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Assessment of acquisition protocols for routine imaging of Y-90 using PET/CT
Springer Science and Business Media LLC - Tập 3 - Trang 1-12 - 2013
Despite the early theoretical prediction of the 0+-0+ transition of 90Zr,
90Y-PET underwent only recently a growing interest for the development of
imaging radioembolization of liver tumors. The aim of this work was to determine
the minimum detectable activity (MDA) of 90Y by PET imaging and the impact of
time-of-flight (TOF) reconstruction on detectability and quantitative accuracy
according to t...
Could 18 F-DPA-714 PET imaging be interesting to use in the early post-stroke period?
Springer Science and Business Media LLC - Tập 4 - Trang 1-8 - 2014
Cerebral stroke is a severe and frequent condition that requires rapid and
reliable diagnosis. If administered shortly after the first symptoms manifest
themselves, IV thrombolysis has been shown to increase the functional prognosis
by restoring brain reperfusion. However, a better understanding of the
pathophysiology of stroke should help to identify potential new therapeutic
targets. Stroke is k...
[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma
Springer Science and Business Media LLC - Tập 13 Số 1
Abstract Background Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC)
are widely used for detection of pheochromocytomas/paraganglioma (PPGL).
However, direct comparisons of the performance of the two tracers are only
available in small series. We conducted a retrospective comparative analysis of
FDOPA and DOTATOC to assess their sensitivity and accuracy in detecting PPGL
when administere...
18 F-fluorothymidine uptake in follicular lymphoma and error-prone DNA repair
Springer Science and Business Media LLC - Tập 4 - Trang 1-7 - 2014
We observed a disproportional 18 F-fluorothymidine (F-FLT) uptake in follicular
lymphoma (FL) relative to its low cell proliferation. We tested the hypothesis
that the ‘excess’ uptake of 18 F-FLT in FL is related to error-prone DNA repair
and investigated whether this also contributes to 18 F-FLT uptake in diffuse
large B cell lymphoma (DLBCL). We performed immunohistochemical stainings to
assess ...
Cell injury after ischemia and reperfusion in the porcine kidney evaluated by radiolabelled microspheres, sestamibi, and lactadherin
Springer Science and Business Media LLC - Tập 3 Số 1 - 2013
Abstract Background The purpose of the present study was to quantify renal cell
injury after ischemia and reperfusion in a pig model using 99mTc-lactadherin as
a marker of apoptosis and 99mTc-sestamibi as a marker of mitochondrial
dysfunction. Methods Thirty-four pigs were randomized into unilateral renal warm
ischemia of 120 (WI120) or 240 min (WI240). The glomerular filtration rate (GFR)
was cal...
KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver
Springer Science and Business Media LLC - Tập 10 - Trang 1-13 - 2020
Deriving individual tumor genomic characteristics from patient imaging analysis
is desirable. We explore the predictive value of 2-[18F]FDG uptake with regard
to the KRAS mutational status of colorectal adenocarcinoma liver metastases
(CLM). 2-[18F]FDG PET/CT images, surgical pathology and molecular diagnostic
reports of 37 patients who underwent PET/CT-guided biopsy of CLM were reviewed
under an ...
Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
Springer Science and Business Media LLC - - 2012
Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand
for dopamine transporters (DATs), has been used for in vivo studies in humans,
monkeys, and rats but has not yet been used extensively in mice. To validate the
imaging and analysis methods for preclinical DAT imaging, wild-type healthy mice
were scanned using 123I-β-CIT. The pharmacokinetics and reliability of
123I-β-CIT...
Contrast-noise-ratio (CNR) analysis and optimisation of breast-specific gamma imaging (BSGI) acquisition protocols
Springer Science and Business Media LLC - Tập 3 Số 1 - Trang 1-9 - 2013
Breast cancer is one of the most prevalent forms of cancer in women.
Breast-specific gamma imaging (BSGI) is a diagnostic imaging method that uses
sestamibi-labelled 99Tc and a dedicated gamma camera to localize malignant
lesions in breast tissue. The aim of this study is to investigate if the current
acquisition protocol for BSGI at our hospital is optimized for the detection of
lesions in our pa...
[18F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection
Springer Science and Business Media LLC - Tập 10 - Trang 1-12 - 2020
The objective of this study was to investigate the prognostic value of
2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake of bone marrow (BM) and
metabolic parameters of primary tumor on positron emission tomography/computed
tomography (PET/CT) for predicting distant recurrence in patients with breast
cancer. Pretreatment [18F]FDG PET/CT images of 345 breast cancer patients were
retrospectively eva...
A novel 11C-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography
Springer Science and Business Media LLC - Tập 5 - Trang 1-9 - 2015
Nucleoside analogs labeled with positrons, such as 11C and 18F, are considered
valuable in visualizing the proliferative activity of tumor cells in vivo using
positron emission tomography (PET). We recently developed the 11C-labeled
thymidine analogs [11C]zidovudine ([11C]AZT) and [11C]stavudine ([11C]d4T) via
the Pd(0)-Cu(I) co-mediated rapid C–C coupling reaction. In this study, to
examine wheth...
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