A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes Tập 4 Số 1 - 2013
Paul D. Fey, Jennifer L. Endres, Vijaya Kumar Yajjala, Todd J. Widhelm, Robert Boissy, Jeffrey L. Bose, Kenneth W. Bayles
ABSTRACT To enhance the research capabilities of investigators interested in
Staphylococcus aureus , the Nebraska Center for Staphylococcal Research (CSR)
has generated a sequence-defined transposon mutant library consisting of 1,952
strains, each containing a single mutation within a nonessential gene of the
epidemic community-associated methicillin-resistant S. aureus (CA-MRSA) isolate
USA300. T... hiện toàn bộ
Functional Molecular Ecological Networks Tập 1 Số 4 - 2010
Jizhong Zhou, Ye Deng, Feng Luo, Zhili He, Qichao Tu, Zhi Xiao
ABSTRACT Biodiversity and its responses to environmental changes are central
issues in ecology and for society. Almost all microbial biodiversity research
focuses on “species” richness and abundance but not on their interactions.
Although a network approach is powerful in describing ecological interactions
among species, defining the network structure in a microbial community is a
great challenge.... hiện toàn bộ
Phylogenetic Molecular Ecological Network of Soil Microbial Communities in Response to Elevated CO 2 Tập 2 Số 4 - 2011
Jizhong Zhou, Ye Deng, Feng Luo, Zhili He, Yunfeng Yang
ABSTRACT Understanding the interactions among different species and their
responses to environmental changes, such as elevated atmospheric concentrations
of CO 2 , is a central goal in ecology but is poorly understood in microbial
ecology. Here we describe a novel random matrix theory (RMT)-based conceptual
framework to discern phylogenetic molecular ecological networks using
metagenomic sequencin... hiện toàn bộ
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis Tập 9 Số 5 - 2018
Lisa E. Gralinski, Timothy P. Sheahan, Thomas E. Morrison, Vineet D. Menachery, Kara Jensen, Sarah R. Leist, Alan C. Whitmore, Mark T. Heise, Ralph S. Baric
The complement system is a critical part of host defense to many bacterial,
viral, and fungal infections. It works alongside pattern recognition receptors
to stimulate host defense systems in advance of activation of the adaptive
immune response. In this study, we directly test the role of complement in
SARS-CoV pathogenesis using a mouse model and show that respiratory disease is
significantly re... hiện toàn bộ
Conditionally Rare Taxa Disproportionately Contribute to Temporal Changes in Microbial Diversity Tập 5 Số 4 - 2014
Ashley Shade, Stuart E. Jones, J. Gregory Caporaso, Jo Handelsman, Rob Knight, Noah Fierer, Jack A. Gilbert
ABSTRACT Microbial communities typically contain many rare taxa that make up the
majority of the observed membership, yet the contribution of this microbial
“rare biosphere” to community dynamics is unclear. Using 16S rRNA amplicon
sequencing of 3,237 samples from 42 time series of microbial communities from
nine different ecosystems (air; marine; lake; stream; adult human skin, tongue,
and gut; i... hiện toàn bộ
Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials Tập 6 Số 6 - 2015
Sarah L. Warnes, Zoë R. Little, C. W. Keevil
ABSTRACT The evolution of new and reemerging historic virulent strains of
respiratory viruses from animal reservoirs is a significant threat to human
health. Inefficient human-to-human transmission of zoonotic strains may
initially limit the spread of transmission, but an infection may be contracted
by touching contaminated surfaces. Enveloped viruses are often susceptible to
environmental stresse... hiện toàn bộ
Identification of Novel Mobilized Colistin Resistance Gene mcr-9 in a Multidrug-Resistant, Colistin-Susceptible Salmonella enterica Serotype Typhimurium Isolate Tập 10 Số 3 - 2019
Laura M. Carroll, Ahmed Gaballa, Claudia Guldimann, Genevieve Sullivan, Lory O. Henderson, Martin Wiedmann
Colistin is a last-resort antibiotic that is used to treat severe infections
caused by MDR and extensively drug-resistant (XDR) bacteria. The World Health
Organization (WHO) has designated colistin as a “highest priority critically
important antimicrobial for human medicine” (WHO, Critically Important
Antimicrobials for Human Medicine , 5th revision , 2017,
https://www.who.int/foodsafety/publicati... hiện toàn bộ
Flavin Electron Shuttles Dominate Extracellular Electron Transfer by Shewanella oneidensis Tập 4 Số 1 - 2013
Nicholas J. Kotloski, Jeffrey A. Gralnick
ABSTRACTShewanella oneidensisstrain MR-1 is widely studied for its ability to
respire a diverse array of soluble and insoluble electron acceptors. The ability
to breathe insoluble substrates is defined as extracellular electron transfer
and can occur via direct contact or by electron shuttling inS. oneidensis. To
determine the contribution of flavin electron shuttles in extracellular electron
tran... hiện toàn bộ