Wiley
0022-3034
1097-4695
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Excitotoxic cell death
Tập 23 Số 9 - Trang 1261-1276 - 1992
AbstractExcitotoxicity refers to the ability of glutamate or related excitatory
amino acids to mediate the death of central neurons under certain conditions,
for example, after intense exposure. Such excitotoxic neuronal death may
contribute to the pathogenesis of brain or spinal cord injury associated with
several human disease states. Excitotoxicity has substantial cellular
specificity and, in m...
The Trk family of neurotrophin receptors
Tập 25 Số 11 - Trang 1386-1403 - 1994
AbstractAccumulating evidence indicates that the Trk family of tyrosine protein
kinase receptors, Trk (also known as TrkA), TrkB, and TrkC, are responsible for
mediating the trophic effects of the NGF family of neurotrophins. Nerve growth
factor (NGF) specifically recognizes Trk, a receptor indentified in all major
NGF targets, including sympathetic, trigeminal, and dorsal root ganglia as well
as ...
Overview of retinoid metabolism and function
Tập 66 Số 7 - Trang 606-630 - 2006
AbstractRetinoids (vitamin A) are crucial for most forms of life. In chordates,
they have important roles in the developing nervous system and notochord and
many other embryonic structures, as well as in maintenance of epithelial
surfaces, immune competence, and reproduction. The ability of all‐trans retinoic
acid to regulate expression of several hundred genes through binding to nuclear
transcrip...
Genetic and environmental influences on human psychological differences
Tập 54 Số 1 - Trang 4-45 - 2003
AbstractPsychological researchers typically distinguish five major domains of
individual differences in human behavior: cognitive abilities, personality,
social attitudes, psychological interests, and psychopathology (Lubinski, 2000).
In this article we: discuss a number of methodological errors commonly found in
research on human individual differences; introduce a broad framework for
interpretin...
Conditional modification of behavior inDrosophilaby targeted expression of a temperature‐sensitiveshibireallele in defined neurons
Tập 47 Số 2 - Trang 81-92 - 2001
AbstractBehavior is a manifestation of temporally and spatially defined neuronal
activities. To understand how behavior is controlled by the nervous system, it
is important to identify the neuronal substrates responsible for these
activities, and to elucidate how they are integrated into a functional circuit.
I introduce a novel and general method to conditionally perturb anatomically
defined neur...
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Tập 60 Số 2 - Trang 236-248 - 2004
AbstractChronic stress produces deficits in cognition accompanied by alterations
in neural chemistry and morphology. Medial prefrontal cortex is a target for
glucocorticoids involved in the stress response. We have previously demonstrated
that 3 weeks of daily corticosterone injections result in dendritic
reorganization in pyramidal neurons in layer II–III of medial prefrontal cortex.
To determine...
Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase
Tập 54 Số 4 - Trang 618-627 - 2003
AbstractDopamine (DA) is the only catecholaminergic neurotransmitter in the
fruit fly Drosophila melanogaster. Dopaminergic neurons have been identified in
the larval and adult central nervous system (CNS) in Drosophila and other
insects, but no specific genetic tool was available to study their development,
function, and degeneration in vivo. In Drosophila as in vertebrates, the
rate‐limiting ste...
Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscle
Tập 4 Số 4 - Trang 343-361 - 1973
AbstractThe properties of the cholinesterase activity in homogenates of whole
rat diaphragm and of innervated (+EP) and non‐innervated (−EP) regions of the
muscle have been investigated. Under standard assay conditions, over 90% of the
cholinesterase activity of whole muscle homogenates was due to specific
acetylcholinesterases. The specific activity of acetylcholinesterase was higher
in +EP regio...
Cellular and synaptic mechanisms of nicotine addiction
Tập 53 Số 4 - Trang 606-617 - 2002
AbstractThe tragic health effects of nicotine addiction highlight the importance
of investigating the cellular mechanisms of this complex behavioral phenomenon.
The chain of cause and effect of nicotine addiction starts with the interaction
of this tobacco alkaloid with nicotinic acetylcholine receptors (nAChRs). This
interaction leads to activation of reward centers in the CNS, including the
meso...
Cholinergic interneuron characteristics and nicotinic properties in the striatum
Tập 53 Số 4 - Trang 590-605 - 2002
AbstractThe neostriatum (dorsal striatum) is composed of the caudate and
putamen. The ventral striatum is the ventral conjunction of the caudate and
putamen that merges into and includes the nucleus accumbens and striatal
portions of the olfactory tubercle. About 2% of the striatal neurons are
cholinergic. Most cholinergic neurons in the central nervous system make diffuse
projections that sparsel...