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Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells
Springer Science and Business Media LLC - Tập 9 - Trang 578-585 - 2013
Definitive endoderm can be derived from human embryonic stem cells using low serum medium with cytokines involved in the epithelial-to-mesenchymal transition, including Activin A and Wnt3A. The purpose of this study was to develop an improved protocol that permits the induction of definitive endoderm while avoiding the high rate of cell death that often occurs with existing protocols. By including......
Co-culture with Mature Islet Cells Augments the Differentiation of Insulin-Producing Cells from Pluripotent Stem Cells
Springer Science and Business Media LLC - Tập 11 - Trang 62-74 - 2014
Islet transplantation has been hampered by the shortage of islet donors available for diabetes therapy. However, pluripotent stem cells (PSCs) can be an alternative source of insulin-producing cells (IPCs) because of their capacity for self-renewal and differentiation. We described a method to efficiently differentiate PSCs into IPCs by co-culturing mature islets with directed-differentiated pancr......
Signaling Pathways in Cancer and Embryonic Stem Cells
Springer Science and Business Media LLC - Tập 3 Số 1 - Trang 7-17 - 2007
Double cord blood transplants
Springer Science and Business Media LLC - Tập 2 - Trang 81-86 - 2006
Over the last decade, umbilical cord blood (CB) has become a viable option for hematopoietic stem cell transplants. A limiting factor has been the 10-fold lower cell dose in a CB unit compared with harvested bone marrow or peripheral blood stem cells. The low cell dose leads to delayed engraftment and an increase in graft failure. Double cord blood transplants represent a novel strategy to overcom......
Fueling Hope: Stem Cells in Social Media
Springer Science and Business Media LLC - - 2015
Social media is broadening opportunities to engage in discussions about biomedical advances such as stem cell research. However, little is known about how information pertaining to stem cells is disseminated on platforms such as Twitter. To fill this gap, we conducted a content analysis of tweets containing (i) a stem cell keyword, and (ii) a keyword related to either spinal cord injury (SCI) or P......
Beneficial Role of Low-Intensity Laser Irradiation on Neural β-tubulin III Protein Expression in Human Bone Marrow Multipotent Mesenchymal Stromal Cells
Springer Science and Business Media LLC - Tập 14 - Trang 585-598 - 2018
The purpose of the present study was to evaluate the neural protein expression pattern of human multipotent mesenchymal stromal cells (hMSCs) treated with forskolin (free-form/FF). The study investigated forskolin’s capacity to enhance intracellular levels of cyclic adenosine monophosphate (cAMP) by activating adenylate cyclase and probably by inducing neuron-like cells in vitro. In addition, beca......
Allogenic Myocytes and Mesenchymal Stem Cells Partially Improve Fatty Rotator Cuff Degeneration in a Rat Model
Springer Science and Business Media LLC - Tập 14 - Trang 847-859 - 2018
Rotator cuff (RC) tears result not only in functional impairment but also in RC muscle atrophy, muscle fattening and eventually to muscle fibrosis. We hypothesized that allogenic bone marrow derived mesenchymal stem cells (MSC) and myocytes can be utilized to improve the rotator cuff muscle fattening and increase the atrophied muscle mass in a rat model. The right supraspinatus (SSP) tendons of 10......
Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways
Springer Science and Business Media LLC - Tập 13 - Trang 17-23 - 2016
Dramatic advances have been made in the understanding of cancer over the past decade. Prime among those are better appreciation of the biology of cancer and the development of targeted therapies. Despite these improvements, however, most tumors remain refractory to anti-cancer medications and frequently recur. Cancer Stem Cells (CSCs), which in some cases express markers of pluripotency (e.g., Oct......
Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner
Springer Science and Business Media LLC - Tập 15 - Trang 139-154 - 2018
Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid (LPA), have emerged as important mediators regulating the trafficking of normal and cancer cells. While the role of S1P in regulating migration of hematopoietic cells is well established, in this work we compared its biological effect......
Strategies to Enhance the Effectiveness of Adult Stem Cell Therapy for Ischemic Heart Diseases Affecting the Elderly Patients
Springer Science and Business Media LLC - Tập 12 - Trang 214-223 - 2016
Myocardial infarctions and chronic ischemic heart disease both commonly and disproportionately affect elderly patients more than any other patient population. Despite available treatments, heart tissue is often permanently damaged as a result of cardiac injury. This review aims to summarize recent literature proposing the use of modified autologous adult stem cells to promote healing of post-infar......
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