The Protein Journal

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Harold A. Scheraga [1921–2020]: Eminent Researcher, Mentor, Teacher, Friend
The Protein Journal - Tập 39 - Trang 397-399 - 2020
Mahesh Narayan
Functional Analysis of Single Nucleotide Polymorphism in ZUFSP Protein and Implication in Pathogenesis
The Protein Journal - - 2021
Mary B. Ajadi, Opeyemi Soremekun, Adeniyi T. Adewumi, Hezekiel M. Kumalo, Mahmoud E. S. Soliman
Characterization of a Long-Acting Site-Specific PEGylated Murine GM-CSF Analog and Analysis of Its Hematopoietic Properties in Normal and Cyclophosphamide-Treated Neutropenic Rats
The Protein Journal - Tập 39 - Trang 160-173 - 2020
George N. Cox, Ji I. Lee, Mary S. Rosendahl, Elizabeth A. Chlipala, Daniel H. Doherty
Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. However, we could not evaluate the hematological properties of the PEG-A3C protein in rats because human GM-CSF is inactive in rodents. To study the biolog...... hiện toàn bộ
Reminiscence: Miguel Llinás (1938–2020)
The Protein Journal - Tập 40 - Trang 459-461 - 2021
Juliette T. J. Lecomte
Probing Structure–Function Relationships of Serine Hydrolases and Proteases with Carbamate and Thiocarbamate Inhibitors
The Protein Journal - Tập 25 - Trang 33-43 - 2006
G. Lin, S. -Y. Chiou, B. -C. Hwu, C. -W. Hsieh
Benzene-1,3-di-N-n-octylcarbamate (1), benzene-1-hydroxyl-3-N-n-octylcarbamate (2), benzene-1,3-di-N-n-ocztylthiocarbamate (3), and benzene-1-hydroxyl-3-N-n-octylthiocarbamate (4) are synthesized from 1,3-benzene-diol and are characterized as the pseudo-substrate inhibitors of acetylcholinesterase, butyrylcholinesterase, cholesterol esterase, lipase, trypsin, and chymotrypsin. For these six enzyme...... hiện toàn bộ
Herman Berendsen and Water: Personal Memories
The Protein Journal - Tập 42 - Trang 156-158 - 2023
Piet Jan Andree
In this contribution I describe my personal memories of my work with Herman Berendsen and the Biophysical chemistry group in Groningen in the period of years from 1967 to 1975.
Practical Considerations When Using Temperature to Obtain Rate Constants and Activation Thermodynamics of Enzymes with Two Catalytic Steps: Native and N460T-β-Galactosidase (E. coli) as Examples
The Protein Journal - Tập 28 - Trang 96-103 - 2009
John C. Kappelhoff, Su Yi Judy Liu, Megan L. Dugdale, Dayna L. Dymianiw, Larry R. Linton, Reuben E. Huber
The values of the rate constants and the associated enthalpies and entropies of enzymes with two catalytic steps can be measured by determining the effects of temperature on the k cat values. Practical considerations that should be taken into account when doing this are presented. The narrow temperature range available with enzymes and the sensitivity of pH to temperature ...... hiện toàn bộ
Calcium Ions and a Secreted Peroxidase in Euphorbia characias Latex are Made for Each Other
The Protein Journal - - 2011
Francesca Pintus, Delia Spanò, Rosaria Medda, Giovanni Floris
This minireview deals of a protein, a class III secreted peroxidase, present as unique isoform in the latex of the perennial Mediterranean shrub Euphorbia characias. The paper reports on the molecular properties, on the structures (primary, secondary and tertiary), and on the catalytic mechanism of this enzyme. Here is also reported the extraordinary effect of calcium ions ...... hiện toàn bộ
SDS Induced Structural Changes in α-Crystallin and It’s Effect on Refolding
The Protein Journal - Tập 23 - Trang 529-538 - 2004
Ashis Biswas, Kali P. Das
α-Crystallin, a major eye lens protein and a key member of the small heat shock protein family, acts like a chaperone by preventing aggregation of substrate proteins. One of the hallmarks of most small heat shock proteins is their existence as a large oligomer, the role of which in its function is not understood at present. We have studied the role of the oligomer in the stability of its structure...... hiện toàn bộ
Most Probable Druggable Pockets in Mutant p53-Arg175His Clusters Extracted from Gaussian Accelerated Molecular Dynamics Simulations
The Protein Journal - Tập 41 - Trang 27-43 - 2022
Morad Mustafa, Mohammed Gharaibeh
p53, a tumor suppressor protein, is essential for preventing cancer development. Enhancing our understanding of the human p53 function and its modifications in carcinogenesis will aid in developing more highly effective strategies for cancer prevention and treatment. In this study, we have modeled five human p53 forms, namely, inactive, distal-active, proximal-active, distal-Arg175His mutant, and ...... hiện toàn bộ
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