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Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes
E. chaffeensis
infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand mimicry cellular reprogramming strategy that involved a ... ... hiện toàn bộ
mBio - Tập 13 Số 2 - 2022
Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA GeneABSTRACT
Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn
2+
and K
+
-dependent glutathione
S<... ... hiện toàn bộ
mBio - Tập 8 Số 4 - 2017
Horizontal Transfer of the Salmonella enterica Serovar Infantis Resistance and Virulence Plasmid pESI to the Gut Microbiota of Warm-Blooded HostsABSTRACT
Salmonella enterica
serovar Infantis is one of the prevalent salmonellae worldwide. Recently, we showed that the emergence of
S
. Infantis in Israel was facilitated by the acquisition of a unique megapl... ... hiện toàn bộ
mBio - Tập 7 Số 5 - 2016
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 PatientsCOVID-19 has presented various paradoxes that, if understood better, may provide clues to controlling the pandemic, even before a COVID-19 vaccine is widely available. First, young children are largely spared from severe disease. Second, numerous countries have COVID-19 death rates that are as low as 1% of the death rates of other countries. Third, many people, despite prolonged close cont... ... hiện toàn bộ
mBio - Tập 11 Số 6 - 2020
Extracellular Enzymes Facilitate Electron Uptake in Biocorrosion and BioelectrosynthesisABSTRACT
Direct, mediator-free transfer of electrons between a microbial cell and a solid phase in its surrounding environment has been suggested to be a widespread and ecologically significant process. The high rates of microbial electron uptake observed during microbially influenced corrosion of iron [Fe(0)] and during microbial electrosynt... ... hiện toàn bộ
mBio - Tập 6 Số 2 - 2015
Malaria Parasites Produce Volatile Mosquito AttractantsABSTRACT
The malaria parasite
Plasmodium falciparum
contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes... ... hiện toàn bộ
mBio - Tập 6 Số 2 - 2015
First Evidence for Internal Ribosomal Entry Sites in Diverse Fungal Virus GenomesABSTRACT
In contrast to well-established internal ribosomal entry site (IRES)-mediated translational initiation in animals and plants, no IRESs were established in fungal viral or cellular RNAs. To identify IRES elements in mycoviruses, we developed a luciferase-based dual-reporter detection system in
Cryphonectria pa... ... hiện toàn bộ
mBio - Tập 9 Số 2 - 2018
The KGD Motif of Epstein-Barr Virus gH/gL Is Bifunctional, Orchestrating Infection of B Cells and Epithelial CellsABSTRACT
Epstein-Barr virus (EBV), a member of the herpesvirus family, is the causative agent of common human infections and specific malignancies. EBV entry into target cells, including B cells and epithelial cells, requires the interaction of multiple virus-encoded glycoproteins. Glycoproteins H and L (gH/gL) cooperate with glycoprotein B (gB) to mediat... ... hiện toàn bộ
mBio - Tập 3 Số 1 - 2012
Predicting the Next Eye Pathogen: Analysis of a Novel AdenovirusABSTRACT
For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach to study the pathogenicity of a novel human adenovirus with a naturally occurring deletion of the canonical pento... ... hiện toàn bộ
mBio - Tập 4 Số 2 - 2013
H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral LoadABSTRACT
The genotype of the host is one of several factors involved in the pathogenesis of an infectious disease and may be a key parameter in the epidemiology of highly pathogenic H5N1 influenza virus infection in humans. Gene polymorphisms may affect the viral replication rate or alter the host’s immune response to the virus. In humans, it is unclear w... ... hiện toàn bộ
mBio - Tập 2 Số 5 - 2011
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