Crosstalk between oncolytic viruses and autophagy in cancer therapy

Kelly, 2007, History of oncolytic viruses: genesis to genetic engineering, Mol. Ther., 15, 651, 10.1038/sj.mt.6300108

Hu, 2017, Targeting autophagy for oncolytic immunotherapy, Biomedicines, 5, 5, 10.3390/biomedicines5010005

Dikic, 2018, Mechanism and medical implications of mammalian autophagy, Nat. Rev. Mol. Cell Biol., 19, 349, 10.1038/s41580-018-0003-4

Kudchodkar, 2009, Viruses and autophagy, Rev. Med. Virol., 19, 359, 10.1002/rmv.630

Dong, 2013, Autophagy and viruses: adversaries or allies?, J. Innate Immun., 5, 480, 10.1159/000346388

Beljanski, 2015, The intersection between viral oncolysis, drug resistance, and autophagy, Biol. Chem., 396, 1269, 10.1515/hsz-2015-0147

Goradel, 2019, Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches, J. Cell. Physiol., 234, 8636, 10.1002/jcp.27850

Alemany, 2014, Oncolytic adenoviruses in cancer treatment, Biomedicines, 2, 36, 10.3390/biomedicines2010036

Liang, 2018, Oncorine, the world first oncolytic virus medicine and its update in China, Curr. Cancer Drug Targets, 18, 171, 10.2174/1568009618666171129221503

Russell, 2018, The emerging role of oncolytic virus therapy against cancer, Chinese Clin. Oncol., 7, 16, 10.21037/cco.2018.04.04

Heise, 2000, An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy, Nat. Med., 6, 1134, 10.1038/80474

Fueyo, 2000, A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo, Oncogene, 19, 2, 10.1038/sj.onc.1203251

Philbrick, 2019, DNX-2401: an investigational drug for the treatment of recurrent glioblastoma, Expert Opin. Investig. Drugs, 28, 1041, 10.1080/13543784.2019.1694000

Kuryk, 2019, Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model, Oncoimmunology, 8, 10.1080/2162402X.2018.1532763

Hemminki, 2014, Oncolytic immunotherapy: where are we clinically?, Scientifica (Cairo)., 2014

Eriksson, 2017, Shaping the tumor stroma and sparking immune activation by CD40 and 4-1BB signaling induced by an armed oncolytic virus, Clin. Cancer Res., 23, 5846, 10.1158/1078-0432.CCR-17-0285

Kaur, 2012, Oncolytic HSV-1 virotherapy: clinical experience and opportunities for progress, Curr. Pharm. Biotechnol., 13, 1842, 10.2174/138920112800958814

Kohlhapp, 2016, Molecular pathways: mechanism of action for talimogene laherparepvec, a new oncolytic virus immunotherapy, Clin. Cancer Res., 22, 1048, 10.1158/1078-0432.CCR-15-2667

Conry, 2018, Talimogene laherparepvec: first in class oncolytic virotherapy, Hum. Vaccin. Immunother., 14, 839, 10.1080/21645515.2017.1412896

Tomazin, 1998, Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP, J. Virol., 72, 2560, 10.1128/JVI.72.3.2560-2563.1998

Streby, 2017, Intratumoral injection of HSV1716, an oncolytic herpes virus, is safe and shows evidence of immune response and viral replication in young cancer patients, Clin. Cancer Res., 23, 3566, 10.1158/1078-0432.CCR-16-2900

Eissa, 2017, Genomic signature of the natural oncolytic herpes simplex virus HF10 and its therapeutic role in preclinical and clinical trials, Front. Oncol., 7, 149, 10.3389/fonc.2017.00149

Smith, 1983, Infectious poxvirus vectors have capacity for at least 25 000 base pairs of foreign DNA, Gene, 25, 21, 10.1016/0378-1119(83)90163-4

Yang, 2005, Anti-viral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction, J. Clin. Invest., 115, 379, 10.1172/JCI200523220

Haddad, 2017, Genetically engineered vaccinia viruses as agents for cancer treatment, imaging, and transgene delivery, Front. Oncol., 7, 96, 10.3389/fonc.2017.00096

Breitbach, 2015, The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594), Oncolytic Virother., 4, 25, 10.2147/OV.S59640

