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Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene
mBio - Tập 8 Số 4 - 2017
ABSTRACT Fosfomycin is a decades-old antibiotic which is being revisited because
of its perceived activity against many extensively drug-resistant Gram-negative
pathogens. FosA proteins are Mn 2+ and K + -dependent glutathione S
-transferases which confer fosfomycin resistance in Gram-negative bacteria by
conjugation of glutathione to the antibiotic. Plasmid-borne fosA variants have
been reported ...
Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance
mBio - Tập 6 Số 4 - 2015
ABSTRACT The fungal cell wall confers cell morphology and protection against
environmental insults. For fungal pathogens, the cell wall is a key
immunological modulator and an ideal therapeutic target. Yeast cell walls
possess an inner matrix of interlinked β-glucan and chitin that is thought to
provide tensile strength and rigidity. Yeast cells remodel their walls over time
in response to environ...
Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses
mBio - Tập 9 Số 1 - 2018
ABSTRACT Receptor-mediated endocytosis is a cellular process commonly hijacked
by viruses to enter cells. The stages of entry are well described for certain
viruses, but the host factors that mediate each step are less well
characterized. We previously identified endosomal cation channel mucolipin-2
(MCOLN2) as a host factor that promotes viral infection. Here, we assign a role
for MCOLN2 in modul...
Bactofencin A, a New Type of Cationic Bacteriocin with Unusual Immunity
mBio - Tập 4 Số 6 - 2013
ABSTRACT Bacteriocin production is an important probiotic trait of intestinal
bacteria. In this study, we identify a new type of bacteriocin, bactofencin A,
produced by a porcine intestinal isolate Lactobacillus salivarius DPC6502, and
assess its potency against pathogenic species including Staphylococcus aureus
and Listeria monocytogenes . Genome sequencing of the bacteriocin producer
revealed bf...
Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production
mBio - Tập 10 Số 3 - 2019
Toxoplasma gondiiis a protozoan parasite and a leading cause of foodborne
illness. Infection is initiated when the parasite invades the intestinal
epithelium, and in many host species, this leads to intense inflammation and a
dramatic disruption of the normal microbial ecosystem that resides in the
healthy gut (the so-called microbiome). One characteristic change in the
microbiome during infection...
Drivers of Microbiome Biodiversity: A Review of General Rules, Feces, and Ignorance
mBio - Tập 9 Số 4 - 2018
The alpha diversity of ecologic communities is affected by many biotic and
abiotic drivers and, in turn, affects ecosystem functioning. Yet, patterns of
alpha diversity in host-associated microbial communities (microbiomes) are
poorly studied and the appropriateness of general theory is untested.
Spatial-Temporal Survey and Occupancy-Abundance Modeling To Predict Bacterial Community Dynamics in the Drinking Water Microbiome
mBio - Tập 5 Số 3 - 2014
ABSTRACT Bacterial communities migrate continuously from the drinking water
treatment plant through the drinking water distribution system and into our
built environment. Understanding bacterial dynamics in the distribution system
is critical to ensuring that safe drinking water is being supplied to customers.
We present a 15-month survey of bacterial community dynamics in the drinking
water syste...
A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague
mBio - Tập 9 Số 5 - 2018
Following the deadly anthrax attacks of 2001, the Centers for Disease Control
and Prevention (CDC) determined that Bacillus anthracis and Yersinia pestis that
cause anthrax and plague, respectively, are two Tier 1 select agents that pose
the greatest threat to the national security of the United States. Both cause
rapid death, in 3 to 6 days, of exposed individuals. We engineered a virus
nanoparti...
Extracellular Enzymes Facilitate Electron Uptake in Biocorrosion and Bioelectrosynthesis
mBio - Tập 6 Số 2 - 2015
ABSTRACT Direct, mediator-free transfer of electrons between a microbial cell
and a solid phase in its surrounding environment has been suggested to be a
widespread and ecologically significant process. The high rates of microbial
electron uptake observed during microbially influenced corrosion of iron [Fe(0)]
and during microbial electrosynthesis have been considered support for a direct
electron...
Ecological Patterns of nifH Genes in Four Terrestrial Climatic Zones Explored with Targeted Metagenomics Using FrameBot, a New Informatics Tool
mBio - Tập 4 Số 5 - 2013
ABSTRACT Biological nitrogen fixation is an important component of sustainable
soil fertility and a key component of the nitrogen cycle. We used targeted
metagenomics to study the nitrogen fixation-capable terrestrial bacterial
community by targeting the gene for nitrogenase reductase ( nifH ). We obtained
1.1 million nifH 454 amplicon sequences from 222 soil samples collected from 4
National Ecol...
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