Medical Virology of Hepatitis B: how it began and where we are now

Wolfram H. Gerlich1
1Institute for Medical Virology, National Reference Center for Hepatitis B and D, Justus Liebig University Giessen, Schubert Str. 81, 35392, Giessen, Germany

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Blumberg BS: Hepatitis B - The hunt for a killer virus. 2002, Princeton: Princeton University Press

Lürmann A: Eine Icterusepidemie. Ber Klin Wochenschr. 1885, 22: 20-23.

MacCallum FO: 1971 International symposium on viral hepatitis. Historical perspectives. Can Med Assoc J. 1972, 106 (Suppl): 423-426.

Seeff LB, Beebe GW, Hoofnagle JH, Norman JE, Buskell-Bales Z, Waggoner JG, Kaplowitz N, Koff RS, Petrini JL, Schiff ER, et al: A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army. N Engl J Med. 1987, 316: 965-970. 10.1056/NEJM198704163161601.

Barker LF, Murray R: Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis–associated antigen. Am J Med Sci. 1972, 263: 27-33. 10.1097/00000441-197201000-00005.

Krugman S, Giles JP, Hammond J: Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967, 200: 365-373. 10.1001/jama.1967.03120180053006.

Prince AM: Relation of Australia and SH antigens. Lancet. 1968, 2 (7565): 462-463.

Ling CM, Overby LR: Prevalence of hepatitis B virus antigen as revealed by direct radioimmune assay with 125 I-antibody. J Immunol. 1972, 109: 834-841.

Le Bouvier GL, McCollum RW, Hierholzer WJ, Irwin GR, Krugman S, Giles JP: Subtypes of Australia antigen and hepatitis-B virus. JAMA. 1972, 222: 928-930. 10.1001/jama.1972.03210080020005.

Bancroft WH, Mundon FK, Russell PK: Detection of additional antigenic determinants of hepatitis B antigen. J Immunol. 1972, 109: 842-848.

Millman I, Loeb LA, Bayer ME, Blumberg BS: Australia antigen (a hepatitis-associated antigen): purification and physical properties. J Exp Med. 1970, 131: 1190-1199. 10.1084/jem.131.6.1190.

Gerlich W, May G: Hepatitis-associated antigen: purification and properties. Zentralbl Bakteriol Orig A. 1973, 224: 49-60. German

Griffith JS: Self-replication and scrapie. Nature. 1967, 215: 1043-1044. 10.1038/2151043a0.

Dane DS, Cameron CH, Briggs M: Virus-like particles in serum of patients with Australia-antigen-associated hepatitis. Lancet. 1970, 1 (7649): 695-698.

Almeida JD, Rubenstein D, Stott EJ: New antigen-antibody system in Australia-antigen-positive hepatitis. Lancet. 1971, 2 (7736): 1225-1227.

Seitz S, Urban S, Antoni C, Böttcher B: Cryo-electron microscopy of hepatitis B virions reveals variability in envelope capsid interactions. EMBO J. 2007, 26: 4160-4167. 10.1038/sj.emboj.7601841.

Hirschman SZ, Vernace SJ, Schaffner F: D.N.A. polymerase in preparations containing Australia antigen. Lancet. 1971, 1 (7709): 1099-1103.

Kaplan PM, Greenman RL, Gerin JL, Purcell RH, Robinson WS: DNA polymerase associated with human hepatitis B antigen. J Virol. 1973, 12: 995-1005.

Robinson WS, Clayton DA, Greenman RL: DNA of a human hepatitis B virus candidate. J Virol. 1974, 14: 384-391.

Berg P, Baltimore D, Brenner S, Roblin RO, Singer MF: Summary statement of the Asilomar conference on recombinant DNA molecules. Proc Natl Acad Sci USA. 1975, 72: 1981-1984. 10.1073/pnas.72.6.1981.

Charnay P, Pourcel C, Louise A, Fritsch A, Tiollais P: Cloning in Escherichia coli and physical structure of hepatitis B virion DNA. Proc Natl Acad Sci USA. 1979, 76: 2222-2226. 10.1073/pnas.76.5.2222.

