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Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease
Springer Science and Business Media LLC - Tập 62 - Trang 344-355 - 2017
Fatemeh Nouri Emamzadeh
Parkinson’s disease (PD) is a progressive brain disorder that interferes with activities of normal life. The main pathological feature of this disease is the loss of more than 80% of dopamine-producing neurons in the substantia nigra (SN). Dopaminergic neuronal cell death occurs when intraneuronal, insoluble, aggregated proteins start to form Lewy bodies (LBs), the most important component of whic...... hiện toàn bộ
Oligomers of D2 dopamine receptors
Springer Science and Business Media LLC - Tập 26 - Trang 155-160 - 2005
Philip G. Strange
There is increasing evidence that G protein-coupled receptors form oligomers and that this might be important for their function. We have studied this phenomenon for the D2 dopamine receptor and have shown—using a variety of biochemical and biophysical techniques—that this receptor forms dimers or higher-order oligomers. Using ligand-binding studies, we have also found evidence that this oligomer ...... hiện toàn bộ
NKCC1 Inhibition Attenuates Chronic Cerebral Hypoperfusion-Induced White Matter Lesions by Enhancing Progenitor Cells of Oligodendrocyte Proliferation
Springer Science and Business Media LLC - Tập 64 - Trang 449-458 - 2018
Ying Yu, Peicai Fu, Zhiyuan Yu, Minjie Xie, Wei Wang, Xiang Luo
Cerebral white matter is vulnerable to ischemic condition. However, no effective treatment to alleviate or restore the myelin damage caused by chronic cerebral hypoperfusion has been found. Na+-K+-Cl− cotransporter 1 (NKCC1), a Na+-K+-Cl− cotransporter widely expressed in the central nervous system (CNS), involves in regulation of cell swelling, EAA release, cell apoptosis, and proliferation. Neve...... hiện toàn bộ
Oligodendrocytes Take Center Stage
Springer Science and Business Media LLC - Tập 35 - Trang 1-2 - 2008
Christiane Richter-Landsberg
Combination Therapy with Nanomicellar-Curcumin and Temozolomide for In Vitro Therapy of Glioblastoma Multiforme via Wnt Signaling Pathways
Springer Science and Business Media LLC - Tập 70 Số 10 - Trang 1471-1483 - 2020
Ali Bagherian, Rajab Mardani, Bostan Roudi, Mohsen Taghizadeh, Hamid Reza Banfshe, Amir Ghaderi, Amirhossein Davoodvandi, Samane Shamollaghamsari, Michael R. Hamblin, Hamed Mirzaei
Anti-aging Klotho Protects SH-SY5Y Cells Against Amyloid β1–42 Neurotoxicity: Involvement of Wnt1/pCREB/Nrf2/HO-1 Signaling
Springer Science and Business Media LLC - Tập 71 - Trang 19-27 - 2020
Mohsen Sedighi, Tourandokht Baluchnejadmojarad, Siamak Afshin-Majd, Mona Amiri, Malihe Aminzade, Mehrdad Roghani
Alzheimer’s disease (AD) is considered a prevalent neurological disorder with a neurodegenerative nature in elderly people. Oxidative stress and neuroinflammation due to amyloid β (Aβ) peptides are strongly involved in AD pathogenesis. Klotho is an anti-aging protein with multiple protective effects that its deficiency is involved in development of age-related disorders. In this study, we investig...... hiện toàn bộ
Roundtable Discussion of Session 3: Eicosanoids in Brain Function
Springer Science and Business Media LLC - Tập 33 - Trang 100-104 - 2007
Paul A. Watkins, James A. Hamilton
Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex
Springer Science and Business Media LLC - - 2018
Ci-Di Chen, Ella Zeldich, Yuexuan Li, Andrea Yuste, Carmela R. Abraham
The Evidence for the Contribution of the Autism Susceptibility Candidate 2 (AUTS2) Gene in Heroin Dependence Susceptibility
Springer Science and Business Media LLC - Tập 54 - Trang 811-819 - 2014
Wei Dang, Qian Zhang, Yong-Sheng Zhu, Xiao-Yun Lu
The single-nucleotide polymorphisms (SNP) rs6943555 in autism susceptibility candidate 2 (AUTS2) has been reported to be significantly associated with alcohol consumption in Europeans. In this study, we identified the SNP in AUTS2 contributing to the genetic susceptibility to heroin dependence. The potential association between heroin dependence and 21 SNPs (rs2270162, rs2851510, rs513150, rs59568...... hiện toàn bộ
Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization
Springer Science and Business Media LLC - Tập 55 - Trang 437-448 - 2014
Cora Sin, Hongyan Li, Dorota A. Crawford
FOXP1, FOXP2, and FOXP4 are three members of the FOXP gene subfamily of transcription factors involved in the development of the central nervous system. Previous studies have shown that the transcriptional activity of FOXP1/2/4 is regulated by homo- and heterodimerization. However, their transcriptional gene targets in the developing brain are still largely unknown. FOXP2 regulate...... hiện toàn bộ
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