Association of the Polymorphism of rs1799822 on Carnitine Palmitoyltransferase II Gene with Severe Enterovirus 71 Encephalitis in Chinese ChildrenSpringer Science and Business Media LLC - Tập 69 - Trang 188-196 - 2019
Ya Guo, Yu Zhang, Peipei Liu, Fei Li, Dandan Xin, Hongfang He, Yedan Liu, Chengqing Yang, Zongbo Chen
Mutations of the CPT2 gene cause CPT2 deficiency and affect the β-oxidation of fatty acids. This study examined the consequence of a polymorphism of rs1799822 in the CPT2 gene with respect to EV71 encephalitis in Chinese children. The study included 406 cases of both mild and severe EV71 infection diagnosed by RT-PCR, together with controls (n = 348). We used an improved multiplex ligation detecti...... hiện toàn bộ
Network-Based Analysis of Cognitive Impairment and Memory Deficits from Transcriptome DataSpringer Science and Business Media LLC - Tập 71 - Trang 2415-2428 - 2021
Elif Emanetci, Tunahan Çakır
Aging is an inevitable process that negatively affects all living organisms and their vital functions. The brain is one of the most important organs in living beings and is primarily impacted by aging. The molecular mechanisms of learning, memory and cognition are altered over time, and the impairment in these mechanisms can lead to neurodegenerative diseases. Transcriptomics can be used to study ...... hiện toàn bộ
AnnouncementSpringer Science and Business Media LLC - Tập 9 - Trang 141-141 - 1997
Comparison of the Anti-inflammatory and Anti-nociceptive Effects of Cortistatin-14 and Somatostatin-14 in Distinct In Vitro and In Vivo Model SystemsSpringer Science and Business Media LLC - Tập 46 - Trang 40-50 - 2011
Adrienn Markovics, Éva Szőke, Katalin Sándor, Rita Börzsei, Teréz Bagoly, Ágnes Kemény, Krisztián Elekes, Erika Pintér, János Szolcsányi, Zsuzsanna Helyes
We showed that somatostatin (SST) exerts anti-inflammatory and anti-nociceptive effects through somatostatin receptor subtypes 4 and 1 (sst4/sst1). Since cortistatin (CST) is a structurally similar peptide, we aimed at comparing the sst1- and sst4-binding and activating abilities, as well as the effects of SST-14 and CST-14 on inflammatory and nociceptive processes. CST-14 concentration-dependentl...... hiện toàn bộ
Increased gene expression of interleukin-1α and interleukin-6 in rat primary glial cells induced by β-amyloid fragmentSpringer Science and Business Media LLC - Tập 17 - Trang 341-350 - 2001
Veronica Cortes Toro, Roya Tehranian, Maria Zetterström, Gun Eriksson, Ulo Langel, Tamas Bartfai, Kerstin Iverfeldt
One of the pathological hallmarks of Alzheimer’s disease (AD) is the presence of amyloid plaques. The main constituent of the amyloid plaques is the amyloid β-peptide (Aβ) shown to activate glial cells in vitro. A growing body of evidence suggests that these cells contribute to neurotoxicity through production of inflammatory cytokines, chemokines, and neurotoxic substances, such as reactive oxyge...... hiện toàn bộ
Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43Springer Science and Business Media LLC - Tập 45 - Trang 402-408 - 2011
Ian R. A. Mackenzie, Manuela Neumann, Nigel J. Cairns, David G. Munoz, Adrian M. Isaacs
Most cases of frontotemporal lobar degeneration (FTLD) are characterized by the abnormal accumulation of either the microtubule-associated protein tau or the transactive response DNA-binding protein with Mr 43 kDa, TDP-43 (FTLD-tau and FTLD-TDP, respectively). However, there remain ∼10% of cases, composed of a heterogenous collection of uncommon disorders, for which the molecular basis remains unc...... hiện toàn bộ