Valenzuela P, Gray P, Quiroga M, Zaldivar J, Goodman HM, Rutter WJ: Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature. 1979, 280: 815-819. 10.1038/280815a0.

Pasek M, Goto T, Gilbert W, Zink B, Schaller H, MacKay P, Leadbetter G, Murray K: Hepatitis B virus genes and their expression in E. coli. Nature. 1979, 282: 575-579. 10.1038/282575a0.

Wittkop L, Schwarz A, Cassany A, Grün-Bernhard S, Delaleau M, Rabe B, Cazenave C, Gerlich W, Glebe D, Kann M: Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation. Cell Microbiol. 2010, 12: 962-975. 10.1111/j.1462-5822.2010.01444.x.

Will H, Cattaneo R, Koch HG, Darai G, Schaller H, Schellekens H, van Eerd PM, Deinhardt F: Cloned HBV DNA causes hepatitis in chimpanzees. Nature. 1982, 299: 740-742. 10.1038/299740a0.

Hoofnagle JH, Gerety RJ, Barker LF: Antibody to hepatitis-B-virus core in man. Lancet. 1973, 2 (7834): 869-873.

Hoofnagle JH, Seeff LB, Bales ZB, Zimmerman HJ: Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. N Engl J Med. 1978, 298: 1379-1383. 10.1056/NEJM197806222982502.

Galbraith RM, Eddleston AL, Williams R, Zuckerman AJ: Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy. Lancet. 1975, 2 (7934): 528-530.

Flehmig B, Ranke M, Berthold H, Gerth HJ: A solid-phase radioimmunoassay for detection of IgM antibodies to hepatitis A virus. J Infect Dis. 1979, 140: 169-175. 10.1093/infdis/140.2.169.

Gerlich WH, Lüer W: Selective detection of IgM-antibody against core antigen of the hepatitis B virus by a modified enzyme immune assay. J Med Virol. 1979, 4: 227-238. 10.1002/jmv.1890040308.

Gerlich WH, Uy A, Lambrecht F, Thomssen R: Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections. J Clin Microbiol. 1986, 24: 288-293.

Milich DR, McLachlan A: The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science. 1986, 234: 1398-1401. 10.1126/science.3491425.

Magnius LO, Espmark A: A new antigen complex co-occurring with Australia antigen. Acta Pathol Microbiol Scand B Microbiol Immunol. 1972, 80: 335-337.

Standring DN, Ou JH, Masiarz FR, Rutter WJ: A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc Natl Acad Sci USA. 1988, 85: 8405-8409. 10.1073/pnas.85.22.8405.

Bruss V, Gerlich WH: Formation of transmembraneous hepatitis B e-antigen by cotranslational in vitro processing of the viral precore protein. Virology. 1988, 163: 268-275. 10.1016/0042-6822(88)90266-8.

Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC: Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet. 1989, 2 (8663): 588-591.

Milich DR, Chen MK, Hughes JL, Jones JE: The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: a mechanism for persistence. J Immunol. 1998, 160: 2013-2021.

Maynard JE, Berquist KR, Krushak DH, Purcell RH: Experimental infection of chimpanzees with the virus of hepatitis B. Nature. 1972, 237: 514-515. 10.1038/237514a0.

Petersen J, Dandri M, Gupta S, Rogler CE: Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma. Proc Natl Acad Sci USA. 1998, 95: 310-315. 10.1073/pnas.95.1.310.

Köck J, Nassal M, MacNelly S, Baumert TF, Blum HE, von Weizsäcker F: Efficient infection of primary tupaia hepatocytes with purified human and woolly monkey hepatitis B virus. J Virol. 2001, 75: 5084-5089. 10.1128/JVI.75.11.5084-5089.2001.

Glebe D, Urban S, Knoop EV, Çag N, Krass P, Grün S, Bulavaite A, Sasnauskas K, Gerlich WH: Mapping of the hepatitis B virus attachment site by infection-inhibiting preS1 lipopeptides using Tupaia hepatocytes. Gastroenterology. 2005, 129: 234-245. 10.1053/j.gastro.2005.03.090.

Gripon P, Rumin S, Urban S, Le Seyec J, Glaise D, Cannie I, Guyomard C, Lucas J, Trepo C, Guguen-Guillouzo C: Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci USA. 2002, 99: 15655-15660. 10.1073/pnas.232137699.

