Stereotactic Body Radiotherapy: An Emerging Treatment Approach for Localized Prostate Cancer

Technology in Cancer Research and Treatment - Tập 8 Số 5 - Trang 387-392 - 2009
Jay L. Friedland1, Debra Freeman1, Mary Ellen Masterson-McGary2, David M. Spellberg3
1Naples Radiation Oncology, PA
2Cyberknife Centers of Tampa Bay
3Naples Urology Associates, PA

Tóm tắt

Here we report results from the first cohort of over 100 patients treated with hypofractionated, stereotactic body radiotherapy (SBRT) for early stage prostate cancer. Between February 2005 and December 2006, 112 patients with localized, biopsy-proven adenocarcinoma of the prostate (clinical stage T1cN0M0 to T2cN0M0) were treated in Naples, FL on a CyberKnife system (Accuray Incorporated, Sunnyvale, CA). Eighty-one patients had a Gleason score of 3+3. Mean initial PSA was 6.0, and mean initial prostate volume was 46.3cc. Implanted gold fiducials were used for image-guided targeting and tracking. Patients received 35–36 Gy administered in 5 consecutive fractions to the prostate and the proximal seminal vesicles, as identified on CT and MRI scans. At a median follow-up of 24 months, the mean PSA value was 0.78 ng/ml. Two patients have developed biopsy-confirmed local relapse; one developed distant metastases. Acute side effects were generally mild and resolved shortly after treatment. A single Grade 3 rectal complication was reported (bleeding). Eighty-two percent of patients who were sexually potent before treatment maintained erectile function post-treatment. Additional follow-up is required to better evaluate potential late toxicity and long-term PSA outcomes.

Từ khóa


Tài liệu tham khảo

10.1016/S0360-3016(02)02954-1

10.1016/S0022-5347(05)65855-7

10.1001/jama.294.10.1233

10.1016/S0360-3016(01)01607-8

10.1080/02841860410002824

10.1016/S0360-3016(02)03828-2

10.1016/S0360-3016(98)00097-2

10.1016/j.ijrobp.2004.08.014

10.1016/S0360-3016(00)01463-2

10.1016/j.ijrobp.2006.07.660

10.1097/01.ju.0000113299.34404.22

10.1016/j.ijrobp.2006.10.050

10.1016/j.ijrobp.2008.05.059

10.1016/j.ijrobp.2006.07.612

10.1016/j.ijrobp.2007.11.067

10.1038/sj.ijir.3900857

10.1093/jnci/djh259

10.1056/NEJMoa074311

10.1016/j.ijrobp.2005.07.540

ASTRO Emerging Technology Committee. Stereotactic Body Radiotherapy (SBRT) For Primary Management of Early-Stage, Low-Intermediate Risk ProstateCancer. [http://www.astro.org/HealthPolicy/EmergingTechnology/EvaluationProjects/documents/SBRTpros.pdf].

Thông tin
Thông tin xuất bản

Technology in Cancer Research and Treatment

Tập 8 Số 5

387-392

Thông tin tác giả