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Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene
mBio - Tập 8 Số 4 - 2017
Ryota Ito, Mustapha M. Mustapha, Adam D. Tomich, Jake D. Callaghan, Christi L. McElheny, Roberta T. Mettus, Robert M. Q. Shanks, Nicolas Sluis‐Cremer, Yohei Doi
ABSTRACT Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn 2+ and K + -dependent glutathione S<...... hiện toàn bộ
Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance
mBio - Tập 6 Số 4 - 2015
Iuliana V. Ene, Louise A. Walker, Marion Schiavone, Keunsook K. Lee, Hélène Martin‐Yken, Étienne Dague, Neil A. R. Gow, Carol A. Munro, Alistair J. P. Brown
ABSTRACT The fungal cell wall confers cell morphology and protection against environmental insults. For fungal pathogens, the cell wall is a key immunological modulator and an ideal therapeutic target. Yeast cell walls possess an inner matrix of interlinked β-glucan and chitin that is thought to provide tensile strength and rigidity. Yeast ce...... hiện toàn bộ
Bactofencin A, a New Type of Cationic Bacteriocin with Unusual Immunity
mBio - Tập 4 Số 6 - 2013
Eileen F. O'Shea, Paula M. O’Connor, Órla O’Sullivan, Paul D. Cotter, R. Paul Ross, Colin Hill
ABSTRACT Bacteriocin production is an important probiotic trait of intestinal bacteria. In this study, we identify a new type of bacteriocin, bactofencin A, produced by a porcine intestinal isolate Lactobacillus salivarius DPC6502, and assess its pot...... hiện toàn bộ
Drivers of Microbiome Biodiversity: A Review of General Rules, Feces, and Ignorance
mBio - Tập 9 Số 4 - 2018
Aspen T. Reese, Robert R. Dunn
The alpha diversity of ecologic communities is affected by many biotic and abiotic drivers and, in turn, affects ecosystem functioning. Yet, patterns of alpha diversity in host-associated microbial communities (microbiomes) are poorly studied and the appropriateness of general theory is untested.
Spatial-Temporal Survey and Occupancy-Abundance Modeling To Predict Bacterial Community Dynamics in the Drinking Water Microbiome
mBio - Tập 5 Số 3 - 2014
Ameet J. Pinto, Joanna L. Schroeder, Mary Lunn, William T. Sloan, Lutgarde Raskin
ABSTRACT Bacterial communities migrate continuously from the drinking water treatment plant through the drinking water distribution system and into our built environment. Understanding bacterial dynamics in the distribution system is critical to ensuring that safe drinking water is being supplied to customers. We present a 15-month survey of bacterial com...... hiện toàn bộ
Extracellular Enzymes Facilitate Electron Uptake in Biocorrosion and Bioelectrosynthesis
mBio - Tập 6 Số 2 - 2015
Jörg S. Deutzmann, Merve Şahin, Alfred M. Spormann
ABSTRACT Direct, mediator-free transfer of electrons between a microbial cell and a solid phase in its surrounding environment has been suggested to be a widespread and ecologically significant process. The high rates of microbial electron uptake observed during microbially influenced corrosion of iron [Fe(0)] and during microbial electrosynt...... hiện toàn bộ
Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
mBio - Tập 9 Số 3 - 2018
Eric V. Stabb
ABSTRACT Pheromone signaling (PS) underlies many important bacterial behaviors, yet its ecological functions remain unresolved. Because pheromone-mediated behaviors require high cell density, the term “quorum sensing” is widely used to describe and make sense of PS. However, while this term has unified and popularized the field, bacterial PS ...... hiện toàn bộ
Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses
mBio - Tập 11 Số 2 - 2020
Nancy A. Chow, José F. Muñoz, Lalitha Gade, Elizabeth L. Berkow, Li Xiao, Rory M. Welsh, Kaitlin Forsberg, Shawn R. Lockhart, Rodney D. Adam, Alexandre Alanio, Ana Alastruey‐Izquierdo, Sahar Althawadi, Ana Belén Araúz, Ronen Ben‐Ami, Amrita Bharat, Belinda Calvo, Marie Desnos‐Ollivier, Patricia Escandón, Dianne Gardam, Gunturu Revathi, Christopher H. Heath, Oliver Kurzai, Ronny Martin, Anastasia P. Litvintseva, Christina A. Cuomo
In less than a decade, C. auris has emerged in health care settings worldwide; this species is capable of colonizing skin and causing outbreaks of invasive candidiasis. In contrast to other Candida species, ... hiện toàn bộ
Escherichia coli ST131- H 22 as a Foodborne Uropathogen
mBio - Tập 9 Số 4 - 2018
Cindy M. Liu, Marc Stegger, Maliha Aziz, Timothy J. Johnson, Kara Waits, Lora Nordstrom, Lori Gauld, Brett Weaver, Diana Rolland, Sally Statham, Joseph Horwinski, Sanjeev Sariya, Gregg S. Davis, Evgeni V. Sokurenko, Paul Keim, James R. Johnson, Lance B. Price
E. coli ST131 is an important extraintestinal pathogen that can colonize the gastrointestinal tracts of humans and food animals. Here, we combined detection of accessory traits associated with avian adaptation (ColV plasmids) with high-resolution phylogenetics to quantify the portion of human inf...... hiện toàn bộ
Antimicrobial Actions of Reactive Oxygen Species
mBio - Tập 2 Số 5 - 2011
Ferric C. Fang
ABSTRACT Everything should be as simple as it can be, but not simpler. —Attributed to Albert Einstein (1) ...... hiện toàn bộ
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