Wiley
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Appearance of α‐smooth‐muscle‐actin‐positive cells in hepatic fibrosis
Wiley - Tập 11 Số 2 - Trang 100-105 - 1991
ABSTRACT— The appearance of α‐smooth‐muscle‐actin (α‐smA)‐positive cells during
hepatic fibrosis was studied immunohistochemically in rat and human livers. In
the normal rat liver, α‐smA was observed only in vascular smooth muscle cells.
With the progression of fibrosis induced by CCl4 injection, α‐smA‐positive cells
appeared in the perisinusoidal space and the fibrous septa, and ultimately
surrou...
Signal transduction in hepatic stellate cells
Wiley - Tập 18 Số 1 - Trang 2-13 - 1998
ABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key
cell types involved in the progression of liver fibrosis and in the related
pathophysiological and clinical complications. Following acute or chronic liver
tissue damage, HSC undergo a process of activation towards a phenotype
characterised by increased proliferation, motility, contractility and synthesis
of extracellu...
Distribution of hepatitis C virus RNA in the liver and its relation to histopathological changes
Wiley - Tập 16 Số 1 - Trang 55-60 - 1996
Abstract: To investigate a cellular mode of HCV‐infection in the liver and its
pathological implications in relation to histopathological changes or clinical
data, we studied the distribution of HCV‐RNA in the livers of 21 patients with
HCV‐related chronic liver disease (chronic active hepatitis, 14 cases;
cirrhosis, 7 cases) using the in situ hybridization technique. In situ
hybridization was per...
The detection of acetaldehyde/liver plasma membrane protein adduct formed in vivo by alcohol feeding
Wiley - Tập 7 Số 6 - Trang 364-368 - 1987
ABSTRACT— In order to assess whether acetaldehyde adducts with liver plasma
membrane proteins are formed in vivo during alcohol ingestion, liver plasma
membranes were prepared from control rats and rats fed on 10% ethanol from
weaning and the amino acid constituents of liver plasma membrane proteins were
assessed by reversed phase liquid chromatography of an acid hydrolysate of the
membranes. The ...
Down‐regulation of vascular α1‐adrenoceptors does not account for the loss of vascular responsiveness to catecholamines in experimental cholestasis
Wiley - Tập 19 Số 3 - Trang 193-198 - 1999
Abstract: Aims/Background: Vascular hyporesponsiveness to sympathomimetic
stimulation occurs in jaundice. Recently, we reported that this vascular
adrenergic hyporesponsiveness was associated with the loss of reactivity of
vascular α1‐adrenoceptors. This study examines the possibility that the vascular
adrenergic hyporesponsiveness is due to down‐regulation of vascular
α1‐adrenoceptors. Methods: T...
Involvement of platelet‐activating factor in hepatic apoptosis and necrosis in chronic ethanol‐fed rats given endotoxin
Wiley - Tập 22 Số 5 - Trang 394-403 - 2002
Abstract: Background/Aims: Platelet‐activating factor (PAF)—a potent activator
of neutrophils—plays an important role in the pathogenesis of endotoxin‐induced
tissue injury. However, the role of PAF in hepatic damage during alcoholic
hepatitis remains unclear. The aims of the present study were to test whether
PAF contributes to hepatic injury in an animal model of alcoholic hepatitis and
to inves...
Long interval between HCV infection and development of hepatocellular carcinoma
Wiley - Tập 15 Số 3 - Trang 159-163 - 1995
Abstract: A high prevalence of HCV infection has been reported in patients with
hepatocellular carcinoma. The progression from acute transfusion‐associated
hepatitis to hepatic cirrhosis and hepatocellular carcinoma has been suggested
in several studies to be very long. We have investigated the prevalence of
anti‐HCV and the interval between HCV infection and hepatocellular carcinoma
among 191 con...
Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronan
Wiley - Tập 7 Số 6 - Trang 339-346 - 1987
ABSTRACT— Serum concentrations of the aminoterminal propeptide of type III
procollagen and of the 7S domain of type IV collagen, presumed to reflect
fibrotic activity in liver tissue, and of the glycosamonoglycan hyaluronan, were
obtained from 40 alcohol abusers, at the time of liver biopsy. The serological
results were related to morphological findings in liver tissue, i.e. no
fibrosis, fibrosis ...
Serum aminoterminal procollagen type III peptide in acute viral hepatitis. A long‐term follow‐up study
Wiley - Tập 7 Số 2 - Trang 96-105 - 1987
ABSTRACT— The development of chronic viral liver disease is associated with
increased deposition of connective tissue in the liver. The aminoterminal
propeptide of procollagen type III (P‐III‐NP) is considered to reflect the
metabolism of collagen type III, one of the major collagen types in liver
fibrosis. The purpose of the present study was to elucidate, whether S‐P‐III‐NP
in patients with vira...
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