Wiley
0022-3034
1097-4695
Cơ quản chủ quản: N/A
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Các bài báo tiêu biểu
Excitotoxic cell deathAbstract Excitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states. E...
Tập 23 Số 9 - Trang 1261-1276 - 1992
The Trk family of neurotrophin receptorsAbstract Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk (also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the NGF family of neurotrophins. Nerve growth factor (NGF) specifically recognizes Trk, a receptor indentified in all major NGF targets, including sympathetic, trigeminal, an... ...
Tập 25 Số 11 - Trang 1386-1403 - 1994
Overview of retinoid metabolism and functionAbstract Retinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles in the developing nervous system and notochord and many other embryonic structures, as well as in maintenance of epithelial surfaces, immune competence, and reproduction. The ability of all‐trans retinoic acid to regulate expression o... ...
Tập 66 Số 7 - Trang 606-630 - 2006
Genetic and environmental influences on human psychological differencesAbstract Psychological researchers typically distinguish five major domains of individual differences in human behavior: cognitive abilities, personality, social attitudes, psychological interests, and psychopathology (Lubinski, 2000). In this article we: discuss a number of methodological errors commonly found in research on human individual differences; introduce ... ...
Tập 54 Số 1 - Trang 4-45 - 2003
Conditional modification of behavior inDrosophilaby targeted expression of a temperature‐sensitiveshibireallele in defined neuronsAbstract Behavior is a manifestation of temporally and spatially defined neuronal activities. To understand how behavior is controlled by the nervous system, it is important to identify the neuronal substrates responsible for these activities, and to elucidate how they are integrated into a functional circuit. I introduce a novel and general method to conditionally ... ...
Tập 47 Số 2 - Trang 81-92 - 2001
Chronic stress alters dendritic morphology in rat medial prefrontal cortexAbstract Chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. Medial prefrontal cortex is a target for glucocorticoids involved in the stress response. We have previously demonstrated that 3 weeks of daily corticosterone injections result in dendritic reorganization in pyramidal neurons in layer II–III of media... ...
Tập 60 Số 2 - Trang 236-248 - 2004
Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylaseAbstract Dopamine (DA) is the only catecholaminergic neurotransmitter in the fruit fly Drosophila melanogaster . Dopaminergic neurons have been identified in the larval and adult central nervous system (CNS) in Drosophila and other insects, but no specific genetic tool was available to s... ...
Tập 54 Số 4 - Trang 618-627 - 2003
Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscleAbstract The properties of the cholinesterase activity in homogenates of whole rat diaphragm and of innervated (+EP) and non‐innervated (−EP) regions of the muscle have been investigated. Under standard assay conditions, over 90% of the cholinesterase activity of whole muscle homogenates was due to specific acetylcholinesterases. The specific activity of acetylcholi... ...
Tập 4 Số 4 - Trang 343-361 - 1973
Cellular and synaptic mechanisms of nicotine addictionAbstract The tragic health effects of nicotine addiction highlight the importance of investigating the cellular mechanisms of this complex behavioral phenomenon. The chain of cause and effect of nicotine addiction starts with the interaction of this tobacco alkaloid with nicotinic acetylcholine receptors (nAChRs). This interaction leads to activation of reward cente... ...
Tập 53 Số 4 - Trang 606-617 - 2002
Cholinergic interneuron characteristics and nicotinic properties in the striatumAbstract The neostriatum (dorsal striatum) is composed of the caudate and putamen. The ventral striatum is the ventral conjunction of the caudate and putamen that merges into and includes the nucleus accumbens and striatal portions of the olfactory tubercle. About 2% of the striatal neurons are cholinergic. Most cholinergic neurons in the central nervous system make... ...
Tập 53 Số 4 - Trang 590-605 - 2002