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Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq
Springer Science and Business Media LLC - Tập 1 - Trang 1-13 - 2020
Shaoqian Ma, Yongyou Zhang
Chromatin regulatory landscape plays a critical role in many disease processes and embryo development. Epigenome sequencing technologies such as chromatin immunoprecipitation sequencing (ChIP-seq) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) have enabled us to dissect the pan-genomic regulatory landscape of cells and tissues in both time and space dimen...... hiện toàn bộ
Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS
Springer Science and Business Media LLC - Tập 1 Số 1 - 2020
Anupam Sarma, Malay K. Das
AbstractNeuroAIDS (Neuro Acquired Immunodeficiency Syndrome) or HIV (Human Immunodeficiency Virus) associated neuronal abnormality is continuing to be a significant health issue among AIDS patients even under the treatment of combined antiretroviral therapy (cART). Injury and damage to neurons of the brain are the prime causes of neuroAIDS, which happens due to the...... hiện toàn bộ
RNA modification: mechanisms and therapeutic targets
Springer Science and Business Media LLC - Tập 4 - Trang 1-56 - 2023
Lei Qiu, Qian Jing, Yanbo Li, Junhong Han
RNA modifications are dynamic and reversible chemical modifications on substrate RNA that are regulated by specific modifying enzymes. They play important roles in the regulation of many biological processes in various diseases, such as the development of cancer and other diseases. With the help of advanced sequencing technologies, the role of RNA modifications has caught increasing attention in h...... hiện toàn bộ
Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy
Springer Science and Business Media LLC - Tập 4 - Trang 1-12 - 2023
Sara Jaber, Marine Warnier, Christopher Leers, Mathieu Vernier, Delphine Goehrig, Jean-Jacques Médard, David Vindrieux, Dorian V. Ziegler, David Bernard
Pancreatic cancer is one of the deadliest cancers owing to its late diagnosis and of the strong resistance to available treatments. Despite a better understanding of the disease in the last two decades, no significant improvement in patient care has been made. Senescent cells are characterized by a stable proliferation arrest and some resistance to cell death. Increasing evidence suggests that mul...... hiện toàn bộ
Update on treatment and preventive interventions against COVID-19: an overview of potential pharmacological agents and vaccines
Springer Science and Business Media LLC - - 2020
Yu Xiao, Hanyue Xu, Wen Guo, Ying Zhao, Yuling Luo, Ming Wang, Zhiyao He, Zhangfan Ding, Jiyan Liu, Lei Deng, Fushen Sha, Xuelei Ma
AbstractThe outbreak of coronavirus disease 2019 (COVID-19) triggered by the new member of the coronaviridae family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an unprecedented challenge for global health. In addition to mild to moderate clinical manifestations such as fever, cough, and fatigue, severe cases often developed lethal com...... hiện toàn bộ
The inhibition of protein translation promotes tumor angiogenic switch
Springer Science and Business Media LLC - Tập 3 - Trang 1-15 - 2022
Hui Luo, Yuge Shen, Weiting Liao, Qiqi Li, Ni Wu, Jian Zhong, Chaoxin Xiao, Jia Gan, Yun Yang, E. Dong, Guimin Zhang, Binrui Liu, Xiaozhu Yue, Lin Xu, Yan Liu, Chengjian Zhao, Qian Zhong, Hanshuo Yang
The ‘angiogenic switch’ is critical for tumor progression. However, the pathological details and molecular mechanisms remain incompletely characterized. In this study, we established mammal xenografts in zebrafish to visually investigate the first vessel growth (angiogenic switch) in real-time, by inoculating tumor cells into the perivitelline space of live optically transparent Transgenic (flk1:E...... hiện toàn bộ
Post-translational modifications of CDK5 and their biological roles in cancer
Springer Science and Business Media LLC - - 2021
Gui-Bin Gao, Yue Sun, Run-Dong Fang, Ying Wang, Yang Wang, Qing‐Yu He
AbstractPost-translational modifications (PTMs) of Cyclin-dependent kinase 5 (CDK5) have emerged as important regulatory mechanisms that modulate cancer development in patients. Though CDK5 is an atypical member of the cyclin-dependent kinase family, its aberrant expression links to cell proliferation, DNA damage response, apoptosis, migration and angiogenesis in c...... hiện toàn bộ
Mibefradil alters intracellular calcium concentration by activation of phospholipase C and IP3 receptor function
Springer Science and Business Media LLC - Tập 2 - Trang 1-13 - 2021
Guilherme H. Souza Bomfim, Erna Mitaishvili, Talita Ferreira Aguiar, Rodrigo S. Lacruz
Mibefradil is a tetralol derivative originally developed as an antagonist of T-type voltage-gated calcium (Ca2+) channels to treat hypertension when used at nanomolar dosage. More recently, its therapeutic application in hypertension has declined and has been instead repurposed as a treatment of cancer cell proliferation and solid tumor growth. Beyond its function as a Cav blocker, the micromolar ...... hiện toàn bộ
SARS-CoV-2 is less likely to infect aquatic food animals: sequence and phylogeny analysis of ACE2 in mammals and fish
Springer Science and Business Media LLC - Tập 1 - Trang 1-4 - 2020
Dong Chen, Yuchen Liu, Huihui Yang, Lisa Liu, Weiren Huang, Yongsheng Zhao
SARS-CoV-2 RNA persists in the central nervous system of non-human primates despite clinical recovery
Springer Science and Business Media LLC - Tập 4 - Trang 1-4 - 2023
Hailong Li, Kristen A. McLaurin, Charles F. Mactutus, Jay Rappaport, Prasun K. Datta, Rosemarie M. Booze
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