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Could 18 F-DPA-714 PET imaging be interesting to use in the early post-stroke period?
Springer Science and Business Media LLC - Tập 4 - Trang 1-8 - 2014
Maria-Joao Ribeiro, Isabelle Bonnaud, Michael Kassiou, Johnny Vercouillie, Samuel Banister, Vincent Camus, Jean-Philippe Cottier, Denis Guilloteau, Severine Debiais, Nicolas Arlicot
Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic targets. Stroke is k...... hiện toàn bộ
Contrast-noise-ratio (CNR) analysis and optimisation of breast-specific gamma imaging (BSGI) acquisition protocols
Springer Science and Business Media LLC - Tập 3 Số 1 - Trang 1-9 - 2013
Dieckens, Dennis, Lavalaye, Jules, Romijn, Leo, Habraken, Jan
Breast cancer is one of the most prevalent forms of cancer in women. Breast-specific gamma imaging (BSGI) is a diagnostic imaging method that uses sestamibi-labelled 99Tc and a dedicated gamma camera to localize malignant lesions in breast tissue. The aim of this study is to investigate if the current acquisition protocol for BSGI at our hospital is optimized for the detection of lesions in our pa...... hiện toàn bộ
Effective dose estimation for oncological and neurological PET/CT procedures
Springer Science and Business Media LLC - Tập 7 - Trang 1-8 - 2017
Josep M. Martí-Climent, Elena Prieto, Verónica Morán, Lidia Sancho, Macarena Rodríguez-Fraile, Javier Arbizu, María J. García-Velloso, José A. Richter
The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds. PET/CT studies of 210 patients were reviewed including Torso (n = 123), Whole body (WB) (n = 36), Head and Neck Tumor (HNT) (n = 10), and Brain (n = 41) protocols with 18FDG (n = 170), 11C-CHOL (n = 10), 18FDOPA (n = 10...... hiện toàn bộ
Automated computer quantification of breast cancer in small-animal models using PET-guided MR image co-segmentation
Springer Science and Business Media LLC - Tập 3 - Trang 1-13 - 2013
Ulas Bagci, Gabriela Kramer-Marek, Daniel J Mollura
Care providers use complementary information from multiple imaging modalities to identify and characterize metastatic tumors in early stages and perform surveillance for cancer recurrence. These tasks require volume quantification of tumor measurements using computed tomography (CT) or magnetic resonance imaging (MRI) and functional characterization through positron emission tomography (PET) imagi...... hiện toàn bộ
Pharmacokinetic modeling of [18F]fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds
Springer Science and Business Media LLC - Tập 6 Số 1 - Trang 1-11 - 2016
Khamwan, Kitiwat, Plyku, Donika, O’Reilly, Shannon E., Goodkind, Alison, Cao, Xinhua, Fahey, Frederic H., Treves, S. Ted, Bolch, Wesley E., Sgouros, George
Absorbed dose estimates for pediatric patients require pharmacokinetics that are, to the extent possible, age-specific. Such age-specific pharmacokinetic data are lacking for many of the diagnostic agents typically used in pediatric imaging. We have developed a pharmacokinetic model of [18F]fluorodeoxyglucose (FDG) applicable to premature infants and to 0- (newborns) to 5-year-old patients, which ...... hiện toàn bộ
Measurement of metabolic tumor volume: static versus dynamic FDG scans
Springer Science and Business Media LLC - Tập 1 - Trang 1-9 - 2011
Patsuree Cheebsumon, Floris HP van Velden, Maqsood Yaqub, Corneline J Hoekstra, Linda M Velasquez, Wendy Hayes, Otto S Hoekstra, Adriaan A Lammertsma, Ronald Boellaard
Metabolic tumor volume assessment using positron-emission tomography [PET] may be of interest for both target volume definition in radiotherapy and monitoring response to therapy. It has been reported, however, that metabolic volumes derived from images of metabolic rate of glucose (generated using Patlak analysis) are smaller than those derived from standardized uptake value [SUV] images. The pur...... hiện toàn bộ
The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy
Springer Science and Business Media LLC - Tập 12 - Trang 1-14 - 2022
Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by application of therapeutic radionuclides. This review highlights the remarkable progress during the last two decades in the development of the NIS gene ther...... hiện toàn bộ
Use of a beta microprobe system to measure arterial input function in PET via an arteriovenous shunt in rats
Springer Science and Business Media LLC - Tập 1 - Trang 1-11 - 2011
Geoff Warnock, Mohamed-Ali Bahri, David Goblet, Fabrice Giacomelli, Christian Lemaire, Joel Aerts, Alain Seret, Xavier Langlois, Andre Luxen, Alain Plenevaux
Kinetic modeling of physiological function using imaging techniques requires the accurate measurement of the time-activity curve of the tracer in plasma, known as the arterial input function (IF). The measurement of IF can be achieved through manual blood sampling, the use of small counting systems such as beta microprobes, or by derivation from PET images. Previous studies using beta microprobe s...... hiện toàn bộ
Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising
Springer Science and Business Media LLC - Tập 7 - Trang 1-12 - 2017
Sandeep S. V. Golla, Mark Lubberink, Bart N. M. van Berckel, Adriaan A. Lammertsma, Ronald Boellaard
Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution of PET studies without the need for structural information (e.g. MR scans). On the other hand, deconvolution also...... hiện toàn bộ
Development and evaluation of a rapid analysis for HEPES determination in 68Ga-radiotracers
Springer Science and Business Media LLC - Tập 8 - Trang 1-10 - 2018
Sarah Pfaff, Tina Nehring, Verena Pichler, Jens Cardinale, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak
HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantification, but this analysis suffers from low reliability and reproducibility and is based on...... hiện toàn bộ
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