AbstractHand, foot and mouth disease (HFMD), a common contagious disease that usually affects children, is normally mild but can have life-threatening manifestations. It can be caused by enteroviruses, particularly Coxsackieviruses and human enterovirus 71 (HEV71) with highly variable clinical manifestations. In the spring of 2008, a large, unprecedented...... hiện toàn bộ
Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding the evolutionary history of MeV could answer questions related to divergence times ...... hiện toàn bộ
Keivan Zandi, Boon‐Teong Teoh, Sing‐Sin Sam, Pooi-Fong Wong, Mohd Rais Mustafa, Sazaly AbuBakar
AbstractBackgroundDengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant-derived polyphenolic compounds with many potential health benefits. In the present study, antiviral activ...... hiện toàn bộ
Brian L. Ellis, Matthew Hirsch, Jenny C. Barker, Jon P. Connelly, Robert J. Steininger, Matthew H. Porteus
AbstractBackgroundThe ability to deliver a gene of interest into a specific cell type is an essential aspect of biomedical research. Viruses can be a useful tool for this delivery, particularly in difficult to transfect cell types. Adeno-associated virus (AAV) is a useful gene transfer vector b...... hiện toàn bộ
Kshama Kumari, Shelly Gulati, David F. Smith, Upma Gulati, Richard D. Cummings, Gillian M. Air
AbstractBackgroundHuman influenza viruses are known to bind to sialic acid linked α2-6 to galactose, but the binding specificity beyond that linkage has not been systematically examined. H3N2 human influenza isolates lost binding to chicken red cells in the 1990s but viruses isolated since 2003 have re-acquired the ability to aggl...... hiện toàn bộ