Springer Science and Business Media LLC
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Muscle spindle function in healthy and diseased muscle
Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2021
Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this information, the CNS computes the position and movement of our extremities in space, which is a requirement for motor control, for maintaining posture and for a stable gait. Many neuromuscular......
The effects of neuregulin-1β on intrafusal muscle fiber formation in neuromuscular coculture of dorsal root ganglion explants and skeletal muscle cells
Springer Science and Business Media LLC - - 2018
The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration
Springer Science and Business Media LLC - Tập 6 - Trang 1-10 - 2016
Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its dual role as an epigenetic regulator and in the regulation of non-histone proteins through direct methylation, G9a has been implicated in a number of biological processes relevant to cell fate control. Recent reports employing in vitro cell l......
Treatment with rGDF11 does not improve the dystrophic muscle pathology of mdx mice
Springer Science and Business Media LLC - Tập 6 - Trang 1-8 - 2016
Duchenne muscular dystrophy (DMD) is an inherited lethal muscle wasting disease characterized by cycles of degeneration and regeneration, with no effective therapy. Growth differentiation factor 11 (GDF11), a member of the TGF-β superfamily and myostatin homologous, has been reported to have the capacity to reverse age-related skeletal muscle loss. These initial findings led us to investigate the ......
High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity
Springer Science and Business Media LLC - Tập 4 - Trang 1-11 - 2014
Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic alterations at the D4Z4 macrosatellite repeat locus on chromosome 4, resulting in inappropriate expression of the DUX4 protein. The DUX4 protein is therefore the primary molecular target for therapeutic intervention. We have developed a high-throughput screen based on the toxicity of DUX4 when overexpressed in C2C12 myoblasts, a......
Heme oxygenase and carbon monoxide protect from muscle dystrophy
Springer Science and Business Media LLC - Tập 6 - Trang 1-12 - 2016
Duchenne muscle dystrophy (DMD) is one of the most common lethal genetic diseases of children worldwide and is 100% fatal. Steroids, the only therapy currently available, are marred by poor efficacy and a high side-effect profile. New therapeutic approaches are urgently needed. Here, we leverage PGC-1α, a powerful transcriptional coactivator known to protect against dystrophy in the mdx murine mod......
PPARδ regulates satellite cell proliferation and skeletal muscle regenerationAbstract
Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism. Whereas PPARδ has been shown to regulate mitochondrial biosynthesis and slow-muscle fiber types, its function in skeletal muscle progenitors (satellite cells) is unknown. Since constitutive mutation ... ...
Springer Science and Business Media LLC - Tập 1 Số 1 - 2011
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells
Springer Science and Business Media LLC - Tập 4 - Trang 1-16 - 2014
Via the hepatocyte growth factor receptor (Met), hepatocyte growth factor (HGF) exerts key roles involving skeletal muscle development and regeneration. Heparan sulfate proteoglycans (HSPGs) are critical modulators of HGF activity, but the role of specific HSPGs in HGF regulation is poorly understood. Glypican-1 is the only HSPG expressed in myoblasts that localize in lipid raft membrane domains, ......
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
Springer Science and Business Media LLC - Tập 3 - Trang 1-19 - 2013
The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases. We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a......
Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell lines
Springer Science and Business Media LLC - Tập 6 - Trang 1-12 - 2016
hTERT/cdk4 immortalized myogenic human cell lines represent an important tool for skeletal muscle research, being used as therapeutically pertinent models of various neuromuscular disorders and in numerous fundamental studies of muscle cell function. However, the cell cycle is linked to other cellular processes such as integrin regulation, the PI3K/Akt pathway, and microtubule stability, raising t......
Tổng số: 292
- 1
- 2
- 3
- 4
- 5
- 6
- 10