Appearance of α‐smooth‐muscle‐actin‐positive cells in hepatic fibrosis

Wiley - Tập 11 Số 2 - Trang 100-105 - 1991
Toshihiko Nouchi1, Yujiro Tanaka2, Toyohiro Tsukada3, Chifumi Sato2, Fumiaki Marumo2
1Second Department of Internal Medicine, Tokyo Medical and Dental University - Japan
2Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
3Second Department of Internal Medicine, Sanraku Hospital, Tokyo, Japan

Tóm tắt

ABSTRACT— The appearance of α‐smooth‐muscle‐actin (α‐smA)‐positive cells during hepatic fibrosis was studied immunohistochemically in rat and human livers. In the normal rat liver, α‐smA was observed only in vascular smooth muscle cells. With the progression of fibrosis induced by CCl4 injection, α‐smA‐positive cells appeared in the perisinusoidal space and the fibrous septa, and ultimately surrounded regenerative nodules. An increase of desmin‐positive cells was recognized in the fibrotic areas and the perisinusoidal area. In the human liver, α‐smA‐positive cells appeared in the fibrotic area, whereas no desmin‐positive cells were observed, except in vascular walls of the central vein and the portal tract. α‐smA is a good marker for the detection of myofibroblast‐like cells, and the appearance of α‐smA in liver mesenchymal cells seems closely related to the process of hepatic fibrosis in both rat and man.

Từ khóa


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Thông tin
Thông tin xuất bản

Wiley

Tập 11 Số 2

100-105

Thông tin tác giả