Stem Cell Reviews and Reports

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Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury
Stem Cell Reviews and Reports - Tập 19 - Trang 2024-2037 - 2023
Tianyu Han, Peiwen Song, Zuomeng Wu, Yunlei Liu, Wang Ying, Cailiang Shen
Cell‒cell communication following spinal cord injury (SCI) plays a key role in remyelination and neurological recovery. Although communication between neuron-neural stem cells (NSCs) affects remyelination, its precise mechanism remains unclear. The present study investigated the biological effects of extracellular vesicles (EVs) derived from neurons on the differentiation of NSCs and the remyelina...... hiện toàn bộ
Stem Cells Delivered Oncolytic Virus to Destroy Formidable Brain Tumor
Stem Cell Reviews and Reports - - 2022
Vignesh Balaji E, K. Sreedhara Ranganath Pai
Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications
Stem Cell Reviews and Reports - Tập 16 - Trang 3-32 - 2019
Gele Liu, Brian T. David, Matthew Trawczynski, Richard G. Fessler
Over the past 20 years, and particularly in the last decade, significant developmental milestones have driven basic, translational, and clinical advances in the field of stem cell and regenerative medicine. In this article, we provide a systemic overview of the major recent discoveries in this exciting and rapidly developing field. We begin by discussing experimental advances in the generation and...... hiện toàn bộ
Role of Adult Tissue-Derived Pluripotent Stem Cells in Bone Regeneration
Stem Cell Reviews and Reports - Tập 16 - Trang 198-211 - 2019
Liudmila Leppik, K. Sielatycka, D. Henrich, Z. Han, H. Wang, M. J. Eischen-Loges, K. M. C. Oliveira, M. B. Bhavsar, M. Z. Ratajczak, J. H. Barker
Bone marrow-derived mononuclear cells (BM-MNC) consist of a heterogeneous mix of mesenchymal stem cells (MSC), hematopoietic progenitor cells (HPC), endothelial progenitor cells (EPC), monocytes, lymphocytes and pluripotent stem cells. Whereas the importance of MSC and EPC has been well documented in bone healing and regeneration studies, the role of pluripotent stem cells is still poorly understo...... hiện toàn bộ
Human Urine-Derived Stem Cells Improve Partial Bladder Outlet Obstruction in Rats: Preliminary Data and microRNA-mRNA Expression Profile
Stem Cell Reviews and Reports - Tập 18 Số 7 - Trang 2403-2413 - 2022
Menjiang Tu, Rui Wang, Ping Zhu, Qingqing Wang, Bishao Sun, Keshi Lu, Jiawei Zhang, Weihua Xie, Huan Guo, Shulin Li, Yuqi Wu, Xiangwei Wang
AbstractPartial bladder outlet obstruction (pBOO) often results in bladder tissue inflammation and remodeling. As human urine-derived stem cells (USCs) have demonstrated therapeutic benefits, we used a rat model to investigate the effect of USCs on bladder function and explore the miRNA and gene expression profiles in bladder tissue using RNA sequencing. Eighteen r...... hiện toàn bộ
Correction to: Induced Pluripotent Stem Cells as a Possible Approach for Exploring the Pathophysiology of Polycystic Ovary Syndrome (PCOS)
Stem Cell Reviews and Reports - Tập 20 - Trang 583-583 - 2023
Masuma Khatun, Karolina Lundin, Florence Naillat, Liisa Loog, Ulla Saarela, Timo Tuuri, Andres Salumets, Terhi T. Piltonen, Juha S. Tapanainen
TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells with gain of 20q11.21
Stem Cell Reviews and Reports - Tập 19 - Trang 1466-1481 - 2023
Ho-Chang Jeong, Young-Hyun Go, Joong-Gon Shin, Yun-Jeong Kim, Min-Guk Cho, Dasom Gwon, Hyun Sub Cheong, Haeseung Lee, Jae-Ho Lee, Chang-Young Jang, Hyoung Doo Shin, Hyuk-Jin Cha
Despite highly effective machinery for the maintenance of genome integrity in human embryonic stem cells (hESCs), the frequency of genetic aberrations during in-vitro culture has been a serious issue for future clinical applications. By passaging hESCs over a broad range of timepoints (up to 6 years), the isogenic hESC lines with different passage numbers with distinct cellular characteristics, we...... hiện toàn bộ
Stem Cell Therapy in Spinal Cord Injury-Induced Neurogenic Lower Urinary Tract Dysfunction
Stem Cell Reviews and Reports - Tập 19 - Trang 1691-1708 - 2023
Yin-Chien Ou, Chi-Chen Huang, Yao-Lin Kao, Pei-Chuan Ho, Kuen-Jer Tsai
Spinal cord injury (SCI) is a devastating condition that enormously affects an individual’s health and quality of life. Neurogenic lower urinary tract dysfunction (NLUTD) is one of the most important sequelae induced by SCI, causing complications including urinary tract infection, renal function deterioration, urinary incontinence, and voiding dysfunction. Current therapeutic methods for SCI-induc...... hiện toàn bộ
Metabolic Regulation: A Potential Strategy for Rescuing Stem Cell Senescence
Stem Cell Reviews and Reports - Tập 18 - Trang 1728-1742 - 2022
Wenxin Zhang, Jiayu Li, Yuchi Duan, Yanlin Li, Yanan Sun, Hui Sun, Xiao Yu, Xingyu Gao, Chang Zhang, Haiying Zhang, Yingai Shi, Xu He
Stem cell senescence and exhaustion are closely related to organ failure and individual aging, which not only induces age-related diseases, but also hinders stem cell applications in regenerative medicine. Thus, it’s imminent to find effective ways to delay and retrieve stem cell senescence. Metabolic abnormalities are one of the main characteristics of age-associated declines in stem cell functio...... hiện toàn bộ
Granulocytes Negatively Regulate Secretion of Transforming Growth Factor β1 by Bone Marrow Mononuclear Cells via Secretion of Erythropoietin Receptors in the Milieu
Stem Cell Reviews and Reports - Tập 18 - Trang 1408-1416 - 2021
Vaijayanti Kale
In my previous study, I demonstrated that bone marrow-derived mononuclear cells (BM MNCs) secrete copious amounts of Transforming Growth Factor β1 (TGFβ1) in response to erythropoietin (EPO). In this study, I investigated the principal cell type involved in the process. I found that a large percentage of various marrow cells, but not their mature counterparts present in the peripheral blood, expre...... hiện toàn bộ
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