Mell, 2017, Phase I trial of intravenous oncolytic vaccinia virus (GL-ONC1) with cisplatin and radiotherapy in patients with locoregionally advanced head and neck carcinoma, Clin. Cancer Res., 23, 5696, 10.1158/1078-0432.CCR-16-3232

Al Yaghchi, 2015, Vaccinia virus, a promising new therapeutic agent for pancreatic cancer, Immunotherapy, 7, 1249, 10.2217/imt.15.90

Lusky, 2010, Oncolytic vaccinia virus: a silver bullet?, Expert Rev. Vaccines, 9, 1353, 10.1586/erv.10.137

Moss, 2006, Global measles elimination, Nat. Rev. Microbiol., 4, 900, 10.1038/nrmicro1550

Aref, 2016, Measles to the rescue: a review of oncolytic measles virus, Viruses, 8, 294, 10.3390/v8100294

Ungerechts, 2016, Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses, Mol. Ther. Clin. Dev., 3, 16018, 10.1038/mtm.2016.18

Hutzen, 2015, Advances in the design and development of oncolytic measles viruses, Oncolytic Virother., 4, 109

Reddi, 2012, Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy, Cancer Gene Ther., 19, 659, 10.1038/cgt.2012.47

Jhiang, 1998, An immunohistochemical study of Na+/I− symporter in human thyroid tissues and salivary gland tissues, Endocrinology, 139, 4416, 10.1210/endo.139.10.6329

Spitzweg, 2002, The sodium iodide symporter: its pathophysiological and therapeutic implications, Clin. Endocrinol. (Oxf)., 57, 559, 10.1046/j.1365-2265.2002.01640.x

Dingli, 2003, In vivo imaging and tumor therapy with the sodium iodide symporter, J. Cell. Biochem., 90, 1079, 10.1002/jcb.10714

Russell, 2019, Near-Complete Genome Sequences of Vesicular Stomatitis Virus Indiana Laboratory Strains HR and T1026R1 and Plaque Isolates 22-20 and 22-25, Microbiol Resour Announc., 8, e00012, 10.1128/MRA.00012-19

Melzer, 2017, Oncolytic vesicular stomatitis virus as a viro-immunotherapy: defeating cancer with a “hammer” and “anvil,”, Biomedicines, 5, 8, 10.3390/biomedicines5010008

Hastie, 2012, Vesicular stomatitis virus as a flexible platform for oncolytic virotherapy against cancer, J. Gen. Virol., 93, 2529, 10.1099/vir.0.046672-0

Brun, 2010, Identification of genetically modified Maraba virus as an oncolytic rhabdovirus, Mol. Ther., 18, 1440, 10.1038/mt.2010.103

Felt, 2017, Recent advances in vesicular stomatitis virus-based oncolytic virotherapy: a 5-year update, J. Gen. Virol., 98, 2895, 10.1099/jgv.0.000980

Parzych, 2014, An overview of autophagy: morphology, mechanism, and regulation, Antioxid. Redox Signal., 20, 460, 10.1089/ars.2013.5371

Peker, 2020, Autophagy as a cellular stress response mechanism in the nervous system, J. Mol. Biol., 432, 2560, 10.1016/j.jmb.2020.01.017

Sridharan, 2011, Regulation of autophagy by kinases, Cancers (Basel)., 3, 2630, 10.3390/cancers3022630

Onorati, 2018, Targeting autophagy in cancer, Cancer, 124, 3307, 10.1002/cncr.31335

Wei, 2015, The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation, Elife, 4, 10.7554/eLife.05289

Qu, 2003, Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene, J. Clin. Invest., 112, 1809, 10.1172/JCI20039

Liang, 1999, Induction of autophagy and inhibition of tumorigenesis by beclin 1, Nature, 402, 672, 10.1038/45257

Chude, 2017, Targeting autophagy in cancer: update on clinical trials and novel inhibitors, Int. J. Mol. Sci., 18, 1279, 10.3390/ijms18061279

Santana-Codina, 2017

Huang, 2018, Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma, World J. Gastroenterol., 24, 4643, 10.3748/wjg.v24.i41.4643

