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Assessment of acquisition protocols for routine imaging of Y-90 using PET/CT
Springer Science and Business Media LLC - Tập 3 - Trang 1-12 - 2013
Thomas Carlier, Thomas Eugène, Caroline Bodet-Milin, Etienne Garin, Catherine Ansquer, Caroline Rousseau, Ludovic Ferrer, Jacques Barbet, Frédéric Schoenahl, Françoise Kraeber-Bodéré
Despite the early theoretical prediction of the 0+-0+ transition of 90Zr, 90Y-PET underwent only recently a growing interest for the development of imaging radioembolization of liver tumors. The aim of this work was to determine the minimum detectable activity (MDA) of 90Y by PET imaging and the impact of time-of-flight (TOF) reconstruction on detectability and quantitative accuracy according to t...... hiện toàn bộ
Could 18 F-DPA-714 PET imaging be interesting to use in the early post-stroke period?
Springer Science and Business Media LLC - Tập 4 - Trang 1-8 - 2014
Maria-Joao Ribeiro, Isabelle Bonnaud, Michael Kassiou, Johnny Vercouillie, Samuel Banister, Vincent Camus, Jean-Philippe Cottier, Denis Guilloteau, Severine Debiais, Nicolas Arlicot
Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic targets. Stroke is k...... hiện toàn bộ
[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma
Springer Science and Business Media LLC - Tập 13 Số 1
Peter Iversen, Stine Kramer, Andreas Ebbehøj, Esben Søndergaard, Kirstine Stochholm, Per Løgstrup Poulsen, Karin Hjorthaug
Abstract Background Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only available in small series. We c...... hiện toàn bộ
18 F-fluorothymidine uptake in follicular lymphoma and error-prone DNA repair
Springer Science and Business Media LLC - Tập 4 - Trang 1-7 - 2014
Marielle J Wondergem, Ken Herrmann, Sergei Syrbu, Josée M Zijlstra, Nikie Hoetjes, Otto S Hoekstra, Saskia AGM Cillessen, Laura M Moesbergen, Andreas K Buck, Julie M Vose, Malik E Juweid
We observed a disproportional 18 F-fluorothymidine (F-FLT) uptake in follicular lymphoma (FL) relative to its low cell proliferation. We tested the hypothesis that the ‘excess’ uptake of 18 F-FLT in FL is related to error-prone DNA repair and investigated whether this also contributes to 18 F-FLT uptake in diffuse large B cell lymphoma (DLBCL). We performed immunohistochemical stainings to assess ...... hiện toàn bộ
Cell injury after ischemia and reperfusion in the porcine kidney evaluated by radiolabelled microspheres, sestamibi, and lactadherin
Springer Science and Business Media LLC - Tập 3 Số 1 - 2013
Stine Søgaard Pedersen, Anna Krarup Keller, Marie Kaldahl Nielsen, Bente Jespersen, Lise Falborg, Jan T. Rasmussen, Christian W. Heegaard, Michael Rehling
Abstract Background The purpose of the present study was to quantify renal cell injury after ischemia and reperfusion in a pig model using 99mTc-lactadherin as a marker of apoptosis and 99mTc-sestamibi as a marker of mitochondrial dysfunction. ...... hiện toàn bộ
KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver
Springer Science and Business Media LLC - Tập 10 - Trang 1-13 - 2020
M. Popovic, O. Talarico, J. van den Hoff, H. Kunin, Z. Zhang, D. Lafontaine, S. Dogan, J. Leung, E. Kaye, C. Czmielewski, M. E. Mayerhoefer, P. Zanzonico, R. Yaeger, H. Schöder, J. L. Humm, S. B. Solomon, C. T. Sofocleous, A. S. Kirov
Deriving individual tumor genomic characteristics from patient imaging analysis is desirable. We explore the predictive value of 2-[18F]FDG uptake with regard to the KRAS mutational status of colorectal adenocarcinoma liver metastases (CLM). 2-[18F]FDG PET/CT images, surgical pathology and molecular diagnostic reports of 37 patients who underwent PET/CT-guided biopsy of CLM were reviewed under an ...... hiện toàn bộ
Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
Springer Science and Business Media LLC - - 2012
Miia Pitkonen, Eero Hippeläinen, Mari Raki, Jaan-Olle Andressoo, Arto Urtti, Pekka T Männistö, Sauli Savolainen, Mart Saarma, Kim Bergström
Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, wild-type healthy mice were scanned using 123I-β-CIT. The pharmacokinetics and reliability of 123I-β-CIT...... hiện toàn bộ
Contrast-noise-ratio (CNR) analysis and optimisation of breast-specific gamma imaging (BSGI) acquisition protocols
Springer Science and Business Media LLC - Tập 3 Số 1 - Trang 1-9 - 2013
Dieckens, Dennis, Lavalaye, Jules, Romijn, Leo, Habraken, Jan
Breast cancer is one of the most prevalent forms of cancer in women. Breast-specific gamma imaging (BSGI) is a diagnostic imaging method that uses sestamibi-labelled 99Tc and a dedicated gamma camera to localize malignant lesions in breast tissue. The aim of this study is to investigate if the current acquisition protocol for BSGI at our hospital is optimized for the detection of lesions in our pa...... hiện toàn bộ
[18F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection
Springer Science and Business Media LLC - Tập 10 - Trang 1-12 - 2020
Jeong Won Lee, Sung Yong Kim, Sun Wook Han, Jong Eun Lee, Hyun Ju Lee, Nam Hun Heo, Sang Mi Lee
The objective of this study was to investigate the prognostic value of 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake of bone marrow (BM) and metabolic parameters of primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in patients with breast cancer. Pretreatment [18F]FDG PET/CT images of 345 breast cancer patients were retrospectively eva...... hiện toàn bộ
A novel 11C-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography
Springer Science and Business Media LLC - Tập 5 - Trang 1-9 - 2015
Tsuyoshi Tahara, Zhouen Zhang, Masahiro Ohno, Yukako Hirao, Nami Hosaka, Hisashi Doi, Masaaki Suzuki, Hirotaka Onoe
Nucleoside analogs labeled with positrons, such as 11C and 18F, are considered valuable in visualizing the proliferative activity of tumor cells in vivo using positron emission tomography (PET). We recently developed the 11C-labeled thymidine analogs [11C]zidovudine ([11C]AZT) and [11C]stavudine ([11C]d4T) via the Pd(0)-Cu(I) co-mediated rapid C–C coupling reaction. In this study, to examine wheth...... hiện toàn bộ
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