Wiley
0106-9543
1600-0676
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Các bài báo tiêu biểu
Signal transduction in hepatic stellate cellsABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key cell types involved in the progression of liver fibrosis and in the related pathophysiological and clinical complications. Following acute or chronic liver tissue damage, HSC undergo a process of activation towards a phenotype characterised by increased proliferation, motility, contractil...
Tập 18 Số 1 - Trang 2-13 - 1998
Appearance of α‐smooth‐muscle‐actin‐positive cells in hepatic fibrosisABSTRACT— The appearance of α‐smooth‐muscle‐actin (α‐smA)‐positive cells during hepatic fibrosis was studied immunohistochemically in rat and human livers. In the normal rat liver, α‐smA was observed only in vascular smooth muscle cells. With the progression of fibrosis induced by CCl4 injection, α‐smA‐positive cells appeared in the perisinusoida...
Tập 11 Số 2 - Trang 100-105 - 1991
The role of hepatic peroxisome proliferator‐activated receptors (PPARs) in health and diseaseAbstract: The liver has long been known to respond to exposure to certain chemicals with hyperplasia and proliferation of the peroxisomal compartment. This response is now known to be mediated by specific receptors. The peroxisome proliferator‐activated receptors (PPARs) were cloned 10 years ago, and in that interval, have been found to serve as receptors for a numbe...
Tập 20 Số 3 - Trang 191-199 - 2000
Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitisAbstract: Background/Aims: Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are two autoimmune diseases with unknown etiologies that primarily target the liver. In both diseases, liver lesions are accompanied by large infiltrates of mononuclear cells. The purpose of this study was to determine if either the Fas‐mediated or th...
Tập 21 Số 4 - Trang 272-279 - 2001
Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Thl‐like response in chronic hepatitis CAbstract: Background/Aims : The involvement of a direct viral cytopathic effect or an immune‐mediated mechanism in the progression of hepatic damage in chronic hepatitis C is controversial. The type of immune response is itself a matter of controversy, and histological data are lacking. The aim of this study was to identify the factors ass...
Tập 19 Số 3 - Trang 212-219 - 1999
Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulusABSTRACT— Regression of bile ductular hyperplasia following elimination of the proliferative stimulus is widely recognised but the mode of deletion of the excess biliary epithelial cells (BEC) is not understood. Apoptosis, a process of cell death distinct from coagulative necrosis, is known to be involved in both atrophy and physiological involution of various organs...
Tập 5 Số 6 - Trang 311-325 - 1985
Long interval between HCV infection and development of hepatocellular carcinomaAbstract: A high prevalence of HCV infection has been reported in patients with hepatocellular carcinoma. The progression from acute transfusion‐associated hepatitis to hepatic cirrhosis and hepatocellular carcinoma has been suggested in several studies to be very long. We have investigated the prevalence of anti‐HCV and the interval between HCV infection and hepato...
Tập 15 Số 3 - Trang 159-163 - 1995
Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronanABSTRACT— Serum concentrations of the aminoterminal propeptide of type III procollagen and of the 7S domain of type IV collagen, presumed to reflect fibrotic activity in liver tissue, and of the glycosamonoglycan hyaluronan, were obtained from 40 alcohol abusers, at the time of liver biopsy. The serological results were related to morphological findings in liver tiss...
Tập 7 Số 6 - Trang 339-346 - 1987
Expression of human telomerase reverse transcriptase in regenerative and precancerous lesions of cirrhotic liversAbstract: Background/Aims:
The catalytic subunit of human telomerase (hTERT) is known to be expressed in a variety of malignant tumours, including hepatocellular carcinoma (HCC). We studied hTERT expression in regenerative and precancerous lesions arising in cirrhosis. Methods/Results: As shown by ... hiện toàn bộ
Tập 22 Số 1 - Trang 57-69 - 2002