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Excluding external iliac node irradiation during neoadjuvant radiotherapy decreases lower intestinal toxicity without compromising efficacy in T4b rectal cancer patients with tumours involving the anterior structures
Springer Science and Business Media LLC -
Abstract Purpose To explore the impact of excluding the external iliac node
(EIN) from the clinical target volume (CTV) during preoperative radiotherapy in
T4b rectal cancer with anterior structure invasion. Methods We retrospectively
identified 132 patients with T4b rectal cancer involving the anterior structures
who received radiotherapy followed by surgery between May 2010 and June 2019.
Twenty...
Necrosis score as a prognostic factor in stage I–III colorectal cancer: a retrospective multicenter study
Springer Science and Business Media LLC - Tập 14 Số 1
Abstract Background Tumor necrosis results from failure to meet the requirement
for rapid proliferation of tumor, related to unfavorable prognosis in colorectal
cancer (CRC). However, previous studies used traditional microscopes to evaluate
necrosis on slides, lacking a simultaneous phase and panoramic view for
assessment. Therefore, we proposed a whole-slide images (WSIs)-based method to
develop...
Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials
Springer Science and Business Media LLC - Tập 13 Số 1
Abstract Purpose Metastatic spread of prostate cancer to the skeleton may result
in debilitating bone pain. In this review, we address mechanisms underpinning
the pathobiology of metastatic prostate cancer induced bone pain (PCIBP) that
include sensitization and sprouting of primary afferent sensory nerve fibres in
bone. We also review current treatments and pain responses evoked by various
treatm...
Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2
Springer Science and Business Media LLC - Tập 15 Số 1
Abstract Objective Glioma, a malignant primary brain tumor, is notorious for its
high incidence rate. However, the clinical application of temozolomide (TMZ) as
a treatment option for glioma is often limited due to resistance, which has been
linked to hypoxic glioma cell-released exosomes. In light of this, the present
study aimed to investigate the role of exosomal pyruvate kinase M2 (PKM2) in
gl...
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Springer Science and Business Media LLC - Tập 14 Số 1
Abstract Background Lung cancer (LC) causes more deaths worldwide than any other
cancer type. Despite advances in therapeutic strategies, the fatality rate of LC
cases remains high (95%) since the majority of patients are diagnosed at late
stages when patient prognosis is poor. Analysis of the International Association
for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is...
Late effects of high-dose methotrexate in childhood cancer survivors: a Swiss single centre observational study
Springer Science and Business Media LLC - Tập 15 Số 1
Abstract Importance Childhood cancer survivors (CCS) are at risk for late
effects of different organ systems. The currently available screening
recommendations for those treated with high-dose methotrexate (HD-MTX) are not
uniform and the available literature is limited. Objective We aim to assess the
prevalence and severity of late effects in CCS treated with HD-MTX at a single
centre in Switzerl...
Silencing of long non-coding RNA TUC338 inhibits the malignant phenotype of nasopharyngeal cancer cells via modulating the miR-1226-3p/FGF2 axis
Springer Science and Business Media LLC -
AbstractLong noncoding RNAs (lncRNAs) have been suggested as essential
regulators in the cancer progression. LncRNA TUC338 was found to promote the
malignancy of various cancers, however, the involvement of TUC338 in
nasopharyngeal cancer (NPC) has not been well characterized. Here, our results
found the significant overexpression of TUC338 in NPC tissues. Higher level of
TUC338 was also observed ...
The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989
Springer Science and Business Media LLC -
Abstract Background The incidence of uveal melanoma increases with latitude. In
this study, we examine the importance of latitude for uveal melanoma prognosis.
Methods All uveal melanoma patients born in Sweden between 1947 and 1990 were
included (n = 745). The latitude of patients’ birthplaces and home counties at
the time of uveal melanoma diagnosis were collected. For all latitudes, data on
sun...
Effect of miR-27b on the proliferation and apoptosis of diffuse large b-cell lymphoma cells by targeting the regulation of MET/PI3K/AKT pathway
Springer Science and Business Media LLC - Tập 13 Số 1
Abstract Background This study aimed to explore the regulation of miR-27b
expression on MET/PI3K/AKT pathway, and to explain its effect on biological
functions of DLBCL cells. Methods The expressions of miR-27b and MET gene in
DLBCL cells and normal human B cell lines were determined by qRT-PCR. miR-27b
expression in DLBCL cell line Toledo was over-expressed with the cell
transfection method. The ...
Re-immunotherapy with nivolumab plus ipilimumab in advanced non-small cell lung cancer patients previously treated with anti-programmed death-1 and/or anti-programmed death ligand-1 antibodies
Springer Science and Business Media LLC - - 2023
The role of re-immunotherapy in advanced non-small cell lung cancer (NSCLC)
remains unclear. No studies have evaluated the re-immunotherapy regimen
including anti-cytotoxic T-lymphocyte antigen-4 antibody for lung cancer
treatment. This study aimed to investigate the efficacy and safety of
re-immunotherapy with nivolumab plus ipilimumab in patients with advanced NSCLC
previously treated with anti-...
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