Quint WG, Heijtink RA, Schirm J, Gerlich WH, Niesters HG: Reliability of methods for hepatitis B virus DNA detection. J Clin Microbiol. 1995, 33: 225-228.

Gerlich WH, Robinson WS: Hepatitis B virus contains protein attached to the 5’ terminus of its complete DNA strand. Cell. 1980, 21: 801-809. 10.1016/0092-8674(80)90443-2.

Saldanha J, Gerlich W, Lelie N, Dawson P, Heermann K, Heath A, WHO Collaborative Study Group: An international collaborative study to establish a World Health Organization international standard for hepatitis B virus DNA nucleic acid amplification techniques. Vox Sang. 2001, 80: 63-71. 10.1046/j.1423-0410.2001.00003.x.

Tabuchi A, Tanaka J, Katayama K, Mizui M, Matsukura H, Yugi H, Shimada T, Miyakawa Y, Yoshizawa H: Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes. J Med Virol. 2008, 80: 2064-2068. 10.1002/jmv.21320.

Allain JP, Mihaljevic I, Gonzalez-Fraile MI, Gubbe K, Holm-Harritshøj L, Garcia JM, Brojer E, Erikstrup C, Saniewski M, Wernish L, Bianco L, Ullum H, Candotti D, Lelie N, Gerlich WH, Chudy M: Infectivity of blood products from donors with occult hepatitis B virus infection. Transfusion. 2013, doi: 10.1111/trf.12096. [Epub ahead of print]

Gunson RN, Shouval D, Roggendorf M, Zaaijer H, Nicholas H, Holzmann H, de Schryver A, Reynders D, Connell J, Gerlich WH, Marinho RT, Tsantoulas D, Rigopoulou E, Rosenheim M, Valla D, Puro V, Struwe J, Tedder R, Aitken C, Alter M, Schalm SW, Carman WF, European Consensus Group: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in health care workers (HCWs): guidelines for prevention of transmission of HBV and HCV from HCW to patients. J Clin Virol. 2003, 27: 213-230. 10.1016/S1386-6532(03)00087-8.

Couroucé-Pauty AM, Soulier JP: Further data on HBs antigen subtypes - geographical distribution. Vox Sang. 1974, 27: 533-549. 10.1111/j.1423-0410.1974.tb02451.x.

Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M: Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988, 69: 2575-2583. 10.1099/0022-1317-69-10-2575.

Norder H, Couroucé AM, Coursaget P, Echevarria JM, Lee SD, Mushahwar IK, Robertson BH, Locarnini S, Magnius LO: Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes. Intervirology. 2004, 47: 289-309. 10.1159/000080872.

Andernach IE, Nolte C, Pape JW, Muller CP: Slave trade and hepatitis B virus genotypes and subgenotypes in Haiti and Africa. Emerg Infect Dis. 2009, 15: 1222-1228. 10.3201/eid1508.081642.

Kramvis A, Kew MC: Molecular characterization of subgenotype A1 (subgroup Aa) of hepatitis B virus. Hepatol Res. 2007, 37 (Suppl 1): S27-S32.

Davies J, Littlejohn M, Locarnini SA, Whiting S, Hajkowicz K, Cowie BC, Bowden DS, Tong SY, Davis JS: The molecular epidemiology of Hepatitis B in the Indigenous people of northern Australia. J Gastroenterol Hepatol. 2013, 10.1111/jgh.12177. [Epub ahead of print]

Paraskevis D, Magiorkinis G, Magiorkinis E, Ho SY, Belshaw R, Allain JP, Hatzakis A: Dating the origin and dispersal of hepatitis B virus infection in humans and primates. Hepatology. 2013, 57: 908-916. 10.1002/hep.26079.

Shi W, Zhu C, Zheng W, Zheng W, Ling C, et al: Subgenotyping of genotype C hepatitis B virus: correcting misclassifications and identifying a novel subgenotype. PLoS ONE. 2012, 7 (10): e47271-10.1371/journal.pone.0047271.

