Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

mBio - Tập 13 Số 2 - 2022
LaNisha L. Patterson1, Thangam S. Velayutham1, Caitlan D. Byerly1, Duc‐Cuong Bui1, Jignesh Patel1, Veljko Veljković2, Slobodan Paessler1, Jere W. McBride3,1,4,5,6
1Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
2Biomed Protection, LLC, Galveston, Texas, USA
3Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA
4Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA
5Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
6Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA

Tóm tắt

E. chaffeensis infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand mimicry cellular reprogramming strategy that involved a short linear motif (SLiM), which enabled E. chaffeensis to exploit host cell signaling to establish and maintain infection. E. chaffeensis TRP120 is a moonlighting effector that has been associated with cellular activation and other functions, including ubiquitin ligase activity.

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