Double cord blood transplants
Tóm tắt
Over the last decade, umbilical cord blood (CB) has become a viable option for hematopoietic stem cell transplants. A limiting factor has been the 10-fold lower cell dose in a CB unit compared with harvested bone marrow or peripheral blood stem cells. The low cell dose leads to delayed engraftment and an increase in graft failure. Double cord blood transplants represent a novel strategy to overcome this limitation. This review will cover the rationale behind and clinical results of double cord blood transplant studies. The chimerism data from these studies reveal that typically only one CB “wins the battle” for engraftment. These results may have important scientific implications in terms of understanding the nature of the hematopoietic stem cell niche and how modulation of this niche may impact transplant outcomes.
Tài liệu tham khảo
Allogeneic Stem Cell Sources by Recipient Age, 1996–2002. Available at: www.marrow.org/PHYSICIAN/hemato poietic_cell_sources.html#ucb.Accessed February 26, 2006.
United States General Accounting Office: Bone Marrow Transplants, October 2002. Available at:www.gao.gov/new.items/ d03182.pdf.Accessed February 26, 2006.
Wagner JE, Barker JN, DeFor TE, et al. Blood 2002;100:1611–1618.
Gluckman E, Rocha V, Arcese W, et al. Exp. Hematol. 2004;32: 397–407.
Barker JN, Scaradavou A, Stevens CE, Rubinstein P. Blood 2005;106:92A-93A.
Rocha V, Cornish J, Sievers EL, et al. Blood 2001;97:2962–2671.
Laughlin MJ, Eapen M, Rubinstein P, et al. N Engl J Med 2004;351:2265–2275.
Takahashi S, Iseki T, Ooi J, et al. Blood 2004;104:3813–3820.
Kögler G, Enczmann J, Rocha V, et al. Bone Marrow Transplant 2005;36:1033–1041.
Barker JN, Krepski TP, DeFor TE, et al. Biol Blood Marrow Transplant 2002;8:257–260.
Dalle JH, Duval M, Moghrabi A, et al. Bone Marrow Transplant 2004;33:605–611.
Stevens CE, Scaradavous A, Carrier C, et al. Blood 2005;106:579A.
Steinbrook R. N Engl J Med 2004;351:2255–2257.
Ballen KK. Blood 2005;15:3786–3792.
Laughlin MJ, Barker J, Bambach B, et al. N Engl J Med 2001;344:1815–1822.
Rocha V, Labopin M, Sanz G, et al. N Engl J Med 2004;351:2276–2285.
Takahashi S, Ooi J, Tomonari A, et al. Blood 2005;106:93A.
Sanz MA, N Engl J Med 2004;351;2328–2330.
Majhail NS, Weisdorf DJ, Wagner JE, et al. Blood 2006; 107:3804–3807.
Barker JN, Weisdorf DJ, DeFor TE, et al. Blood 2005;105:1343–1347.
Verneris MR, Brunstein C, DeFor TE, et al. Blood 2005;106:93A.
Yoo KH, Kang HJ, Lee SH, et al. Blood 2005;106:578A.
Pérez-Simón JA, Díez-Campelo M, Martino R, et al. Blood 2003;102:1108–1113.
Baron F, Maris MB, Storer BE, et al. Leukemia 2005;19:822–828.
Barker JN, Weisdorf DJ, DeFor TE, et al. Blood 2003;102: 1915–1919.
Brunstein CG, Barker JN, DeFor TE, et al. Blood 2005;106:166A.
Ballen KK, Spitzer TR, Yeap B, et al. Blood 2005;106:579A-580A.
Baron F, Little MT, Storb R. Blood Rev 2005;19:153–164.
De Lima M, St John LS, Wieder ED, et al. Haematol 2002;119:773–776.
Barker JN, Weisdorf DJ, Wagner JE. N Engl J Med 2001;344:1870–1871.
Haspel RL, Kao GS, Yeap BY, et al. Transfusion 2005;45:2A.
Schofield R. Blood Cells 1978;4:7–25.
Nilsson SK, Johnston HM, Coverdale JA. Blood 2001;97:2293–2299.
Zhang CN, Ye L, Huang H, et al. Nature 2003;425:836–841.
Calvi LM, Adams GB, Weibrecht KW, et al. Nature 2003;425:841–846.
Haspel RL, Kao, GS, Yeap B, et al. Blood 2005;106:848A.
Barker JN, Weisdorf DJ, DeFor TE, et al. Blood 2005;106:813A.
Bensidhoum M, Chapel A, Francois S, et al. Blood 2004;103:3313–3319.
Kim D-W, Chung Y-J, Kim T-G, et al. Blood 2004;103:1941–1948.
Noort WA, Kruisselbrink AB, in't Anker PS, et al. Exp Hematol 2002;30:870–878.