Novel Insights into the Roles of Rho Kinase in Cancer

Archivum Immunologiae et Therapiae Experimentalis - Tập 64 - Trang 259-278 - 2016
Lei Wei1,2, Michelle Surma1, Stephanie Shi1, Nathan Lambert-Cheatham1, Jianjian Shi1
1Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, USA
2Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, USA

Tóm tắt

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in the organization of the actin cytoskeleton, and is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, proliferation, and apoptosis. Since the discovery of effective inhibitors such as fasudil and Y27632, the biological roles of ROCK have been extensively explored in numerous diseases, including cancer. Accumulating evidence supports the concept that ROCK plays important roles in tumor development and progression through regulating many key cellular functions associated with malignancy, including tumorigenicity, tumor growth, metastasis, angiogenesis, tumor cell apoptosis/survival and chemoresistance as well. This review focuses on the new advances of the most recent 5 years from the studies on the roles of ROCK in cancer development and progression; the discussion is mainly focused on the potential value of ROCK inhibitors in cancer therapy.

Tài liệu tham khảo

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