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Radioprotection by pretreatment with deuterated water: cytokinetic changes in the small intestine of the mouse
Springer Science and Business Media LLC - Tập 54 - Trang 214-220 - 1987
All mice partially deuterated by ingestion of 29% heavy water for 12 days survived whole body gamma irradiation (8.5 Gy) from a60Co source, whereas 42% of nondeuterated control animals died from bone marrow failure. The incorporation of3HTdR into enterocytic DNA, as measured by autoradiography and liquid scintillation spectrometry, was used to assess the proliferative activity of small intestinal ...... hiện toàn bộ
The response of the mouse R-E system to infection withToxoplasma gondii
Springer Science and Business Media LLC - Tập 20 - Trang 55-69 - 1976
Groups of mice were inoculated with strains ofToxoplasma gondii of either high or low virulence strains. The response of the lymph nodes, spleen and thymus was studied histologically and antibodies were assessed by the dye-test technique. The low-virulence strain induced changes in all three organs indicative of an immunological response, both in respect of cellular and humoral immunity. The high-...... hiện toàn bộ
Ultrastructural and functional changes in pancreatic acinar cells during autolysis
Springer Science and Business Media LLC - Tập 24 - Trang 197-207 - 1977
Effects of anoxemic cell injury on rat pancreatic acinar cells were studied in a preparation where tissue samples were incubated at temperature between 18–20° C in a moist atmosphere for 0, 0.5, 1, 3, 6, 12, and 24 h in vitro. Electron microscopy revealed that disintegration of acinar cells began by swelling of various cell compartments and gradual breakdown of cell membranes. Zymogen granules rem...... hiện toàn bộ
Characterization of proteoglycans and glycosaminoglycans in bovine renal AA-type amyloidosis
Springer Science and Business Media LLC - Tập 60 - Trang 321-328 - 1991
Highly sulfated glycosaminoglycans (GAG) or proteoglycans (PG), especially heparan sulfate (HS) and heparan sulfate proteoglycan (HSPG), are considered to be intimately associated with amyloid deposits in different types of amyloidosis. Based on this relationship an important role for HS has been suggested in amyloidogenesis. The present immunohistological and ultrastructural study shows that in b...... hiện toàn bộ
The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats
Springer Science and Business Media LLC - Tập 36 - Trang 59-63 - 1981
Daily oral administration of 20 or 60 mg/kg chlorphentermine for 1 week produced a dose-related increase in the number of myeloid bodies in renal tissue of both adult and newborn rats. In adults myeloid bodies were present throughout the kidney while in neonates these bodies were found predominantly in the medullary region. Simultaneous administration of phenobarbital and either chlorphentermine d...... hiện toàn bộ
Immune suppression and histophysiology of the immune response
Springer Science and Business Media LLC - Tập 43 - Trang 43-54 - 1983
Seven daily intramuscular (im) injections of cortisone acetate (25 mg/Kg b.w.) given to rats or rabbits produced, (i) a pronounced reduction in the numbers of small lymphocytes in thymus-independent areas, (ii) atrophy of the thymic cortex, (iii) atrophy of germinal centres and (iv) a consequent depressed production of germinal centre-derived cells. Lymphocyte depletion was not caused by cell lysi...... hiện toàn bộ
Human hepatocyte polyploidization kinetics in the course of life cycle
Springer Science and Business Media LLC - Tập 64 - Trang 387-393 - 1993
The processes of polyploidization in normal human liver parenchyma from 155 individuals aged between 1 day and 92 years were investigated by Feulgen-DNA cytophotometry. It was shown that polyploid hepatocytes appear in individuals from 1 to 5 years old. Up to the age of 50 years the accumulation rate of binucleate and polyploid cells is very slow, but subsequently hepatocyte polyploidization is in...... hiện toàn bộ
Lack of mast cell reactivity during leukemic infiltration of the rat mesentery under syngeneic and allogeneic conditions
Springer Science and Business Media LLC - Tập 49 - Trang 277-284 - 1985
The ultrastructural morphology of mast cells localized in rat mesenteries was studied after intraperitoneal implantation of L 5222 rat leukemia cells in syngeneic and allogenic hosts. It became evident that the mast cells in the syngeneic (BDIX rat) as well as the allogeneic system (BN rat) showed nor morphological alterations. Degranulation was never observed. This is in contrast to the behavior ...... hiện toàn bộ
Cell proliferation at different sites along the length of the rat colon
Springer Science and Business Media LLC - Tập 32 - Trang 75-87 - 1980
This study has been undertaken in order to compare in detail cell proliferation in the mucosal crypts at several sites along the length of the large bowel of the rat. The techniques which have been used include simple morphometry, calculation of mitotic and tritiated thymidine labelling indices, metaphase arrest with vincristine, and the fraction of labelled mitoses method. Major differences exist...... hiện toàn bộ
Extracellular matrix of cultivated, poorly differentiated human gastric adenocarcinoma cells promotes attachment and spreading of mesenchymal cells
Springer Science and Business Media LLC - Tập 55 - Trang 293-298 - 1988
To clarify interactions between carcinoma and mesenchymal cells, we examined the extracellular matrix-substance remaining on culture dishes after confluent growths of gastric carcinoma cells were removed with EDTA. The matrix synthesized by poorly differentiated adenocarcinoma cells (cell lines KATO-III and MKN-45) cultivated in serum-free medium has a fibroblast (cell line WI38)-attachment activi...... hiện toàn bộ
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