Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Natural Compounds Endowed with Cholinergic or Anticholinergic Activity. Enhancement of Acetylcholine Release by a Quaternary Derivative of l-Hyoscyamine
Springer Science and Business Media LLC - - 2009
Caden Souccar, Ana Lucia V. Salamanca, Mirtes M. Tanae, Maria Teresa R. Lima-Landman, Antonio José Lapa
New compounds that target nicotinic receptors (nAChRs) have been sought to correct disorders affecting cholinergic transmission in central and peripheral synapses. A quaternary derivate of l-hyoscyamine, phenthonium (Phen), was shown by our group to enhance the spontaneous acetylcholine (ACh) release without altering the nerve-induced transmitter release at the neuromuscular junction. The effect w...... hiện toàn bộ
Association of the Polymorphism of rs1799822 on Carnitine Palmitoyltransferase II Gene with Severe Enterovirus 71 Encephalitis in Chinese Children
Springer Science and Business Media LLC - Tập 69 - Trang 188-196 - 2019
Ya Guo, Yu Zhang, Peipei Liu, Fei Li, Dandan Xin, Hongfang He, Yedan Liu, Chengqing Yang, Zongbo Chen
Mutations of the CPT2 gene cause CPT2 deficiency and affect the β-oxidation of fatty acids. This study examined the consequence of a polymorphism of rs1799822 in the CPT2 gene with respect to EV71 encephalitis in Chinese children. The study included 406 cases of both mild and severe EV71 infection diagnosed by RT-PCR, together with controls (n = 348). We used an improved multiplex ligation detecti...... hiện toàn bộ
Characterization of Proteasome Inhibition on Astrocytes Cell Cycle
Springer Science and Business Media LLC - Tập 38 - Trang 83-83 - 2009
Qing-Guo Ren, Ying Yu, Xiang Luo, Xie-Min Jie, Deng-Ji Pan, Wei Wang
Network-Based Analysis of Cognitive Impairment and Memory Deficits from Transcriptome Data
Springer Science and Business Media LLC - Tập 71 - Trang 2415-2428 - 2021
Elif Emanetci, Tunahan Çakır
Aging is an inevitable process that negatively affects all living organisms and their vital functions. The brain is one of the most important organs in living beings and is primarily impacted by aging. The molecular mechanisms of learning, memory and cognition are altered over time, and the impairment in these mechanisms can lead to neurodegenerative diseases. Transcriptomics can be used to study ...... hiện toàn bộ
Announcement
Springer Science and Business Media LLC - Tập 9 - Trang 141-141 - 1997
Emerging Role of Non-coding RNAs in Autism Spectrum Disorder
Springer Science and Business Media LLC - Tập 72 Số 2 - Trang 201-216 - 2022
Soudeh Ghafouri‐Fard, Rezvan Noroozi, Serge Brand, Bashdar Mahmud Hussen, Reyhane Eghtedarian, Mohammad Taheri, Kaveh Ebrahimzadeh
Comparison of the Anti-inflammatory and Anti-nociceptive Effects of Cortistatin-14 and Somatostatin-14 in Distinct In Vitro and In Vivo Model Systems
Springer Science and Business Media LLC - Tập 46 - Trang 40-50 - 2011
Adrienn Markovics, Éva Szőke, Katalin Sándor, Rita Börzsei, Teréz Bagoly, Ágnes Kemény, Krisztián Elekes, Erika Pintér, János Szolcsányi, Zsuzsanna Helyes
We showed that somatostatin (SST) exerts anti-inflammatory and anti-nociceptive effects through somatostatin receptor subtypes 4 and 1 (sst4/sst1). Since cortistatin (CST) is a structurally similar peptide, we aimed at comparing the sst1- and sst4-binding and activating abilities, as well as the effects of SST-14 and CST-14 on inflammatory and nociceptive processes. CST-14 concentration-dependentl...... hiện toàn bộ
Increased gene expression of interleukin-1α and interleukin-6 in rat primary glial cells induced by β-amyloid fragment
Springer Science and Business Media LLC - Tập 17 - Trang 341-350 - 2001
Veronica Cortes Toro, Roya Tehranian, Maria Zetterström, Gun Eriksson, Ulo Langel, Tamas Bartfai, Kerstin Iverfeldt
One of the pathological hallmarks of Alzheimer’s disease (AD) is the presence of amyloid plaques. The main constituent of the amyloid plaques is the amyloid β-peptide (Aβ) shown to activate glial cells in vitro. A growing body of evidence suggests that these cells contribute to neurotoxicity through production of inflammatory cytokines, chemokines, and neurotoxic substances, such as reactive oxyge...... hiện toàn bộ
Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43
Springer Science and Business Media LLC - Tập 45 - Trang 402-408 - 2011
Ian R. A. Mackenzie, Manuela Neumann, Nigel J. Cairns, David G. Munoz, Adrian M. Isaacs
Most cases of frontotemporal lobar degeneration (FTLD) are characterized by the abnormal accumulation of either the microtubule-associated protein tau or the transactive response DNA-binding protein with Mr 43 kDa, TDP-43 (FTLD-tau and FTLD-TDP, respectively). However, there remain ∼10% of cases, composed of a heterogenous collection of uncommon disorders, for which the molecular basis remains unc...... hiện toàn bộ
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Springer Science and Business Media LLC - - 2023
Daniel Kruglyakov, Shashank Kumar Ojha, Maryam Kartawy, Manish Kumar Tripathi, Wajeha Hamoudi, Wisam Bazbaz, Igor Khaliulin, Haitham Amal
Tổng số: 2,834   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10