Mason WS, Gerlich WH, Taylor JM, Kann M, Loeb D, Sureau S, Magnius L, Norder H: Virus taxonomy, ninth report of the international committee on taxonomy of viruses. Family Hepadnaviridae. 2012, Amsterdam: Elsevier, 445-455.

Lanford RE, Chavez D, Brasky KM, Burns RB, Rico-Hesse R: Isolation of a hepadnavirus from the woolly monkey, a new world primate. Proc Natl Acad Sci USA. 1998, 95: 5757-5761. 10.1073/pnas.95.10.5757.

Dreesman JM, Baillot A, Hamschmidt L, Monazahian M, Wend UC, Gerlich WH: Outbreak of hepatitis B in a nursing home associated with capillary blood sampling. Epidemiol. Infect. 2006, 26: 1102-1113.

Guidotti LG, Chisari FV: Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol. 2006, 1: 23-61. 10.1146/annurev.pathol.1.110304.100230.

Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M, Craxì A, Donato F, Ferrari C, Gaeta GB, Gerlich WH, Levrero M, Locarnini S, Michalak T, Mondelli MU, Pawlotsky JM, Pollicino T, Prati D, Puoti M, Samuel D, Shouval D, Smedile A, Squadrito G, Trépo C, Villa E, Will H, Zanetti AR, Zoulim F: Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol. 2008, 49: 652-657. 10.1016/j.jhep.2008.07.014.

Westhoff TH, Jochimsen F, Schmittel A, Stöffler-Meilicke M, Schäfer JH, Zidek W, Gerlich WH, Thiel E: Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy. Blood. 1930, 2003: 102-

Blaich A, Manz M, Dumoulin A, Schüttler CG, Hirsch HH, Gerlich WH, Frei R: Reactivation of hepatitis B virus with mutated HBsAg in a liver transplant recipient receiving a graft from an anti-HBs and anti-HBc positive donor. Transfusion. 2012, 52: 1999-2006. 10.1111/j.1537-2995.2011.03537.x.

Turelli P, Mangeat B, Jost S, Vianin S, Trono D: Inhibition of hepatitis B virus replication by APOBEC3G. Science. 2004, 303: 1829-10.1126/science.1092066.

Szmuness W: Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol. 1978, 24: 40-69.

Beasley RP, Hwang LY, Lin CC, Chien CS: Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet. 1981, 2 (8256): 1129-1133.

Alexander JJ, Bey EM, Geddes EW, Lecatsas G: Establishment of a continuously growing cell line from primary carcinoma of the liver. S Afr Med J. 1976, 50: 2124-2128.

Edman JC, Gray P, Valenzuela P, Rall LB, Rutter WJ: Integration of hepatitis B virus sequences and their expression in a human hepatoma cell. Nature. 1980, 286: 535-538. 10.1038/286535a0.

Kekulé AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R: The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature. 1990, 343: 457-461. 10.1038/343457a0.

Höhne M, Schaefer S, Seifer M, Feitelson MA, Paul D, Gerlich WH: Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO Journal. 1990, 9: 1137-1145.

Lucifora J, Arzberger S, Durantel D, Belloni L, Strubin M, Levrero M, Zoulim F, Hantz O, Protzer U: Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. J Hepatol. 2011, 55: 996-1003. 10.1016/j.jhep.2011.02.015.

Dejean A, Bougueleret L, Grzeschik KH, Tiollais P: Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature. 1986, 322: 70-72. 10.1038/322070a0.

Mason WS, Liu C, Aldrich CE, Litwin S, Yeh MM: Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection. J Virol. 2010, 84: 8308-8315. 10.1128/JVI.00833-10.

Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, Huang GT, Iloeje UH: REVEAL-HBV Study Group: Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006, 295: 65-73. 10.1001/jama.295.1.65.

Summers J, Smolec JM, Snyder R: A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA. 1978, 75: 4533-4537. 10.1073/pnas.75.9.4533.

Marion PL, Oshiro LS, Regnery DC, Scullard GH, Robinson WS: A virus in Beechey ground squirrels that is related to hepatitis B virus of humans. Proc Natl Acad Sci USA. 1980, 77: 2941-2945. 10.1073/pnas.77.5.2941.

