Technology in Cancer Research and Treatment
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SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation
Technology in Cancer Research and Treatment - Tập 19 - Trang 153303382094748 - 2020
Breast cancer (Bca) remains the most common form of malignancy affecting females
in China, leading to significant reductions in the mental and physical health of
those with this condition. While spindle and kinetochore associated complex
subunit 3 (SKA3) is known to be linked with cervical cancer progression, whether
it is similarly associated with Bca progression remains unknown. Using shRNA, we
...
A Review of Progress in Clinical Photodynamic Therapy
Technology in Cancer Research and Treatment - Tập 4 Số 3 - Trang 283-293 - 2005
Photodynamic therapy (PDT) has received increased attention since the regulatory
approvals have been granted to several photosensitizing drugs and light
applicators worldwide. Much progress has been seen in basic sciences and
clinical photodynamics in recent years. This review will focus on new
developments of clinical investigation and discuss the usefulness of various
forms of PDT techniques for...
Image-Guided Stereotactic Body Radiation Therapy for Clinically Localized Prostate Cancer: Preliminary Clinical Results
Technology in Cancer Research and Treatment - Tập 9 Số 5 - Trang 473-477 - 2010
Stereotactic body radiotherapy (SBRT) is a new treatment modality for prostate
cancer. The current study evaluates CyberKnife® SBRT and reports toxicity and
early Prostate-Specific Antigen (PSA) kinetics. From June 2006 to August 2009,
45 low-and intermediate-risk prostate cancer patients received Cyberknife SBRT
of 35 Gy in five fractions with 95% minimum target coverage. Median follow-up
was 20-...
Stereotactic Body Radiotherapy: An Emerging Treatment Approach for Localized Prostate Cancer
Technology in Cancer Research and Treatment - Tập 8 Số 5 - Trang 387-392 - 2009
Here we report results from the first cohort of over 100 patients treated with
hypofractionated, stereotactic body radiotherapy (SBRT) for early stage prostate
cancer. Between February 2005 and December 2006, 112 patients with localized,
biopsy-proven adenocarcinoma of the prostate (clinical stage T1cN0M0 to T2cN0M0)
were treated in Naples, FL on a CyberKnife system (Accuray Incorporated,
Sunnyval...
CyberKnife Radiotherapy for Localized Prostate Cancer: Rationale and Technical Feasibility
Technology in Cancer Research and Treatment - Tập 2 Số 1 - Trang 25-29 - 2003
There is a clear dose response for localized prostate cancer radiotherapy and
there probably is a radiobiological rationale for hypo-fractionation. Combining
the two should maximize tumor control and increase the therapeutic ratio. This
study examines the rationale and technical feasibility of CyberKnife
radiotherapy (a robotic arm-driven linear accelerator) for localized prostate
cancer. Its abil...
Low Generation Polypropylenimine Dendrimer Graft β-cyclodextrin: An Efficient Vector for Gene Delivery System
Technology in Cancer Research and Treatment - Tập 7 Số 2 - Trang 103-108 - 2008
The purpose of this study was to evaluate the characterization of a new cationic
vector. Low generation polypropylenimine (DAB-8) was conjugated to
β-cyclodextrin (β-CyD), and the chemical characters of the vector were
investigated and confirmed by 1 H NMR, FT-IR, TGA, TEM, particle size, and zeta
potential assay. The biological property was identified by MTT assay and gene
transfer efficiency was...
The Diagnostic Efficacy and Biological Effects of microRNA-29b for Colon Cancer
Technology in Cancer Research and Treatment - Tập 15 Số 6 - Trang 772-779 - 2016
Background: Colorectal cancer is one of the most common cancers worldwide in
terms of both incidence and mortality. The associations of expressions of tissue
and plasma miR-29b were not detected in this study. Methods: There are 400
healthy age- and gender-matched controls enrolled in this study in a rate of
1:2. The receiver operating characteristic curve analysis was undertaken using
the express...
The Assessment of Clinical Usage and Prognostic Value of YKL-40 Serum Levels in Patients With Rectal Cancer Without Distant Metastasis
Technology in Cancer Research and Treatment - Tập 17 - 2018
Background: Colorectal cancer is one of the most common and significant
malignancies in the world. YKL-40 (chitinase-3-like protein 1) is involved in
cell proliferation, migration, inflammation, and tissue remodeling; and serum
levels of YKL-40 are associated with patient outcome in various cancers. The aim
of this study was to assess the potential clinical usage of YKL-40 pretreatment
serum level...
Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules
Technology in Cancer Research and Treatment - Tập 21 - 2022
Purpose: Microwave ablation has become an alternative treatment for pulmonary
ground-glass nodules (GGN) and is widely accepted by clinicians. However, its
effect on lung function remains unknown. Therefore, this retrospective study
aimed to explore pulmonary function changes and associated risk factors in
patients undergoing computed tomography (CT)-guided microwave ablation (MWA) for
treating pu...
A Competing Endogenous RNA Network Reveals Novel lncRNA, miRNA and mRNA Biomarkers With Diagnostic and Prognostic Value for Early Breast Cancer
Technology in Cancer Research and Treatment - Tập 19 - Trang 153303382098329 - 2020
Background: This study aims to reveal early breast cancer (BC) specific
competing endogenous RNA (ceRNA) network through the expression profiles of
microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and mRNAs. Methods: Based on
The Cancer Genome Atlas (TCGA), we obtained the differentially expressed mRNAs,
miRNAs, and lncRNAs (DEmRNAs, DEmiRNAs and DElncRNAs) between early BC and
normal samples. T...
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