Wiley

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Signal transduction in hepatic stellate cells
Wiley - Tập 18 Số 1 - Trang 2-13 - 1998
Massimo Pinzani, Fabio Marra, Vinicio Carloni
ABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key cell types involved in the progression of liver fibrosis and in the related pathophysiological and clinical complications. Following acute or chronic liver tissue damage, HSC undergo a process of activation towards a phenotype characterised by increased proliferation, motility, contractil...... hiện toàn bộ
Distribution of hepatitis C virus RNA in the liver and its relation to histopathological changes
Wiley - Tập 16 Số 1 - Trang 55-60 - 1996
S. Kojima, Yukië Tanaka, Nobuyuki Enomoto, Fumiaki Marumo, Chifumi Sato
Abstract: To investigate a cellular mode of HCV‐infection in the liver and its pathological implications in relation to histopathological changes or clinical data, we studied the distribution of HCV‐RNA in the livers of 21 patients with HCV‐related chronic liver disease (chronic active hepatitis, 14 cases; cirrhosis, 7 cases) using the in situ... hiện toàn bộ
The detection of acetaldehyde/liver plasma membrane protein adduct formed in vivo by alcohol feeding
Wiley - Tập 7 Số 6 - Trang 364-368 - 1987
R. E. Barry, Alistair J.K. Williams, J D McGivan
ABSTRACT— In order to assess whether acetaldehyde adducts with liver plasma membrane proteins are formed in vivo during alcohol ingestion, liver plasma membranes were prepared from control rats and rats fed on 10% ethanol from weaning and the amino acid constituents of liver plasma membrane proteins were assessed by reversed phase liquid ch...... hiện toàn bộ
Involvement of platelet‐activating factor in hepatic apoptosis and necrosis in chronic ethanol‐fed rats given endotoxin
Wiley - Tập 22 Số 5 - Trang 394-403 - 2002
Go Murohisa, Yoshimasa Kobayashi, T Kawasaki, Satoshi Nakamura, Hirotoshi Nakamura
Abstract: Background/Aims: Platelet‐activating factor (PAF)—a potent activator of neutrophils—plays an important role in the pathogenesis of endotoxin‐induced tissue injury. However, the role of PAF in hepatic damage during alcoholic hepatitis remains unclear. The aims of the present study were to test whether PAF contributes to hepatic injury ...... hiện toàn bộ
Serum aminoterminal procollagen type III peptide in acute viral hepatitis. A long‐term follow‐up study
Wiley - Tập 7 Số 2 - Trang 96-105 - 1987
Kirsten D. Bentsen, Kim Hørslev‐Petersen, Peter Junker, E Juhl, I. Lorenzen
ABSTRACT— The development of chronic viral liver disease is associated with increased deposition of connective tissue in the liver. The aminoterminal propeptide of procollagen type III (P‐III‐NP) is considered to reflect the metabolism of collagen type III, one of the major collagen types in liver fibrosis. The purpose of the present study was to elucidate, whether S...... hiện toàn bộ
Submassive hepatic necrosis induced by dichloropropanol
Wiley - Tập 13 Số 3 - Trang 123-129 - 1993
Joji Haratake, Akiko Furuta, Toshio Iwasa, Choei Wakasugi, Kazuhiko Imazu
ABSTRACT— A hitherto undescribed industrial liver injury of fulminant form induced by dichloropropanol is reported. Two middle‐aged men developed severe hepatic injury just after cleaning a dichloropropanol tank at a plant producing dichloropropanol. They died from hepatic failure 4 and 11 days respectively, after carrying out the work. Liver specimens taken at autop...... hiện toàn bộ
The role of hepatic peroxisome proliferator‐activated receptors (PPARs) in health and disease
Wiley - Tập 20 Số 3 - Trang 191-199 - 2000
Lynn M Everett, Andrea Galli, David W. Crabb
Abstract: The liver has long been known to respond to exposure to certain chemicals with hyperplasia and proliferation of the peroxisomal compartment. This response is now known to be mediated by specific receptors. The peroxisome proliferator‐activated receptors (PPARs) were cloned 10 years ago, and in that interval, have been found to serve as receptors for a numbe...... hiện toàn bộ
Appearance of α‐smooth‐muscle‐actin‐positive cells in hepatic fibrosis
Wiley - Tập 11 Số 2 - Trang 100-105 - 1991
Toshihiko Nouchi, Yujiro Tanaka, Toyohiro Tsukada, Chifumi Sato, Fumiaki Marumo
ABSTRACT— The appearance of α‐smooth‐muscle‐actin (α‐smA)‐positive cells during hepatic fibrosis was studied immunohistochemically in rat and human livers. In the normal rat liver, α‐smA was observed only in vascular smooth muscle cells. With the progression of fibrosis induced by CCl4 injection, α‐smA‐positive cells appeared in the perisinusoida...... hiện toàn bộ
Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Thl‐like response in chronic hepatitis C
Wiley - Tập 19 Số 3 - Trang 212-219 - 1999
Gianluca Svegliati‐Baroni, Alfredo Pastorelli, Aldo Manzin, A. Benedetti, Luca Marucci, Laura Solforosi, A. Di Sario, E. Brunelli, F. Orlandi, Massimo Clementi, Giampiero Macarri
Abstract: Background/Aims: The involvement of a direct viral cytopathic effect or an immune‐mediated mechanism in the progression of hepatic damage in chronic hepatitis C is controversial. The type of immune response is itself a matter of controversy, and histological data are lacking. The aim of this study was to identify the factors ass...... hiện toàn bộ
Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis
Wiley - Tập 21 Số 4 - Trang 272-279 - 2001
Christine K. Fox, Alex Furtwaengler, Ronald R. Nepomuceno, Olivia M. Martinez, Sheri M. Krams
Abstract: Background/Aims: Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are two autoimmune diseases with unknown etiologies that primarily target the liver. In both diseases, liver lesions are accompanied by large infiltrates of mononuclear cells. The purpose of this study was to determine if either the Fas‐mediated or th...... hiện toàn bộ
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