Fourel G, Trepo C, Bougueleret L, Henglein B, Ponzetto A, Tiollais P, Buendia MA: Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature. 1990, 347: 294-298. 10.1038/347294a0.

Mason WS, Seal G, Summers J: Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. J Virol. 1980, 36: 829-836.

Sprengel R, Kaleta EF, Will H: Isolation and characterization of a hepatitis B virus endemic in herons. J Virol. 1988, 62: 3832-3839.

Suh A, Brosius J, Schmitz J, Kriegs JO: The genome of a mesozoic paleovirus reveals the evolution of hepatitis B viruses. Nature Communications. 2013, 4: 1791-

Summers J, Mason WS: Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell. 1982, 29: 403-415. 10.1016/0092-8674(82)90157-X.

Nassal M: Hepatitis B viruses: reverse transcription a different way. Virus Res. 2008, 134: 235-249. 10.1016/j.virusres.2007.12.024.

Rabe B, Vlachou A, Panté N, Helenius A, Kann M: Nuclear import of hepatitis B virus capsids and release of the viral genome. Proc Natl Acad Sci USA. 2003, 100: 9849-9854. 10.1073/pnas.1730940100.

Gerelsaikhan T, Tavis JE, Bruss V: Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. J Virol. 1996, 70: 4269-4274.

Bruss V, Lu X, Thomssen R, Gerlich WH: Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein. EMBO J. 1994, 13: 2273-2279.

Lambert C, Döring T, Prange R: Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. J Virol. 2007, 81: 9050-9060. 10.1128/JVI.00479-07.

Sells MA, Chen ML, Acs G: Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci USA. 1987, 84: 1005-1009. 10.1073/pnas.84.4.1005.

Zahn P, Allain JP: Hepatitis C virus and hepatitis B virus bind to heparin: purification of largely IgG-free virions from infected plasma by heparin chromatography. J Gen Virol. 2005, 86: 677-685. 10.1099/vir.0.80614-0.

Sureau C, Salisse J: A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus a-determinant. Hepatology. 2013, 57: 985-994. 10.1002/hep.26125.

Heermann KH, Goldmann U, Schwartz W, Seyffarth T, Baumgarten H, Gerlich WH: Large surface proteins of hepatitis B virus containing the pre-s sequence. J Virol. 1984, 52: 396-402.

Neurath AR, Kent SB, Strick N, Parker K: Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus. Cell. 1986, 46: 429-436. 10.1016/0092-8674(86)90663-X.

Ishikawa T, Ganem D: The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses. Proc Natl Acad Sci USA. 1995, 92: 6259-6263. 10.1073/pnas.92.14.6259.

Eng FJ, Novikova EG, Kuroki K, Ganem D, Fricker LD: Gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity. J Biol Chem. 1998, 273: 8382-8388. 10.1074/jbc.273.14.8382.

Glebe D, Aliakbari M, Krass P, Knoop EV, Valerius KP, Gerlich WH: Pre-s1 antigen-dependent infection of Tupaia hepatocyte cultures with human hepatitis B virus. J Virol. 2003, 77: 9511-9521. 10.1128/JVI.77.17.9511-9521.2003.

Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012, 1: e00049-10.7554/eLife.00049.

Greenberg HB, Pollard RB, Lutwick LI, Gregory PB, Robinson WS, Merigan TC: Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N Engl J Med. 1976, 295: 517-522. 10.1056/NEJM197609022951001.

Petersen J, Buti M: Considerations for the long-term treatment of chronic hepatitis B with nucleos(t)ide analogs. Expert Rev Gastroenterol Hepato. 2012, 6: 683-693. 10.1586/egh.12.52.

Gerlich W, Stamm B, Thomssen R: Prognostic significance of quantitative HBsAg determination in acute hepatitis B. Partial report of a cooperative clinical study of the DFG-focus of “virus hepatitis”. Verh Dtsch Ges Inn Med. 1977, 83: 554-557. German

Doong SL, Tsai CH, Schinazi RF, Liotta DC, Cheng YC: Inhibition of the replication of hepatitis B virus in vitro by 2′,3′-dideoxy-3′-thiacytidine and related analogues. Proc Natl Acad Sci USA. 1991, 88: 8495-8499. 10.1073/pnas.88.19.8495.

