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Các bài báo tiêu biểu
Cancer vaccines: past, present and future; a review article
Tập 13 Số 1 - 2022
AbstractImmunotherapy and vaccines have revolutionized disease treatment and
prevention. Vaccines against infectious diseases have been in use for several
decades. In contrast, only few cancer vaccines have been approved for human use.
These include preventative vaccines against infectious agents associated with
cancers, and therapeutic vaccines used as immunotherapy agents to treat cancers.
Chall...
Focal adhesion kinase inhibitor BI 853520 inhibits cell proliferation, migration and EMT process through PI3K/AKT/mTOR signaling pathway in ovarian cancer
- 2021
AbstractFocal adhesion kinase (FAK) activation has been reported to be
associated with cell progression and metastasis in a wide variety of cancer
cells. Target treatment by inhibiting FAK has achieved remarkable effects in
several cancers, but the effect in ovarian cancer has not been reported. In this
study, we determined the role and the underlying molecular mechanism of
BI853520, a novel small...
DCE-MRI radiomics nomogram can predict response to neoadjuvant chemotherapy in esophageal cancer
- 2022
Abstract Objectives To assess volumetric DCE-MRI radiomics nomogram in
predicting response to neoadjuvant chemotherapy (nCT) in EC patients. Methods
This retrospective analysis of a prospective study enrolled EC patients with
stage cT1N + M0 or cT2-4aN0-3M0 who received DCE-MRI within 7 days before
chemotherapy, followed by surgery. Response assessment was graded from 1 to 5
according to the tumor...
The relationship between CD204 M2-polarized tumour-associated macrophages (TAMs), tumour-infiltrating lymphocytes (TILs), and microglial activation in glioblastoma microenvironment: a novel immune checkpoint receptor target
- 2021
Abstract Background Tumour associated macrophages (TAMs) and tumour infiltrating
lymphocytes (TILs) are considered dominant cells in glioblastoma
microenvironment. Aim The purpose of this study was to assess the expression of
CD204+ M2-polarized TAMs in glioblastomas and their relationship with CD4+TILs,
Iba+microglia, and IDH1 mutation. We also exploreed the prognostic value of
these markers on t...
Clinicopathological factors and survival outcomes of signet-ring cell and mucinous carcinoma versus adenocarcinoma of the colon and rectum: a systematic review and meta-analysis
- 2021
Abstract Background Histological subtypes of colorectal cancer may be associated
with varied prognostic features. This systematic review and meta-analysis aimed
to compare clinicopathological characteristics, recurrence and overall survival
between colorectal signet-ring cell (SC) and mucinous carcinoma (MC) to
conventional adenocarcinoma (AC). Methods A literature search of MEDLINE,
EMBASE, Ovid ...
Comprehensive analysis of the MIR4435-2HG/miR-1-3p/MMP9/miR-29-3p/DUXAP8 ceRNA network axis in hepatocellular carcinoma
Tập 12 Số 1 - 2021
AbstractA growing number of studies have shown that competitive endogenous RNA
(ceRNA) regulatory networks might play important roles during the process of
hepatocellular carcinoma (HCC). This study assessed the role of the ceRNA
network in immune cell infiltration in HCC. Immune-related gene sets were
downloaded from Molecular Signatures Database, and differentially expressed
genes were screened ...
Systematic review and meta-analysis of lung cancer brain metastasis and primary tumor receptor expression discordance
Tập 12 Số 1 - 2021
Abstract Background Treatment paradigms for metastatic non-small cell lung
cancer are increasingly based on biomarker-driven therapies, with the most
common alteration being mutation in the epidermal growth factor receptor (EGFR).
Change in expression of such biomarkers could have a profound impact on the
choice and efficacy of a selected targeted therapeutic, and hence the objective
of this study...
Silencing of long non-coding RNA TUC338 inhibits the malignant phenotype of nasopharyngeal cancer cells via modulating the miR-1226-3p/FGF2 axis
AbstractLong noncoding RNAs (lncRNAs) have been suggested as essential
regulators in the cancer progression. LncRNA TUC338 was found to promote the
malignancy of various cancers, however, the involvement of TUC338 in
nasopharyngeal cancer (NPC) has not been well characterized. Here, our results
found the significant overexpression of TUC338 in NPC tissues. Higher level of
TUC338 was also observed ...
Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors
- 2021
Abstract Aim Neuroblastoma is a heterogeneous childhood cancer derived from the
neural crest. The dual cell identities of neuroblastoma include Mesenchymal
(MES) and Adrenergic (ADRN). These identities are conferred by a small set of
tightly-regulated transcription factors (TFs) binding super enhancers,
collectively forming core regulatory circuitries (CRCs). The purpose of this
study was to gain ...
Identification hub genes of consensus molecular subtype correlation with immune infiltration and predict prognosis in gastric cancer
Tập 12 Số 1 - 2021
AbstractGastric cancer (GC) has a great fatality rate, meanwhile, there is still
a lack of available biomarkers for prognosis. The goal of the research was to
discover key and novel potential biomarkers for GC. We screened for the
expression of significantly altered genes based on survival rates from two
consensus molecular subtypes (CMS) of GC. Subsequently, functional enrichment
analysis showed ...