Wiley
0106-9543
1600-0676
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Signal transduction in hepatic stellate cells
Tập 18 Số 1 - Trang 2-13 - 1998
ABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key
cell types involved in the progression of liver fibrosis and in the related
pathophysiological and clinical complications. Following acute or chronic liver
tissue damage, HSC undergo a process of activation towards a phenotype
characterised by increased proliferation, motility, contractility and synthesis
of extracellu...
Appearance of α‐smooth‐muscle‐actin‐positive cells in hepatic fibrosis
Tập 11 Số 2 - Trang 100-105 - 1991
ABSTRACT— The appearance of α‐smooth‐muscle‐actin (α‐smA)‐positive cells during
hepatic fibrosis was studied immunohistochemically in rat and human livers. In
the normal rat liver, α‐smA was observed only in vascular smooth muscle cells.
With the progression of fibrosis induced by CCl4 injection, α‐smA‐positive cells
appeared in the perisinusoidal space and the fibrous septa, and ultimately
surrou...
The role of hepatic peroxisome proliferator‐activated receptors (PPARs) in health and disease
Tập 20 Số 3 - Trang 191-199 - 2000
Abstract: The liver has long been known to respond to exposure to certain
chemicals with hyperplasia and proliferation of the peroxisomal compartment.
This response is now known to be mediated by specific receptors. The peroxisome
proliferator‐activated receptors (PPARs) were cloned 10 years ago, and in that
interval, have been found to serve as receptors for a number of endogenous lipid
compounds...
Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis
Tập 21 Số 4 - Trang 272-279 - 2001
Abstract: Background/Aims: Autoimmune hepatitis (AIH) and primary biliary
cirrhosis (PBC) are two autoimmune diseases with unknown etiologies that
primarily target the liver. In both diseases, liver lesions are accompanied by
large infiltrates of mononuclear cells. The purpose of this study was to
determine if either the Fas‐mediated or the granule‐exocytosis pathways
contribute to apoptosis in th...
Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Thl‐like response in chronic hepatitis C
Tập 19 Số 3 - Trang 212-219 - 1999
Abstract: Background/Aims: The involvement of a direct viral cytopathic effect
or an immune‐mediated mechanism in the progression of hepatic damage in chronic
hepatitis C is controversial. The type of immune response is itself a matter of
controversy, and histological data are lacking. The aim of this study was to
identify the factors associated with the progression of liver injury in 30
HCV/RNA‐p...
Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus
Tập 5 Số 6 - Trang 311-325 - 1985
ABSTRACT— Regression of bile ductular hyperplasia following elimination of the
proliferative stimulus is widely recognised but the mode of deletion of the
excess biliary epithelial cells (BEC) is not understood. Apoptosis, a process of
cell death distinct from coagulative necrosis, is known to be involved in both
atrophy and physiological involution of various organs. Therefore, a time course
hist...
Long interval between HCV infection and development of hepatocellular carcinoma
Tập 15 Số 3 - Trang 159-163 - 1995
Abstract: A high prevalence of HCV infection has been reported in patients with
hepatocellular carcinoma. The progression from acute transfusion‐associated
hepatitis to hepatic cirrhosis and hepatocellular carcinoma has been suggested
in several studies to be very long. We have investigated the prevalence of
anti‐HCV and the interval between HCV infection and hepatocellular carcinoma
among 191 con...
Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronan
Tập 7 Số 6 - Trang 339-346 - 1987
ABSTRACT— Serum concentrations of the aminoterminal propeptide of type III
procollagen and of the 7S domain of type IV collagen, presumed to reflect
fibrotic activity in liver tissue, and of the glycosamonoglycan hyaluronan, were
obtained from 40 alcohol abusers, at the time of liver biopsy. The serological
results were related to morphological findings in liver tissue, i.e. no
fibrosis, fibrosis ...
Expression of human telomerase reverse transcriptase in regenerative and precancerous lesions of cirrhotic livers
Tập 22 Số 1 - Trang 57-69 - 2002
Abstract: Background/Aims: The catalytic subunit of human telomerase (hTERT) is
known to be expressed in a variety of malignant tumours, including
hepatocellular carcinoma (HCC). We studied hTERT expression in regenerative and
precancerous lesions arising in cirrhosis. Methods/Results: As shown by in situ
hybridisation, hTERT mRNA was absent in normal liver, but present in varying
numbers of hepat...