Transgenic Research
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Improved metabolic action of a bacterial lysine decarboxylase gene in tobacco hairy root cultures by its fusion to arbcS transit peptide coding sequence
Transgenic Research - Tập 5 - Trang 193-201 - 1996
The gene of a bacterial lysine decarboxylase (ldc) fused to arbcS transit peptide coding sequence (tp), and under the control of the CaMV 35S promoter, was expressed in hairy root cultures ofNicotiana tabacum. The fusion of theldc to the targeting signal sequence improved the performance of the bacterial gene in the plant cells in many respects. Nearly all transgenic hairy root cultures harbouring...... hiện toàn bộ
The HIV-1 Pr55gag polyprotein binds to plastidial membranes and leads to severe impairment of chloroplast biogenesis and seedling lethality in transplastomic tobacco plants
Transgenic Research - Tập 24 - Trang 319-331 - 2014
Chloroplast genetic engineering has long been recognised as a powerful technology to produce recombinant proteins. To date, however, little attention has been given to the causes of pleiotropic effects reported, in some cases, as consequence of the expression of foreign proteins in transgenic plastids. In this study, we investigated the phenotypic alterations observed in transplastomic tobacco pla...... hiện toàn bộ
Erratum to: Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice
Transgenic Research - - 2011
Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring
Transgenic Research - Tập 22 - Trang 737-745 - 2012
The safety of HIV-1 based vectors was evaluated during the production of transgenic sheep. Vectors were introduced into the perivitelline space of in vivo derived one-cell sheep embryos by microinjection then transferred into the oviducts of recipient females. At 60–70 days of gestation, a portion of the recipients were euthanized and tissues collected from both surrogates and fetuses. Other ewes ...... hiện toàn bộ
Gene Silencing-Based Disease Resistance
Transgenic Research - Tập 11 - Trang 639-653 - 2002
The definition of a disease is fundamentally difficult, even if one considers only genetically based diseases. In its broadest sense, disease can be defined as any deviation from the norm that results in a physiological disadvantage. Natural selection ensures that the norm for any given species is constantly changing. In addition, some disadvantages are latent and might only manifest under certain...... hiện toàn bộ
Heterogeneity in the distribution of genetically modified and conventional oilseed rape within fields and seed lots
Transgenic Research - Tập 17 - Trang 805-816 - 2008
The implementation of co-existence in the commercialisation of GM crops requires GM and non-GM products to be segregated in production and supply. However, maintaining segregation in oilseed rape will be made difficult by the highly persistent nature of this species. An understanding of its population dynamics is needed to predict persistence and develop potential strategies for control, while to ...... hiện toàn bộ
Improvement of recombinant miraculin production in transgenic tomato by crossbreeding-based genetic background modification
Transgenic Research - - 2022
An important optimization step in plant-based recombinant protein production systems is the selection of an appropriate cultivar after a potential host has been determined. Previously, we have shown that transgenic tomatoes of the variety ‘Micro-Tom’ accumulate incredibly high levels of miraculin (MIR) due to the introduction of MIR gene controlled by a CaMV35S promoter and a heat-shock protein te...... hiện toàn bộ
Stability of gene silencing-based resistance to Plum pox virus in transgenic plum (Prunus domestica L.) under field conditions
Transgenic Research - Tập 13 - Trang 427-436 - 2004
Plum pox virus (PPV) is one of the most devastating diseases of Prunus species. Since few sources of resistance to PPV have been identified, transgene-based resistance offers a complementary approach to developing PPV-resistant stone fruit cultivars. C5, a transgenic clone of Prunus domestica L., containing the PPV coat protein (CP) gene, has been described as highly resistant to PPV in greenhouse...... hiện toàn bộ
Expression of hGM-CSF in silk glands of transgenic silkworms using gene targeting vector
Transgenic Research - Tập 21 - Trang 101-111 - 2011
The silk gland of the silkworm is a highly specialized organ that has the wonderful ability to synthesize and secrete silk protein. To express human granucyto-macrophage colony-stimulating factor (hGM-CSF) in the posterior silk glands of gene-targeted silkworms, a targeting vector pSK-FibL-L-A3GFP-PH-GMCSF-LPA-FibL-R was constructed, harboring a 1.2 kb portion of the left homogenous arm (FibL-L), ...... hiện toàn bộ
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