Wiley

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Folic acid–containing supplement consumption during pregnancy and risk for oral clefts: A meta‐analysis
Wiley - Tập 79 Số 1 - Trang 8-15 - 2007
Rachel Badovinac, Martha M. Werler, Paige L. Williams, Karl T. Kelsey, Catherine Hayes
AbstractBACKGROUND: There is equivocal evidence in the published literature that folic acid supplementation during pregnancy may protect against the common congenital anomalies cleft lip with or without cleft palate (CLP) and cleft palate alone (CP). We undertook this meta‐analysis to test the hypothesis that nonsyndromic oral cleft birth prevalences are different for those whose mothers took foli... hiện toàn bộ
Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population
Wiley - Tập 88 Số 11 - Trang 980-986 - 2010
Andréia Bufalino, Lívia Máris Ribeiro Paranaíba, Sibele Nascimento de Aquino, Hercílio Martelli, Mário Sérgio Oliveira Swerts, Ricardo D. Coletta
AbstractBACKGROUNDPolymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with s... hiện toàn bộ
Folate‐related gene polymorphisms as risk factors for cleft lip and cleft palate
Wiley - Tập 82 Số 9 - Trang 636-643 - 2008
William H. James, Anne M. Molloy, Anne Parle‐McDermott, James Troendle, Lawrence C. Brody, Mary Conley, Christopher Cox, Faith Pangilinan, Donald P. Orr, Michael Earley, Eamon McKiernan, Ena Lynn, Anne Doyle, John M. Scott, Peadar N. Kirke
AbstractBACKGROUND:Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folate‐related genes associated with clefts have, however, often been inconclusive. This study examined four SNPs related to folate metabolism (MTHFR 677 C→T, MTHFR 1298 A→C, MTHFD1 1958 G→A, and TC II 776 C→... hiện toàn bộ
Folate pathway and nonsyndromic cleft lip and palate
Wiley - Tập 91 Số 1 - Trang 50-60 - 2011
Susan H. Blanton, Robin R. Henry, Quiping Yuan, John B. Mulliken, Samuel Stal, Richard H. Finnell, Jacqueline T. Hecht
AbstractBACKGROUNDNonsyndromic cleft lip with or without cleft palate (NSCLP) is a common complex birth defect. Periconceptional supplementation with folic acid, a key component in DNA synthesis and cell division, has reduced the birth prevalence of neural tube defects and may similarly reduce the birth prevalence of other complex birth defects including NSCLP. Past studies investigating the role ... hiện toàn bộ
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure
Wiley - Tập 88 Số 8 - Trang 653-669 - 2010
M. J. Harris, D. M. Juriloff
AbstractThe number of mouse mutants and strains with neural tube defects (NTDs) now exceeds 240, including 205 representing specific genes, 30 for unidentified genes, and 9 multifactorial strains. These mutants identify genes needed for embryonic neural tube closure. Reports of 50 new NTD mutants since our 2007 review (Harris and Juriloff,2007) were considered in relation to the previously reviewe... hiện toàn bộ
Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects
Wiley - Tập 79 Số 3 - Trang 187-210 - 2007
M. J. Harris, D. M. Juriloff
AbstractBACKGROUND: The number of mouse mutants and strains with neural tube closure defects (NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes, and eight “multifactorial” strains. METHODS: The emerging patterns of mouse NTDs are considered in relation to the unknown genetics of the common human NTDs, anencephaly, and spina bifida aperta. RESULTS: Of the 150 mo... hiện toàn bộ
AXIN2andCDH1polymorphisms, tooth agenesis, and oral clefts
Wiley - Tập 85 Số 2 - Trang 169-173 - 2009
Ariadne Letra, Renato Menezes, José Mauro Granjeiro, Alexandre R. Vieira
AbstractBACKGROUND:AXIN2andCDH1genes play important roles during craniofacial morphogenesis. Mutations in these genes have been described in families presenting colorectal cancer and tooth agenesis, and gastric cancer and cleft lip/palate (CL/P). Oral clefts have been associated with tooth agenesis. We investigated ifAXIN2andCDH1polymorphisms were associated with clefts or with any associated dent... hiện toàn bộ
Platelet‐derived growth factor C plays a role in the branchial arch malformations induced by retinoic acid
Wiley - Tập 79 Số 3 - Trang 221-230 - 2007
Jing Han, Li Li, Zhaofeng Zhang, Ying Xiao, Jiuxiang Lin, Liping Zheng, Yong Li
AbstractBACKGROUND: All‐trans‐retinoic acid (RA) can produce branchial arch abnormalities in postimplantation rodent embryos cultured in vitro. Platelet‐derived growth factor C (PDGF‐C) was recently identified as a member of the PDGF ligand family. Many members of the PDGF family are essential for branchial arch morphogenesis and can be regulated by RA. The roles of PDGF‐C in branchial arch malfor... hiện toàn bộ
Emerging data on the use of anti‐tumor necrosis factor‐alpha medications in pregnancy
Wiley - Tập 94 Số 8 - Trang 607-611 - 2012
Christina Chambers, Diana Johnson
AbstractAnti‐tumor necrosis factor (TNF) α medications are used for the treatment of a number of autoimmune diseases. Evaluation of pregnancy safety for these medications is complicated by the contribution of the underlying maternal disease to adverse pregnancy outcomes, such as preterm delivery and reduced birth weight. Placental transport of these medications is thought to be minimal in the firs... hiện toàn bộ
Teratogen update: Methotrexate
Wiley - Tập 94 Số 4 - Trang 187-207 - 2012
Sara C. Hyoun, Sarah Običan, Anthony R. Scialli
AbstractMethotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been used for the treatment of malignancy, rheumatic disorders, and psoriasis and termination of intrauterine pregnancy. Recently, methotrexate has become a standard treatment for ectopic pregnancy... hiện toàn bộ
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