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Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells
Springer Science and Business Media LLC - Tập 9 - Trang 578-585 - 2013
Betty R. Lawton, Julie Ann Sosa, Sanziana Roman, Diane S. Krause
Definitive endoderm can be derived from human embryonic stem cells using low serum medium with cytokines involved in the epithelial-to-mesenchymal transition, including Activin A and Wnt3A. The purpose of this study was to develop an improved protocol that permits the induction of definitive endoderm while avoiding the high rate of cell death that often occurs with existing protocols. By including...... hiện toàn bộ
Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways
Springer Science and Business Media LLC - Tập 13 - Trang 17-23 - 2016
Ohad Oren, B. Douglas Smith
Dramatic advances have been made in the understanding of cancer over the past decade. Prime among those are better appreciation of the biology of cancer and the development of targeted therapies. Despite these improvements, however, most tumors remain refractory to anti-cancer medications and frequently recur. Cancer Stem Cells (CSCs), which in some cases express markers of pluripotency (e.g., Oct...... hiện toàn bộ
Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres
Springer Science and Business Media LLC - Tập 7 - Trang 394-403 - 2010
Lina Ziegler, Sergei Grigoryan, In Hong Yang, Nitish V. Thakor, Ronald S. Goldstein
Schwann cells (SC), the glial cells of peripheral nerves, are involved in many diseases including Charcot Marie Tooth and neurofibromatosis, and play a pivotal role in peripheral nerve regeneration. Although it is possible to obtain human SC from nerve biopsies, they are difficult to maintain and expand in culture. Here we describe an efficient system for directing the differentiation of human emb...... hiện toàn bộ
Separation of SSEA-4 and TRA-1–60 Labelled Undifferentiated Human Embryonic Stem Cells from A Heterogeneous Cell Population Using Magnetic-Activated Cell Sorting (MACS) and Fluorescence-Activated Cell Sorting (FACS)
Springer Science and Business Media LLC - Tập 5 - Trang 72-80 - 2009
Chui Yee Fong, Gary S. L. Peh, Kalamegam Gauthaman, Ariff Bongso
A major concern in human embryonic stem cell (hESC)-derived cell replacement therapy is the risk of tumorigenesis from undifferentiated hESCs residing in the population of hESC-derived cells. Separation of these undifferentiated hESCs from the differentiated derivatives using cell sorting methods may be a plausible approach in overcoming this problem. We therefore explored magnetic activated cell ...... hiện toàn bộ
A Novel Stem Cell Tag-Less Sorting Method
Springer Science and Business Media LLC - Tập 5 - Trang 420-427 - 2009
Barbara Roda, Giacomo Lanzoni, Francesco Alviano, Andrea Zattoni, Roberta Costa, Arianna Di Carlo, Cosetta Marchionni, Michele Franchina, Francesca Ricci, Pier Luigi Tazzari, Pasqualepaolo Pagliaro, Sergio Zaccaria Scalinci, Laura Bonsi, Pierluigi Reschiglian, Gian Paolo Bagnara
Growing interest in stem cell research has led to the development of a number of new methods for isolation. The lack of homogeneity in stem cell preparation blurs standardization, which however is recommended for successful applications. Among stem cells, mesenchymal stem cells (MSCs) are promising candidates for cell therapy applications. This paper presents a fractionation protocol based on a ta...... hiện toàn bộ
Effects of Preoperative Short Term Use of Atorvastatin on Endothelial Progenitor Cells after Coronary Surgery: A Randomized, Controlled Trial
Springer Science and Business Media LLC - Tập 8 - Trang 963-971 - 2011
Çağdaş Baran, Serkan Durdu, Klara Dalva, Çagın Zaim, Arın Dogan, Gokhan Ocakoglu, Günhan Gürman, Önder Arslan, Ahmet Rüçhan Akar
We investigated the effects of short-term use of atorvastatin on CD34+/VEGF-R2+/CD133+/CD45- endothelial progenitor cell (EPC) count after on-pump coronary artery bypass surgery (CABG). Between Feb-2010 and May-2010, we randomly assigned, in a placebo-controlled, double-blind study, 60 consecutive patients who underwent isolated, first-time CABG to receive either 14-day atorvastatin (40 mg/day) or...... hiện toàn bộ
Practical Issues with the Use of Stem Cells for Cancer Gene Therapy
Springer Science and Business Media LLC - Tập 11 - Trang 688-698 - 2015
Faranak Salman Nouri, Debabrata Banerjee, Arash Hatefi
Stem cell-based drug delivery for cancer therapy has steadily gained momentum in the past decade as several studies have reported stem cells’ inherent tropism towards tumors. Since this science is still in its early stages and there are many factors that could significantly impact tumor tropism of stem cells, some contradictory results have been observed. This review starts by examining a number o...... hiện toàn bộ
Cultured Mesenchymal Stem Cells Stimulate an Immune Response by Providing Immune Cells with Toll-Like Receptor 2 Ligand
Springer Science and Business Media LLC - Tập 11 - Trang 826-840 - 2015
Ada Weinstock, Meirav Pevsner-Fischer, Ziv Porat, Michael Selitrennik, Dov Zipori
Mesenchymal stem cells (MSCs) serve as supporting and regulatory cells, by providing tissues with multiple factors and are also known for their immunosuppressive capabilities. Our laboratory had previously shown that MSCs expressed toll-like receptor (TLR) 2 and are activated by its ligand Pam3Cys. TLR2 is an important component of the innate immune system, as it recognizes bacterial lipopeptides,...... hiện toàn bộ
Modeling Neurodevelopmental Disorders Using Human Pluripotent Stem Cells
Springer Science and Business Media LLC - Tập 10 - Trang 494-511 - 2014
Michael Telias, Dalit Ben-Yosef
Neurodevelopmental disorders (NDs) are impairments that affect the development and growth of the brain and the central nervous system during embryonic and early postnatal life. Genetically manipulated animals have contributed greatly to the advancement of ND research, but many of them differ considerably from the human phenotype. Cellular in vitro models are also valuable, but the availability of ...... hiện toàn bộ
Identity, Fate and Potential of Cells Grown as Neurospheres: Species Matters
Springer Science and Business Media LLC - Tập 7 Số 4 - Trang 815-835 - 2011
Steffenhagen, Carolin, Kraus, Sabrina, Dechant, Franz-Xaver, Kandasamy, Mahesh, Lehner, Bernadette, Poehler, Anne-Maria, Furtner, Tanja, Siebzehnrubl, Florian A., Couillard-Despres, Sebastien, Strauss, Olaf, Aigner, Ludwig, Rivera, Francisco J.
It is commonly accepted that adult neurogenesis and gliogenesis follow the same principles through the mammalian class. However, it has been reported that neurogenesis might differ between species, even from the same order, like in rodents. Currently, it is not known if neural stem/progenitor cells (NSPCs) from various species differ in their cell identity and potential. NSPCs can be expanded ex v...... hiện toàn bộ
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