Ribatti D, Nico B, Crivellato E, Roccaro AM, Vacca A. The history of the angiogenic switch concept. Leukemia. 2007;21(1):44–52. https://doi.org/10.1038/sj.leu.2404402.
Baeriswyl V, Christofori G. The angiogenic switch in carcinogenesis. Semin Cancer Biol. 2009;19(5):329–37. https://doi.org/10.1016/j.semcancer.2009.05.003.
Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature. 1989;339(6219):58–61. https://doi.org/10.1038/339058a0.
Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol. 1995;11:73–91. https://doi.org/10.1146/annurev.cb.11.110195.000445.
Ramjiawan RR, Griffioen AW, Duda DG. Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy? Angiogenesis. 2017;20(2):185–204. https://doi.org/10.1007/s10456-017-9552-y.
Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, et al. Dual programmed death receptor-1 and vascular endothelial growth factor receptor-2 blockade promotes vascular normalization and enhances antitumor immune responses in hepatocellular carcinoma. Hepatology. 2020;71(4):1247–61. https://doi.org/10.1002/hep.30889.
Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Lin YL, et al. Evaluation of antitumor immunity by a combination treatment of high-dose irradiation, anti-PDL1, and anti-angiogenic therapy in murine lung tumors. Cancer Immunol Immunother. 2020. https://doi.org/10.1007/s00262-020-02690-w.
Wallin JJ, Bendell JC, Funke R, Sznol M, Korski K, Jones S, et al. Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma. Nat Commun. 2016;7:12624. https://doi.org/10.1038/ncomms12624.
Hashimoto T, Shibasaki F. Hypoxia-inducible factor as an angiogenic master switch. Front Pediatr. 2015;3:33. https://doi.org/10.3389/fped.2015.00033.
Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003;9(6):677–84. https://doi.org/10.1038/nm0603-677.
Wang JC, Li GY, Li PP, Sun X, Li WM, Li Y, et al. Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion. Oncotarget. 2017;8(43):73892–904. https://doi.org/10.18632/oncotarget.18029.
Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, et al. Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome. Nat Cell Biol. 2015;17(4):511–23. https://doi.org/10.1038/ncb3130.
Zimna A, Kurpisz M. Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies. Biomed Res Int. 2015;2015:549412. https://doi.org/10.1155/2015/549412.
Chung AS, Lee J, Ferrara N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer. 2010;10(7):505–14. https://doi.org/10.1038/nrc2868.
Ben-Yosef Y, Miller A, Shapiro S, Lahat N. Hypoxia of endothelial cells leads to MMP-2-dependent survival and death. Am J Physiol Cell Physiol. 2005;289(5):C1321–1331. https://doi.org/10.1152/ajpcell.00079.2005.
Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, et al. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J. 2009;23(5):1338–46. https://doi.org/10.1096/fj.08-125344.
Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001;280(6):C1358-1366. https://doi.org/10.1152/ajpcell.2001.280.6.C1358.
Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2002;2(10):795–803. https://doi.org/10.1038/nrc909.
Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20(21):4368–80. https://doi.org/10.1200/JCO.2002.10.088.
Norrby K. In vivo models of angiogenesis. J Cell Mol Med. 2006;10(3):588–612. https://doi.org/10.1111/j.1582-4934.2006.tb00423.x.
Hasan J, Shnyder SD, Bibby M, Double JA, Bicknel R, Jayson GC. Quantitative angiogenesis assays in vivo–a review. Angiogenesis. 2004;7(1):1–16. https://doi.org/10.1023/B:AGEN.0000037338.51851.d1.
Nicoli S, Presta M. The zebrafish/tumor xenograft angiogenesis assay. Nat Protoc. 2007;2(11):2918–23. https://doi.org/10.1038/nprot.2007.412.
Lawson ND, Weinstein BM. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol. 2002;248(2):307–18. https://doi.org/10.1006/dbio.2002.0711.
Vitale G, Gaudenzi G, Dicitore A, Cotelli F, Ferone D, Persani L. Zebrafish as an innovative model for neuroendocrine tumors. Endocr Relat Cancer. 2014;21(1):R67-83. https://doi.org/10.1530/ERC-13-0388.
van der Ent W, Jochemsen AG, Teunisse AF, Krens SF, Szuhai K, Spaink HP, et al. Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. J Pathol. 2014;233(4):415–24. https://doi.org/10.1002/path.4378.
Zhao C, Wang X, Zhao Y, Li Z, Lin S, Wei Y, et al. A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors. PLoS ONE. 2011;6(7):e21768. https://doi.org/10.1371/journal.pone.0021768.
Schito L. Hypoxia-dependent angiogenesis and lymphangiogenesis in cancer. In: Gilkes DM, editor. Hypoxia and cancer metastasis, vol. 1136. Cham: Springer International Publishing Ag; 2019. p. 71–85.
