEB J, 26, 2175, 10.1096/fj.11-196543 Zhao, 2013, Mitochondrial dynamics regulates migration and invasion of breast cancer cells, Oncogene, 32, 4814, 10.1038/onc.2012.494 Wan, 2014, Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells, Oncol Reports, 32, 619, 10.3892/or.2014.3235 Hagenbuchner, 2013, BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery, Oncogene, 32, 4748, 10.1038/onc.2012.500 Inoue-Yamauchi, 2012, Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells, Biochem Biophys Res Commun, 421, 81, 10.1016/j.bbrc.2012.03.118 Kashatus, 2015, Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth, Mol Cell, 57, 537, 10.1016/j.molcel.2015.01.002 Caino, 2015, PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion, Proc Natl Acad Sci U S A, 112, 8638, 10.1073/pnas.1500722112 Ni, 2015, Mitochondrial dynamics and mitochondrial quality control, Redox Biol, 4, 6, 10.1016/j.redox.2014.11.006 Gong, 2014, Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins, Nat Genet, 46, 588, 10.1038/ng.2981 Katajisto, 2015, Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness, Science, 348, 340, 10.1126/science.1260384 Xie, 2015, Mitochondrial control by DRP1 in brain tumor initiating cells, Nat Neurosci, 18, 501, 10.1038/nn.3960 Wang, 2011, Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease, J Biol Chem, 286, 11649, 10.1074/jbc.M110.144238 Che, 2015, Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC, Oncotarget, 6, 37349, 10.18632/oncotarget.5736 Desai, 2013, Mitochondrial localization and the persistent migration of epithelial cancer cells, Biophys J, 104, 2077, 10.1016/j.bpj.2013.03.025 Ferreira-da-Silva, 2015, Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration, PLoS One, 10, e0122308, 10.1371/journal.pone.0122308 Zhang, 2015, Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer, Oncotarget Mujcic, 2014, Hypoxia signaling and the metastatic phenotype, Curr Mol Med, 14, 565, 10.2174/1566524014666140603115831 Han, 2015, Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells, Int J Oncol, 46, 691, 10.3892/ijo.2014.2781 Escobar-Henriques, 2014, Dynamic survey of mitochondria by ubiquitin, EMBO Reports, 15, 231, 10.1002/embr.201338225 Franz, 2015, Double-edged alliance: mitochondrial surveillance by the UPS and autophagy, Curr Opin Cell Biol, 37, 18, 10.1016/j.ceb.2015.08.004 Qi, 2015, Dysregulation of ubiquitin ligases in cancer, Drug Resistance Updates, 23, 1, 10.1016/j.drup.2015.09.001 Scortegagna, 2014, Fine tuning of the UPR by the ubiquitin ligases Siah1/2, PLoS Genet, 10, e1004348, 10.1371/journal.pgen.1004348 Kim, 2015, Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control, FEBS J Park, 2010, Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1, J Cell Sci, 123, 619, 10.1242/jcs.061481 Fang, 2012, Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model, PLoS One, 7, e52637, 10.1371/journal.pone.0052637 Park, 2014, MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival, Cell Death Disease, 5, e1172, 10.1038/cddis.2014.142 Nagashima, 2014, Roles of mitochondrial ubiquitin ligase MITOL/MARCH5 in mitochondrial dynamics and diseases, J Biochem, 155, 273, 10.1093/jb/mvu016 Xu, 2015, Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein, Mol Biol Cell Tondera, 2009, SLP-2 is required for stress-induced mitochondrial hyperfusion, EMBO J, 28, 1589, 10.1038/emboj.2009.89 Zemirli, 2014, Mitochondrial hyperfusion promotes NF-kappaB activation via the mitochondrial E3 ligase MULAN, FEBS J, 281, 3095, 10.1111/febs.12846 van Vliet, 2014, New functions of mitochondria associated membranes in cellular signaling, Biochim Biophys Acta, 1843, 2253, 10.1016/j.bbamcr.2014.03.009 Sugiura, 2013, MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2, Molecular Cell, 51, 20, 10.1016/j.molcel.2013.04.023 Ward, 2012, Metabolic reprogramming: a cancer hallmark even warburg did not anticipate, Cancer Cell, 21, 297, 10.1016/j.ccr.2012.02.014 Taguchi, 2007, Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission, J Biol Chem, 282, 11521, 10.1074/jbc.M607279200 Qi, 2011, Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo, Mol Biol Cell, 22, 256, 10.1091/mbc.E10-06-0551 Cribbs, 2007, Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death, EMBO Reports, 8, 939, 10.1038/sj.embor.7401062 Han, 2008, CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology, J Cell Biol, 182, 573, 10.1083/jcb.200802164 Wang, 2012, Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells, Cell Metabol, 15, 186, 10.1016/j.cmet.2012.01.009 Bossy, 2010, S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease, J Alzheimer's Disease: JAD, 20, S513, 10.3233/JAD-2010-100552 Cho, 2009, S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury, Science, 324, 102, 10.1126/science.1171091 Gawlowski, 2012, Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes, J Biol Chem, 287, 30024, 10.1074/jbc.M112.390682 Zunino, 2009, Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis, J Biol Chem, 284, 17783, 10.1074/jbc.M901902200 Zunino, 2007, The SUMO protease SENP5 is required to maintain mitochondrial morphology and function, J Cell Sci, 120, 1178, 10.1242/jcs.03418 Guo, 2013, SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia, EMBO J, 32, 1514, 10.1038/emboj.2013.65 Horn, 2011, Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability, Mol Biol Cell, 22, 1207, 10.1091/mbc.E10-07-0567 Pyakurel, 2015, Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis, Mol Cell, 58, 244, 10.1016/j.molcel.2015.02.021 Lee, 2014, MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria, J Cell Sci, 127, 4954, 10.1242/jcs.157321 Leboucher, 2012, Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis, Mol Cell, 47, 547, 10.1016/j.molcel.2012.05.041 Senyilmaz, 2015, Regulation of mitochondrial morphology and function by stearoylation of TFR1, Nature, 525, 124, 10.1038/nature14601 Gegg, 2010, Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy, Human Mol Genet, 19, 4861, 10.1093/hmg/ddq419 Glauser, 2011, Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1, J Neurochem, 118, 636, 10.1111/j.1471-4159.2011.07318.x Anton, 2013, Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways, Mol Cell, 49, 487, 10.1016/j.molcel.2012.12.003