Benhamou Y, Dohin E, Lunel-Fabiani F, Poynard T, Huraux JM, Katlama C, Opolon P, Gentilini M: Efficacy of lamivudine on replication of hepatitis B virus in HIV-infected patients. Lancet. 1995, 345 (8946): 396-397. 10.1016/S0140-6736(95)90388-7.

Dienstag JL, Perrillo RP, Schiff ER, Bartholomew M, Vicary C, Rubin M: A preliminary trial of lamivudine for chronic hepatitis B infection. N Engl J Med. 1995, 333: 1657-1661. 10.1056/NEJM199512213332501.

Torresi J, Locarnini S: Antiviral chemotherapy for the treatment of hepatitis B virus infections. Gastroenterology. 2000, 118 (Suppl 1): S83-S103.

Warner N, Locarnini S: The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound. Hepatology. 2008, 48: 88-98. 10.1002/hep.22295.

van Bömmel F, Wünsche T, Mauss S, Reinke P, Bergk A, Schürmann D, Wiedenmann B, Berg T: Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. Hepatology. 2004, 40: 1421-1425. 10.1002/hep.20464.

Han GR, Cao MK, Zhao W, Jiang HX, Wang CM, Bai SF, Yue X, Wang GJ, Tang X, Fang ZX: A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection. J Hepatol. 2011, 55: 1215-1221. 10.1016/j.jhep.2011.02.032.

Volz T, Allweiss L, Barek MB M, Warlich M, Lohse AW, Pollok JM, Alexandrov A, Urban S, Petersen J, Lütgehetmann M, Dandri M: The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus. J Hepatol. 2013, 58: 861-867. 10.1016/j.jhep.2012.12.008.

Kosinska AD, Zhang E, Johrden L, Liu J, Seiz PL, Zhang X, Ma Z, Kemper T, Fiedler M, Glebe D, Wildner O, Dittmer U, Lu M, Roggendorf M: Combination of DNA prime - adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model. PLoS Pathog. 2013, 9: e1003391-10.1371/journal.ppat.1003391.

Beasley RP, Hwang LY, Lin CC, Stevens CE, Wang KY, Sun TS, Hsieh FJ, Szmuness W: Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Initial report of a randomised double-blind placebo-controlled trial. Lancet. 1981, 2 (8243): 388-393.

Krugman S, Giles JP, Hammond J: Viral hepatitis, type B (MS-2 strain). Studies on active immunization. JAMA. 1971, 217: 41-45. 10.1001/jama.1971.03190010023005.

Purcell RH, Gerin JL: Hepatitis B subunit vaccine: a preliminary report of safety and efficacy tests in chimpanzees. Am J Med Sci. 1975, 270: 395-399. 10.1097/00000441-197509000-00024.

Maupas P, Goudeau A, Coursaget P, Drucker J, Bagros P: Immunisation against hepatitis B in man. Lancet. 1976, 1 (7974): 1367-1370.

Szmuness W, Stevens CE, Harley EJ, Zang EA, Oleszko WR, William DC, Sadovsky R, Morrison JM, Kellner A: Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med. 1980, 303: 833-841. 10.1056/NEJM198010093031501.

Peterson DL, Roberts IM, Vyas GN: Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen. Proc Natl Acad Sci USA. 1977, 74: 1530-1534. 10.1073/pnas.74.4.1530.

Valenzuela P, Medina A, Rutter WJ, Ammerer G, Hall BD: Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature. 1982, 298: 347-350. 10.1038/298347a0.

Harford N, Cabezon T, Crabeel M, Simoen E, Rutgers A, De Wilde M: Expression of hepatitis B surface antigen in yeast. Dev Biol Stand. 1983, 54: 125-130.

McAleer WJ, Buynak EB, Maigetter RZ, Wampler DE, Miller WJ, Hilleman MR: Human hepatitis B vaccine from recombinant yeast. Nature. 1984, 307: 178-180. 10.1038/307178a0.

Poovorawan Y, Sanpavat S, Pongpunlert W, Chumdermpadetsuk S, Sentrakul P, Safary A: Protective efficacy of a recombinant DNA hepatitis B vaccine in neonates of HBe antigen-positive mothers. JAMA. 1989, 261: 3278-3281. 10.1001/jama.1989.03420220092033.

