Mitoses and binucleated cells in perinatal human hearts
Tóm tắt
Cells from hardened formalin-fixed human hearts were isolated with potash lye. In perinatal hearts mitoses and evidence of irregular chromosomal movement such as chromatin bridges and micronuclei were observed in small numbers during normal development. A quantitative analysis of binucleated cells shows 8.8 ± 5.3% in the left and 11.7 ± 4.0% in the right ventricular wall around the time of birth. The number increases during the first year of life to 56.8 + 17.4% in the left and 42.0 ± 18.1% in the right heart. This development precedes normal polyploidisation of the human heart by years.
Tài liệu tham khảo
Adler CP (1976) DNS in Kinderherzen. Biochemische und zytophotometrische Untersuchungen. Beitr Pathol 158:173–202
Adler CP, Hueck C (1971) Der DNS-Gehalt im wachsenden Menschenherzen. Verh dtsch Ges Pathol 55:464–471
Avtandilov GG, Babaev VR (1977) Sequential changes in the content of nuclear DNA in the cardiac myocyte nuclei after experimental myocardial infarction in rats [Russian]. Acad Med Sci Bull Expt Biol 366–368
Brodsky WY, Uryvaeva IV (1977) Cell polyploidy: Its relation to tissue growth and function. Int Rev Cytol 50:275–332
Brodsky WY, Arefyeva AM, Uryvaeva IV (1980) Mitotic polyploidisation of mouse heart mycocytes during the first postnatal week. Cell Tissue Res 210:133–144
David H, Marx I (1977) Quantitative and qualitative Veränderungen der Herzmuskulatur des linken Ventrikels männlicher Ratten während der Entwicklung und Reifung in den ersten 6 Lebensmonaten. Z Mikros Anat Forsch 91:709–736
Ebert J, Pfitzer P (1977) Nuclear DNA of myocardial cells in the periphery of infarctions and scars. Virchows Arch [Cell-Pathol] 24:209–217
Gräbner W, Pfitzer P (1974) Number of nuclei in isolated myocardial cells of pigs. Virchows Arch [Cell Pathol] 15:279–294
Hort W (1953) Quantitative histologische Untersuchungen an wachsenden Herzen. Virchows Arch [Pathol Anat] 323:223–242
Katzberg A, Farmer B, Harris B (1977) The predominance of binucleation in isolated rat heart myocytes. Am J Anat 149:489–500
Klinge O (1967) Proliferations- und Regenerationsvorgänge am Myocard. Lichtmikroskopische und autoradiographische Untersuchungen am unversehrten und infarzierten Herzmuskel erwachsener Ratten. Z Zellforsch 80:488–517
Klinge O, Stöcker E (1968) Die DNS-Synthese im Rattenherzen als Funktion des Lebensalters. Autoradiographische Untersuchungen mit3H-Thymidin. Experientia [Basel] 24:167–168
Klinge O (1970) Karyokinese und Kernmuster im Herzmuskel wachsender Ratten. Virchows Arch [Cell Pathol] 6:208–219
Klinge O (1971) Das Kernmuster im postnatalen Rattenherzen als Funktion der mitotischen Aktivität. Verh Dtsch Ges Pathol 55:458–464
Kogan ME, Belov LN, Leontjeva TA (1976) Estimation of the cell number in various organs and tissues after alkaline dissociation [Russian]. Arch Pathol [USSR] 38:77–80
Langes K, Arnold G, Pfitzer P (1983) Postnatal DNA-synthesis and mitoses in hearts of dwarf pigs. J Mol Cell Cardiol 15:831–844
MacMahon HE (1938) Hypertrophy of the heart in infants. Am J Dis Child 55:93–99
Murphy GE, Becker CG (1966) Occurance of caterpillar nuclei within normal immature and normal appearing and altered mature heart muscle cells and the evolution of Anitschkow cells from the latter. Am J Pathol 48:931–957
Oberpriller JO, Ferrans VJ, Carroll RJ (1983) Changes in DNA content, number of nuclei and cellular dimensions of young rat atrial myocytes in response to left coronary artery ligation. J Mol Cell Card 15:31–42
Pfitzer P (1971) Nuclear DNA content of human myocardial cells. Curr Topics Pathol 54:125–168
Pfitzer P (1980) Amitosis: a historical misinterpretation? Pathol Res Pract 167:292–300
Rumyantsev PP (1977) Interrelations of the proliferation and differentiation processes during cardiac myogenesis and regeneration. Int Rev Cytol 51:187–273
Rumyantsev PP (1982) Cardiomyocytes in reproduction, differentiation and regeneration [Russian]. Academy of Sciences Leningrad USSR
Schmid G (1983) Mitosen und Mitosespuren im kindlichen Myokard. Diss Med Fakult Düsseldorf
Schneider R, Pfitzer P (1973) Die Zahl der Kerne in isolierten Zellen des menschlichen Myocards. Virchows Arch [Cell Pathol] 12:238–258
Shozawa T, Kawamura K (1980) Double nuclei in the regenerating process of cardiac muscle fibres in experimental diphtheria In: Sekiguchi M, Olsen EG, (eds). Cardiomyopathy, clinical, pathological and theoretical aspects. University of Tokyo Press Tokyo, University Park Press, Baltimore, pp 185–196
Solger B (1900) Zur Kenntnis und Beurteilung der Kernreihen im Myokard. Anat Anz 18:115–121
Weismann A (1861) Über die Musculatur des Herzens beim Menschen und in der Tierreihe. Arch Anat Physiol Wiss Med: 42–63
Zak R (1973) Cell proliferation during cardiac growth. Am J Cardiol 31:211–219
Zak R (1974) Development and proliferation capacity of cardiac muscle cells. Circ Res [Suppl 35] 2:17–26