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Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene
mBio - Tập 8 Số 4 - 2017
Ryota Ito, Mustapha M. Mustapha, Adam D. Tomich, Jake D. Callaghan, Christi L. McElheny, Roberta T. Mettus, Robert M. Q. Shanks, Nicolas Sluis‐Cremer, Yohei Doi
ABSTRACT Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn 2+ and K + -dependent glutathione S<...... hiện toàn bộ
Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance
mBio - Tập 6 Số 4 - 2015
Iuliana V. Ene, Louise A. Walker, Marion Schiavone, Keunsook K. Lee, Hélène Martin‐Yken, Étienne Dague, Neil A. R. Gow, Carol A. Munro, Alistair J. P. Brown
ABSTRACT The fungal cell wall confers cell morphology and protection against environmental insults. For fungal pathogens, the cell wall is a key immunological modulator and an ideal therapeutic target. Yeast cell walls possess an inner matrix of interlinked β-glucan and chitin that is thought to provide tensile strength and rigidity. Yeast ce...... hiện toàn bộ
Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses
mBio - Tập 9 Số 1 - 2018
Nicholas Rinkenberger, John W. Schoggins
ABSTRACT Receptor-mediated endocytosis is a cellular process commonly hijacked by viruses to enter cells. The stages of entry are well described for certain viruses, but the host factors that mediate each step are less well characterized. We previously identified endosomal cation channel mucolipin-2 (MCOLN2) as a host factor that promotes vir...... hiện toàn bộ
Bactofencin A, a New Type of Cationic Bacteriocin with Unusual Immunity
mBio - Tập 4 Số 6 - 2013
Eileen F. O'Shea, Paula M. O’Connor, Órla O’Sullivan, Paul D. Cotter, R. Paul Ross, Colin Hill
ABSTRACT Bacteriocin production is an important probiotic trait of intestinal bacteria. In this study, we identify a new type of bacteriocin, bactofencin A, produced by a porcine intestinal isolate Lactobacillus salivarius DPC6502, and assess its pot...... hiện toàn bộ
Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production
mBio - Tập 10 Số 3 - 2019
Shuai Wang, Ayah El‐Fahmawi, David A. Christian, Qun Fang, Enrico Radaelli, Longfei Chen, Megan C. Sullivan, Ana M. Misic, Jodi A. Ellringer, Xing Zhu, Sebastian Winter, Christopher A. Hunter, Daniel P. Beiting
Toxoplasma gondiiis a protozoan parasite and a leading cause of foodborne illness. Infection is initiated when the parasite invades the intestinal epithelium, and in many host species, this leads to intense inflammation and a dramatic disruption of the normal microbial ecosystem that resides in the healthy gut (the so-ca...... hiện toàn bộ
Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes
mBio - Tập 13 Số 2 - 2022
LaNisha L. Patterson, Thangam S. Velayutham, Caitlan D. Byerly, Duc‐Cuong Bui, Jignesh Patel, Veljko Veljković, Slobodan Paessler, Jere W. McBride
E. chaffeensis infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand mimicry cellular reprogramming strategy that involved a ...... hiện toàn bộ
Drivers of Microbiome Biodiversity: A Review of General Rules, Feces, and Ignorance
mBio - Tập 9 Số 4 - 2018
Aspen T. Reese, Robert R. Dunn
The alpha diversity of ecologic communities is affected by many biotic and abiotic drivers and, in turn, affects ecosystem functioning. Yet, patterns of alpha diversity in host-associated microbial communities (microbiomes) are poorly studied and the appropriateness of general theory is untested.
Spatial-Temporal Survey and Occupancy-Abundance Modeling To Predict Bacterial Community Dynamics in the Drinking Water Microbiome
mBio - Tập 5 Số 3 - 2014
Ameet J. Pinto, Joanna L. Schroeder, Mary Lunn, William T. Sloan, Lutgarde Raskin
ABSTRACT Bacterial communities migrate continuously from the drinking water treatment plant through the drinking water distribution system and into our built environment. Understanding bacterial dynamics in the distribution system is critical to ensuring that safe drinking water is being supplied to customers. We present a 15-month survey of bacterial com...... hiện toàn bộ
A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague
mBio - Tập 9 Số 5 - 2018
Tao Pan, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Jian Sha, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Following the deadly anthrax attacks of 2001, the Centers for Disease Control and Prevention (CDC) determined that Bacillus anthracis and Yersinia pestis that cause anthrax and plague, respec...... hiện toàn bộ
Extracellular Enzymes Facilitate Electron Uptake in Biocorrosion and Bioelectrosynthesis
mBio - Tập 6 Số 2 - 2015
Jörg S. Deutzmann, Merve Şahin, Alfred M. Spormann
ABSTRACT Direct, mediator-free transfer of electrons between a microbial cell and a solid phase in its surrounding environment has been suggested to be a widespread and ecologically significant process. The high rates of microbial electron uptake observed during microbially influenced corrosion of iron [Fe(0)] and during microbial electrosynt...... hiện toàn bộ
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