Wang, 2020, The role of mitochondrial dynamics and Mitophagy in carcinogenesis, metastasis and therapy, Front. Cell Dev. Biol., 8, 413, 10.3389/fcell.2020.00413

Russell, 2014, Autophagy regulation by nutrient signaling, Cell Res., 24, 42, 10.1038/cr.2013.166

Levy, 2017, Targeting autophagy in cancer, Nat. Rev. Cancer, 17, 528, 10.1038/nrc.2017.53

Vera-Ramirez, 2018, Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence, Nat. Commun., 9, 1, 10.1038/s41467-018-04070-6

Yamamoto, 2020, Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I, Nature, 581, 100, 10.1038/s41586-020-2229-5

Li, 2013, Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition, Carcinogenesis, 34, 1343, 10.1093/carcin/bgt063

Peng, 2014, Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling, Cell Death Dis., 5, 10.1038/cddis.2014.297

Kong, 2020, Autophagy inhibits TLR4‐mediated invasiveness of oral cancer cells via the NF‐κB pathway, Oral Dis., 10.1111/odi.13355

Kim, 2013, Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells, Autophagy, 9, 1579, 10.4161/auto.25987

Qin, 2015, Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells, Oncotarget, 6, 39839, 10.18632/oncotarget.5674

Yao, 2017, Autophagy promotes apoptosis induction through repressed nitric oxide generation in the treatment of human breast cancer MCF-7 cells with L-A03, a dihydroartemisinin derivative, Med. Chem. Res., 26, 1427, 10.1007/s00044-017-1868-z

Kuballa, 2012, Autophagy and the immune system, Annu. Rev. Immunol., 30, 611, 10.1146/annurev-immunol-020711-074948

Sumpter Rhea, 2011, Selective autophagy and viruses, Autophagy, 7, 260, 10.4161/auto.7.3.14281

Meiffren, 2010, Pathogen recognition by the cell surface receptor CD46 induces autophagy, Autophagy, 6, 299, 10.4161/auto.6.2.11132

Shahnazari, 2009, Eating twice for the sake of immunity: a phagocytic receptor that activates autophagy, Cell Host Microbe, 6, 297, 10.1016/j.chom.2009.10.003

Richetta, 2013, Sustained autophagy contributes to measles virus infectivity, PLoS Pathog., 9, 10.1371/journal.ppat.1003599

Petkova, 2013, IRGM in autophagy and viral infections, Front. Immunol., 3, 426, 10.3389/fimmu.2012.00426

Hansen, 2017, Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M, Proc. Natl. Acad. Sci., 114, E3462, 10.1073/pnas.1616683114

Kim, 2013, The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy, Int. J. Oncol., 42, 1337, 10.3892/ijo.2013.1812

Rodriguez-Rocha, 2011, Adenoviruses induce autophagy to promote virus replication and oncolysis, Virology, 416, 9, 10.1016/j.virol.2011.04.017

Botta, 2012, Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl 922–947 against glioma cells in vitro and in vivo, Hum. Gene Ther., 23, 623, 10.1089/hum.2011.120

Cheng, 2013, Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells, Virol. J., 10, 293, 10.1186/1743-422X-10-293

Zeng, 2013, Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells, J. Virol., 87, 2307, 10.1128/JVI.02014-12

Yu, 2010, A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models, Neuro. Oncol., 13, 14, 10.1093/neuonc/noq148

Ebrahimi, 2017, Interferon‐mediated tumor resistance to oncolytic virotherapy, J. Cell. Biochem., 118, 1994, 10.1002/jcb.25917

Xia, 2014, Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling, J. Virol., 88, 5152, 10.1128/JVI.03851-13

Nguyên, 2008, Chemical targeting of the innate anti-viral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis, Proc. Natl. Acad. Sci., 105, 14981, 10.1073/pnas.0803988105

Katsura, 2009, The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells, Cancer Gene Ther., 16, 237, 10.1038/cgt.2008.81

Shulak, 2014, Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy, J. Virol., 88, 2927, 10.1128/JVI.03406-13

Yokoyama, 2008, Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells, Gene Ther., 15, 1233, 10.1038/gt.2008.98

Jiang, 2011, Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity, J. Virol., 85, 4720, 10.1128/JVI.02032-10

Galluzzi, 2018, Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death Differ., 25, 486, 10.1038/s41418-017-0012-4

