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Construction and in vitro evaluation of pH-sensitive nanoparticles to reverse drug resistance of breast cancer stem cells
Springer Science and Business Media LLC - Tập 15 Số 1
Weinan Li, Yuhan Fu, Jialin Sun, Hexin Gong, Rong Yan, Yanhong Wang
AbstractBreast cancer is a major threat to safety and health of women. The breast cancer stem cells (BCSCs) have multi-drug resistance to chemotherapy drugs, which leads to chemotherapy failure. We proposed a strategy of delivery of tumor-killing drugs and a resistance reversal agent, to enhance inhibition of BCSCs. Here, schisandrin B (SchB)/AP NPs are constructed...... hiện toàn bộ
Excluding external iliac node irradiation during neoadjuvant radiotherapy decreases lower intestinal toxicity without compromising efficacy in T4b rectal cancer patients with tumours involving the anterior structures
Springer Science and Business Media LLC -
Anchuan Li, Miaobin Mao, Runfan Chen, Pan Chi, Ying Huang, Junxin Wang, Benhua Xu
Abstract Purpose To explore the impact of excluding the external iliac node (EIN) from the clinical target volume (CTV) during preoperative radiotherapy in T4b rectal cancer with anterior structure invasion. Methods... hiện toàn bộ
Necrosis score as a prognostic factor in stage I–III colorectal cancer: a retrospective multicenter study
Springer Science and Business Media LLC - Tập 14 Số 1
Huifen Ye, Yi-Ting Wang, Su Yao, Zaiyi Liu, Changhong Liang, Yaxi Zhu, Yanfen Cui, Ke Zhao
Abstract Background Tumor necrosis results from failure to meet the requirement for rapid proliferation of tumor, related to unfavorable prognosis in colorectal cancer (CRC). However, previous studies used traditional microscopes to evaluate necrosis on slides, lacking a simultaneous phase and panor...... hiện toàn bộ
Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials
Springer Science and Business Media LLC - Tập 13 Số 1
Amy E. Smith, Arjun Muralidharan, Maree T. Smith
Abstract Purpose Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. In this review, we address mechanisms underpinning the pathobiology of metastatic prostate cancer induced bone pain (PCIBP) that include sensitization and sprouting of primary afferent sensory...... hiện toàn bộ
Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2
Springer Science and Business Media LLC - Tập 15 Số 1
Guofu Li, Zhuo Xiong, Ying Liu, Cong Yan, Yingying Cheng, Yuwen Wang, Jingwei Li, Zifeng Dai, Dongdong Zhang, Du Wang, Chunyang Men, Changbin Shi
Abstract Objective Glioma, a malignant primary brain tumor, is notorious for its high incidence rate. However, the clinical application of temozolomide (TMZ) as a treatment option for glioma is often limited due to resistance, which has been linked to hypoxic glioma cell-released exosomes. In light ...... hiện toàn bộ
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Springer Science and Business Media LLC - Tập 14 Số 1
Karla Rubio, Jochen Müller, Aditi Mehta, Iris Watermann, Till Olchers, Ina Koch, Sabine Wessels, Marc A. Schneider, Tania Araujo-Ramos, Indrabahadur Singh, Christian Kügler, Mircea Gabriel Stoleriu, Mark Kriegsmann, Martin Eichhorn, Thomas Muley, Olivia M. Merkel, Thomas Braun, Ole Ammerpohl, Martin Reck, Achim Tresch, Guillermo Barreto
Abstract Background Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the Inter...... hiện toàn bộ
Late effects of high-dose methotrexate in childhood cancer survivors: a Swiss single centre observational study
Springer Science and Business Media LLC - Tập 15 Số 1
Kevin Brunold, Maria Otth, Katrin Scheinemann
Abstract Importance Childhood cancer survivors (CCS) are at risk for late effects of different organ systems. The currently available screening recommendations for those treated with high-dose methotrexate (HD-MTX) are not uniform and the available literature is limited. ... hiện toàn bộ
Silencing of long non-coding RNA TUC338 inhibits the malignant phenotype of nasopharyngeal cancer cells via modulating the miR-1226-3p/FGF2 axis
Springer Science and Business Media LLC -
Jian Wang, Liping Li, Xue Jiang, Bin Wang, Xiaodong Hu, Weiwei Liu, Ying Zhang
AbstractLong noncoding RNAs (lncRNAs) have been suggested as essential regulators in the cancer progression. LncRNA TUC338 was found to promote the malignancy of various cancers, however, the involvement of TUC338 in nasopharyngeal cancer (NPC) has not been well characterized. Here, our results found the significant overexpression of TUC338 in NPC tissues. Higher l...... hiện toàn bộ
The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989
Springer Science and Business Media LLC -
Gustav Stålhammar, Pete A. Williams, Tomas Landelius
Abstract Background The incidence of uveal melanoma increases with latitude. In this study, we examine the importance of latitude for uveal melanoma prognosis. Methods All uveal melanoma pat...... hiện toàn bộ
Effect of miR-27b on the proliferation and apoptosis of diffuse large b-cell lymphoma cells by targeting the regulation of MET/PI3K/AKT pathway
Springer Science and Business Media LLC - Tập 13 Số 1
Rui Zhang, Tianjiao Huang, Jinfeng Li, Hong Zhou, Xuemei Wang
Abstract Background This study aimed to explore the regulation of miR-27b expression on MET/PI3K/AKT pathway, and to explain its effect on biological functions of DLBCL cells. Methods The ex...... hiện toàn bộ
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