thumbnail

Wiley

  0022-3034

  1097-4695

 

Cơ quản chủ quản:  N/A

Lĩnh vực:

Các bài báo tiêu biểu

Excitotoxic cell death
Tập 23 Số 9 - Trang 1261-1276 - 1992
Dennis W. Choi
AbstractExcitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states. E...... hiện toàn bộ
The Trk family of neurotrophin receptors
Tập 25 Số 11 - Trang 1386-1403 - 1994
Mariano Barbacid
AbstractAccumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk (also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the NGF family of neurotrophins. Nerve growth factor (NGF) specifically recognizes Trk, a receptor indentified in all major NGF targets, including sympathetic, trigeminal, an...... hiện toàn bộ
Overview of retinoid metabolism and function
Tập 66 Số 7 - Trang 606-630 - 2006
Rune Blomhoff, Heidi Kiil Blomhoff
AbstractRetinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles in the developing nervous system and notochord and many other embryonic structures, as well as in maintenance of epithelial surfaces, immune competence, and reproduction. The ability of all‐trans retinoic acid to regulate expression o...... hiện toàn bộ
Genetic and environmental influences on human psychological differences
Tập 54 Số 1 - Trang 4-45 - 2003
Thomas J. Bouchard, Matt McGue
AbstractPsychological researchers typically distinguish five major domains of individual differences in human behavior: cognitive abilities, personality, social attitudes, psychological interests, and psychopathology (Lubinski, 2000). In this article we: discuss a number of methodological errors commonly found in research on human individual differences; introduce ...... hiện toàn bộ
Conditional modification of behavior inDrosophilaby targeted expression of a temperature‐sensitiveshibireallele in defined neurons
Tập 47 Số 2 - Trang 81-92 - 2001
Toshihiro Kitamoto
AbstractBehavior is a manifestation of temporally and spatially defined neuronal activities. To understand how behavior is controlled by the nervous system, it is important to identify the neuronal substrates responsible for these activities, and to elucidate how they are integrated into a functional circuit. I introduce a novel and general method to conditionally ...... hiện toàn bộ
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Tập 60 Số 2 - Trang 236-248 - 2004
Susan C. Cook, Cara L. Wellman
AbstractChronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. Medial prefrontal cortex is a target for glucocorticoids involved in the stress response. We have previously demonstrated that 3 weeks of daily corticosterone injections result in dendritic reorganization in pyramidal neurons in layer II–III of media...... hiện toàn bộ
Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase
Tập 54 Số 4 - Trang 618-627 - 2003
Florence Friggi‐Grelin, Hélène Coulom, Margaret Meller, Delphine Gomez, Jay Hirsh, Serge Birman
AbstractDopamine (DA) is the only catecholaminergic neurotransmitter in the fruit fly Drosophila melanogaster. Dopaminergic neurons have been identified in the larval and adult central nervous system (CNS) in Drosophila and other insects, but no specific genetic tool was available to s...... hiện toàn bộ
Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscle
Tập 4 Số 4 - Trang 343-361 - 1973
Zach W. Hall
AbstractThe properties of the cholinesterase activity in homogenates of whole rat diaphragm and of innervated (+EP) and non‐innervated (−EP) regions of the muscle have been investigated. Under standard assay conditions, over 90% of the cholinesterase activity of whole muscle homogenates was due to specific acetylcholinesterases. The specific activity of acetylcholi...... hiện toàn bộ
Cellular and synaptic mechanisms of nicotine addiction
Tập 53 Số 4 - Trang 606-617 - 2002
Huibert D. Mansvelder, Daniel S. McGehee
AbstractThe tragic health effects of nicotine addiction highlight the importance of investigating the cellular mechanisms of this complex behavioral phenomenon. The chain of cause and effect of nicotine addiction starts with the interaction of this tobacco alkaloid with nicotinic acetylcholine receptors (nAChRs). This interaction leads to activation of reward cente...... hiện toàn bộ
Cholinergic interneuron characteristics and nicotinic properties in the striatum
Tập 53 Số 4 - Trang 590-605 - 2002
Fu‐Ming Zhou, Charles J. Wilson, John A. Dani
AbstractThe neostriatum (dorsal striatum) is composed of the caudate and putamen. The ventral striatum is the ventral conjunction of the caudate and putamen that merges into and includes the nucleus accumbens and striatal portions of the olfactory tubercle. About 2% of the striatal neurons are cholinergic. Most cholinergic neurons in the central nervous system make...... hiện toàn bộ