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Natural Compounds Endowed with Cholinergic or Anticholinergic Activity. Enhancement of Acetylcholine Release by a Quaternary Derivative of l-Hyoscyamine
Springer Science and Business Media LLC - - 2009
Caden Souccar, Ana Lucia V. Salamanca, Mirtes M. Tanae, Maria Teresa R. Lima-Landman, Antonio José Lapa
New compounds that target nicotinic receptors (nAChRs) have been sought to correct disorders affecting cholinergic transmission in central and peripheral synapses. A quaternary derivate of l-hyoscyamine, phenthonium (Phen), was shown by our group to enhance the spontaneous acetylcholine (ACh) release without altering the nerve-induced transmitter release at the neuromuscular junction. The effect w...... hiện toàn bộ
Association of the Polymorphism of rs1799822 on Carnitine Palmitoyltransferase II Gene with Severe Enterovirus 71 Encephalitis in Chinese Children
Springer Science and Business Media LLC - Tập 69 - Trang 188-196 - 2019
Ya Guo, Yu Zhang, Peipei Liu, Fei Li, Dandan Xin, Hongfang He, Yedan Liu, Chengqing Yang, Zongbo Chen
Mutations of the CPT2 gene cause CPT2 deficiency and affect the β-oxidation of fatty acids. This study examined the consequence of a polymorphism of rs1799822 in the CPT2 gene with respect to EV71 encephalitis in Chinese children. The study included 406 cases of both mild and severe EV71 infection diagnosed by RT-PCR, together with controls (n = 348). We used an improved multiplex ligation detecti...... hiện toàn bộ
Network-Based Analysis of Cognitive Impairment and Memory Deficits from Transcriptome Data
Springer Science and Business Media LLC - Tập 71 - Trang 2415-2428 - 2021
Elif Emanetci, Tunahan Çakır
Aging is an inevitable process that negatively affects all living organisms and their vital functions. The brain is one of the most important organs in living beings and is primarily impacted by aging. The molecular mechanisms of learning, memory and cognition are altered over time, and the impairment in these mechanisms can lead to neurodegenerative diseases. Transcriptomics can be used to study ...... hiện toàn bộ
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Springer Science and Business Media LLC - Tập 9 - Trang 141-141 - 1997
Emerging Role of Non-coding RNAs in Autism Spectrum Disorder
Springer Science and Business Media LLC - Tập 72 Số 2 - Trang 201-216 - 2022
Soudeh Ghafouri‐Fard, Rezvan Noroozi, Serge Brand, Bashdar Mahmud Hussen, Reyhane Eghtedarian, Mohammad Taheri, Kaveh Ebrahimzadeh
Comparison of the Anti-inflammatory and Anti-nociceptive Effects of Cortistatin-14 and Somatostatin-14 in Distinct In Vitro and In Vivo Model Systems
Springer Science and Business Media LLC - Tập 46 - Trang 40-50 - 2011
Adrienn Markovics, Éva Szőke, Katalin Sándor, Rita Börzsei, Teréz Bagoly, Ágnes Kemény, Krisztián Elekes, Erika Pintér, János Szolcsányi, Zsuzsanna Helyes
We showed that somatostatin (SST) exerts anti-inflammatory and anti-nociceptive effects through somatostatin receptor subtypes 4 and 1 (sst4/sst1). Since cortistatin (CST) is a structurally similar peptide, we aimed at comparing the sst1- and sst4-binding and activating abilities, as well as the effects of SST-14 and CST-14 on inflammatory and nociceptive processes. CST-14 concentration-dependentl...... hiện toàn bộ
Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43
Springer Science and Business Media LLC - Tập 45 - Trang 402-408 - 2011
Ian R. A. Mackenzie, Manuela Neumann, Nigel J. Cairns, David G. Munoz, Adrian M. Isaacs
Most cases of frontotemporal lobar degeneration (FTLD) are characterized by the abnormal accumulation of either the microtubule-associated protein tau or the transactive response DNA-binding protein with Mr 43 kDa, TDP-43 (FTLD-tau and FTLD-TDP, respectively). However, there remain ∼10% of cases, composed of a heterogenous collection of uncommon disorders, for which the molecular basis remains unc...... hiện toàn bộ
Pathways Involved in Oxygen Glucose Deprivation Damage of Astrocytes
Springer Science and Business Media LLC - Tập 61 - Trang 115-122 - 2016
Shuyong Wei, Jie Tong, Qiang Xue, Yang Liu, Xiaoyu Xu
This present paper focus on transcriptome changes of astrocytes before and after oxygen glucose deprivation (OGD) injury. Cortical astrocytes of Sprague-Dawley (SD) rats were cultured in OGD condition for 6 h, and the damage of cells was analyzed by cell’s activity detection, lactate dehydrogenase leakage rate detection, annexin V-FITC (fluorescein isothiocyanate)/PI (propidium iodide) apoptosis d...... hiện toàn bộ
Expression of MicroRNAs miR-145, miR-181c, miR-199a and miR-1183 in the Blood and Hippocampus of Patients with Mesial Temporal Lobe Epilepsy
Springer Science and Business Media LLC - Tập 69 - Trang 580-587 - 2019
Luana Grupioni Lourenço Antônio, Priscila Freitas-Lima, Gabriela Pereira-da-Silva, João Alberto Assirati, Caio Marconato Matias, Mucio Luiz Assis Cirino, Luis Fernando Tirapelli, Tonicarlo Rodrigues Velasco, Americo Ceiki Sakamoto, Carlos Gilberto Carlotti, Daniela Pretti da Cunha Tirapelli
The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to investigate whether these can be used as diagnosis and prognosis biomarkers for epilepsy. Hippocampus and blood samples were collected from 20 patients ...... hiện toàn bộ
Human Prion Protein Mutants with Deleted and Inserted Octarepeats Undergo Different Pathways to Trigger Cell Apoptosis
Springer Science and Business Media LLC - - 2011
Kailin Xu, Xin Wang, Qi Shi, Cao Chen, Chan Tian, Xiaoli Li, Rong Zhou, Yangyang Chu, Xiao-Ping Dong
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