Springer Science and Business Media LLC
ESCI-ISI SCOPUS (2020-2025)
2662-8651
Cơ quản chủ quản: SPRINGER , Springer Nature
Lĩnh vực:
Molecular MedicineMolecular Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy
Tập 3 Số 1
AbstractIntracellular vesicle trafficking is the fundamental process to maintain
the homeostasis of membrane-enclosed organelles in eukaryotic cells. These
organelles transport cargo from the donor membrane to the target membrane
through the cargo containing vesicles. Vesicle trafficking pathway includes
vesicle formation from the donor membrane, vesicle transport, and vesicle fusion
with the targ...
Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy
- 2022
AbstractTriple negative breast cancer (TNBC) is a subtype of breast cancer, with
estrogen receptor, human epidermal growth factor receptor 2 and progesterone
receptor negative. TNBC is characterized by high heterogeneity, high rates of
metastasis, poor prognosis, and lack of therapeutic targets. Now the treatment
of TNBC is still based on surgery and chemotherapy, which is effective only in
initia...
Tiến triển trong các dấu ấn khối u liên quan đến exosome và các phương pháp phát hiện của chúng Dịch bởi AI
Tập 1 Số 1 - 2020
Tóm tắtExosome được tiết ra bởi các tế bào và hiện diện rộng rãi trong dịch cơ
thể. Exosome chứa nhiều thành phần phân tử có nguồn gốc từ tế bào của chúng như
protein, mRNA, miRNA, DNA, lipid và glycans, tất cả đều tương tự như nội dung
trong các tế bào khối u. Những thành phần này đóng vai trò quan trọng trong
nhiều giai đoạn phát triển của khối u, và làm cho exosome có nguồn gốc từ khối u
trở th...
Cancer metabolism and intervention therapy
Tập 2 Số 1 - 2021
AbstractMetabolic reprogramming with heterogeneity is a hallmark of cancer and
is at the basis of malignant behaviors. It supports the proliferation and
metastasis of tumor cells according to the low nutrition and hypoxic
microenvironment. Tumor cells frantically grab energy sources (such as glucose,
fatty acids, and glutamine) from different pathways to produce a variety of
biomass to meet their ...
Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences
Tập 1 Số 1 - 2020
AbstractThe global pandemic of COVID-19 has attracted extensive drug searching
interets for the new coronavirus SARS-CoV-2. Although currently several of
clinically used “old” drugs have been repurposed to this new disease for the
urgent clinical investigation, there is still great demand for more effective
therapies for the anti-infections. Here we report the discovery that an “old”
drug Emetine ...
Development of therapeutic antibodies for the treatment of diseases
AbstractSince the first monoclonal antibody drug, muromonab-CD3, was approved
for marketing in 1986, 165 antibody drugs have been approved or are under
regulatory review worldwide. With the approval of new drugs for treating a wide
range of diseases, including cancer and autoimmune and metabolic disorders, the
therapeutic antibody drug market has experienced explosive growth. Monoclonal
antibodies...
G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease
- 2021
AbstractAlzheimer’s disease is a progressive neurodegenerative disease
characterized by the presence of amyloid-β plaques in the extracellular
environment and aggregates of Tau protein that forms neurofibrillary tangles
(NFTs) in neuronal cells. Along with these pathological proteins, the disease
shows neuroinflammation, neuronal death, impairment in the immune function of
microglia and synaptic l...
Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS
Tập 1 Số 1 - 2020
AbstractNeuroAIDS (Neuro Acquired Immunodeficiency Syndrome) or HIV (Human
Immunodeficiency Virus) associated neuronal abnormality is continuing to be a
significant health issue among AIDS patients even under the treatment of
combined antiretroviral therapy (cART). Injury and damage to neurons of the
brain are the prime causes of neuroAIDS, which happens due to the ingress of HIV
by direct permeat...
Alterations of the fecal microbiota in relation to acute COVID-19 infection and recovery
AbstractPeople with acute COVID-19 due to SARS-CoV-2 infection experience a
range of symptoms, but major factors contributing to severe clinical outcomes
remain to be understood. Emerging evidence suggests associations between the gut
microbiome and the severity and progression of COVID-19. To better understand
the host-microbiota interactions in acute COVID-19, we characterized the
intestinal mic...
GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB
Tập 2 Số 1 - 2021
AbstractThe congenital disorders of glycosylation (CDG) are a family of
metabolic diseases in which glycosylation of proteins or lipids is deficient.
GDP-mannose pyrophosphorylase B (GMPPB) mutations lead to CDG, characterized by
neurological and muscular defects. However, the genotype-phenotype correlation
remains elusive, limiting our understanding of the underlying mechanism and
development of ...