Transgenic Research

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Pancreas specific expression of oncogenes in a porcine model
Transgenic Research - Tập 26 - Trang 603-612 - 2017
Martin F. Berthelsen, Morten M. Callesen, Tanja S. Østergaard, Ying Liu, Rong Li, Henrik Callesen, Frederik Dagnæs-Hansen, Stephen Hamilton-Dutoit, Jannik E. Jakobsen, Martin K. Thomsen
Pancreatic cancer is the fourth leading course of cancer death and early detection of the disease is crucial for successful treatment. However, pancreatic cancer is difficult to detect in its earliest stages and once symptoms appear, the cancer has often progressed beyond possibility for curing. Research into the disease has been hampered by the lack of good models. We have generated a porcine mod...... hiện toàn bộ
Characterization and activity enhancement of the phloem-specific pumpkin PP2 gene promoter
Transgenic Research - Tập 13 Số 6 - Trang 559-566 - 2004
Hao Guo, Xiaoying Chen, Haili Zhang, Rongxiang Fang, Zhengqiang Yuan, Zhenshan Zhang, Yingchuan Tian
Rederivation of Transgenic and Gene-Targeted Mice by Embryo Transfer
Transgenic Research - Tập 13 - Trang 363-371 - 2004
Margaret L. Van Keuren, Thomas L. Saunders
Research on genetically engineered mice provides insights into the etiology, therapy, and genetic basis of human diseases. An important variable that affects the results of mouse studies is the health status of the animals. Pathogen burdens may confound observations and obscure underlying mechanisms. Mouse resource centers frequently rederive infected mouse strains. We review our experience on the...... hiện toàn bộ
Rapid screening for dominant negative mutations in the beet necrotic yellow vein virus triple gene block proteins P13 and P15 using a viral replicon
Transgenic Research - Tập 10 - Trang 293-302 - 2001
Emmanuelle Lauber, Laurence Janssens, G. Weyens, G. Jonard, K.E. Richards, M. Lefèbvre, H. Guilley
Point mutations were introduced into the genes encoding the triple gene bock movement proteins P13 and P15 of beet necrotic yellow vein virus (BNYVV). Mutations which disabled viral cell-to-cell movement in Chenopodium quinoa were then tested for their ability to act as dominant negative inhibiters of movement of wild-type BNYVV when expressed from a co-inoculated BNYVV RNA 3-based replicon. For P...... hiện toàn bộ
Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis
Transgenic Research - Tập 27 - Trang 15-23 - 2017
Mika Ohta, Aki Sugano, Naoya Hatano, Hirotaka Sato, Hirofumi Shimada, Hitoshi Niwa, Toshiyuki Sakaeda, Hajime Tei, Yoshiyuki Sakaki, Ken-ichi Yamamura, Yutaka Takaoka
The disease model of familial amyloidotic polyneuropathy—7.2-hMet30 mice—manifests amyloid deposition that consists of a human amyloidogenic mutant transthyretin (TTR) (TTR V30M). Our previous study found amyloid deposits in 14 of 27 7.2-hMet30 mice at 21–24 months of age. In addition, non-fibrillar TTR deposits were found in amyloid-negative 7.2hMet30 mice. These results suggested that TTR amyloi...... hiện toàn bộ
Ubiquitin promoter-based vectors for high-level expression of selectable and/or screenable marker genes in monocotyledonous plants
Transgenic Research - Tập 5 Số 3 - Trang 213-218 - 1996
Alan H. Christensen, Peter H. Quail
Standing genetic variation and compensatory evolution in transgenic organisms: a growth-enhanced salmon simulation
Transgenic Research - Tập 20 - Trang 583-597 - 2010
Robert N. M. Ahrens, Robert H. Devlin
Genetically modified strains usually are generated within defined genetic backgrounds to minimize variation for the engineered characteristic in order to facilitate basic research investigations or for commercial application. However, interactions between transgenes and genetic background have been documented in both model and commercial agricultural species, indicating that allelic variation at t...... hiện toàn bộ
Field trials to evaluate effects of Bt-transgenic silage corn expressing the Cry1Ab insecticidal toxin on non-target soil arthropods in northern New England, USA
Transgenic Research - Tập 18 - Trang 425-443 - 2008
Amanda L. Priestley, Michael Brownbridge
Traditionally, control of European corn borer (Ostrinia nubilalis) Hübner has been achieved through the use of chemical insecticides. With increasing emphasis on reducing pesticide inputs in agricultural production, alternative management technologies are now being used including transgenic silage corn modified to express Cry1Ab protein toxins derived from Bacillus thuringiensis (Bt) Berliner. The...... hiện toàn bộ
Liver, renal and subcutaneous histopathology in PEPCK-bGH transgenic pigs
Transgenic Research - Tập 3 - Trang 401-405 - 1994
C. A. Pinkert, E. J. Galbreath, C. W. Yang, L. J. Striker
Transgenic pigs were created that harboured a phosphoenol pyruvate carboxykinase-bovine growth hormone construct (PEPCK-bGH). Four founder animals and two transgenic offspring from one line were evaluated between 61/2 and 12 months of age. There was no evidence of severe hepatic or renal lesions in these pigs, which characterised transgenic PEPCK-bGH mice previously described. While glomerular and...... hiện toàn bộ
Recombinant Human Protein C Expression in the Milk of Transgenic Pigs and the Effect on Endogenous Milk Immunoglobulin and Transferrin Levels
Transgenic Research - Tập 10 - Trang 43-51 - 2001
Kevin E. Van Cott, Henryk Lubon, F.C. Gwazdauskas, James Knight, William N. Drohan, William H. Velander
Colostrum and milk are natural vehicles for acquiring passive immunity and are valuable tools for decreasing neonatant mortality from diarrheal disease. The effects of recombinant human protein C (rhPC) expression levels on endogenous immunoglobulin and transferrin content of the milk of different lineages of transgenic pigs were studied. The levels of rhPC in the milk ranged from 40 to 1200 μg/ml...... hiện toàn bộ
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