Tazawa, 2012, Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1‐microRNA‐7‐epidermal growth factor receptor axis, Int. J. Cancer, 131, 2939, 10.1002/ijc.27589

Tong, 2013, Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia, Oncotarget, 4, 860, 10.18632/oncotarget.1018

Li, 2018, Combing oncolytic adenovirus expressing Beclin-1 with chemotherapy agent doxorubicin synergistically enhances cytotoxicity in human CML cells in vitro, Acta Pharmacol. Sin., 39, 251, 10.1038/aps.2017.100

Lei, 2020, Enhancing therapeutic efficacy of oncolytic vaccinia virus armed with Beclin-1, an autophagic Gene in leukemia and myeloma, Biomed. Pharmacother., 125, 10.1016/j.biopha.2020.110030

Furukawa, 2017, Role of autophagy in oncolytic herpes simplex virus type 1-induced cell death in squamous cell carcinoma cells, Cancer Gene Ther., 24, 393, 10.1038/cgt.2017.33

Harris, 2011, Autophagy and cytokines, Cytokine, 56, 140, 10.1016/j.cyto.2011.08.022

Inoue, 2014, Multimodal immunogenic cancer cell death as a consequence of anti-cancer cytotoxic treatments, Cell Death Differ., 21, 39, 10.1038/cdd.2013.84

Kroemer, 2013, Immunogenic cell death in cancer therapy, Annu. Rev. Immunol., 31, 51, 10.1146/annurev-immunol-032712-100008

Pawaria, 2011, CD91-dependent programming of T-helper cell responses following heat shock protein immunization, Nat. Commun., 2, 1, 10.1038/ncomms1524

Elliott, 2009, Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance, Nature, 461, 282, 10.1038/nature08296

Ghiringhelli, 2009, Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors, Nat. Med., 15, 1170, 10.1038/nm.2028

Galluzzi, 2015, Autophagy in malignant transformation and cancer progression, EMBO J., 34, 856, 10.15252/embj.201490784

Hou, 2013, Strange attractors: DAMPs and autophagy link tumor cell death and immunity, Cell Death Dis., 4, 10.1038/cddis.2013.493

Garg, 2010, Immunogenic cell death, DAMPs and anti-cancer therapeutics: an emerging amalgamation, Biochim. Biophys. Acta (BBA)-Reviews Cancer, 1805, 53, 10.1016/j.bbcan.2009.08.003

Thorburn, 2009, Autophagy regulates selective HMGB1 release in tumor cells that are destined to die, Cell Death Differ., 16, 175, 10.1038/cdd.2008.143

Apetoh, 2007, The interaction between HMGB1 and TLR4 dictates the outcome of anti-cancer chemotherapy and radiotherapy, Immunol. Rev., 220, 47, 10.1111/j.1600-065X.2007.00573.x

Koks, 2015, Newcastle disease virotherapy induces long‐term survival and tumor‐specific immune memory in orthotopic glioma through the induction of immunogenic cell death, Int. J. Cancer, 136, E313, 10.1002/ijc.29202

Panzarini, 2013, Immunogenic cell death: can it be exploited in PhotoDynamic Therapy for cancer?, Biomed Res. Int., 2013, 10.1155/2013/482160

Singh-Jasuja, 2000, Cross-presentation of glycoprotein 96–associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis, J. Exp. Med., 191, 1965, 10.1084/jem.191.11.1965

Hickman-Miller, 2004, The immune response under stress: the role of HSP-derived peptides, Trends Immunol., 25, 427, 10.1016/j.it.2004.05.011

Lehner, 2004

Shao, 2019, STAT3 contributes to oncolytic newcastle disease virus-induced immunogenic cell death in melanoma cells, Front. Oncol., 9, 436, 10.3389/fonc.2019.00436

Jonchère, 2013, STAT3 as a new autophagy regulator, Jak-Stat., 2, 667, 10.4161/jkst.24353

Baird, 2008, Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer, Oncogene, 27, 3081, 10.1038/sj.onc.1210977

Li, 2018, Deficiency of the IRE1α-autophagy axis enhances the antitumor effects of the oncolytic virus M1, J. Virol., 92, e01331, 10.1128/JVI.01331-17