Wiley
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Signal transduction in hepatic stellate cellsABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key cell types involved in the progression of liver fibrosis and in the related pathophysiological and clinical complications. Following acute or chronic liver tissue damage, HSC undergo a process of activation towards a phenotype characterised by increased proliferation, motility, contractil...
Wiley - Tập 18 Số 1 - Trang 2-13 - 1998
Distribution of hepatitis C virus RNA in the liver and its relation to histopathological changesAbstract: To investigate a cellular mode of HCV‐infection in the liver and its pathological implications in relation to histopathological changes or clinical data, we studied the distribution of HCV‐RNA in the livers of 21 patients with HCV‐related chronic liver disease (chronic active hepatitis, 14 cases; cirrhosis, 7 cases) using the in situ...
Wiley - Tập 16 Số 1 - Trang 55-60 - 1996
The detection of acetaldehyde/liver plasma membrane protein adduct formed in vivo by alcohol feedingABSTRACT— In order to assess whether acetaldehyde adducts with liver plasma membrane proteins are formed in vivo during alcohol ingestion, liver plasma membranes were prepared from control rats and rats fed on 10% ethanol from weaning and the amino acid constituents of liver plasma membrane proteins were assessed by reversed phase liquid ch...
Wiley - Tập 7 Số 6 - Trang 364-368 - 1987
Down‐regulation of vascular α1‐adrenoceptors does not account for the loss of vascular responsiveness to catecholamines in experimental cholestasisAbstract: Aims/Background : Vascular hyporesponsiveness to sympathomimetic stimulation occurs in jaundice. Recently, we reported that this vascular adrenergic hyporesponsiveness was associated with the loss of reactivity of vascular α1 ‐adrenoceptors. This study examines the possibility that the vascular adrenergic hypo...
Wiley - Tập 19 Số 3 - Trang 193-198 - 1999
Involvement of platelet‐activating factor in hepatic apoptosis and necrosis in chronic ethanol‐fed rats given endotoxinAbstract: Background/Aims: Platelet‐activating factor (PAF)—a potent activator of neutrophils—plays an important role in the pathogenesis of endotoxin‐induced tissue injury. However, the role of PAF in hepatic damage during alcoholic hepatitis remains unclear. The aims of the present study were to test whether PAF contributes to hepatic injury ...
Wiley - Tập 22 Số 5 - Trang 394-403 - 2002
Long interval between HCV infection and development of hepatocellular carcinomaAbstract: A high prevalence of HCV infection has been reported in patients with hepatocellular carcinoma. The progression from acute transfusion‐associated hepatitis to hepatic cirrhosis and hepatocellular carcinoma has been suggested in several studies to be very long. We have investigated the prevalence of anti‐HCV and the interval between HCV infection and hepato...
Wiley - Tập 15 Số 3 - Trang 159-163 - 1995
Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronanABSTRACT— Serum concentrations of the aminoterminal propeptide of type III procollagen and of the 7S domain of type IV collagen, presumed to reflect fibrotic activity in liver tissue, and of the glycosamonoglycan hyaluronan, were obtained from 40 alcohol abusers, at the time of liver biopsy. The serological results were related to morphological findings in liver tiss...
Wiley - Tập 7 Số 6 - Trang 339-346 - 1987
Serum aminoterminal procollagen type III peptide in acute viral hepatitis. A long‐term follow‐up studyABSTRACT— The development of chronic viral liver disease is associated with increased deposition of connective tissue in the liver. The aminoterminal propeptide of procollagen type III (P‐III‐NP) is considered to reflect the metabolism of collagen type III, one of the major collagen types in liver fibrosis. The purpose of the present study was to elucidate, whether S...
Wiley - Tập 7 Số 2 - Trang 96-105 - 1987
Expression of human telomerase reverse transcriptase in regenerative and precancerous lesions of cirrhotic liversAbstract: Background/Aims:
The catalytic subunit of human telomerase (hTERT) is known to be expressed in a variety of malignant tumours, including hepatocellular carcinoma (HCC). We studied hTERT expression in regenerative and precancerous lesions arising in cirrhosis. Methods/Results: As shown by ...
Wiley - Tập 22 Số 1 - Trang 57-69 - 2002
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