Rohan SM, Xiao Y, Liang Y, Dudas ME, Al-Ahmadie HA, Fine SW, et al. Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol. 2011;24(9):1207–20. https://doi.org/10.1038/modpathol.2011.80.
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604–13. https://doi.org/10.1128/mcb.16.9.4604.
Pang YL, Poruri K, Martinis SA. tRNA synthetase: tRNA aminoacylation and beyond. Wiley Interdiscip Rev RNA. 2014;5(4):461–80. https://doi.org/10.1002/wrna.1224.
Naik HM, Majewska NI, Betenbaugh MJ. Impact of nucleotide sugar metabolism on protein N-glycosylation in Chinese Hamster Ovary (CHO) cell culture. Curr Opin Chem Eng. 2018;22:167–76. https://doi.org/10.1016/j.coche.2018.10.002.
Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006;34:7–11. https://doi.org/10.1042/bst0340007.
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000;6(5):1099–108. https://doi.org/10.1016/s1097-2765(00)00108-8.
Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Trevino-Villarreal JH, et al. Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production. Cell. 2018;173(1):117–129 e114. https://doi.org/10.1016/j.cell.2018.03.001.
Lee SL, Rouhi P, Dahl Jensen L, Zhang D, Ji H, Hauptmann G, et al. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A. 2009;106(46):19485–90. https://doi.org/10.1073/pnas.0909228106.
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998;12(2):149–62. https://doi.org/10.1101/gad.12.2.149.
Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002;8(7):702–10. https://doi.org/10.1038/nm721.
Ramirez-Bergeron DL, Runge A, Adelman DM, Gohil M, Simon MC. HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell. 2006;11(1):81–92. https://doi.org/10.1016/j.devcel.2006.04.018.
Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, et al. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS ONE. 2010;5(3):e9575. https://doi.org/10.1371/journal.pone.0009575.
Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008;451(7181):1008–12. https://doi.org/10.1038/nature06613.
Rollins JA, Shaffer D, Snow SS, Kapahi P, Rogers AN. Dietary restriction induces posttranscriptional regulation of longevity genes. Life Sci Alliance. 2019;2(4). https://doi.org/10.26508/lsa.201800281.
Castranova D, Davis AE, Lo BD, Miller MF, Paukstelis PJ, Swift MR, et al. Aminoacyl-transfer RNA synthetase deficiency promotes angiogenesis via the unfolded protein response pathway. Arterioscler Thromb Vasc Biol. 2016;36(4):655–62. https://doi.org/10.1161/ATVBAHA.115.307087.
Jennings MD, Kershaw CJ, Adomavicius T, Pavitt GD. Fail-safe control of translation initiation by dissociation of eIF2 alpha phosphorylated ternary complexes. Elife. 2017;6:e24542. https://doi.org/10.7554/eLife.24542.
Adomavicius T, Guaita M, Zhou Y, Jennings MD, Latif Z, Roseman AM, et al. The structural basis of translational control by eIF2 phosphorylation. Nat Commun. 2019;10:10. https://doi.org/10.1038/s41467-019-10167-3.
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, et al. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science. 2019;364(6439):491–+. https://doi.org/10.1126/science.aaw2922.
Pakos-Zebrucka K, Koryga I, Mnich K, Ljujic M, Samali A, Gorman AM. The integrated stress response. EMBO Rep. 2016;17(10):1374–95. https://doi.org/10.15252/embr.201642195
Fujimoto A, Kawana K, Taguchi A, Adachi K, Sato M, Nakamura H, et al. Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis. Oncotarget. 2016;7(32):51854–64. https://doi.org/10.18632/oncotarget.10126.
Zhao C, Gomez GA, Zhao Y, Yang Y, Cao D, Lu J, et al. ETV2 mediates endothelial transdifferentiation of glioblastoma. Signal Transduct Target Ther. 2018;3:4. https://doi.org/10.1038/s41392-018-0007-8.
Zhao C, Zhang W, Zhao Y, Yang Y, Luo H, Ji G, et al. Endothelial cords promote tumor initial growth prior to vascular function through a paracrine mechanism. Sci Rep. 2016;6:19404. https://doi.org/10.1038/srep19404.
Holmgaard A, Askou AL, Benckendorff JNE, Thomsen EA, Cai Y, Bek T, et al. In vivo knockout of the Vegfa gene by lentiviral delivery of CRISPR/Cas9 in mouse retinal pigment epithelium cells. Mol Ther Nucleic Acids. 2017;9:89–99. https://doi.org/10.1016/j.omtn.2017.08.016.
Yu C, Yao X, Zhao L, Wang P, Zhang Q, Zhao C, et al. Wolf-hirschhorn syndrome candidate 1 (whsc1) functions as a tumor suppressor by governing cell differentiation. Neoplasia. 2017;19(8):606–16. https://doi.org/10.1016/j.neo.2017.05.001.