Lavanchy D: Viral hepatitis: global goals for vaccination. J Clin Virol. 2012, 55: 296-302. 10.1016/j.jcv.2012.08.022.

Chang MH, You SL, Chen CJ, Liu CJ, Lee CM, Lin SM, Chu HC, Wu TC, Yang SS, Kuo HS, Chen DS, Taiwan Hepatoma Study Group: Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study. J Natl Cancer Inst. 2009, 101: 1348-1355. 10.1093/jnci/djp288.

Su WJ, Liu CC, Liu DP, Chen SF, Huang JJ, Chan TC, Chang MH: Effect of age on the incidence of acute hepatitis B after 25 years of a universal newborn hepatitis B immunization program in Taiwan. J Infect Dis. 2012, 205: 757-762. 10.1093/infdis/jir852.

Poovorawan Y, Chongsrisawat V, Theamboonlers A, Leroux-Roels G, Kuriyakose S, Leyssen M, Jacquet J-M: Evidence of protection against clinical and chronic hepatitis B infection 20 years after infant vaccination in a high endemicity region. J Viral Hepat. 2011, 18: 369-375. 10.1111/j.1365-2893.2010.01312.x.

Coates T, Wilson R, Patrick G, André F, Watson V: Hepatitis B vaccines: assessment of the seroprotective efficacy of two recombinant DNA vaccines. Clin Ther. 2001, 23: 392-403. 10.1016/S0149-2918(01)80044-8.

Wolters B, Junge U, Dziuba S, Roggendorf M: Immunogenicity of combined hepatitis A and B vaccine in elderly persons. Vaccine. 2003, 21: 3623-3628. 10.1016/S0264-410X(03)00399-2.

Hsu HY, Chang MH, Ni YH, Chiang CL, Chen HL, Wu JF, Chen PJ: No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization. J Infect Dis. 2010, 201: 1192-1200. 10.1086/651378.

Stramer SL, Wend U, Candotti D, Foster GA, Hollinger FB, Dodd RY, Allain J-P, Gerlich W: Nucleic acid testing to detect HBV infection in blood donors. New Engl J Med. 2011, 364: 236-247. 10.1056/NEJMoa1007644.

Feeney SA, McCaughey C, Watt AP, El Agnaf MR, McDougal N, Morris K, Wend UC, Gerlich WH, Coyle PV: Reactivation of occult hepatitis B virus infection following cytotoxic lymphoma therapy in an anti-HBc negative patient. J Med Virol. 2013, 85: 597-601. 10.1002/jmv.23513.

Bremer CM, Sominskaya I, Skrastina D, Pumpens P, El Wahed AA, Beutling U, Frank R, Fritz HJ, Hunsmann G, Gerlich WH, Glebe D: N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus. J Hepatol. 2011, 55: 29-37. 10.1016/j.jhep.2010.10.019.

Chen D-S: Toward elimination and eradication of hepatitis B. J Gastroenterol Hepatol. 2010, 25: 11-25.

Zuckerman JN, Zuckerman AJ: Recombinant hepatitis B triple antigen vaccine: Hepacare. Expert Rev Vaccines. 2002, 1: 141-144. 10.1586/14760584.1.2.141.

Shouval D: Hepatitis B, vaccines. J Hepatol. 2003, 39 (Suppl 1): S70-S76.

Rendi-Wagner P, Shouval D, Genton B, Lurie Y, Rümke H, Boland G, Cerny A, Heim M, Bach D, Schroeder M, Kollaritsch H: Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine. Vaccine. 2006, 24: 2781-2789. 10.1016/j.vaccine.2006.01.007.

Niedre-Otomere B, Bogdanova A, Skrastina D, Zajakina A, Bruvere R, Ose V, Gerlich WH, Garoff H, Pumpens P, Glebe D, Kozlovska T: Recombinant Semliki forest virus vectors encoding hepatitis B virus small surface and pre-S1 antigens induce broadly reactive neutralizing antibodies. J Viral Hepatitis. 2012, 19: 664-673. 10.1111/j.1365-2893.2012.01594.x.