Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats

Molecular Brain - Tập 16 - Trang 1-12 - 2023
Hyun Jung Jee1,2, Elaine Zhu1, Mengqi Sun1, Weizhuo Liu1, Qiaosheng Zhang1,2, Jing Wang1,2,3,4
1Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University Grossman School of Medicine, New York, USA
2Interdisciplinary Pain Research Program, New York University Langone Health, New York, USA
3Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, USA
4Neuroscience Institute, New York University Grossman School of Medicine, New York, USA

Tóm tắt

Negative pain expectation including pain catastrophizing is a well-known clinical phenomenon whereby patients amplify the aversive value of a painful or oftentimes even a similar, non-painful stimulus. Mechanisms of pain catastrophizing, however, remain elusive. Here, we modeled pain catastrophizing behavior in rats, and found that rats subjected to repeated noxious pin pricks on one paw demonstrated an aversive response to similar but non-noxious mechanical stimuli delivered to the contralateral paw. Optogenetic inhibition of pyramidal neuron activity in the anterior cingulate cortex (ACC) during the application of repetitive noxious pin pricks eliminated this catastrophizing behavior. Time-lapse calcium (Ca2+) imaging in the ACC further revealed an increase in spontaneous neural activity after the delivery of noxious stimuli. Together these results suggest that the experience of repeated noxious stimuli may drive hyperactivity in the ACC, causing increased avoidance of subthreshold stimuli, and that reducing this hyperactivity may play a role in treating pain catastrophizing.

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Molecular Brain

Tập 16

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