Spatial distribution of Langerhans’ cells and T-lymphocyte subpopulations in human tympanic membrane and aural cholesteatoma

Springer Science and Business Media LLC - Tập 52 - Trang 143-152 - 1986
C. M. van Dijk1, C. E. Visser1, J. E. Veldman2
1Laboratory of Histophysiology and Exp. Pathology, University of Utrecht, The Netherlands
2Department of Otorhinolaryngology, University Hospital, GV Utrecht, The Netherlands

Tóm tắt

Immunohistochemical analysis of human cholesteatoma matrices revealed the presence of Langerhans’ cells and T-lymphocytes. Through cell-to-cell interaction, Langerhans’ cells probably play a key role in skin-related disorders, including cholesteatomas. They probably originate from a mobile cell population of monocyte origin and migrate into and out of the body’s lining. Their custodial function is often carried out in close relation with T-lymphocytes. Monoclonal antibodies against Langerhans’ cells and T-lymphocyte membrane receptors reveal the presence of these cell populations in cholesteatoma matrices but not in the tympanic membrane. Langerhans’ cells and T-cell “traffic” through cholesteatomas are discussed in relation to the pathogenesis, natural course and recurrence of cholesteatomas. Through immunopathologic evaluation the clinical aggressiveness of a cholesteatoma may become predictable. It may even have consequences for the future handling of cholesteatomas.

Tài liệu tham khảo

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