Springer Science and Business Media LLC
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway
Springer Science and Business Media LLC - Tập 4 - Trang 1-19 - 2023
Immunocompromised individuals are particularly vulnerable to viral infections and reactivation, especially endogenous herpes viruses such as Epstein-Barr virus (EBV), a member of oncogenic gamma-herpesviruses, which are commonly linked to pneumonia and consequently significant morbidity and mortality. In the study of human and animal oncogenic gammaherpesviruses, the murine gamma-herpesviruses-68 ...... hiện toàn bộ
Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies
Springer Science and Business Media LLC - Tập 2 - Trang 1-12 - 2021
Repurposing of existing drugs and drug candidates is an ideal approach to identify new potential therapies for SARS-CoV-2 that can be tested without delay in human trials of infected patients. Here we applied a virtual screening approach using Autodock Vina and molecular dynamics simulation in tandem to calculate binding energies for repurposed drugs against the SARS-CoV-2 RNA-dependent RNA polyme...... hiện toàn bộ
Cleavage of the selective autophagy receptor SQSTM1/p62 by the SARS-CoV-2 main protease NSP5 prevents the autophagic degradation of viral membrane proteins
Springer Science and Business Media LLC - Tập 3 - Trang 1-13 - 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) global pandemic. Omicron, a new variant of SARS-CoV-2, has the characteristics of strong transmission and pathogenicity, short incubation period, and rapid onset progression, and has spread rapidly around the world. The high replication rate and intracellular accumulation of SARS-CoV-2 a...... hiện toàn bộ
Transglutaminase-2 mediates acquisition of neratinib resistance in metastatic breast cancerAbstract Acquisition of resistance to targeted therapies remains a major clinical obstacle for the HER2+ subtype of breast cancer. Using an isogeneic progression series of HER2+ breast cancer metastasis we demonstrate that metastatic cells have an increased capacity to acquire resistance to the covalent, pan-ErbB inhibitor, ... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 3 Số 1 - 2022
Fat mass and obesity-associated protein (FTO) mediated m6A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay
Springer Science and Business Media LLC - - 2024
Gastric cancer (GC) is a common malignant tumor worldwide, especially in East Asia, with high incidence and mortality rate. Epigenetic modifications have been reported to participate in the progression of gastric cancer, among which m6A is the most abundant and important chemical modification in RNAs. Fat mass and obesity-associated protein (FTO) is the first identified RNA demethylase but little ...... hiện toàn bộ
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
Springer Science and Business Media LLC - Tập 4 - Trang 1-30 - 2023
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathway can lead to severe immunodeficiencies and malignancies, and its role extends to neurotransduction and pro-inflammatory signaling mechanisms. Although JAK in...... hiện toàn bộ
Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
Springer Science and Business Media LLC - Tập 2 - Trang 1-19 - 2021
Cardiovascular diseases such as myocardial infarction (MI) is a major contributor to human mortality and morbidity. The mammalian adult heart almost loses its plasticity to appreciably regenerate new cardiomyocytes after injuries, such as MI and heart failure. The neonatal heart exhibits robust proliferative capacity when exposed to varying forms of myocardial damage. The ability of the neonatal h...... hiện toàn bộ
MSCs overexpressing GDNF restores brain structure and neurological function in rats with intracerebral hemorrhage
Springer Science and Business Media LLC - Tập 4 - Trang 1-18 - 2023
Mesenchymal stem cells (MSCs) have been applied in transplantation to treat intracerebral hemorrhage (ICH) but with limited efficacy. Accumulated evidence has shown that glial cell-derived neurotrophic factor (GDNF) plays a crucial part in neuronal protection and functional recovery of the brain after ICH; however, GDNF has difficulty crossing the blood–brain barrier, which limits its application....... hiện toàn bộ
Cancer metabolism and intervention therapyAbstract Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutrition and hypoxic microenvironment. Tumor cells frantically grab energy sources (such as glucose, fatty acids, and glutamine) from different pathways to produce a ... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 2 Số 1 - 2021
Tiến triển trong các dấu ấn khối u liên quan đến exosome và các phương pháp phát hiện của chúng Dịch bởi AI Tóm tắt Exosome được tiết ra bởi các tế bào và hiện diện rộng rãi trong dịch cơ thể. Exosome chứa nhiều thành phần phân tử có nguồn gốc từ tế bào của chúng như protein, mRNA, miRNA, DNA, lipid và glycans, tất cả đều tương tự như nội dung trong các tế bào khối u. Những thành phần này đóng vai trò quan trọng trong nhiều giai đoạn phát triển của khối u, và làm cho exos... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 1 Số 1 - 2020
Tổng số: 108
- 1
- 2
- 3
- 4
- 5
- 6
- 10