Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T CellsStem Cell Reviews and Reports - - 2021
Jia Feng, Hai-chan Xu, Andrew Cinquina, Zehua Wu, Qi Chen, Ping Zhang, Xingen Wang, Huiming Shan, Lei Xu, Qian Zhang, Lihua Sun, Wenli Zhang, Kevin G. Pinz, M. Wada, Xun Jiang, William Hanes, Yupo Ma, Hongyu Zhang
AbstractWhile treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies for T-cell malignancies have been limited. Additionally, T-cell leukemias and lymphomas can commonly metastasize to the CNS, where outcomes are poor and treatment options are associated with severe side effects. Consequently, the devel...... hiện toàn bộ
Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem CellsStem Cell Reviews and Reports - Tập 17 - Trang 2314-2331 - 2021
Rui Liu, Fangxu Sun, Lawrence C. Armand, Ronghu Wu, Chunhui Xu
Chronic alcohol consumption in adults can induce cardiomyopathy, arrhythmias, and heart failure. In newborns, prenatal alcohol exposure can increase the risk of congenital heart diseases. Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. In this study, cardiomyocytes derived from human plurip...... hiện toàn bộ
Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord InjuryStem Cell Reviews and Reports - Tập 19 - Trang 2024-2037 - 2023
Tianyu Han, Peiwen Song, Zuomeng Wu, Yunlei Liu, Wang Ying, Cailiang Shen
Cell‒cell communication following spinal cord injury (SCI) plays a key role in remyelination and neurological recovery. Although communication between neuron-neural stem cells (NSCs) affects remyelination, its precise mechanism remains unclear. The present study investigated the biological effects of extracellular vesicles (EVs) derived from neurons on the differentiation of NSCs and the remyelina...... hiện toàn bộ
Culture Protocol and Transcriptomic Analysis of Murine SVZ NPCs and OPCsStem Cell Reviews and Reports - Tập 19 - Trang 983-1000 - 2023
Nicole L. Dittmann, Pouria Torabi, Adrianne E. S. Watson, Scott A. Yuzwa, Anastassia Voronova
The mammalian adult brain contains two neural stem and precursor (NPC) niches: the subventricular zone [SVZ] lining the lateral ventricles and the subgranular zone [SGZ] in the hippocampus. From these, SVZ NPCs represent the largest NPC pool. While SGZ NPCs typically only produce neurons and astrocytes, SVZ NPCs produce neurons, astrocytes and oligodendrocytes throughout life. Of particular impor...... hiện toàn bộ
Genetically Modified Mesenchymal Stromal/Stem Cells: Application in Critical IllnessStem Cell Reviews and Reports - Tập 16 - Trang 812-827 - 2020
Amir K. Varkouhi, Ana Paula Teixeira Monteiro, James N. Tsoporis, Shirley H. J. Mei, Duncan J. Stewart, Claudia C. dos Santos
Critical illnesses including sepsis, acute respiratory distress syndromes, ischemic cardiovascular disorders and acute organ injuries are associated with high mortality, morbidity as well as significant health care system expenses. While these diverse conditions require different specific therapeutic approaches, mesenchymal stem/stromal cell (MSCs) are multipotent cells capable of self-renewal, tr...... hiện toàn bộ
Nuclear Tubulin Enhances CXCR4 Transcription and Promotes Chemotaxis Through TCF12 Transcription Factor in human Hematopoietic Stem CellsStem Cell Reviews and Reports - Tập 19 - Trang 1328-1339 - 2023
Nanxi Geng, Ziqin Yu, Xingchao Zeng, Danhua Xu, Hai Gao, Min Yang, Xinxin Huang
Tubulins are cytoskeleton components in all eukaryotic cells and play crucial roles in various cellular activities by polymerizing into dynamic microtubules. A subpopulation of tubulin has been shown to localize in the nucleus, however, the function of nuclear tubulin remains largely unexplored. Here we report that microtubule depolymerization specifically upregulates surface CXCR4 expression in h...... hiện toàn bộ
Tracking Neural Stem Cells in vivo: Achievements and LimitationsStem Cell Reviews and Reports - Tập 18 - Trang 1774-1788 - 2022
Chun-Ran Xue, Kan Wang, Meng-Ze Zhang, Ze Wang, Ya-Ying Song, Hao-Jun Yu, Yong Hao, Yang-Tai Guan
Neural stem cell (NSC) therapies are developing rapidly and have been proposed as a treatment option for various neurological diseases, such as stroke, Parkinson's disease and multiple sclerosis. However, monitoring transplanted NSCs, exploring their location and migration, and evaluating their efficacy and safety have all become serious and important issues. Two main problems in tracking NSCs hav...... hiện toàn bộ