Springer Science and Business Media LLC
ESCI-ISI SCOPUS (2020-2023)
2662-8651
Cơ quản chủ quản: SPRINGER , Springer Nature
Lĩnh vực:
Molecular MedicineMolecular Biology
Các bài báo tiêu biểu
Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapyAbstract Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from the donor membrane to the target membrane through the cargo containing vesicles. Vesicle trafficking pathway includes vesicle formation from the donor membrane, vesicle transport,... ... hiện toàn bộ
Tập 3 Số 1
Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapyAbstract Triple negative breast cancer (TNBC) is a subtype of breast cancer, with estrogen receptor, human epidermal growth factor receptor 2 and progesterone receptor negative. TNBC is characterized by high heterogeneity, high rates of metastasis, poor prognosis, and lack of therapeutic targets. Now the treatment of TNBC is still based on surgery and chemotherapy, ... ... hiện toàn bộ
- 2022
Tiến triển trong các dấu ấn khối u liên quan đến exosome và các phương pháp phát hiện của chúng Dịch bởi AI Tóm tắt Exosome được tiết ra bởi các tế bào và hiện diện rộng rãi trong dịch cơ thể. Exosome chứa nhiều thành phần phân tử có nguồn gốc từ tế bào của chúng như protein, mRNA, miRNA, DNA, lipid và glycans, tất cả đều tương tự như nội dung trong các tế bào khối u. Những thành phần này đóng vai trò quan trọng trong nhiều giai đoạn phát triển của khối u, và làm cho exos... ... hiện toàn bộ
Tập 1 Số 1 - 2020
Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidencesAbstract The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several of clinically used “old” drugs have been repurposed to this new disease for the urgent clinical investigation, there is still great demand for more effective therapies for the anti-infections. Here we report the disc... ... hiện toàn bộ
Tập 1 Số 1 - 2020
Cancer metabolism and intervention therapyAbstract Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutrition and hypoxic microenvironment. Tumor cells frantically grab energy sources (such as glucose, fatty acids, and glutamine) from different pathways to produce a ... ... hiện toàn bộ
Tập 2 Số 1 - 2021
Development of therapeutic antibodies for the treatment of diseases Abstract Since the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in 1986, 165 antibody drugs have been approved or are under regulatory review worldwide. With the approval of new drugs for treating a wide range of diseases, including cancer and autoimmune and metabolic disorders, the therapeutic antibody drug market has experienced explos... ... hiện toàn bộ
G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s diseaseAbstract Alzheimer’s disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal cells. Along with these pathological proteins, the disease shows neuroinflammation, neuronal death, impairment in the immune fun... ... hiện toàn bộ
- 2021
Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDSAbstract NeuroAIDS (Neuro Acquired Immunodeficiency Syndrome) or HIV (Human Immunodeficiency Virus) associated neuronal abnormality is continuing to be a significant health issue among AIDS patients even under the treatment of combined antiretroviral therapy (cART). Injury and damage to neurons of the brain are the prime causes of neuroAIDS, which happens due to the... ... hiện toàn bộ
Tập 1 Số 1 - 2020
Alterations of the fecal microbiota in relation to acute COVID-19 infection and recovery Abstract People with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing to severe clinical outcomes remain to be understood. Emerging evidence suggests associations between the gut microbiome and the severity and progression of COVID-19. To better understand the host-microbiota interactions in acute COVID-19, we... ... hiện toàn bộ
GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPBAbstract The congenital disorders of glycosylation (CDG) are a family of metabolic diseases in which glycosylation of proteins or lipids is deficient. GDP-mannose pyrophosphorylase B (GMPPB) mutations lead to CDG, characterized by neurological and muscular defects. However, the genotype-phenotype correlation remains elusive, limiting our understanding of the underly... ... hiện toàn bộ
Tập 2 Số 1 - 2021