Christopher S. Fry, Micah J. Drummond, Erin L. Glynn, Jared M. Dickinson, David M. Gundermann, Kyle L. Timmerman, D.M.H. Walker, Shaheen Dhanani, Elena Volpi, Blake B. Rasmussen
Abstract Background Sarcopenia, the loss of skeletal muscle mass during aging,
increases the risk for falls and dependency. Resistance exercise (RE) training
is an effective treatment to improve muscle mass and strength in older adults,
but aging is associated with a smaller amount of training-induced hypertrophy.
This may be due in part to an inability to stimulate muscle-protein synthesis
(MPS) ... hiện toàn bộ
Abstract Background As the resident stem cells of skeletal muscle, satellite
cells are activated by extracellular cues associated with local damage. Once
activated, satellite cells will re-enter the cell cycle to proliferate and
supply a population of myoblasts, which will repair or replace damaged myofibers
by differentiating and fusing either with an existing myofiber or with each
other. There i... hiện toàn bộ